MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE -------------PAAAPAAAPADSKPNGG---TGNGGSGLASAAPPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESIPEGQAQQRRPYRRRRYPPYYMRRPYGRRPQYSNPPVQGEIVEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAAEPPAENTSAPEAEQGGAE MSSEAETQQPPAAPPAA--LSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNLYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE ----------------------------------GSGGPGGLTSAAaPAGGDKKVIARKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAD TSSEAKTQQPPAAPpPAAPALSAADTKPGTTGSSAGSGGPGGLTSAALAGGDKKVIATKVLGTVKWFNVRNGYGYINRNDTKEDGFVHQTAIKKNNPRKYLRSVRDGETVEFDV-EGEKGAEAANVTGPGGVPVQGSKYAADRNHYRGYPRRRGPPRNYQQNYQNSESGEKNEGSESAPfrslsrdKAQAQQRRPYRRRRFPPYYMQRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPGEDGNEEDKENQGDETQGQQPPQRWYRRNFNYRRRRPENPKPRDGKETKAADPPAENSYAPEAEQGRAE ----------------------------------GNGGSGLASAAPPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGAENIPEGQAQQRRPYRRRRYPPYYMRRPYGRRPQYSNPPVQGEIVEGADNQGAGDQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQSQQPPQRRYRRNFNYRRRRPENPKPQDGKETKTAEPPAENTSAPEAEQGGAE MSSEAPTQQPPAAP--A--LSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIARKVLGTVKWFNVRNGYGFINRNDTKEDAFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGMPVQGSKYAADRNHCRKYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFP--------GRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE ---------------------RCRHQARHHGQRRRERGPGRPHIGGACRRG-KV--TKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE --------------SAAPALSAADTKAGTTRSCLGSGCPGGLTSAAPAGGDKKVIARKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEEGAEAANVTGPGGVPVPGSKYAADRNHYRRYPCRRGPPCNYQQNYQNSESGEKNEGSEGAPEGQAQQ-XPXRRRRFPPYYMRRPCGRRPQYANPPVQGEVMEGADNQGAGEQGRPMRQNTYRGYRPRFRRGPPHQRQPREDSNEEDKENQGDETQGQQPPQRRYRRNFSYQHRRPENPKPQDGKETKAADPPAEDASAPEAEQGGAE MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIGegrtgtgsptrslprvargrgapptqagvgraaasftcspprgracppglharpswartrgaagsrthprgprgrrrgqpgdseekgcqvaaacrrgawrdrmlkrggfeKDVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQ---------------------------------------------------- -----------------------------------------------AAGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPRNYQQNYQNDGEGEKREGGESAPEGQAQQqqRRPtYPgRRRYPPYYMRRRYGRRPPYSN-PVQGEVMEgeGDENQGGGDQGnRPVRQNYYRGYRPRFRRGPPRPRPPREDGNEEDKENQGEEGQGQQPRQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE ----------------------------------------------------------------------------RNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRQVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE MSSEAETQQPPPAP--A--LSSTDTKPGTTGSGAGNGVLGGLTSAAPAGGDKKVIATKVLATVKWFNIRNRYGFIKRNDTKEDVFVPQTAIE-NNPRKYLPRV-DRETMEFDV-EGEKGGEAAHVTGPGGVPVQGSKYAADYNHYRRYPXRGGPPRNYQQNYQNSESGERNEGSGSAPEGQAQQRRPYGRQRFPPDSMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQRRPVRQNMYWGYRPRFRRGPPRQRQPREHGNKEDKENQGGDTQGQQPPQRRYLRNFNYRRKRPENPKPQDGKETKAADPPVQNSSTPEAEQGRL- --------------------------------------------------------------------------FHRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQPNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGEETKAADAPAENSSAPEAEQGGAE -------------------------SPAGPAVAQGVAAPGGLTSAAPAGGDKKVFAAKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGEIVEFDVVEGEESAEAANFTGPGGVGVQGSKYAADYNYYRYSPRRRGPPRNYQQNYQNRESGKKNGGVM-----------------------------------------------------EGADNQGNMYRAYRPRLRRGPARQRQPREDSNEEDKENQGDETQGQQLPQRRYRRNFSYPRRRPENPKPQDGKETKARIHQLREFVRSPGEQGGAE MSSEAETQQPPAAPPAA--LSDADTKPGTTASG---------------GGEKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPRNYQQNYQ-SESGEKRESSEISPEGQaqSQQRRPYpRRRRYPPYFVRRPYGRRPQYSNPPRQGEGMEGADNQGGGEQGKPVRQNMYRGYRP-FRRGPPRQRQPRED--EEDKENQGEETQGQQPPRRRYRCNFNYR-----NPKPQGGKQSKAAEPSAEKESAPKAEQGGAE ------------------------------GSPASNGGPGGLTSAAPSSGDKKVIERKVLGTVKWFNVRDGYGFINRNDTKVDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGENGVEAANVTGPGGAPVQGSIYAAERN--RRCPRRKGPLRNCQQNCQNNESEEKNEGSESGPEDQAQQCQPYHRQR-PC-------SFRPQQSNPPSQQEVMEGADHQSAGKQGRPVRQNMYQCYRQRSHRGPPPQRQPREDSHEQYEENQRDETQGQQPPQRQYRCNFNYRRRRPENPKPQNGKETKNSNPPAKIVFTPKAEQGRPE -------------------------------ARPRRRKAVRWSRAAAE----RARATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRR----------------------------------------------------------------------------- --LEAETQQPPAVPAAA--LSAADTKPGSTGSGAGSGGPGGLTSAAPASRDKKVIATKFLGTVKWFNVRNRYGFINRNATKEDAFVHQTAIKNNNPRKYLHSVGDGETVEFDVVEGEKGAEAANVTGPGGVPIPGSKYAADCTHYRRYPRRRGPPRNYHINYQNSESGEKNEGLESAPEGQAQQR-XYRRRRFPPYYMRRPYGRRPQYSNPPVQAEVMEGADNQGAGEQGRPVRQNMCWGYRPRF------------------------------------------------------------------------------- ----------------------------------GSRSCHRLTSLAPAGGDKKVITRKVLGTVKWFRVRNRYGFINRNDTEEDAFVHQTAIKNRSPXKHLHGAGDGETAELDVGEGENGPEVATVTRPAGAPVQGSKYAADRNHSRHSLRRRGLPHNSQQNYQNHESGEKSEGSESVPKVQTQQRQPFRRRRLPPYYMRRPSGRRPQYANRPVQGEVTEGAANQGAGEQGRPVRQNMYWGCRPPFRRXPSPQGQPRQDGNEEGKKNQGDEIQGQQPRHCRYRHNFNCQRRRPENPKLRDGKETKAADPPAENSSTPGLNR---- MSSEAETQ-PPAAPlPAAAPIAPAESKPN---GGTGNGGSGMASAAPPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSDSIPEGQAQQRRPYRRRRYPPYYMRRPYGRRPQYSNPPVQGEIVE--------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------FLFSCRNDTKEDVMSSEAETQQ-PPQPA---VADAESPSSPAAaasAGDKKVIATKVLGT----VKWFNYAADRNRYRRYPRRRGPPRNYQQNYQSSGSGEKREGSESAPEGQAQQRRPYGRRRYPPYYVRRPYGRRPQYSNPPVQGEMTEGADNQGAGDQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENTSAPEAEQGGAE --------------------------------------------------------------------------------------------------------------------PRGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRCRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVKEGADNQGA-EQGRPVRQSMYRGYGPRFRRGSPRQRQPREDGSEEDKENQGDETQGQQPPQRRHHRNFNYRRRRPENPKPQDGKEPKAADPPAENSSAPEAEQGGAE MSSEAETQQPP-QP--A-----AD-----------AESPSSPAAAA-SAGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPRDYPENYQSDEG-------ESVPEGPSQQ----------------------------------EGEENQGGPDQGnRPVRQNYYRGFRPRRPRGPPRPRPVRDG--EEDKENQGGDGQNQRPRQRRYRRNFNYRRRRPqTGGKPgQDGKEAKTNDEPsAEKTSAPEAEQGGAE MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGE-----------------------------------------------------------------------------------------------------KGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE -------------------LSATATKPRSKENGTGSGGPGGPTSEAPANQDkKKVIQTKVLGTVKWFNVRNGYGFITRNDTKEDVFVHHMAIKKNNPRKYFHSVGDGETVEFDIVEGDRGAEAANVTGPGGIEVQGSKYAADRNT--RCADQRGPPGRHQQNCQ---SEEKSEGAESSTEDQAPQRWPFPERRFTPFTMRRHCGRRPQYSSRPGQRKVMEDADKQGAREKGRPVRPNMYQGYTPRSRRGPPRQRQPSEDHKEEDKEHQGAsGTQGLQPPQGRRGRNFTYRCRHPEIRKPQDGKETKA-DPPAENPQAPQAEQGGAD ------------------------------SQGAGSGGPGGLTSAAPAGGDREVIATKVLGTVKWFNVRDGHGLINRNDTKEDVFVHQTAIKKNDPRKCLRGVGDGDTVELDVVEGEEGAEAASVTGPGALvpwclvpwwsPSAGRTYAADRQHHRRCPRRRGPARNYQQDYQHSESGDKIEGSESAPEGQAQQRRPYRRRRLPPDYLRGPCGTLRDPGGPC--GTLRA---------AATTVFQPPCAGR--RDGRGPPRQRQPREDGKEEDKENQGDETQGQQPPQRrRYRRSFSYPRRRPENPKPQEGKETKAADPPAENWSAPRLSRAGL- -------------------LSAAATKPSSNNNGTGSGGPGAPTSEAPANLDkKKVIQTKVLGTVKWFNVRNGYGFITRNDTKEDVFVHHMAIKKNNPRKYFHSVGDGETVEFDIVEGDRGAEAANVTGPGGIAVQGSKYAADRNT--RCADQRGPPGHHQHNCQNSQSEEKSEGGKSSTEGQAPQRWPFPERGSAPFTMRRRCGRRPQCSSRPGQGKAIEGADKQGAREKGRPVRPNMYQGYTPRSRRGPPRQRQPSEDHKEEDKEHQGaSETQGLQPPQGRRGRNFTYRCRYPELPKPQAGKETKAADPPADNLQAPQAEQGGAD MSSDAETQQPPPHP--P--PNAADTQPGTK----GSSSPGGLTSEVPAGGDK-IIATKVLGTVKWFNVRNGYGFINRNDTKEDVFIHQTAIKKNNPRKYLRSIGDGETVEFNVVEGEKGAEAANITGHGGVPVQGSKYAADRNHYRHYRRRRGPPRNYQQNYQNSESGEKNEGSERAPEG------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------MAMKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKHAADCNRYRRYPRRRCPPRNYQQNYQNSESGKKNEGSENPPEGQQQQHRPYYRRRFPPYFTRRPYGRRPQYSNPPVQGEVMRV-------------------------------------------------------------------------------------------------------- TSSEAETQQPHAAP--APALSAADTKPCTMGSGAGSGGPGGLTSAAPASGGKKVIAMKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLLSVGEGETVEFDVVEGEKGAEAANVAGPGGVPVQGSKHAADCNRYRRSPRRRCPPRNYQQNYQNSESGKKNEGSESAPEGQAQQHQPYRRRRFPPYYTRRPYGRRPQYSNPPVQGEVMRV-------------------------------------------------------------------------------------------------------- MSSEAETQQPP-QP-AA--D--AE-SP------------SSP-AAAATAGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPRDYQDNYPSDGEGDKKEAGDSAGEGDQQQRKPSFpgRRRYPPYYVRRRYGRRPPYTNAPPRGEMTEggeGEENQGGQDQGnKPVRQNYYRGYRPRFR------------------------------------------------------------------------------ ------------------------------------------------GGGGSSAATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQ------------------------------GAEAANVTGPGGTPVQGSKYAADRNRYRRYPRRRGPPRNYQQNYQSdgDEGGEKREGMENVPDGEiqTQQRRpPFPRRRYPPYYVRRRYGRRPPYTNAPPRGESTEgveGDINQGAvDPSAKPMRQNYYRGYRPRFLpRGPPRPRPPRDDANEEDKENQGDGAQNDQPRQRRYRRNFNYRRRRPQNPKPQDGKENKAAEPPAEKTSAPEAEQGGAE --------------------------------------------------EKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGE-------EEEEGSGSsegfeppAADGQfsgarSQLRRPqyrpQYRRRFPPYHVGQTFDRRSRVFPhpsRMQAGEIGEMKDGVpeGAQLQG-PVHRNP--TYRPRYRRGPPRPRPAPAVGEAEDKENQQAANGPNQPSARRgYRRPYNYRRRpRPPNAPSQDGKETKAGEAPSENP-APATEQSSA- --------------------------------------------------EKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGEEE-EEGSGSSEGFEPpATDGQfsgarSQLRRpqyrpQYRQRRFPPYHVGQTFDRRSrvfphpNRMQAGEIGEMKDGV-PEGAQLQG-PVHRNPT--YRPRYRRGPPRPRPAPAVGEAEDKENQQAANGPNQPSARrGYRRPYNYRRRpRPPNAPSQDGKETKAGEAPSENPA-PATEQSSA- ------------------------------------------------ETEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRS----------GEEGEIKDGVTEGG----------------------------------------QLQQ------QVHRNP--TYRPRYRRGPPRPRPAPAVGEAENKENQHEANAMsQQPLRRGYRRPYNYRRRpRPPNAPAQDGKETKATETPAENP-APVTEQSGAE -------------------------------------------------LEKPILATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRSVSGESLE-ESGSSQG-SGPSCTGQFSGlsqlrrpqCrPQLR--RFPPYHVGQTFDRRSRVLphpNRLSQggeGEIKDGV---TEGGQLhQQVHRNPT--YRPRYRRGPPRPRPAPVAGEAENKENHHEANaMSQQPLRRGYRRPYNYRRRpRPPNAPAQDGKETKVTETPAENP-APVTEQSGAE ------------------------------------------------------IATKVLGTVKWFNVRNGYGFINRNDTKDDVFVHQTAIKKNNPRKYLRSVGDGEIVEFDVVEGEKGAEAANVTGPAGVPVQGSKYAADRNRYRRYPRRRGPARDgeYPDNYQSDGEGEgerpprkSREGAESAPEGEmqTQQRRPSFpgRRRYPPYF------------NA-PRGEMTEggeGDENQGGPDQGNkPMRQNYYRGFRPSRGGGPPRPRPVR-DGEGENKENQGGDGENQEPRQRRYRRNFNYRRRRPQTGgKPQDGKEAKADgEPSAEKTSAPAAEQGGAE ------------------------------------------------------------------QPMNEYGFIHREDNQDDIFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPRGYQINYQTSGSGEKDEGNENGPEGQPQQRRPFfrGRRRYPPYRGRRRYGRRPEYGNDP-QGEGEEGGENQGGGDQGKPMRQNPYRGRRPRFRIV---------------------------------------------------------------------------- MSSEAETQQPPAAPTAI--LS--DVKPSSMGSSSDS--PGSLisASAVPA-RDKKVIARKVLGTVKWFNVRNRYGFINRNDTREDIFIHQSAIKKNNPRKYLYSVEEGESVEFDIVEGEKGAEAANVMGPGGVPVQGSKYASDHNHYRCNPFHRGPPRNYQQNYQNSESGEKNEQSECTHEGQAQQV------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------DAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRN---------AGEIGEMKDGVPEGA----------------------------------------QLQG------PVHRNP--TYRPRYRRGPPRPRPAPAVGEAEDKENQQAANGPNQPSARRgYRRPYNYRRRpRPPNAPSQDGKETKAGEAPTENPA-PATEQS--- --------------------------------------------------ERKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRS----------GGEGEIKDGVPEGG----------------------------------------QLQQ------QVhRNPT---YRPRYRRGPPRPRPAPVTGEAENKENQHEANAMsQQPLRRGYRRPYNYRRRpRPPNAPAQDGKETKVTETPAENP-APVTEQSGAE -------------PATAPTLSAADTKPGRTGS----SARTGLIWAAPAGRDKKIITTKVLGTVKWLSVRNGYGFINGNDTKEDVFVYQTAIKNNNPRKYLHSIGDGETAEFDVVEGEKGAEAANVTGPGG--VQWVLYAITSRITR-----------------------------------------IARGGSPSYYIRRPYAHQPQYSNPSVQGEVMEGADHQEHNS-----------RNRPRFRRSPPCLRQPREDY----------KTQGQQPPQGQYHCNFNYRCRCPENRK--DGKETKAADPPAENSS----EQGGAE ------------------------------------------------DAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGE-------EEEEGSGSsegfdppATDRQfsgarnqlrrPQYRPQYRQRRFPPYHVGQTFDRRSRVlphPNRIQAGEIGEMKDGVPEGaqLQG-PVHRNP--TYRPRYRsRGPPRPRPAPAVGEAEDKENQQASSGPNQPSvRRGYRRPYNYRRRpRPPNAPSQDGKEAKAGEAPTENPAPPTQ------ ------------------------------------------------DAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYA-------GEEEEEGSGS-SEGFDXQ---Y-RRRFPPYHVGQTSDRRSRAfPHPSrmQAGEIGEIKDGVpdGAQLQG-PVHRNP--TYRPRFRRGPPRPRPAPVVGETEDKENQQAASGPNQPSARrGYRRPYNYRRRpRPPNAPAQDGKETKAGDAPSENP-APATEQSSAE MSSEAETQQPPAAP--A--LSAADTKPGNTGSGAGSGGPGSLTSAAPAGGDKKVIARKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQ------------------------------------------------------------------------------------------------------------------------------GGVMEGADNQGAGEQGRPLRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRT------------------------------------------- -SSEAETQQPPDTTPPSPGPQrcrhhqAQHLLRPSGPAAQRAAARGCLTSASPSSGDKKVLARKVLGTVKCFNVRHGYGFINRNDTKEDVLVHQTAIKKNNPRKYLRSVGDGETMEFHA-EGEKGAEAADVTGPGGAPVQGSKYAADHNHYRRCPRPRGPPRNYQPNDQN-RVGEKNEGSQSAPEGQAQQRRPSHRRRFPPYYKRRSYGR------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------VLATKVLGTVKWFNVRNGYGFINRDDTKDDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPPDYPQNYQSDGEGEgseKREgqGQESVPEGEiqPQQRRpPFPKRRYPPYYVQRRYGRRPPYTNTSPRGESTE-CENIG--------------------------------------------------------------------------------------------------- -----------------------------------------------AESAKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRS----------GGE--------------------------------------------GEIKDGVTEGGQIH--QQVHRN--PTYRPRYRRGPPRPRPAPVAGEAENKENHHEAnAMSQQPLRRGYRRPYNYRRRpRPPSAPAQDGKETKVTETPAENP-APVTEQSGAE ------------------------------------------------AGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRGPPRDYQENYQSDGEA------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------EVITTNVLGTVKWFSVRNGYGFINRNDTKEDVFVHQTAIK-INPRKYLYSVGDGKTMEFDVVEGEKGVEGATVAGPGGIPVQGSN------------------------YLNSESWGKR---------------MWDWR---VFLKARP-------SNAGPTGEVMEGADNQGAGEQGRPDRI----CYRPQFRRGFPCQRQPREDGDEEDKESPGDEAQVQQSPQSWHCPNFNYQRRHSENPKPQDGKATKAVHPPAENLWAPEAELGGAE ---SSETQQPPAAP--A--LSAADTEPGLTGSGAGSGGPGGLTLAVPASGDKKVITTKVWGTVKWFNVRNGYGFIKRNDIEEDVFVHQTAIKKKNPRKYLRSVGDRETVAFDVIEGEKDAETANGTGPRGVPAQGGTCAPDHNHYRRSPHRRGLPRNHQQNYQSSESGEKDEGSESAPAGQAL--------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LMMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE --------------------------------------------------EKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGEEE---EEEEEEGSTCsegfeppAADGQfpgarSQLRRPqyhaqYRQQrWLPPYHVGQTSDHrRARvlaHPSRTQAGEIGDLKDSGPEGTQP-PIHRN--PTYRPRFRRGPTRPRPAPANGETEDKENQQAASGPNQPPRRGFRRPYNYRRRpRPPNSVSQDGKEAKAGEVASENP-APAAEPR--- -------------------------------------------------AEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRSYAGEEEEEGSG-SSEGFEPpATDGQfpgarTQLRRPqyrpqYRQRRFPPYHVGQTFDRRARVfSHpnRMQAGEIGEMKDGIPDGAQlPGPVHRNP--TYRPRYRRGPPRPRPAPVVGEAEDKENQQAASGPNQPSARrGYRRPYNYRRRpRPPNAPSQDGKEVGPA------------------ ------------------------------------------------GGDKQGIAAKVLGTVKWFNVRKGHGLINRTDPKAHVFAHQTAIKKNNPRKCLRGVGGGDTVGFDAVEGEKDAEAANVTGPGGLPGKavnvpqtvsitdavhvaGALHAITSRITR-IV----------------RVGKRTRDPKGLPKARPSSPGPTTGDGpPPPRLRARPDGRRPQCPNPPVQGEGVGGADKQGAGQQGRPVGHNVYPGYRPRSRRGPPRQRQPGEDGREDDKENQGDDTQGQQPPQRRYRRNCNHRRRRPENPNPREGRETKAADPAAEHWSAPRLSRAG-- -----------------------------------------------TVGEKKVIATKVLGTVKWFNVRNGYGFINRDDTKEDVSVHQTAIKKNNSRKYFCSVGDRETVEFDLVEGKKGTDAANVTGPGGVPVQGSKYAAGCKHYRRYPRRRgGPSRNYQPNYQNSEVGEKPEEAEIVPEGDgSNPQRPYRRRRYPPYYLRRPYERRPQHSNAPVQGEDIE--------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------KKEKKRNGYGLINRNDTKEDAFAHQTAIKKNNPRKYLCSVGDGDTVEFDVAEGEK-----------------------------------------------------------------------------------------------------GADSQGAGGQGRPVRQNMYRGYRPRFRRGPPRQRQPKEDGKEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENWCAPRLSRAGL- -----------------------------------------------TVGEKKVIATKVLGTVKWFNVRNGYGFIYRDDTKEDVFVHQTAIKKNNPSKYLHSVGDGKTVEFDVVEGEKGTEAANVTGPGGVPVQGSKYAADCKHYRRYPRCRgGPSCNYQPNYQNSEVGEKPEEAEIVPEGDgSNQQRLYCRRCYPPYYLQRPYRR-GQVSETPKPAtQTSE-----GISEDESDLEQEQWRSFIPVTQRD---------------------------------------------------------------------------- ------------------------------------------------QADKPVLATQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIPRPRPAA---PP--PMVAEAPSGGTEPGSEGEraedSGQRP-PRRRRPPPFFYRRRFVRGPRPPN---QQQPIEGTDGVEpketaplEGDQQQGDERVPPPRFRPRYRR-PFRPRPPqqptTEGGDGETKPSQGPTDGSRPEPQRqRNRPYFQRRRQQPPGP----------------------------- --------------------------------------------------EKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYPGEEEEEEGSGSSEGLDplitegHIPGSRNQLRRPqYRQRFFPPYRAGQTFDRRSrVYSHAdGTQGGDGEIKD--GVP-EGAQLHQQIHRnpSYRARYRRGPPRPRPAPVVGEAENKENQHEAnAMSQQPSRRGYRRPYNYRRRpRPPNAPSQDGNEIKVAETPPENPA---------- -----------------------------------------------------HIPTKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADWNRYRRYPRRRRPPRNYQDNYQ-SEGRKKRESQEIGPEGVAQP-------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------PTSTKVLGTVKWFNVRNGYGFINR--TKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRS----------GV--------------------------------------------EGEIKDGVTEGGQ--LHQQVHRN--PTYRPRYRRGPPRPRPAPVAGEAENKENQHEAsAVSQQPLRRGYRRPYNYRRRpRPPNTPAQDGKETKVTETPAEN-PAPVTEQSGAE ------------------------------------------------QPEKKVIATQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIPR---PRPAAPPPMVAeaPSGGTEPGSEGERAEDSGQR--PRRRRPPPFFYRRRFVRGPR---PPNQQQPIEGTDGVEPketapleGDQQQGDERVPPPRFRPRYRR-PFRPRPpqqPtTEGGDGETKPSQGPTDGSRPePQRQRNRPYFQRRRQQPPGP----------------------------- MSSEAETQQPPA----A--LSAADTKPGSTGSDAGSGGPSSLTSAASAGGDKKVIAAKVLGTVKGFKVRNGYGFINRNDTKEDIFVHQTAIKKNNPRKYLRSVGDGETEEFDVVEGESGAEAANVTDPGGVPVQGSKYAADHNV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------PILATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRSSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------VSNKKKKVLATRVLGTVKWFNVKNGYGFINRNDTKEDIFVHQTAIKKNNPKKVVRSVGDGETVEFDVVVGEKGNEAANVTGPDGVPVKGSPYAADRRrgRFRGrwMARRRRPPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------ MSS--ETQQPPAAP--A--LSTADPEPGLMGSGAGSGGPGDLTLAVPNGGD-KVIATKVLGTVKWFNVRNGYGFTKRNDTKEDVFVHQTAIKKKNPRKYLRSIGDRETVEFDVVEGEKDAETANVTGPCGVPAQGGTCAPDRNHYRRSPHRRGLPLNHQQNYQNSCI------------------------------------------------------------------------------------------------------------------------------------------------------------- MTSEAKTQQPAVAPDAI--LRAVDTKPGSMSSSAGSDIPGCLTPAVPAIREKNLIARKVLGIVKWFNVKKGYGFIKVNDTKEDIFVHQsaikinnpkkylrrrsmdtgsgqlapespestteaadlvnnspldetqqslqtgvtttaaitseaktqqpavapdailravdtkpgsmsssvgsdipgcltpavpaireknlivndtkedifvhqSAIKINNPKKYLRRVGDGESVEFDIAEGEKGAMALNVTGPGGIAVRGGKYASEHNQYRCYRGRRCSPRNSNQNYRNRKSGGRKEQSECTHEGQAQQDQ---------------------------QRQVIEDAGHQGTKGRGVPVRPDKYRNYRPQFCRGPPRQRQPREDSNEHYEENQGEETQGQQPPRHQNHCNFNHQQRRPKNSKPQDVKEIpKVCDPPYKNLSVAKTNQG--- ------------------------------------SAPSLATSAGSEDAEKKVIATKVWGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYPRCRGPPRNYRC-------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------KPEKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGTAVQGSRYAADRRRYRRgYPRRRGPVNQRaaQQRPPdqrrrapSGGAGTvenGAEVSENRGTVPPsgrQPQQprqrGFRGRRFRGQYRRRPFRPRPQQQEAPADGNKDPK------AEKGLPARR---RYSRPGFRRRTAEQRQEPTA------------------------------------------------------------------ ------------------------------------------------AGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPKKYLRSVGDGETVEFDVVEGEKGGE--------------------------------------------------------------------------------------------------GDENQGGPDQGnKPMRQNYYRGFRPSRGGGPPRPRPVR-DGDGENKENQDGDGENQEPRQRRYRRNFNYRRRRPQTgGKPQDGKEAKTDgEPSTEKTPAPAAEQGGAE -------------------------------------------------AEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGEGEIVEFDVVEGKGGPKATNVTGPDGVPVEGSRYAV----------RRGPPHNA---------GEIRQMKDGVPEG-----------------------------------------------TQ-LLVHRNP--TYRPRFRRGPAHPRTSPYRSLQVFKRRQRASSPVQPSPRRGYRRPYNYRRRpRPPSAPSQDSKEAKAGEAPPENPA---------- ------------------------------------------------AEEKMVIERKVWGTVKWFNVRNGYGFITRSDNKRDVFVHQSAIKKNNPYKYHRSVGDGERVEFDVVLGDKGLEAANVTGPGGIPVQGSIYAADRRKCSLGLRRS-PP---HKSYHLCESVPKNEAATSAPEDG---NLPYSG---QSYLMHTSYGYQPQCSNSVS-AEVVH-AEGQCVhAEQSKPVKQSIYQGFRQLLSLGQHCLRQPREEGGEKcNGSPQANETEDSAISQRCYRPNFSYLRRRPRNAKPLDGKETKETsGPPAEDTMAPET------ --------------------------------------------------EKKVLASKVTGTVKWFNVRNGYGFINRDDNKEDVFVHQTAIIKNNPKKYLRSVGDGEVVEFDVVEGEKGLEAANVTGPDGEPVQGSKYAPDRRRRYyRY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- VSSEAETQQPPAAPAAA--LSSANTKPGSRVSGAGSGGP----------RNKKVTATKVLGIVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGYGETEEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------NSILATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGE-------EEEEGSGSsegfdppATDGQfsgarSQLRRpqyrpQYRQRRFPPYHVGQTFDRRSRVFPHPnrmqvklhlellssphpsillclflllllLQHQELEIkpclwlPDATKA--EARPslgffraliletslkvqphelcnlvlkplggankeityfthpptyaliTYIRMYTVLItslstfnnkpyvlenpclvalvPfalySCSRGPPRPRPAPAVGEAEDKENQQAANGPNQPSARrGYRRPYNYRRRpRPPNAPSQDGKETKAGEAPTENP-APATEQSSAE --------------------------------------------------QVSVPDALPTWARERRHASVGHMSGKRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGEEEEEGSG-SSEGFEPpAIDGQfsgarSQlrrpQYRPQYRRRFPPYHVGQTFDRRSRVFSHPnrmQAGEIGEMKDGVpeGAQLQG-PVHRNP--TYRPRYRRGPPRSRPAPVVGEAEDKENQQAANGPNQPSARRgYRRPYNYRRRpRPPNAPSQDGKEL--------------------- ----------------------------------GGGSPGGGSSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEATNVTGPGGVPVQGSKYAAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------SATTKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRS----------GGE--------------------------------------------GEIKDGVTEGGQL--HQQVHRN--PTYRPRYRRGPPRPRPAPVAGEAENKENHHEAnAMSQQPLRRGYRRPYNYRRRpRPPNAPAQDGKETKVTETPAENP-APVTEQSGAE ------------------------------------------------ESEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRDAPEGQAQQRRPYRRRRFPPYYMRRFYGSRPQYSN-PVQGEVMEGADNQGAGAQDRPGRQNMYRGYRPRFLRGPPRQRQPREDGNEEDKENQGHETQGQQPPLRWYRRNFNYRRRRPENPKPQDGKETKAADAPGY------------- ------------------------------------------------QPEKKVIATQVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGETVEFDVVEGAKGSEAANVTGPGGVPVKGSRYAPNkRRFRRRFFPRRARP---------ADQSGPSDGQESGPEGEGaeegGGPRPRPRRRRP-FFHRRRFGRGPRPEAQPQSITET---------------------------------------------------------------------------------------------------------- ----------------------------------------------------THIPTKVLGTVKW------------NDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRRPLQ----------------SQEIVPEGVaqPQQRRTLFpgRWRYPPYFVRRRYGSRPPYTSAPRKemTEGTEGSDNQGDPDQSKPMRQNYYRGFRPR---SPPCPRLVREG--EEDKENQ-------EPHQRHYRCNINYRP----------------------------------- ----------------------------------------------TTVGEKKVIETKVLGIVKWFNVRNGFGFINRDNTKEDVFVHQTAIKKNNPWKYLCSVGDGETVEFDVVEGEKGTEAANVTGPGGVPVQGSKYAADCKHYRRYPRRRgGPSRNYQPNYQNSEIGEKDHTRE----------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------QPERKVIATLVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVIEAAKGSEAANVTGPGGVPVKGSRYAPNKRRFRRrfFPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------SGEKKVLATKVWGTVKWFNVRNGYGFINRDDTKEDVFVHQTAIKKNNPRKYLRSVGDGEPVEFDVVEGEKGVEAANVTGPGGAPVQGSKYAADRSEYRRGPPRSsgGPPP---QAPRKSRTGcPRAEGPEKPTDGAppagEHETWKSCVPRRPAYPL--HFARRSQYVALALRRGPADGADTElaGGGEQSRVGRRGGFREGRPPLRGAGAGrwGPSVRADGPEDDKENHkGKRIRSQQSPQRRFRRHFSYQHRRPGNPRPSEGREVKAMLS---------------- MSSEAEIQQPSAAPAAA--LSAADTKPGSTGSGAGSGGPPPAASLSaatPslapPqqcrkwrpgslTGGEFIITRKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKYNPRKYLRSVGDGEIVEFDVVEGEKGAEAAIVTGPGGVPVQGSKYAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------AEDVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGGGETVEFDVVEGEKGAEVANVTGPGGVPVQGSKYAADRNRYRRYPRRRRPPRNYQD-------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------KTVEFDVVEGEKGAEAANVTGSGGVPVQGSKYAADRNQCRRYPRRRDPPRNYQQNYQNSESGEKNEGSESAPEGQAQQLRPYRRRRFPLAEkvttcGDPIYGCRPQYFNPPVQGEVMEGADNQGAGEQGRPVRQNMYHD------------------------------------------------------------------------------------ --------------------------------------------------EKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRS-------GEEGDIKDGV--TEGGQLQQ--VHRNPTYRPRYRRSV--------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------PERKVIATGVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVVEATKGSEAANVTGPGGVPVKGSRYAPNKRRFRRrfFPRN-AQPREGEEKAGGAPAGPTSEGEGGEEKGAPQpePRRQRPRRR--------PV---------RPQGegEAGEKNDEEVDGAQQRPPPR----RFRPRYRRPFRPRPPPGEGQQ---------------------------------------------------------------- --------------------------------------------------------DMVLGTVKWFSVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNRYRRYPRRRRPPQVCPTNTSNS--------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------QGTDTVNRNDTKEDVFVLQTAIKKNNPRKYLRSVGDGETVEFGVVEGERGAEAANVTGPGEVPVQGSKYAADHNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGWESSPEGQAQQRP------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------ADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIpRPRpaAPPP----MVAEAPSGGTEPGSEGERAEDSGQ-RP-RRRRPPPFFYRRRFVRGP---RPPNQQQPIEGTDGVEPketaplegdQQQGDE-RV-PPPRFRPRYRRpfrpRPP-QQPTTEGGDGETKPSQGPTDGSRPEPQRPRNRPY-FQRRRQQPPGP--------------------------- -------------------------------------------------QQKEVIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIIKNNPKKAVRSVGDGEVVEFDVVVGEKGNEAANVTGPNGEPVKGSPYAADKRRgYRqwYYPRRGGGRggrrpREGQEGY---ESGEGKQGGEGNGEGGGPPR-RYRpRRRYGGGYYR----------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------PHIDEKKIVAKGVSGVVKWFNVKNGYGFINRTDTNEDIFVHQTAITNNNPNKFLRSLGDGEEVEFDVVEGAKGPEAANVTGPDGGPVQGSKYAADRNserggrRFRRrNFYRggrRGGPS--------GGEGEPEDGAANEHEGDrpeEVVQQNPRYRRPPPFFFRRRRVRGPRAGN------------------------------------------------------------------------------------------------------------------ --------------------------------------------AAASAGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETE--AKTGGEPSAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------TKKVISSKVTGTVKWFNVRRGYGFINRDDTQEDVFVHHTAIVKNNPHKYLRSVGDGEKVEFDVVKGEKGNEAANVTGPEGESVQGSKYAADRRHFRP--RLHGPGQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------ MSSEAETQQPPAAP--A--LSAAETKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGLALvrlrlevTCSWTAIEREKWA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------PQKPEKKVIATKVLGTVKWFNVKNGYGFINRNDTKEDVFIHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGAAVQGSRYAADRGRYRRsYPQRRRPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------FPATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------AVQQKQVIANKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIVKNNPRKAVRSVGDGEVVEFDVVIGEKGHEAANVTGPGGEAVKGSPYAADKRrGYRgqYWPRRGGgrPQREGQEGY---ESGEG-T-GDEAPRGRGGGQRRYRpRRHYDGYYR------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------NVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNISD-------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------TKSYPINSGFRSECPWG--QQVISRKVLGTVKWFNVRNGYGFINRNDTKEDVFVYQSTIKKNNPRKYLHSVGDGETMESDVVEKEKSAHN-----------------------------RG---------QNNN-------------SRIKRVKPFMRQGFPPYYIPNPHPCQPhvsQHSMQSVQGHD-----------------------HSPQFCSSPPCQRQPRENSNEGNKENQSNEAHGQQHLN----------YGLAANPKSQSEKQKSASHPRAENTNAP-------- -------------------------------------------TERPATSGKKVIASKVSGTVKWFNVKSGYGFINREDTKEDVFVHQTAIIKNNPRKYLRSVGDGEKVEFDVVEGEKGNEAANVTGPGGNHVQGSKYAADRRRYRRrwWNRRrRGAAREEGEeAKGDQDDGESGEGAG---SGEDRSRPPMRRR---PYWRRRRFFRGP---------------------------------------------------------------------------------------------------------------------- -----------------------------------------------AQPPKEVIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPSGEPVRGSQYAADKRRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MSSKAKTQQPPAT---APTLSAADTKPGRTGS----SARTGLIWAAPAGRDKKIITTKVLGTVKWLSVRNGYGFINGNDTKEDVFVYQTAIKNNNPRKYLHSIGDGETAEFDVVEGEKGAEAANVTGPGGVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------SNRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGEEEEEGS-GSSEGLEApAAAGQfsaarSQPRRpqfrPQYRRRFPPYHVGQTFDRRSRVFPHPsrmQAGEIGEMKDGVpeGAQLQG-PVHRNP--TYRARYRRGPPRPRPAPAVGEAEDKENQQAANGPNQPPARRgYQRPYNYRRRpRPPNAPSQDGKEGVDGAPKWRNT----------- -------------------------------------------------AEKKVLATKVLGTVKWFNVRNGYGFINR---------YQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGEEEEEGS-GSSEGFEPPAtDRQfsgarNQLRrpqyrPQYRQRRFPPYHVGQTFDRRSR--------------------------------------------------------------------------------------------------------------------- LSSEAETQQPPAAP--A--LSAAYTKPGTRGGGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQ------------------------------GAEAANVTGPGGVPVQGSKYAADVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------QKHHYSRYPRCRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRQPQYSNPPVQGEVMEGADNHGAGEQGRPVRQNMYGVMDNDFAG----------------------------------------------------------------------------- -------------------------------------------------DGKKIVARHIQGTVKWFNVKNGYGFINRADTGEDIFVHQTAVTKNNPNKYLRSLGDGEKVEFDVVEGQKGPEAANVTGPNGTNVEGSRYAADKsdmrgrgRGYRRrfyyggYRPGRGGARRANSEGDR-ADGEEGDGDEGGRRGR----GGFRGRGRGRGFRGRGRGRGGQR-RRASEGDHQEggeTTEDQLNGENV---------------------------------------------------------------------------------------------- -------------------------------------------------ADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIpRPRpaAPPPM----VAEAPSGGTEPGSEGERAEDSGQ-RP-RRRRPPPFFYRRRFVRGPRPPN---QQQPIEGTDGAepketapleGDQQQGDE-RV-PPPRFRPRYRRpfhpRPPQQ-PTTEGGDGETKPSQGPTDGSRPEPQRP-------------------------------------------- ---------------------------------------------------QRLAATQVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGEIVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIPRP---RQAQQPQD----ATRPEVvTETVSEGervdDAVQQRPR-RRRPPPFFFRRRFVRGPrpQPQQ-PQQGsDSTDPKDaTQPEGDQQQQI-QAGERapapRFRPRYRR-PFRPRppqQPtTEGGDGETKAAQAPADGIRPEPQRQRNRPYFQRRRQ--------------------------------- -----------------------------------------------------FAATQVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIPR---PRQAQQPQ----DAPRTEGVaELVSEGeradDAVQQRPR-RRRPPPFFFRRRFVRGPRA--PPQQQQGSdstEPKdATQPEGDQ----QQQIQAGRTPPFRPRPPQQP-TTEGGDGETKAAQAPADGIRPEPQRQRNRPYFQRRR---------------------------------- ------------------------------------------------------STTHVLGMSNGF-VRNGYGFINRDDTKEDVFVHQTAIKKKNHRKYLRSVGDGETVEFDVVEGEKGTEAANVTGPGGVPVQGSKYAADCKHYRRYPRRRGGPSHavIPSKYQNSEVGEKPEEAEIVPEGDgSNQQCPYRRRPYLD-VLRR-TSRRGQVLKTPKQ-------------------------------------------------------------------------------------------------------------- -------------------------------------------------RKKPIVAERILGTVKWFNVKNGYGFINRNDTHEDIFVHQTAITRNNPQKLLRSVGEGETVEFDVVVGDKGCEAANVTGPDGEPVKGSPYAADRRRFRprWIPRRnqrrRGPAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------QKPVIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQTAIIRNNPRKAVRSVGDGEAVEFDVVEGEKGHEAANVTGPGGEPVKGSPYAADRRRgYRRwfYPRGRR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------PERKVIATGVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVVEAAKGSEAANVTGPGGIPVKGSRYAPNK---RRFRR-R----FYPRNAQPAEGEEKapagpiSEGEGSEEKG-APQPRPRRQR--P--------RRRP----VQPQGEGEAGEKNEeVDGAQQRP----PPRRFRPRFRR-PLRPRPppgeaqqtvvPAEEQESPPKESQTNREQTEGQP-RKPRRQFSRRRQrKSESGASKDGDEPEK------------------- --------------------------------------------------------NQGFGNCHMFNVRNGYGYINRDDPKEDLFVHQTAIKKNNPRKYLCIVGDGETVEFDVVEGEKGTEAANVTGPGGVPVQGSKYATDFKYYRRYPRRTgGPSRSYQPNYQNSEVGEKPEE------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------SQADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGAPX-GSRYAPNRRRFRRFM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------QAEKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIpRPRpaAPPP----MVAEVPSGGTEPGSEGERAEDPG-QRP-RRRRPPPFFYRRRFVRGPRPPNQ----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------LNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRSYAGEEEEAGSGS-SEGFEprtadgqfSGAPGQlrqPQFYPRYRQRRFPPYHVGQSFDRRPRAFPQPSrmqAGEIGELKDGVpeGAQLQG-PVHRNP--TYRPRYRRGPPRPRPIVaPIGEAEDKENQQAANGPNQPAARrGYRRPYNYRRRpRPPNAPSQDGKELPE------------------- ------------------------------------------------AEEKMVIERKVWGTVKWFNVRNGYGFITRSDNKRDVFVHQSAIKKNSPYKYHRSVGDGERVEFDVVLGDKGLEAANVTGPGGIPVQGSIYAADRRKCSLGLRRSLPHK----SYHLCERVPKNETATSAPEDG---NLPYSGQ---SYLMHTSYGYQPQCFNS-VSAEVVH-AEGQCVhTEQSKPVKQSIHQGFRHLP---------------------QTNETEDSAISQHFYRPNFSYLRRRPRNVK--DGKETKEIsGPPAEDTLAPET------ -----------------------------------------------AVPEKQIIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAITRNNPRKAVRSVGDGEIVEFDVVVGEKGNEAANVTGPDGEPVKGSPYAADRRrRFRRY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------GLPGLAP-AGDKKIIARKVLGTVKWFNVKKGYGFIHRHDSKEDVFVHHTAITKNNPRKYLHSVGDGETVELDVVEGVKGAEAANVTGPGGAPVQGSQYAPERGHYGRYPRWRRAGRHDR--DSDSDSDSDSEGSQSAAESQARARWPRG--LLCPRCLRGAPGRgRAQRPQPPVQPEGAR--------------------TARPRPS-------RP-----EED-------VPGLQPPDRH----GGDARGPPDASKPRDGLETRAACPAAEKPGAAQA------ -----------------------------------------------TVGEKKVITNKVLGTVKW------------DDTKEDVFVYQTAIKINNPRKYLCRVGDGETVEFDVVIGEKGTEAAIVTGPGGVPVQNSKYAADCKHYRRYPHCRgGPSHNYQPNYQNSEVGEKPEEAEIVPEGDgPNQQRPYRRWPYPPYYLQRPYRR-GQVLKTPKQLETCES-------------------------------------------------------------------------------------------------------- --------------------------------------------------PKKVIAKRVRGSVKWFNVKNGYGFISRHDTQEDVFVHQTAITRNNPHKYQRSVGDGETVEFDVVQGERGTEAANVTGPAGAPVEGSRYAANRPRFRRgfYIRRRAPpPRGPR-GAE-DDVDEGEGSGEGFTVAQGQRRRLpghpqdQRLRRFPPFRRAPAVTRRPsilaptsgpRAAHLPGSAP--------AARPEGAPRrgPGPSYLLSRPRGRGTTPgprPSPGISEELEAEDKESGREAGGPQQRPPPRYG------------------------------------------ ----------------------------------------------ETKQEKKVIATKVTGTVKWFNVKNGYGFINRDDTKEDIFVHQSAIVKNNPQKFQRSVGDGEQVEFDVVQGEKGLEASNVTGPDGAAVQGSEYAANRRSGRgrggfrggqggGRGQR--PPRDRRG-YY-GRGDGGPVGDEDGPGP------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------TVGEKKVITNKVLGTVKW------------DDTKEDVFVYQTAIKINNPRKYLCRVGDGETVEFDVVIGEKGTEAAIVTGPGGVPVQNSKYAADCKHYRRYPHCRgGPSHNYQPNYQNSEVGEKPEEAEIVPEGDgPNQQRPYRRWPYPPYYLQRPYRRG-QVLKTPKQ-------------------------------------------------------------------------------------------------------------- ------------------------------------------------QPERKVIATLVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPKKFLRSVGDGEIVEFDVVQAAKGSEAANVTGPGGVPVKGSRYAPNKRRFRRrfFPRGPQPPP----------PAD-QVKGGDAPLAP-----------------------S------PEGGEVPA-AD--G--------------APRPHPRRRRPRRRQQQVQGEEKDEEDAEGEMVQQRPPPRRFRPRFRRPFRPPLSPEErVEGQQQPTVAP---------------- -----------------------------------------------TVGEKKVITNKVLGTVKW------------DDTKEDVFVYQTAIKINNPRKYLCRVGDGETVEFDVVIGEKGTEAAIVTGPGGVPVQNSKYAADCKHYRRYPHCRgGPSHNYQPNYQNSEVGEKPEEAEIVPEGDgPNQQRPYRRWPYPPYYLQRPYRRG-QVLKTPKQ-------------------------------------------------------------------------------------------------------------- -----------------------------------------------TVGEKKHIATKVLGTVKWFNFQNGYFFINRDDTEEDVFVHQT----------LHSVGDGETVEFDVVEGEKGTEAANVTGPGGVPVQGSKYAADCKHYRHYPRRRgGPSHNYQPNYQNTN-------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------QPERKVIATGVEGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVVEAAKGSEAANVTGPGGIPVKGSRYAPNKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------PAKIIANKVSGTVKWFNVRNGYGFIHRNDTQNDVFVHQTAIVKNNPNKYLRSVGDGETVEFDVVEGVKGHEAINVTGPNGEPVQGSKYAPDKRpRYGGYRRGRGNRGGYRGGrggYRGgkSDVAEDRsdkdnepEDKEATSEHDEQPKRqAFRGRGRGRGYGR--YRRRPQRSE----GSGNEYASQDEGrkGDRDEEseRQEGSARGRRPRwFRRRPRRPPQS--------------------------------------------------------------------- ---------------------------------------------------------------------NEYGFIPRNDTKEVVFAHQTAIKK-TPRKSLGSGGGGQTAESDV-EGEEGVDAANVRGRCA---------A-----------------AVQNYRDSERGERTRDRSVLAKARPSRRRPHRRRRFPPEYVRRPRGCGPQPSNXPVRGEVMEGTrARQGAAEQGRPVTPNVXLGGGPPPRTGPPRQRWFREDGGEDDKEDGRDETPGQPPPPRPSRRNLGYPCRRPENPKPRDSKEAKAADPPAESPSTPDVEQGDA- --------------------------------------------------------MKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQ------------------------------GAEAANVTGPGGVPVQGSKYAADVTIIDAIHV-LGVLHAITSKITRIVRVGKRARDRSAPEAR-----PNKRPTYMVPTLRETLWRQPQYSNPPVQGEVMEGADNQGAGEQGRPVRHNMYG------------------------------------------------------------------------------------- --------------------------------------------EQPANDEKPVVAKGVKGTVKWFNVKNGYGFINRTDTNEDIFVHQTAITNNNPNKYLRSLGDNEEVLFDVVEGAKGPEASNVTGPDGGPVQGSKYAADRNSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------PERKVIASAVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVIEAAKGSEAANVTGPGGVPVKGSRYAPNKRRFRR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- VSSEAETQQPPAAPAAA--LSSANTKPGSRVSGAGSGGP----------RNKKVIATKVLGTVKRFN------------------------------------------------------------------------------------------------NSESGEKNEGSESAPEGQAQQHQPYHRRRFPPYYLRRPYGHQPQYSNPPVQREVMEGADNQGAGEQGRPVRQNVYGVTDHDFA------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------IVSGGKNEGSESAPEGR-----PNSA---PTLLHAETL--------WAWTTEVMEGAGNQGAGEQGRPVRQTMYRGYRPRFRRGLPHQRQPREDSNEEDKEKQGDETQGQQPPQHWYLHNFSYRSRSPENPKPQDGKEIKAADPPAENWSAPEAERGGAE -------------------------------------------------------RNEGLGTVKWF--RNGYGFINRNDTKEDVFVHQ------------------------------GAEAANVTGPGGVPVQGSKHAADRNHSRRYPRLRGPPRNYQQNYQNSESGEKNEGSRVLPKAKPN--------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------CLAATQVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVQGEKGAEAANVTGPGGIAVKGSRYAPNRRQFRRrfFPRA---PRAAAANQV--EGGGPapaagpaSEGEgtgddtAQQPPGPPRRRRPFFRQRFPR--------RRPDaqqGVAAAEEGEVPEGDP---AAQQRV-----PRRRFRPPFRR-PFRPRQPAGGqtpGTEGQPEGqvpsqqpegqTGEQTDAAQPAQaQRPRRQFSRRRQRA-------------------------------- ------------------------------------------------TDTLTHIPTKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVAFTSAEGE-SAPEAEQGGAEGIPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------QPERKVIATGVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVVEAAKGSEAANVTGPGGIPVKGSRYAPNK---RRFR-RRFYPR----NAQPAEGEEKSGGAPAGPisegEGseekGAPQPHPRR--QRPR--------RRP----VQPQGEGEAGEKNEEVdGAQQRPP----PRRFRPRFRRF---------------------------------------------------------------------------- ------------------------------------------------QPERKVIATLVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDVIEAAKGSEAANVTGPGGVPVKGSRYAPNKRRFRR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------AAMGEKVIASKVLGPVKWFTMR-----------NEDVFVNQTTVEFDE------------------VEGEKGAEAANVTGPGGVPVQSNKYAADRNH-RHYPRHRG-----------------------------------------------------------------------GAGEQGRPVRQNMYSGFRPRFRMRPLRQRQPREEVNEEDKENHTDASQGLQSPQRWHHHNYNYRRRCPENTKPQDGKETKVSAP---------------- -----------------------------TGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNRYGFINRNDTKEDVFVPQTAIE-NNPRKYLPRV-DRETMEFDVVEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------RTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGE-------EEEEGSGSsegfappATDGQfpgarSQLRRpqyrPQYRRRFPPYHVGQTSDRRSRAfPHPSrmQAGEIGEIKDGVpdGAQLQG-PVHRNP--TYRPRFRRGPPRPRPAPVVGETEDKENQQAASGPNQPSARrGYRRPYNYRRRpRPPNAPAQDGKELRR------------------- ------------------------------------------NSTAKQTQEKVYLGKGIKGKVKWFNVKNGYGFINRLDTGEDIFVHQTAIIKNNPNKYLRSLGDEEMVEFDVVDGSKGPEAANVTGPEGQPVVGSKYAADRAlHYR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------TAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyFGRRRGPPRS----------G--------------------------------------------IEGEIKDGVTEGGQ--LNQQVHRN--PTYRPRYRRGPPRPRPAPVAGEAENKENHHEAnAMSQQSLRRGYRRPYNYRRRpRPPSAPAQDGKETKVTETPAENP-APVTEQNGAE --------------------------------------------------GKNVIATKVTGTVKWFNVKSGYGFIHRDDTNEDIFVHQTAIVKNNPRKYLRSVGDEEKVEFDIVQGEKGYEAANVTGPNGTSVQGSKYAADRRQYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------APGLLIPAAPASGDKKVIQG---------------SFINRNDTKEDVFVPQTAINKNNPQ------------EFDVVEGRKG----NVTAPGGAPVQGYKYTADGNDYPRYS------CKYLQQYQNRENGERRR-----------------------------------------AGQAVEGADKQGAGEQGRPVRQNMHQDYKPQFHRGQQLK--------REGKPRRGDPRSAAT--PCQYQYNFNYPHRHPENPKPHDGKETKIANPPAENLSALR------- --------------------------------------------------GEKVIATMVLGTV---------------------------IKKNNPRKYLCSVGDGETVEFDVVEGKKGTEASNVTGPGGVPGQGSKYAADCKHYRQYPRHRgGPSSNSEPNYQNSEVAEKPEEAKIVPEGDgSNPQCPCHRWRYPPYYLRRPYERRPQYLNAPVQGEDIE--------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------MFNYRNGYGFINRNDTKEDVFVHQTAIKKNNPSKYLRSVGDGETVEFDVVEGQKGQEQQNVQGPSGIPCQGSKYWADRNHYRRYPRRRGPHATTSKITRIGRVGKRTKDWKSVLKARPNNQQPIQGES------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------PSVAEKKVLATSVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIRKNN--KYLRSV------------GEKGAEAANVSGPGGVPVKGSRFAPNRRRFRRgYFRRRGPAAQGNQLVTQeaAeSCGERQEGALEKGDGL-QQPANQRRHLPPPYFYRSRFRRRPGTPTSPQGGEGTAvsgdelsknkepVADSGQAQPQPQPPSQRAASGAKPRsqFRRRPFRAQSQQE-GLDGVDENKDPKTDQPLPERRRFRRPFFRRRT---------------------------------- -----------------------------------------------PPKEKKVLVKGVKGTVKWFNVMNGYGFINRHDNKEDIFVHQSAIAKNNPDKWQRSVGDGEQVEFDVVEGEKGQEAFNVTGPDGAPVEGSKYAATRYRP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------PIQVHHSVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVKGSRYAPNRRRFRRFIpRPRpaAPPP----MVAEVPSGGTEPGSEGERAEDPG-QRP-RRRRPPPFFYRRRFVRGPRPPN------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPTIHGRRPCGRGPQYSNPPVQ-EVTEGADTRGAGERDRPVKQNMYRGYRPRFRRGPSHQRQPREDSNEEDKENQGDETRGQQRPQRQYRRHFSNRRRCPECPKPQGDKETKAADPPAENSSPPPP------ -----------------------------------------------------HIPTKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAKAADS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------PKKVIAKRVRGSVKWFNVKNGYGFISRHDTQEDVFVHHTAITRNNPHKYQRSVGDGETVEFDVVQGERGTEAANVTGPAGAPVKGSRYAANRPRFRRgfYIHRRAPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------ATKVTGTVKWFNVKSGYGFINRHDTKEDVFVHQSAITKNNPRKYVRSVGDGEEVEFDVVVGEKGNEAANVTGPGGEAVKGSSYAHDRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------KMEKKVVATRITGVVKWFNVKSGYGFINRTDTKEDIFVHQSAILKNNPHKWQRSVGDGEQVEFDVVQGDKGLEAMNVTGPHGVPVQGSKYAADKRRYRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------SEKKVLATKVLGTVKWFNARNGYRFINQNDTNEDVFVHQPAIKKNNPRKYLCSVGEEEIVEFDVVAGKGGPKATNVTGLDGVPVEESRYAADC---HRYGRRRGPHHNAGEI------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------KKPIVAERVLGTVKWFNVKNGYGFINRNDTHEDIFVHQTAITRNNPQKLLRSVGEGETVEFDVVVGDKGCEAANVTGPDGEPVQGSPYAADKRRFRprwiprRNQRRRGPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------RPLPPPSAFSIKNRYGF-NRNDTEEDGFVHQTVIK-----KYLRGVGDGETVESDV-EGGKDVEAANVKGSGRATVQGSKYAATITII-HTILRRGPPSNYPENDQNCESE---DSWESAPEGQASMNQP--------------WG-QPQSSNPPVQGEVLEGADQQGAK----------------------------QERGNEEDTENQGDETQSQQPSQHQYLCNFNNPHRYPENPNHHHGRDK--------------------- ------------------------------------------------QADKQVLATQVLGTVMWFDVRNGYRFINRNDTKEDVFVHQ---------TFLRSVGDGQTVEFDVVEGEKGTEAANVTGPGEVPVKGSHYAPSRRRFRRFVPRPpsvAPPRMVAEIpswgTEPSSEGERAEDS-----GQ----RP--RRRGPPPFYRRRFARGPQPPN--QQQTPLEGHQQQGDERVSRP-------QFRPRYRRpfrpRPP--RQPTtEGGEVETKPSQGPADGSRPEPQGLG------------------------------------------- -------------------------------------------------QQKEIIATKVTGVVKWFNVKSGYGFINRGDTQEDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPQGEPVKGSPYAAEkRRGYRQWWQKRGQRRPQSKDG------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------KNKRVLATRVSGTVKWFNVKNGYGFINRLDTNEDIFVHQTAVVKNNPKKLVRSVGDGETVEFDVVAGEKGNEAANVTGPDGTAVEGSKYAPDRRrFYGRFPRGRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------SGPRKLLEERVKGDVKWFNVKSGYGFIHRHDTDTDIFVHQSAISKNNPNKLQRSLKEGEEVEFYVVEGEKGDEAWEVTGPDGAPVQGSDYAAPRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------VKEKEVLATKVTGTVKWFNVKSGYGFINRHDTKEDVFVHQSAITKNNPRKYVRSVGDGEDVEFDVVVGEKGNEAANVTGPGGEAVKGSPYAHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------YVATRITGVVKWFNVKSGYGFINRSDTKEDIFVHQSAIIRNNPHKWQRSVGDGEAVEFDVVQGDKGLEAMNVTGPKGSFVQGSKYAADKRRYRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------VAQKPVIASRVTGVVKWFNVKSGYGFINRHDTKEDVFVHQSAIIKNNPKKAVRSVGDGEIVEFDVVAGEKGNEAANVTGPNGEPVKGSPYAADKRrnyRPQWyFGARRGgmrggppgrRPRDSQEGYDSPKDDEGQTDGEE----RG-PPRRYRPRRRFGDYGGY---RGGRGGRGPASGDDAYGGEPYDY-------------------------------------------------------------------------------------------------- --------------------------------------------------AKTVIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIVKNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPDGEAVKGSPYAADKRrGFRQYYNRR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------PKEVIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPSGEPVRGSQFAADKrrnyrpwnNRNRRKPQDQGPDGNIQQGV------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------NKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAITKNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPDGEAVKGSPYAADKrRGYRQYYNRRGgsgarpmrRPREGQEGYESGEGGKTG-DEQSGGEGgGSQQRRC----------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------PPKVIAKRVRGSVKWFNVKNGYGFISRHDTQEDVFVHQTAITRNNPHKYQRSVGDGETVEFDVVQGERGTEAANVTGPAGAPVQGSRYAANRPRFRRgfYIRRRAPtPRGPRGAEEDVDEGE--ASGEGFTEAQGQRRRLpggpqdRRLRRFPAFRKASAVSRRPSILTPTsglrpahlpgsTPASRSEGAPRRGPGP--------SYLLSRPKGRGTAPGPRpsgGISEELEAEDKESGHDGSGPQQKPPPRY------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRTPNGHQPQHSYPPAQGEVMEGVDSPGSGEQGGPVKQNMHRGYRPRFRRGPPRPRQPREEGNEEDKNNQGDETQGQQPPQRRYRCNFNYRRRRPGNPKPRDGRDKRS------------------- --------------------------------------------------------MKVLGTVKWLNVKNRYGFITWNDTKEDVFVPQTAKKKNNPRKYLHRVGDEETVKFDRVQGRKGPQAANVTGPGGVPVQGSKYAPNCNYY---LRPRGPPHNY---------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------NGKSVVATKVSGTVKWFNVKSGYGFIHREDTNEDIFVHQTAIVKNNPRKYLRSVGDEEKVEFDIVQGEKGYEAANVTGPNGDSVQGSKYAADRRQYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------EGKGKEVVARKVLGTVKWFNVKSGYGFINRNDTKEDVFVHQTAIVKNNPKKMVRSVGDGEVVEFDVVVGEKGNEASNVSGPEGSAVKGSPYAADRRrgGYRRggrgyYPRRGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------PPALSAADPKPRTTGSGgAGRGGPGGLTPAAPAGGDEKTIASKVLGTAKWFSVRNGCGFINRNDTAEGAFVHRTAIKKKNPRRHLRGVGDGETVESDVVEGEEGAKQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------PIDLFEGVGDGETVEVDVVRGEKGTEAANVTGPVGVPVQGSKYAADCKHYRRYPWCRgGPSRNYRPNYQNSEGGEKPEEAEI---------CLYRRRRYPPYYLRRSYGRRPQYSNAPVQGEDIE--------------------------------------------------------------------------------------------------------- -------------------------------------------------RKKPIVAERVLGTVKWFNVKNGYGFINRNDTHEDIFVYQTAITRNNPQKLLRSVGEGETVEFDVVVGDKGCEAANVTGPDGEPVQGSPYAAHRRPFRprwiprRNQRRRGPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------NIITTKVLGTVKWFNVKNKYGFITQNDTKEDVFVHQTAIKKNNPRKYLRSVGDGQTVEFDIGQRKKGPQAANVTRPGGVPVQGSKHAPNYPH----PKKCCPPYNNQRNE------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------PKEIIATKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPSGEPVRGSQFAADKrRNYRPWNNRnrrkpqggQGPDGNVQQGAE----------GEVRPDGQQQQQRPQRnyrRgggpggpsgpggrggrgRRFNNYFPRNQGGRRSGG----GEGGLIEGGNDQNA-------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEGteRESAPEGQAQQGRPSE-----------------LSSNPPVQREETEGADNQGAGEQGRPVRRNIYQGYTPRFRRG----QEPREDGDEEDKENQGADTQGQQPPQRRDRCNFSYGRRCPENPQPQDGKETKA----AENSSAPQAGQGGA- ---------------------------------------------------------------------------------------QTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYPGEEEEEEGSGSSYGFDPiITKGHqigirNQLRrPQYRQQFFPPYHAGQTFDRRSrVMHHPysMFHGGEGEMKDGVPEGGQLQqQVHRNP--TYRPRYRRYVP-------------------------------------------------------------------------- ------------------------------------------------NAPRPMTEERVRGVVKWFNVKAGYGFITRSDTSSDIFVHQTAISRNNPNKMQRSLQEGEEVEFFVVEGDKGVEASDVTGPDRRPVKGSDYAADR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWRPYGHRPQYSNPCVQGEVMEGADNQGAREQGNPMRQKIYQGYRPQFCRGPPHQRQSRQ-GDTEDKENQGDGNGGQQPPQRWC-------LKCPGNPKPQDGKETKRAELPTENRSAPEAEQGGDE -------------------------------------------------EQKKIVAERVTGIVKWFNVMNGYGFICRDDTNEDIFVHNSAISKNNPEKAQRSLGDGEKVLFDVVEGTKGPEASNVTGPEGQNVVGSKYAADASQQRRYPRRN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------KRILLRRAAGHIVLQEAQ-STDFSAKNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNVALVLK----------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------NKQFLALKVTGTVKWFNVKSGYGFINRKDTGEDVFVHQSAIIKNNPKKAVRSVGDGETVEFDVVEGEKGNEAANVTGPAGEAVKGSPYAADKRRgFRQWFF-RGGPRSRGTRK---PGMEVSDGEEAAEEDDgnqNDKPRRYRNRRFVsggtGYYPRRPSNRPDKNGD----KDGGEGGDDGGE-EDGRPTgeqraergaprgrggRGRRYPVYRGGRQGGPPKSRQQQGDGGDgGAKEGGGGE------------------------------------------------------ -------------------------------------------------ATKQVVAEKVSGTVKWFNVKSGYGFINRDDTKEDVFVHQTAIVRNNPRKAVRSVGDGETVEFAMVVGEKGFEAAGVTGPGGGPVKGSPYAADK--RRGYPRRGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------RKKPIVAERILGTVKWFNVKNGYGFINRNDTHEDIFVHQTAITRNHPQKLLRSVGEGETVEFDVVVGDKGCEAANVTGPDGEPVQGSPYAADRRPFRprwiprRNQRRRGPAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------PKKVIASRVLGTVKWFNVKNGYGFINRHDTNEDVFIHQSAIKKNNPRKMIRSVGDGEVVEFDVVISAKGNEAANVTGPNGSTVQGSKYAANWNYRGRWSARNNfPPfrqmrkspniDNLSQRYN------EDEGKNYAPRRSS--QRPFFR-----KFFQRPPGSKNSYSRERGDNEnkyISRVDDNQRSdynRRQGPPRR-----FFRRYFRRATRRPRSD--------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKTAEPPAENTSAPEAEQGGAE --------------------------------------------------GQKIISRKLSGTVKWFNVVNGYGFINRDDGKGDIFVHHTAIIKNNPNKKLSSLADGEEVKFDVVEGRKGPEAANVTGPNGTPVQGSVHA-D---YPHKLRRQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------KEKKLIVKGVKGTVKWFNVMNGYGFINRSDNNEDIFVHQTAISKNNPEKAVRSLGDGEEVEFDVVEGEKGVEAFNVTGPGGTNVQGSKYASGRG--RRFRGRRGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------QKDTLATKVTGVVKWFNVKAGYGFINRHDTKEDVFVHQTAIVKNNPRKLLRSVGDGEEVEFDVVAGEKGNEAANVTGPEGAPVQGSQYAPDRR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------RKKPIVAKRVLGTVKWFNVKNGYGFINRNDTHEDIFVYQTAITRNNPQKLLRSVGEGETVEFDVVVGDKGCEAANVTGPDGEPVQGSPYAAHRRPFpprwipRRNQRRRGPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --SGAETQQPPARgrdPAAArcPRPHAAGtqprTQPGTTGSAQGAVARAASHR-RRLSGDKKVIATKVLGTVKWFNVRQGYGFINRNDTKEDVIVHQTAMMKNNPRKCLRSAGDGEAVQFDVAEGEKVP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------QKVIATKVLGTVQWFNVRNGYGFINRNDTKEDVF-------------------------FDVVEGEQGAEVATVTDPVGSAVQGSQYATDRNRYKRYPQTTRVT------------G----GLSQAAEVL--T-KAPGRRRYPPYFGS-------------------GGDENQGVPDQGnRPARQNYNRGFKPK---GPPCHRLPWES--EEDKENQEGAGPNQQPL----------------------------------------------- ----------------------------------------AATPAAPPAVERPVIKKGVKGTVKWFNVKNGYGFINREDTNEDIFVHQTAITNNNPKKYLRSLGDGEEVLFDVVEGSKGAEASNVTGPEGEPVQGSKYALDVEQVRTRRRTR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------QKKVIA-HVTGTVKWFNVKSGYGFINRDDTKEDVFVHQTAIVKNNPRKYLRSVGDGEKVEFDVVEGEKGNE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------DGKKIVARHIQGTVKWFNVKNGYGFINRADTGDDIFVHQTAVTKNNPNKYLRSLGDGEKVEFDVVEGQKGPEAANVTGPNGCNVEGSRYAADKSDMR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------IKKKVIANGVSGKVKWFNVKNGYGFISCIDTSEDIFVHQTAITKNNLNKYLRSLEDNEEVEFDVVEGQKEPEAVNFTGPGGAPVKGSRYAANRNQRRR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------AKEKKIIAQKVTGTVKWFNVKAGYGFINRKDTEEDVFVHQSAILKNNPRKFLRSVGDGEEVEFDVVVGEKGNEAANVTGPNGAPVRGSVYAPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------GEGTKKVISSKVTRAVKWFNVRRGYGFINRDNTQgDDVFVHHTAIVKNNPHKYLRSVGDGEKMEFDVMKAEKGNQAANVTGPEKASVQGSKYAADRRHFR--PRLPGP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------GTFSSTATKVTGTVKWFNVKSGYGFINRHDTKEDVFVHQSAITKNNPRKYVRSVGDGEEVEFDVVVGEKGNEAANVTGPGGeavkgspyahdsdVPMQGSPYAADRRrgYRRRYYRRAAP----------GEEGEVvEEGGDYVPNMRGRGRGGFRGRGPRRFYRGRFFGR------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------GKQIIATKVTGTVKWFNVKSGYGFINRNDTKVDVFVHQSAIIKNNRKKAVRSVGDGEVVKFSVVVGEKGNEATNVTGPNGEPVRGSSYAADRR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------AGQQKLIIANKVTGTVKWFNVKSGYGFINRNDTKEDVFVHQSAIVKNNPRKAVRSVGDGEVVEFDVVIGEKGHEAANVTGPSGEAVKGSPYAADKRRgYRGghwYiSQRRGntrtqrRPREGQDGYE---TGEGKTGDEAnTGEGGGQQRRYRVRRQYDGYYR------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------PKEKKIIHKGVKGTVKWFNVMNGYGFINRSDTNEDIFVHQTAIVKNNPEKIVRSLGDGEEVEFDVVEGEKGVEAYNVTGPEGTNVQGSKYATR---GRRYRGRRGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------KEKEVLATKVTGTVKWFNVKSGYGFINRHDTKEDVFVHQSAITKNNPRKYVRSVGDGEEVEFDVVVGEKGNEAANVTGPGGEAVKGSPYAADRRrgYRRRYYRRAAP-G---------EEGEVVEEAgDYVPTMRGRGRGGYRGRGPRRFYRGRFFGrgrgrgaggRGAFYPgfNDYEGGEVAEVVD------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------GNDTKEDVFVHQTAIRRNNPRKFLRSVGDGETVEFDVVEGEKGAEASNVTGPGGVPVKGSRFAPNRRRFRRrFYRPRGE------N--AGESGGEGVTSEQASESErtedsSPQQRPQR-RRPPPFFYRRRFVRGPRSSNQQQPTpEVEDKAepkdpaavpaqDGQTS------DGQRTPRRFRPRFRR-PFRPRtspqQITEGGQGEMKPPSNGGP--QPEPQRQRNRpYFQRRRRQGADPGsgpaQDDGkKETEAANGP--------------- -------------------------------------------------RKKPIVAERVLGMVKWFNVKNGYGFINRNDTHEDIFVHQTTTTRNNPQKLPRSVGEGETIEFDVVIGDQGCEAANVTGPDGEPVQGSPYAANRRPFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------KGIEAANVTGPGGVPVQSNKYAVDHNHYRCYLHCRGPPYNF-QNYQNSESRENNKGWEQVSEGQAQQCWPYLRPQFSPYYLQRPYVLRLQYSNPLVQEEVIEVADIQGAREQGRPVGQNMYQGAL---------------------------------------------------------------------------------- ------------------------------------------------QADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------KKPVLAERVLGTVQWFNVKDGYGFINRNDTREDIFVHQTAITRNNPQKLMRSVSEGETVQFDVVVDEKGREAANVTGPDGEPVQCLPYAMDGRRFrgRWFPRRSqcRPMPNPRHGVQDSD-------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------PATHITGVVKWFNVKSGYGFINRCDTKEDIFVHQSAILKNNPHKWQRSVGDGEQVEFDVVQGDKGLEAMNVTGPHGTHVQGSKYAADKRRYR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------MLATNIKGLVKWFNVKCGYGFINRSDTKQDIFVHQSAILKNNPNKWQRSVGDGEEVEFDIVQGDKGFEAVNVTGPHGDVVQGSKYASDRRPYRSR--SFGRQRNYQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------EVVATKITGTVKWYNVKNNYGFITRDDTGEDLFIHRTAIKRNNPKNYLQSVGDGEVVEFDMVQGRKGLQAANVTGPGGIPVKGSVYAKNINNIHS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------KGFKRFKATRITGTVKWFNVKNGYGFISRNDKeGEDVFVHQSAIKRNNPGKAVRSVGDGEVVEFDIVEGEKGNEAANVTGPNGTPVKGSPFAADRKFSPRgrgNfrrgggGFRRGPPRDGQF----SDGGG--------------GGRSYRGGRGRPFFRRRFF-------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------QTLVLGTVKWLNVRKGYGFINRNDTKETRFW------------------------------EKGAETANVTGPGGVPVQGSKYAADRNRYRWYPRRRGPPRDYQDNYQSdgeSEGREKRESQEIVPEGDAQEQFPWQ--------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------VKVSGVVKWFNVKNGYGFICRDDTQEDVFVHQTAILKNNPKKLRRSVGEGEALEFDVVQGIKGTEANNVTGPEGVPVQGSKYAPDRSRFRggRFRNRRGGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------PAPPTKEVIATKVTGTVKWFNVKSGYGFINRNDTREDVFVHQSAIARNNPKKAVRSVGDGEVVEFDVVIGEKGNEAANVTGPSGEPVRGSQFAADK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MSSEAEIQQPPAAPSAAPALSAADSKPGTTGSGAGSGGPGGLTPVAPAGGDE-VIATKVQETVKCFNVGSGDGFVNS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------PQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRgyYGRRRGPPRNYAGEEEEEGS-GSSEGFEPPAAdrrfsgARSQPRRPpyrpqYRQRRFPPYHVGQTLDRRSRVFPHPyrtQGGEIGEMKDGapEGAQLQG-PVHRNP--TYRPRYRR----------------------------------------------------------------------------- ------------------------------------------------------------------------------NTKEDIFVHQTAIKKNK---------------------KKGAEAANGTGPTGTLVQGSKYAADGKQCRPFQCCSDHPCSYQWNYQNSESGGEIEGWESACEGQAPQHRPYCRWRFPPYYYRDPN--------------MVECADNQGAGEQGGPVRQSIL--------LGSPEQRQSSKKDNEEHKENVKDL------------------------------------------------------ --------------------------------------------------PKQVIAERVSGSVKWFNVKNGYGFITRHDTQEDVFIHQTAITRNNPHKYQRSVGEGETVEFQVVQGKQGIEAANVTGPGGAPVEGSRFSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------QREKVVKKTGVRGVVKWFNVVNRYGFIFRNDNNEDIFVHQTAIAKFNPKKAIASLGDGEEVLFDVVEGEHGPEAANVSGPNGEPVEGSKHAPD-KQSRHFGGRG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------ELLAMNVLGTVRWFNVKNKYCLITRNDNKEDVFVHQTAIKKNNPKKHLHSLGDGEIVEFNIIQGRKGPQAADVTGPGRIPVQGSKHAPHYKPAKYYPRHRSPPHTYQRNRT----------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------GEKVIATKVLGTVKWFNVRNRYGFINRDDPKEDVIVHQTVIKKNNPRKYLHSVGDGEIVEFDVVEGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------HIPTKVLGTVKWLN--------------KHVFVHQT----------------------------KGAETANVTGPGGVPVQGSKYAADRNRYRWYPRRRGPPRDYQDNYQSD--GE--------SE------------------------------------------------------GQNYDRGFRP---RGPPRPRPVREG--EEDKENQGEGNQNQDPRQRRYRRP---------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAQRQPFHRRWRPPYYLQRPSGRGPQYAIRPVQGEVMEGADNQGAGEQG-----------------------QPRQDGNEEGEENQGDEIQGQQPRHCRYRHNFNCQHRRPESPKSQDGKETKAADPPAEREFLHSwAERGRAE -------------------------------------------------------AMAVQGTVKWFNVRNGYGFINRYH---FILCITTAIKKNNPRKFLRSVGDGEVVEFDVIEATKGSEAANVTGPGGIPVKGSRYAPNK---RRF-RRRFFPRNLHPADQST----PTDNQAPAPEGEQteetgATRPPPRRRR----------PRRPRLSTQ--NGQVGEEKDGAAEGDQTqqMPQRRRFFRPYR---------------------------------------------------------------------------------- -------------------------------------------------NGKTVIATKVTGKVKWFNVKSGYGFIQRDDNNDDIFVHQTAIVKNNPQKYLRSVGDDERVEFDIVQGEKGHEAANVTGPNGTNVQGSKYAAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------KERSTKVSGTVKWFNVKSGYGFINRDDTKEDIFVHQTAIEKNNPTNSIRSVGDGEIVEFDVVVGKKGNKAAHVTGPDGTHVEGSPYAADRRKYRRFRGRsyvgrRpKPWSSPPKNFNNEEGSEEQsgEGNNEGPDGK-----PMRRRR---RFVRRPWVSLPRRNN------------------------------------------------------------------------------------------------------------------ ------------------------------------------------PKEKKILVKSVKGTVKWFNVMNGYGFIHREDNNDDIFVHQSAILKNNPDKAVKSLGDGETVEFDVVEGEKGAEAFNVTGPGGVNVEGSKYAGTRGRGrgrggRRYFRggrRGGGPI----GGGNSSGGEGEDGNESGGDGQ----------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------TEKPIIATKVKGIVKWFNVKNGYGFISRQDTNEDVFVHRFAIIKNNPKKVVRSVGDGEIVEFDVVGGEKGHEAANVTGPDGEPVKGSPYAAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------HIPTKVLGTVKWLN--------------KHVFVHQT----------------------------KGAETANVTGPGGVPVQGSKYAADRNRYRWYPRRRGPPRDYQDNYQSD--G--------ESE------------------------------------------------------GQNYDRGFRP---RGPPRPRPVREG--EEDKENQGEGNQNQDPRQRRYRR----------------------------------------- ----------------------------------------------PVPKDKEIIATKVTGIVKWFNVKSGYGFINRSDTKEDVFVHQSAIVKNNPRKLVRSVGDGEEVEFDVVVGEKGNEAANVTGLAGEPVKGSPYAADRRRGGYYRRSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------HIPTKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------PERRVIATLVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVE----PGDDQTPAAEGDGAGE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------HGHDEDVLAKRVSGIVKWFNVKNGYGFINRSDTNEDIFVHQTAITNNNPNKFLRSLGDGEEVRFDVVEGAKGPEASNVTGSDGGPVQGSKYAADRDSDRGAR-GGFRRRNF---YRGGHSGEADGGDQQEEGG---QRRSFRG-------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------IAATSVQGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKFLRSVGDGEVVEFDGKPADGQAPSAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------TIAKKVLGIVKWFNVKNRYGFITRNDTNEDVFVHQTAIKRNNPKKCLRSLGEKELVEFDIIQGKKGLQAANVTGPNGLPVKGSKYAPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------TGKGKKVLAMNILGTVKWFNVKNKYGFITRDGNTEPMFVHQTAIKMNNPQKYLHSLGDGEIVEFNVIQGRKGPQTADVTGRGGVPVQGSKHAPNCKHTKYYPHHRSPPHTYQRH------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------IKGKVKWFNVKNGYGFINRLDTGEDIFVHQTAIIKNNPNKYLRSLGDEEMVEFDVVDGSKGPEAANVTGPEGQPVVGSKYAADRAlHYR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE