MDDLLTLSSSSYPNSPHPFSSPSQPAVVPVSITQRRLESFLSARPEHWSFAIMWSPTPSDPQLLSWAAGQLSTTSHSVPDALDDTLVDWLYATSLTRSFQLTDSSSIIARSLATPAPIWLSGTVKLNSAGCDRAREAQMHGIKTLVCIPIAGGVVELASTNLLQEDSMLLQQVQATFAETPVAACGSVGSAESDPQQQMRRPRKGTDSAVSTDHVSAERQRREKLNHRFYALRSVVPHVSKMDKASLLADAVSYIKELRARVNELESRTRAPKQKRAGAACGFHASRNKQLRGLADCSVQVRMLGEDNVLIKVQSENAESAPARVMWALRELEVGVHHATMSSLKDMMVVDVMGTIPAGSGLETRERMRAALFSKIADE MEELiISPSSSSSL-----VSFSQETP--P--TLQQRLQFIVQSQPEWWVYAIFWQASKDDngRLVLSWGDGHFQGTKdaskksnknfgfnseRKKvMkgiqalfgDDhdidmrVDgDvTDAEWFYVMSLTRSFSAGD-G-IPGRAFSSGSFVWLTGDHELQFYNCERAKEAQMHGIQTLVCIPTSCGVLELGSSDVIKENWGLVQQAKSLFGSDLNnlvpkqpShegpiqfldrnisfaDIgifSGvqqkewsperqegakkeaaklgrssSDSEHSDSDGnflsentEKRTPKKrgrkpGLGRETPLNHVEAERQRREKLNHRFYALRSVVPNVSRMDKASLLSDAVSYINELKAKVEELESKLQRQSKKVKVEMAdnmdNQSTTTSVdqhrpSSsnSgAGNGMEVEVKIVGSD-AMIRVQSENVNYPSARLMNALRDLELQVHHASMSSVNELMLQDVVVRVPDG--LRSEEALKSAILRRLEQ- MEELISPSSSSSP---PPFSMQQSSP--P--SLQQRLQCLLQSRPEWWAYAIFWRASPDHdgRLVLSWGDGHFRGTRdasppRRRtaGDevGLDGvDDAEWFYVVSLTRSFSAGD-AAVPARAFGSGSPVWLAGAHALQTCGCDRAREAQLHGIETLVCIPTPGGVLELGSSDLIGENWGLVQQAKSVFSPPPDANinlsgpaptpeLpasqnqvaglsSSVDSEHSDSDGgltvERRRPKKrgrkpGSGREAPVNHVEAERQRREKLNHRFYALRSVVPNVSRMDKASLLADAVSYIKELRAKVEELEAEAKRAKKEINVEQGNSsgGtpTSTTTSSGGPATMEVEVKLLGSD-AMIRVQSENVNHPPAKLMDALRDLELKVHHASVSSVKELMLQDVVVRVPDG--LQGEDTLRSALLAKLEK- -------------------------------TLQQRLQALIEGARESWTYAIFWQSSYDYsgASVLGWGDGYYKGEEdkgkRKakTssSaaeqehrkkvlrelnslisgssasaDDaVdEEvTDTEWFFLVSMTQSFVNGS-G-LPGQAFFSSSPVWVAGADRLASSPCERARQAQVFGLQTMVCIPSANGVVELGSTELIFQSSDLMNKVRVLFNFNNgleagswplspntpdqgENdpsslwltdpsssieikdsvnNpssvpnstsnspiskqiqfenpssssltenpssihmsnhqqqqqqqqgfFsrelnfSefgfdgsSVrngnshslkpesgeilnfgeskrsscsgngnlfsgqsqfvaeenkkkrsptsrgsneegmlsftsgvilpssvvkssggagDSDHSDLEAsvvkeadssrvvePEKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLQNLESDKEELQSQLeslKKElaskDSRsaPPPPDqDlkMSNhsgSKLIDLDIDVKIIGWD-AMIRIQCSKKNHPAARLMAALKELDLDVHHASVSVVNDLMIQQATVKMGSR--FYTQEQLRAALSSKVGD- -------------------------------TLQQRLQALIEGARESWTYAIFWQSSHDFgsgASVLGWGDGYYKGCEedkRKkKrssasSaaeqehrkrvlrElnslisggggvsdDaVDeEvTDTEWFFLVSMTQSFVNGS-G-LPGQAFLSGSPIWLSGADRLAGSPCERARQAQVFGLQTMVCIPVGNGVVELGSTELIFQSSDLMNKVRALFNFNNGggeagswpfnlnPdqgenDpsmlwisepsvtgiesgvapeIsnsnppsnsdspsssslteNpsSVEnpsqqqnpnfsesglnfsesggilkrnsslsfvenessekkrspvrsnndegmlsfssapvpspaksgdSDHSDLEAsvreeessavvePEKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELRSKLQQLESDKEELQSQLeglKKEggKDsASRpKdRKCSNqdSGRCIEMEIEVKIIGWE-AMIRVQCSKKNHPAARLMEALKELDLEVNHASVSVVNDLMIQQATVKMGSR--FYTQEQLKAALMAKVA-- -------------------------------TLQQRLQALIEGTHEAWTYAIFWQSSYDDasgESVLKWGDGYYKGCEedkRRqrRaSpaeqehrkrvlrElnslisgesspdDaVDeEvTDTEWFFLVSMTQSFVNGS-G-LPGKAFASGNPVWVTGSDQLAGSGCERAKQAGDFGIQTMVCIPVGNGVLELGSTDEIRQNPDLINKIRVLFNFEGSDdfsgapnsnsfqqfstQLNnsggsvtvtrnpspAplfshaaaLNfstgttsrasndgmlsfsSApardgqiksssgdldgsddHSDLvESsvvvEpEKRPKKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAVSYINELKSKLENLESEKEALQIQLeELKEerAGRNARPSpkVmNGgGNASGVEIEVKIIGCD-AMIRVQSSKRNHPAARLMNALMDLDLEVNHASISVVNDLMIQQATVKMGSR--IYTQEQLRAALYSKLNA- MEEIISSSSSSSL------PFCQETS--A--TLQQRLQFILQSRPEWWVYAIFWQASKDSndRIFLSWGDGHFRGNKDlasKRSnknyqpkfgfnkrkkvregiqalfdEDmdldrmvdGGDvTDSEWFYSVSLTRSFAAGD-G-IPGRAFSSGSFVWLTGDHELQFYECERVKEARMHGIQTLVCIPTSCGVLELGSSDMIKEDWGLVQLAKSLFGSDNNrvskSgsggqlipflDIgifsgdqkeqtdtkkaaptnigSSSDSSHSDSDGnftsentMntrsKKRGRKpGSGESTPLNHVEAERQRREKLNHRFYALRSVVPNVSKMDKASLLADAVAYIKELKAKVEELEAKLRVQSQKHKKKKWmNTRQT---SNYGPTLMKVDVKIVGSD-AMIRVQCPDVNYPAARLMDALRALELQVHHASISTVNEQVLQDVIVRVPPG--FINEETLRTAIFQRC--- -------------------------------TLQQRLQALIEGAHECWTYAIFWQSSYDYsgPAVLGWGDGYYKGEEdkgkRklKTSsavaeqehrkkvlrelnslisgstaptDDaVDEevTDTEWFFLVSMTQSFVNGG-G-LPGQAFFNSTPVWVVGSERLASSTCERARQGQVFGLQTMVCIPSANGVVELGSTELIFQSSDLMNKVRVLFNFNNGieagslsmcnniadegeNdpsslwisDpnsgveykeshnnnqnqqisksiqFhdnpssssltenpssiqqqqsqsfsrelnfSdygfdgsnsvrngnsSlLkpesgeilnfgeskrsgnvveenkkkrsptsrgshedgmlsftsgvvlpssgmmkssggagDSDHSDIEAsvvkeaessrvvePEKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKTKLQNAESEKEELQKQLeamKkeLAKKDSSPpPSqNpkTSNhlgNRLIDLEIDVKIIGWD-AMIRIQCSKKNHPAARLMAALKELDLDVQHASVSVVNDLMIQQATVKMGSR--FYTQEQLRLALISKIGD- MEEIMSSASSSFL-----VSASSSTS--SN-ALQQRLQFILQSRPEWWVYSIFWQASKDDdgRLVLEWGDGYFRGMKDREpknSrfnpsQNMDHvNDLEWFYRVSQTRSYSAGE-G-VVGCAFSSGTDVWLSGEDEFEVYECERVREARMHGIKTLVCISTPRGVLELGSTKVLQLDWSLLQLAKSVFESNFLsTGItphkeeehqrRrVLDGsstdsgSKSDHKAegashNiPSMGRRaGRARlPSPLNHVEAERQRREKLNQRFYALRSVVPNVSKMDKASLLSDAVSYINELRSKIDELEGKLKFQPQKsaNKVASGNETeqTIHaSSRSSPSLNmMEVEVKIVGSE-AMIRVQSLNVNHPAARLMDALRDLELEVHHASMSNVKEMMLQDVVVRVPHG--LMSEEALRDAILQRLCE- -------------------------------NLQNKLSDLVERpnaSNFSWNYAIFWQISRSKsgDLVLGWGDGHCREPKEgeesEaTrilNlrledetqqrmrkrvlqklhtcfggsDedNyalgLDRvTDTEMFFLASMYFSFPRGE-G-GPGKCFASGKHIWLSDALSSSSDYCVRSFLAKSAGFQTIVLVPTDSGVVELGSVRSIPESQELLQMIKSVFSSNSvkpipvvsekkdeNsnligekvegvPkifgqDLnlggskfreklairkfeeRpwkayengnrspfpnprnglhgsSwsQnqglgspqevygpqtpvnNvSSlvngvrsdfrlnnyqpqkpvqmqidfsgatsrpsvvgrpfnaeseHSDVEAsckeerpgqaDERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITELQKKLKVMEAERERLGSTS--D---GSLAN--PQEQNPVPEIDIQARQDE-VVVRVSCPLDSHPVSRVIQAFKEAQITVVESKVSAANDTVFHTFVIKSQ-GSEQLTKEKLIAALSRES--- -------------------------------DLQNKLVDLVEGPssGAGWNYAIFWQISRSKsgDLVLGWGDGHCREPRegeedseaaralddeaqqkmRKRVlqklhtlfggsDdeNyalrLDRvTDAEMFFLASMYFSFPRGE-G-APGRALASGKHLWISDPSKSSADYCVRSFLARSAGFRTIVLVPFETGVLELGSVNSIPESFEALQMIRSVFSSGagmersdevavspfkdrSeEcPkifgkDlnigrsevrekpsvakveerpweIqqnsnghrlpfpvrkgrqglnwNhnrsnshqqkfgngvvvpgNevdrsfghhsngvrgdprlnqfqpqkqqppqprqidfsgggssagpviarpgaLESEHSDVEAsckeerpspiDERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITELQKKLKEMESERERFSESSMVD----------PNRRVQCPDIDVQAVHDE-VIVRVSCPLDTHPVSKVIQAFKEAQITVVESKVSAGSDTVLHTFVVKSP-GSEQLTKEKLIAAISREMN-- -------------------------------NLRKQLAVAVRSI--QWSYAIFWSISCPQQGVLEWGDGYYNGDIktRKTVqpmevsadelglqrseqlrelyeslsagEsnqqarrpsaalSPEDlTDTEWYYLVCMSFVFNPGQ-G-LPGRALANGQHIWLCNAHEADSKVFSRSLLAKSASIQTVVCFPFLGGVVELGTTELVQEDPNLIQHVKTSFLDHPKpacsehstsnpanssddhdpmcakldHEidtnqleeeyspeeeedeeeeeLeceeletgSpddssngfepnqpseldsfmsegingsasqvqSwqMDddfsncvhqsmnssdcisqtvdSekassprrEnvndPclqdlqecnhtklSslDlgQDDlhysqtlstilqksshqlilgpsfrncskqssfvswKkgsdhhqkpregtsQWLLKKilfevprmhGkyrlnspkeNGdkdsrwrpeqDELSANHVLSERRRREKLNERFIILRSLVPSVTKMDKASILGDTIEYLKELERRVEELESCREsdmeARtRRKPqdMVERTsDnygnNKiGngkkPsiNkrkaCIdeTepepNrvvSkDGSTDDVKVSIIEKD-VLIEMRCPWREGLLLDIMDALSNLHLDSHSVQSSTNDGILSLTLKSKFKG-KKVASIMEIKQALQRIIP-- -------------------------------NLHHQLQFILQSQPERWDYAIFWKTTRGVdggrPWTLSWGDGYFKPAF-KMEptLvKPDMDDAEWFYMPSITRSFAAGD-G-LPCRAFASSSVVWLTGMDELLSCSCERAKEASIHGIRTLVFSPTSSGVLELGSSEVIEEDWSLVQQVKSLFGSNENDDIGfvstpedgGlspadsekskldLPSPSSDSPApklerPKRRGRKrgrrpGAGG-TPANHVEAERQRREKLNQRFYALRSVVPNVSRMDKASLLADAVSYINELKAKVEELEAELRRHSKVPKWENVnsSNGDGSTVvdqaAATsVNGTMEVEVKIVGSD-AMIRVQSENVNHPSARLMDALRELELQVHHASISRVNDVMLQDVVVRVPDG--LQTEEALKAALLQRLQD- -------------------------------RLQSMLQAAVQSV--QWTYSIFWQLCPQQG-ILVWGDGYYNGAIktRKTVqpmevsteeaglqrseqlrelyeslsagEtnpqtrrpsaalSPEDlTESEWFYLMCVSFSFPPGV-G-LPGKAYARRQHIWLTGANEVDSKVFSRAILAKSASIQTVVCIPLLDGVVELGTTEKVEEDLNLIQHVKSFFLDFQKPicpkpalsehstsnpdsssptHvdhtivlpnnqypaeeefdeeeiLgsdseeaegmtspnGsncetnelmeldmsedirvgSpqdssnnLDSFNlavsqdcraessenggleenvsqiqlpeSDefhpphssldSdEDthysrtvssilqnqsnrwsdsstssckdsfqsafskwKsgsdhHRhdplldgtsqwLLKYilftvpllhAKslksqsanackppHDELSANHVLAERRRREKLNERFLILRSLVPFVTKMDKASILGDTIEYLKQLRKRIQELESARERNsgaREKRKMRVVEGN-----YGRKAVDVQVEVSIIESD-ALVEIECVHREGLLLDVMQALRELGLEVTTVQSSTDDGVFTAELRAKVKvenvNG-RKASIMEVKKAINQIIS-- -------------------------------HLRKQLAAAVRKI--QWSYAIFWSISSRQPGVLAWSDGYYNGDIktRKTTqpvelkadqmglqrseqlrelyeslsagDsnqqmrrpsaslSPEDlTDTEWYYLVCMSFTFNIGQ-G-LPGKALANNQHIWLCNAQFADSKIFSRSLLAKSASIQTVVCFPFMGGVLELGTTELVLEDPALIQQIKTSFLELPNpvcseqsisspqmaendedilcPdhdiddsmaledqnlisdcdpTFglhsyapieqeelvqdkceelntcSpddssndccpnqqledsfmveglngesqqqswqfmddefsnclhgSLNSsdcisqsfvnaqrvvsspkgerInNqmlddqecnqtklssLDLdgDDshyqstlstilknskqlilgpcfpngshessfvvwrkgvntpkpftgtPQKLLKKilfevpwmhgghllksqeENGnrekawrpaDEIGANHVLSERRRREKLNEKFLVLRSLVPSISKVDKASILDDTIEYLKELERRVEELESCRESAeleartRRKHpdVAERTSdNygnKeINNgkkpsankrkacDIdeAepehHwvlSKDGPIDVTVTMKEKE-VLIEMRCPWRECLLLEIMEAISNLHLDPHSVQSSTVDGILSLTIKSKFRG-SKVASPGMIKQALQRVIG-- -------------------------------ELQKQLQAAVQSV--QWTYSLFWQLCPQ-QGVLVWGEGYYNGAIktRKTVqpaelsaeEdahaalqrsrqlrelydslsaaaeahqpatrrpsaalSPEDlTETEWFYLMCMSFSFPPGV-G-LPGRAFARGQHVWLTGANEVDSKVFSRAILAKSAGIQTVVCIPVMDGVLELGTTEKVEEDIGLIQYARSIFMDQHgihmkptlsehstSNptthidhqppqqqmHIgitaqepfdhndeynddemedddEecmsgSetnttdderssgpLQavnmvsndgqampnaasSsELmqvemservrdgcsnNlddeiqmlmscqniqsnlqgqDpchswhflyedlqsgyppatEDqvaspeDahysetvstilhrndqrqqgmniknylavsqqssfsrwNKegsddQRtrspgtsqrmLKSilfevpslhcSyrqespDSRdgegmsrkgasqeDLSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKRIQELESSRNRQesaSRSPSadmVERTsDfnRSksgmkkrKAegvSSSngSNGKGSSTDVQVSIIESD-ALLELRCPYREGLLLRIMQALQELRLEVTSVQSSSADGVLLAELRAKVKEVHgRRASIKEVKRAIHQIIS-- -------------------------------TLQQRLQALIEESRESWTYAIFWQLSYDPagESMLGWGDGYYKGEEekdrkkkRNTiSaeeqehrkkvlrelnslisgssnssDDdvDEDvTDTEWFFLVSMTQSFANGV-G-LPGQAFLSSQPIWLSGSNKLPDSSCDRARQAKMAGIQTMVCVPTENGVVELGSTDLIRESWEVMNKVKMVFNGGGDessmwaadlnpavslqlnNDppamwpsepslsssgtidpsistgsnnstcsndshpIsqhfvgrvqppfispdlnfSssgfnnlpSdngfsgesrlmdekkrvpvsnsfnhegmlsftsglprppssgnrlPDSNHSDLDAsvkeadssrkenvvvePEKKPRKrgrkpANGREEPLNHVQAERQRREKLNQRFYALRAVVPNVSKMDKASLLEDAITYINELQEKLQKAEAELKVFQRQVlastgESKKPNpsrrDSTeSSDeerfrlqesGqrSAplvhTSENKPVISVFVLGEE-AMIRVYCTRHSNFIVHMMSALEKLRLEVIHSNTSSMKDMLLHVVIVKIDSTQ-TYTQEQLGKILER----- -------------------------------QLRNQLAAAVRSI--QWSYAIFWSISTTQPGVLTWKDGFYNGEIktRKITnsyeltadqlglqrseqlrelyesllsgEcdhrarrpsaalSPEDlGDTEWYYLVCMTYAFRPGQ-G-LPGRSFASNEHVWLCNAQYADSKVFSRSLLAKSASIQTVVCIPYMGGVLELGTTDLVLEDPNLVQRIKASFWELQfptcsepssspsanetgDaAiivfeDLdhnnmeimiSqelgeveclsnanleqitkeidefySlceeldvqrplednwiMDGsfEvVsSpapNAtntddaivssssvDGsrassfvawkesdsddvavpvieeSQKLLKKvlAawmnNGGggtartqqEsGIKNHVMSERRRREKLNEMFLVLKSLVPSIHKVDKASILAETIAYLKELERRVEELESSREPSSrpsetrqRKShdvngrKkVSAGNKRKASEIddNEGEdpvlskdGTSSNVNVTVMDKE-VLLEVQCRWRELLMTRVFDAIKSLHLDVLSVQSSTPDGFLGLKIRAKFAGS-AAVSPGMISEALQRAIG-- -------------------------------SLQQRLHALIEGARESWTYAIFWQSSVVDysgGSMLGWGDGYYKGEEdkgkRKAAapssvaeqlhrkkvlrelnslisgaspsaDDsVDEevTDTEWFFLVSMTQSFVNGS-G-LPGQAFFNSSSIWVAGAERLAGSACERVRQGQVFGLQTMVCIPCSNGVVEVGSTELIFQTSDLMNKVRFLFNFNSTelgswsipaeNdpsamyitDpsssvvelrestpiipshnqqyskqngvenpssstvtetpssIhvhnhsshhqnqpphqlthaqtqSsftrelnfsefgydgtSvrngnsqsckpesgdilnfgeskrsscsgngnlfsnhsqfggVeenkkkrsptsrgsndegmlsftsgvilpssgmvkssgcggDSDHSDLEAsvarevessrvpdPEKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLQTSESDKEEMRNQieslkreLSVKESrfSGPPpPDQdlkMSnNgTKLQDIDIDVKIIGWD-AMIRIQCSKKNHPAARLMSALKELDLDVHHASVSVVNDLMIQQATVKMGSR--FYTQEQLRMALSSKIG-- -------------------------------QLHQSLQLVVQSI--QWTYSIFWQFSPQ-RQVLSWADGYYNGVIktRKTVqqpeevgvslendplqrsqqlrElydalvseelppsrsspaglSPEDlTESEWFYLMSMSFSFPPGI-G-LPGRAFERQRHVWLCGANGVDSKVFSRAILAKSAGIQTIVCIPLSDGVLEFGTTEWVEEDLSLIQQAKSVFRENESDptlseqsspvNnspFsfrhlddeaeedydSvrdegpvedlemsedttshnvnSVSkcaqpRDLSDCVGsldHsrrsafkewsprnvplflqqfgkhsQRMLKfmlfTvprlyGgWgdhcsskaeeFqDLLSGKHVLAERRRREKLNERFIALRSLVPFITKMDKASILGDTIEYIKQLQRRIEELESRKEERTTNPETR---KSE-------TPNSTNVHVSIIETD-ALFKLQCPWKDGLLFRIMEKLHELRLETVSITSSSVDGIFKAELRAKVKEINgKKESIVEVKKAIYQIFS-- -------------------------------TLQQRLQALIEGARESWTYGIFWQSSVDAatgASFLGWGDGYYKGYEedkRKQrvaVaasaaeqehrkrvlrelhllisgggssapDEaVDEevTDTEWFFLVSMTQSFINGG-G-LPGQAFYTGAPAWVTGADRLAAAPCDRARQAQLFGLQTMVCVPVGSGVLELGSTDVVFHSPEIMGKIRVLFNFSTPdapsvaswltpqtaaatpaTdqgetdpsvlwltdpsavdikdsvspvsataDLsvtkppiqlennpsssiltespsssmqiqrthnqpqqqlhqssgsdphthlvfskkfnfsefaSngSVvpqsakpepsdilDfagsnrnpspapvtgsffshhqaitaaaddkrnkrstgatsrasnndegmisfssaparppsdvlfkssggggildgpdSDQSDLEAsarevesiqpvePEKRPKKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAVSYINELRSKLEALEIDKEELRAQVeALEKEresnpmpppDHdlRTMNGSGGGRCHGVEMEVKTLESE-AMIRLQCLKRNHPAAKLMAALRDLDLDVHYASVSVVEEFMIQQATVKMSPSR-AYTPEQLRAALYSKLAAE -------------------------------NLQQGLRHVVEGS--DWDYAIFWLASNVNsdGCALIWGDGHCRVQKGnSedTSeqdetkrrvlrklhlsfvgsDdHrlVkSGplSDLDMFYLASMYFSFRCDSPKYGPAGTYVSGKPLWAADLPSCLSYYRVRSFLARSAGFKTVLSVPVKSGVVELGSLKLIPEDKSVIEMVKSVFGGSDFvqakeaPkifgrQLSlggskprSmsinfspkVedDSGFsLesyevigGSnqvygkdEAlyltDEQKPRkrgrKpANGREEALNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQKKIRVYETEKQVMKRRE-S-------------NQITPAEVDYQQRQDD-AVVRVSCPLETHPVSKVIQAFRENEVTPHDSNVAVTEEGVVHTFSIRPQGG---CTAEQLKEKLLAAL--- MEELiISPASSSSL-----VYFTQETSTHS--TIQQCLQFVVQSQLNWWTYAILWQTSNDEhgRLFLSWGDGYFHGTK-DASpaclgsdrskvmkgikaligDNnnefdvsmINGcgvSDAEWFHVMSLTRTFPAGE-G-IPGKALSTGSLVWLTGAHATPFYNCERAIEAQMHGIETLVCIPTSCGVVELGSMEMISENWGLVQQVKSLFGSDPIglvvpkqsgqfPdvnisfaDIgivSgveeedaspdnetkqeipnnrtkkfstktgqsSyVDSEHSDCDRplllatshmEKrnskKRGRKpGLGRETPLNHVEAERQRREKLNHMFYALRAVVPNVSRMDKASLLSDAVSYINELKSKIDELESQLQKECKKLKVETAegmdNQSTTTSaspnNSSaSpatrGSVGLDFNIKIIGKY-AMIRVQSENVNCPAARLMVALRDLEFMIHHASISCVNEITLQDILVAVPDK--LRNEQGLKSALLKRLDQ- -------------------------------SLQHRLQYIFKNQTNyysDWAYAIFWQSSNN-SLSLTWGDGHLNMKT--T----NNKDVEWFYLMSLAQCFSVGE-G-VVGKCFSSDSFVWLTGDQQFEFCHCERAKEAHYvHGINTFVYIPISSGVLELGSSTVIKQDLNLVQQVKSLFFGYETigpiDDFGlftCLeqYGQEAKKGEivvgttpqenkvgfKSKTSKKrgRKGReicETQGNHVEAERQRREKLNSRFYALREVVPNVTKMDKATLLSDAVTYITQLKAKVDELESKLHNnyyyseMKKKHKMENDNVVDNQSSTTSWDHTMEIEVKMVGPD-AMIRVQSENVNYPSTRLMCALQEVELHVYHANISSVNDLMLHDILVKVPQG--LETEDEVKNALLRSLKQ- ----MSSSSSSSM-----ISFGQDAPP-P--TLQQRLQFIVQSRPEWWVYSIFWQASRDAqgHLVLSWGDGYFQGTKgfaGKSgnklSqprfgrrrsgkdiqsvfcEeiDieriVDGdvTDYEWYYTVSVNRSFAIGD-D-IVGKAFGSGSYIWLCGDQELQLYECERVTEARMRGIQTIVFLSTSFGVVELGSSEMIQENWGLVQLAKSIFGSEINclgskhPglgsqlqmstqipflDFGkvaSdqkewiLDDrkqqieakkdtsgllrrSSSDSGAdsemefsvgSKKRGRKsGTGKTTPSNHVEAERLRREKLNHRFYALRSVVPTVSKMDKASLLSDAVAYIKELRSKIDKLDVKLKVQSQKSKLNAInvsNnQRNASTfncIrpTYDyGPNTMEVDVKIVGSE-AMIRVQCPDINYPAARLMDALRDLELHVHHASVSTVNELVLQDVVVILPAG--FISEEMLRTAIFQRCS-- -------------------------------DLQDKLQSLVEGPNpscSTWNYAIFWQISRSEsgDIVFGWGDGHCREPReeeesflhcRRQhhDeahqhmrkrvlqklstfaggsdDeNyalsLDRvTDTEMFFLASMYFSFPRGE-G-APGNVFASGKHIWISDAMpqSSFSNFCVRGSLARSSGIRTVAFVPSETGVLELGSVSSVPENVEAVQMIKSMFLPGPIkpasasrekrdsGvstahtssfrfgeraeeyprifgkDLnlgrsqtnerldtakveerpwnlqansstdnsvpfptirkglhvlnwnqarqvNanqtqnkqqkfskhivimgnevdgshrpfghqsngvredprlnqftaqkqqShplpqprqidfsgaaatsrpvpvksrpntLDSEHSDAEItckedrpvpmEERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYIKELQKNLKEMESERERFSDPNFVD----S------KTGVQCPDIDVQTVHDE-VIVRVSCPLDSHPASKVIHVLKEAQINVVESNVSASNETVLHTFVVKSQG-SEQMMKEKLIAAFSREIH-- -------------------------------QFRSQLAAAVRSI--NWSYAIFWSISTSRPGVLTWNDGFYNGEVktRKISnsadltadqlvlqrseqlrelyesllsgecDhrarrpvaalSPEDlGDTEWYYVVCMTYAFRPGQ-G-LPGRSFASNGSVWLCNAQSADSKTFLRALLAKSASIQTIVCIPFMGGVLELGTTDPVLEDPNLVNRITASFWELQfptcsevpSsspspNetgdaDIvfedlihnaieeeqmispgehelgevevlAdcesnnanleqitmeidefySlceeLDldaleddwpmnggSfqlvsssspEpvaaaaavaANdvdgvansrascfmawkrssDSEVvavpvtgieSQKLLKKavAggawmnNgGRgsvaitqqSSIKNHVMSERRRREKLNEMFLILKSLVPSIHKVDKASILAETITYLKELEKRVKELESSSEPSRRPTEIGQRsRRSeVGvndGDVNdSNAGRvRSNVNVTVMDKV-VLLEVQCRWKELLMTRVFDAIKSLCLDVLSVQASAPDGVLGLKIQAKFACSS-AVAPGIISEALQKAI--- MEELTSCASSSLV-----VPLYHKAS--P--TLQQLVHLILQTRPEDWVYSIFWRPSRDDhgRLVLTWGDGHFRGTTRDPfaSkpttkrvleEaqcpdGkfahGSDiGDPEWYYIFSVTRSYSSED-G-ILGRAFRSGGHIWLSGEDrhELEMYECDeRVKEARMYGIQSIVCISIPngSGVLELGSSEIIKEDWSLVHLAKCLFPSHFSNpRVNPRGENPSnDAKEepalvgaskrpyakpvgtahhniSKKSGRKkivdDDdkesslspSLSGPLSHVEAERQRREKMNQRFYALRSVVPNVSRMDKASLLADAVDYIKELRSRIAALESKLVKSEPsspkRLKSNRAvaDVSetTSlsskNsSTmAatTlavPGPREMAVEVKVVGRE-AVVRVWSPNLGHPCARLMDVLKELGLVVQHASMSCVKGMMLQDVVIRTPVDC-WVSDESIRDAIRGKLGK- -------------------------------SLQSKLQSSVQSI--QWTYSLFWQLCPH-NGNLVWADGYYNGAIktRKTIqsmevsaeeaslqrsqqlrelyDslstgdqasqqparrpsaalQPEDlTESEWFYIMCVSFSFPLGV-G-LPGKAYARRQHVWLTGANEVDSKVFS-AILAQSALIQTVVCIPVLDGVVELGTTEKVEEDLGLVQHVKSFFMDGQSqhppppkpalsehstsNpassssffhsppkpatgdppnnnNkneeneddeeeeneneieaepgldspdstrrvsgnafepselmqmemsedIrvGspddcSnnLDpdiqmlavsqsgndkdnsflheSdrrwpflqEelcsglppQSsagppdealaqeDThysqtvssilqrnsarwsespsanylavssqsafskwtlrgDAhihgravaagatSQWLLKYilftvpflhakyrkEngpsadmrcadarlrKGtpqDDLSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKKIQDLESRTRQMEVEgltdrdrtwsksssekRKMRGVEGTGSS--SVEPPVPTDVQVSIIESD-ALLELQCPHREGLLLDVMQKLRELRIEVTAVQSSSDNGVFVAELRAKVKEnvnGK-KSSISEVKRAIHQIIP-- -------------------------------TLQQRLQSLVETSSEKWNYAIFWQLTDlnDGQQRLEWGDGFFNPKEedRppKTAisapnqqlrqrvlrelqsliiqqnsDdasmfdGLEaDvTDTEWFYLVSMTCSFNIGE-G-TPGQAFATSQYYWICGSDELRSSRCQRANSAQRSGIHTIVCIPTLSGVLELGSTHVINESTELLNSICHTFDP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------CLQQKLQSVAEDGQPSWTYAIFWQLATSAngQQVLCWGDGYFNQNSiaRSPqqspacSesdqqrrrqvlrelqamvggQDlaeldgaFDaDvTDTEWFFLVSMMNTFPIGV-G-TPGIAYATSQCIWLTGSDQAQKIHCTRAQLGQQFGIHTLVCIPTDTGVLELGSTRVIQENFSLLQRVKMYFPDCLWdstllsrcnessqgfssaisgnmaslsamhpcvssPvyglthsyissnesyhkfpgDtseniscsntIspkpegekfsggaqstspsinsllssrseskgtessqelknsrqdeqtSnciassmseepsnmhhcaehmnsvrekimhqqvyawrkvnssksfhhqqsyhepfqgfqrSIstghgmflncqhtdtihhsNSsdgshishsmsDPsmitnpkvsnanthsvkgndkihqkSDvfiqcsnnmpgdnvdnkwihnphciphypnnvspslkdkpvcteVEsenteaeEnlidiqsevaEDQKPKKrgrkpANGRLEPLNHVEAERMRRERLNQHFYALRAVVPNVTKMDKASLLADATTYIQELKTKMQDMELEREGLlaqlealKGRENFNSlmsPGrgAKvsSSccersqfgDqNcCSrsnAGiacPTCRLVVKVKFLVgRE-AMIKVYGNAKNHPVAKVMMKLQDLQLHVHHASISTSQGVIHQTILVKNRSPY-PLNQKQLASVISR----- -------------------------------ELQARLQDLVERGGGAWTYGIFWQESRAGagRAVLGWGDGHCRDggaPHdeeagaaersvaRKRVllrlhalygggDedgaDyalrLDRvTGAEMYFLASMYFSFPEGA-G-GPGRALASGRHAWAAVDPHpsAAPGWYVRASLAQSAGLRTVVFLPCKGGVLELGSVVAVRETPEALRAIQSALAVEPPPedcmrifgkDLSpSrpprpqttgcdADnwaprlggqataSrpakkeaakpkppEPPksiDFTkpgkaqeqagGEERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPKISKMDKASLLSDAIAYIQELEARLRGGAG---------------AA------AARAESPAVEVKAMQDE-VVLRVTTPLDAHPISRVFHAIRDSQLSVVASDVAVADDAVTHTLVVRSAG-PERLTAETVLAAMSRG---- -------------------------------ALQHCLQRLLDARPEWWAYAIFWRASPDHR-LLSFGDGHFRGAR-SVVDrrsGADAvDDAEWFYAVSLSRSFVVAGDAtavaAVPARVYSSLAPVWLAGAHALQACGCDRTREAQLHGIETLACVQVPGGVLELGSTDIIGENWDVMQQAKAVFSTPPHDaalatgaapTIatasspavrkdgaghsSSVDSDHSDSDGgltvahcrPKKRGRKtvSGTREAPASHVEAERQRREKLNHRFYALRSVVPNVSRMDKASLLADAVAYIQELKAKVDKLEAEAKTAMKEITVEQTaghsaDAGaaTSSTtTSattlTSAKAAMEVEVKLLGAE-ALIRVQSVDRGHPSARLMAALRDLDLRVHHASVSSLEQVVLQDVVAKVPTE--LQREDSLRAALLARLDK- ---------------------------------------------------------------------------------LDRvSDIEMFYLTSMYFPLDSGE-G-GPGKCFSSGKHIWISDALSCLSHYQSRSFLAKSAGFQTVVFVPTKSGVVELGSVRSIPEEQSLLQMVKSVFGESLPTqpkpvpkifghelslggsrpvsvsiSFGpkveddssffseshavqkpeqtygnsSngaqfDNGEqkpfpqlnfsgftspPreskISDeaparEErssqaDERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQKKIKEMESEKEMVNNKQ---------------KQLPLPEIDFQARQDD-VIVRVSCPLDSHPVSRVIQTFREHQIIAQESNVSATNDKVFHTFSIRTQGGCAEDLKDKLVAALSKES--- -------------------------------CLQHILQSAVQSV--QWTYSIFWQVCPQ-QGALVWGDGYYNGAIktRKTVqpmevsaeetslqrsqqlrelyDslsaeetDqparrpcaalsPEDlTESEWFYLMSVSFSFPPGI-G-LPGKAFARQQHVWLTGANEVDSKVFSRAILAKSAGVQTVVCIPLIDGVIELGTTERVAEDLGLIQHVKSYFTDHQHhpnpahsehstsnPsttsehphfnssrlmamyssmqpstnanggeneDeveddeddeeedgeseseagtgqdIhhlsthdplhlcdpltqdiamsqaaaepselmqlemsedirlGSpddvsnnLDSdihmlgmnhsmgqvdfhpraestphswpplqdqicnsirqqvsesdqmeeltqEdtHysqtvstilqksssrwSEsspiSDCvgysmqssafskwshqnnhliqvpssgmsqwvlkyilfnvpylhnkyqDEsstkfqdgdtvTRLRKsASQDELSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKRIQDLELRSKGcdvDQRtKsvdtTKAskcNKVqgNDGSVavpDrlvpgSerrkvriVegIGGsktkvldPPSVvsNVLQVSIIEID-ALLELKCAYREGLLLEIMQTLKELRMEVTAVQSSSANGVFSAELRAKVKE--------------------- -------------------------------TLQQRLQALIEGARESWTYAIFWQSSSvDFsgPSVLGWGDGYYKGEEdkgkRKLSsssavaeqehrkkvlrelnslisghpagtDDaVDEevTDTEWFFLISMTQSFVNGS-G-LPGQALYSSSPIWVAGSEKLASSHCERARQAQGFGLQTMVCIPSANGVVELGSTELIFQSSDLMNKVRVLFNFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------DLQNRLQELVESDRpgAGWNYAIFWQLSRTKsgDLVLGWGDGSCREPR-DGemgpaaSagsdeakqrmrkrvlqrlhsafggvDeeDyapgIDQvTDTEMFFLASMYFAFPRRA-G-GPGQVFAAGVPLWIPNTErnVFPANYCYRGYLANAAGFRTIVLVPFESGVLELGSMQQVAESSDTLQTIRSVFAGAIGnkagvqrhegngpadksPglakifgkDlnlgrpsagpgtgvskadersweqrtagggssllpnvqrglqnFtwsqarglNShqqkfgngilivsneatprnngvVDSptatqfqlqkasplqklpqlqkPHqivkpqqlvsqqqlqpqaprqidfsagtSskpgvltkkpagiDGEgaevdglCkdegpppaiEDRRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQKKLKEMEVERERLIESGMV---DPR-------ERTPRPEVDIQVVQDE-VLVRVMSPMENHPVRAIFQAFEEAEVHAGESKITSNNGTAVHSFIIKCPG-AEQQTREKVIAAMSRAMN-- -------------------------------TLQQRLQTLIESAGERWTYAIFWQISHDFdspagesTVILGWGDGYYRGEEdkeKkkKQSsssnpaeqehrkrvirelnsliaggagvsDeaNDEEvTDTEWFFLVSMTQSFVNGV-G-LPGESFLNSRVIWLSGSGALTGSGCERARQGEVYGLQTIVCIAAENGVVELGSSEVISQSSDLMDKVNGLFNGNGGgeasswgfnlnpdqgeNDpalwlsepnItgiepvqetpaienaadlnfSssglnqngnfkqgsssnkkrspvakdeemlsfstvvrsaakSVDSDHSDIEAsvvkeaiivePEKKPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYSLRAVVPNVSKMDKASLLGDAISYINELKTKLQQAETDKE------------------------------------------------------------------------------------------------------------- -------------------------------NLKKHLAVSVRNI--QWSYGIFWSISASQSGVLEWGDGYYNGDIktRKTIqaseikadqlglrrseqlselyeslsvaEssssgaaagsqvtrrasaaalSPEDlADTEWYYLVCMSFVFNIGE-G-MPGRTFANGEPIWLCNAHTADSKVFSRSLLAKSASVKTVVCFPFLGGVVEIGTTEHITEDMNVIQCVKTSFLEAPDPyatilptrsdyhmdnvldpqqilgDeIyapmfSsepfptaspsrttngfdpeheqvaedhdsfmteritggasqvqswqlmddelsncvhqSLNSsdcvsqtfvegaggrvsygarksrvqrlgqiqEQqrnvktlSfDpkNDdvhyqsvistifktnhqlilgpqfrnCDKqssftrwKkssssssgtatvtapsqgMLKKiifevprvhqkeklmldsPEARDETGNHAVLEKKRREKLNERFMILRSIIPSINKIDKVSILDDTIEYLQELERRVQELESCRESTDtetrgtmtmkRKKPCdagERTsanctNNETGNgkkvSVNNvGeaepadtgfTGLTDNLRIGSFGNE-VVIELRCAWREGVLLEIMDVISDLNLDSHSVQSSTGDGLLCLTVNCKHK-GSKIATPGMIKEALQR----- -------------------------------NLRKQLAVAVRSV--QWSYAIFWSLSTKQEGVLEWGEGYYNGDIktRKTVqamelkpdkmglrrseqlrelyesllDgesdlakrpsaslSPEDlSDAEWYYLVCMSFVFNHGQ-S-LPGRALANGQPIWLCSAHCADSKVFSRSLLAKSASIQTVICFPHLGGVIELGVTELVLEDPNLIQHIKTSLLEFSKpvcsekssstarnTdddtdrmctkvdhaivdtvalenfysptdDIkfneerlneldenfcddftmgSpddcsngcdhnqqtedsfmleginggasqvqswhfmdddfsncvqgSMNSsdcisqafvnqEkaisppmcgdvnnlhlkelqecnHtkfSslDLgnDDnlhyrrtlstilrnshllienlcfqncDRkssfvswkkggmvagQRPreqqkmlKK-ILRKVPLMhggsllKLENENDRKdwlwkpendkicvqqalpdkITENEKFLVLKSMVPSLSKIDKASILGDAIEYLKELEARVEELESCIDLTdearvRREyPdMVEQTsdnyenrmidygkkpwiNKRKASDIdetdtelNSvvpNDGPLLDMKVSIKEQE-VLIEMRCPWRDYLLLDVIDAINSLNLDAHTVQSSTVDGILNLTLKSKFRGE-AVASARMIKQALSRIA--- ----------------------------------------------------------------------------------------------MTQSFVNGV-G-LPGQAFLTGTTSWISGGQRLAVVPCERAHQALKFGILTMVCIPVSGGVVELGSTEFVCQSAKIMNKIWFLFSFNAMetmenpspsffpqppvpaqgeaPpralwisDpslveikdsvshqhqnqkhhvpFdsnpssstltenpSsinlptppsfqsmynreisfseqsnatvqpqsckpqsseilnfgegrrtmasqhqitdqnnnkrSmgatsrasnnnegmlsfssapatrpvsgmiipskGDSDHSDLEAsvrevessrvvvpePEKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELRSKVQTLESDKEGLQSQVealKKERLSSSSShsQGEggtANGKCIGVEIEVKILGQE-AMIRVQCHKRNHPAARLMDALRELDLDVHYASVSVVNDLMIQQATVKMMSR--SYTQDQLNAALYSRIAE- -------------------------------RVQSMLQAAVQSL--HWTYTIFWQLSPQQ-RVLRWSDGFYNGEIkvRRTVeaieanksnsnneeaslqrsnqlrdlydlllsDrqgdlifaadppatprpctalSPEDlSESEWYYLMCVSFSFAPGV-G-LPGKAYARRQHVWLQGANEADTKTFSRAILAKSADVKTVVCIPMLDGVVELGTTDKVKEDINLIKHIKSFFIGDHhrpqpKhalsensasNPiteeaqllldseIatlpqsklkelvmaedSsragspddgsnrlnSagllellppesaasLellhgdeydnNSEaetshlcteqegHthysktvstilegssghrPDAvcgllsfqsafatwsssvyNCnqvtvvEnpQRLlknilfrvPylhRKQnrhNsaqtleqlertimpspQDDLISSHVAAERRRREKLNEKFITLRSLVPYVTKMDKASILGDTIEYVKQLHEKVKKLEEEDKRRRSGK----------------KRKERAVEVSVIEGE-ILLEVECMNREGLLLDLMRALKDVGIEVRGVKSSFKGD--------------------------------- -------------------------------QLRNQLAAAARS--INWSYALFWSISSTQPGVLTWTDGFYNGEVktRKISnsveltadqlvmqrseqlrelyeallsgecDrraaparpvgslSPEDlGDTEWYYVICMTYAFRPGQ-G-LPGRSFASNEHMMLCNAQLL----FPRRLK-QSASIQTIVCIPLMGGVLELGTTDTVLEDPDLVNRITTSFWELQFpacseeegpssspsanetgdaDDIvvfedldhnaaetmisegelgeveclSnanlehitkeidefyslceeldvqPLedswimGSsfEVpsspepapaMidDaattsspVDGsrpscftawkrsssdeeaavpvageSQKLLKKvvAggawanNGggGttrraqEsGIKNHVMSERRRREKLNEMFLILKSLVPSIHKVDKASILAETIAYLKELEQRVQELESSREPSSpSEtgrrlHDvpGskrKKVsaGsKRKAPelggDVEeeHhwvlPDdGPSNVVNVTVTDKE-VLLEVQCRWKELLMTRVFDAIKSLRLDVLSVQASTPDGLLGLKIRAQFAG--------------------- -------------------------------QFRKQLAAAVRSI--SWTYAIFWSISTTRPGVLTWKDGFYNGEIktRKIgSstmeltadqlllqrseqlrElyssllsgecahrqrrrrpvtalSPEDlGNMEWFYMVCMTYAFRPGQ-G-LPGKSFASNGCAWLCNAQSADIKAFPRKLLAK-----TIVCVPFMHGVLELGTTDPVSEDPALVNRITASFWETPFracssepapssspsptketGdadivvieDLdGnaavehtttmvpgedeedhvlggdvaeesnaandeqitmdigeiySlceeLdvldDDssswvvdpwsfqlvPTTDpddavvapadgscrssscfvawkrtpLSDevvplasggeySQRLLKKavaGggawmnNgdGSaatmaqgSSIKNHVMSERRRREKLNEMFLILKSVVPSIHKVDKASILAETIAYLKELEKRVEELESSSQPSSRpmettrRRCSEITGkKVSAGakrkhhhWVlSdDQDGerrhcVPSNVNVTVMDNKELLLEVQCRWKELLMTRVFDAIKSLSLDVLSVQASTPDGLLGLKIRAKVV---------------------- -------------------------------QFRKQLAAAVRSI--SWTYAIFWSISTTRPGVLTWNDGFYNGEIktRKIAnnlvteltadqlllqrseqlrelyssllsgesaDqqrrrpitalSPEDlGNAEWYYVVCMTYAFRPGQ-C-LPGKSFASNGCAWLCNAQSADSKAFPRKLLAKHASIKTIVCVPFMNGVLELGTTDPVSEEPNVVNRITTAFWELQLPacsdepissgthssrssppketgDantvliddLflvhSdaipaggdlqeedhqlgndlgqqqaatameidddviySlirnWdnDSssswiellqDHvivspascfvpwkrTDPDKetvagggggggeaAQRLLKKavGGGgawmnRaagSSIKNHVMSERRRREKLNKMFLILKSLVPSIDKVDKASILAETIAYLKELERRVQELESGKKVSRppkRKPCSETIiGGgGggGAGAVkehhhwvlSDSqEGTPSDVRVIIMDKDELHLEVHCRWKELMMTRVFDAIKSLRLDILSVQSSVPDGLLGLKIRAKYA---------------------- -----------------------------------------------LRTAIFQRCS---HLVLSWGDGYFQGTKgfaGKSgnklSqprfgrrrsgkdiqsvfcEeiDieriVDGdvTDYEWYYTVSVNRSFAIGD-D-IVGKAFGSGSYIWLCGDQELQLYECERVTEARMRGIQTIVFLSTSFGVVELGSSEMIQENWGLVQLAKSIFGSEINclgskhPglgsqlqmstqipflDFGkvaSdqkewiLDDrkqqieakkdtsgllrrSSSDSGAdsemefsvgSKKRGRKsGTGKTTPSNHVEAERLRREKLNHRFYALRSVVPTVSKMDKASLLSDAVAYIKELRSKIDKLDVKLKVQSQKSKLNAInvsNnQRNASTfncIrpTYDyGPNTMEVDVKIVGSE-AMIRVQCPDINYPAARLMDALRDLELHVHHASVSTVNELVLQDVVVILPAG--FISEEMLRTAIFQRC--- -------------------------------HLRKQIAATVRKI--QWSYAIFWSISTRQPGVLAWSDGYYNGDIktRKMTqpielkadqiglqrseqlrelyeslsagDsnqqtrrpsaslSPEDlTDAEWYYLVCMTFKFTLGQ-G-LPGKALANKQHIWLNNAQFADSKIFSRSLLAK-----TVVCIPFMGGVLELGTTELILEDVDLVKQITSFFWELPNPicseqsisspqlaergegiicpDIdngidnsipsehhhliadrqtplesdpthfpfpihsyvpaehtesvkveelhqniceepdtcspddSSnecclthqledllgadglngmsrthslqlVDdefsngllhgslsSdEHatmsfvdaqravssatreptrnqmlgglqegshgkhiSlDLDGddshyaEtvatilrtsklvnpvlcflkvsfrssfvvwrrgfnapksfigtpQKLLKKiLMDRAwWRGNHVLSERRRRDKLNEKFLALRSLVPTGGKIDKASILDDTTQYLKHLERRVQELESGTAVLgttdrRKNPDVaERTsDnylgNEITnewkppgNkrkacDMDEgeaehhfvlSKHGPVHVTVTVKEKE-VLVDLRCPWRECLLLEVVESMSNLHLDPISVQSSTVDGMLALTVKSKLRSSN-VASPGMIKRSLQRVIN-- -------------------------------DLQNKLQELVESEGpgTGWNYAIFWQLSRTKsgDLVLGWGDGSCREPR-DGevvgaaatagSddtkqrmrkrvlqrlhiafgvaDeeDyapgIDQvTDTEMFFLASMYFAFPRRV-G-GPGQVFAAGIPLWIPNNERkvFPANYCYRGFLANSAGFKTIVLVPFESGVLELGSMQHIAESSDTIQNIRSVFAGARGnkaavqrhegngstptppersPglakifgkDLnlgrpsavpavggvskvderpweqrsaaagtsilpnvqkglqnftwsqarglNShqqkfgngvlivsneaahrnngaADSpsatqfhlqkapqlqklqlqklPHiqktpqlvnqqalqpqvprqidfsagSssksgvlvtraavlDGenaevDglCkeegpppviEDRRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQKKLKEMETERERLLESGMVD---P-------RERAPRPEVDIQVVQDE-VLVRVMSPMDNHPVKKVFQAFEEAEVRVGEARI-------------------------------------- -------------------------------GLNEKLSRLVDSPNpesFSWNYAVFWQQTVsrSGQQVLAWGDGCCREPKEEESmaynleeemrwqymrkrvlqklhrmfggsDedDyalsLENvTATEMFFLASMYFFFNHGE-G-GPGRCFASGRHVWLSDAV--GSDYCFRSFMVKSAGIRTVVMVPTDAGVLELGSVWSLPENVELVRSVQGLFARRVKppnmsgGkihklfgqelNIShhnnngStigytsqeIdvkvqenvnvvvvDDkNHkvmktSCNekrpasllpEGvsvvEEKRPRKrgrkpANGREEALNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAISYIKELQERVKIIEAEAVSESN---------TMT---TKGEESQEVVDVQAGEEE-VIVRVVSPLESHPASRIIQAMRNSEvVSVMESKLSLAEDRLFHTFVVKNNNGSDPLTKEKVIAA-------- -------------------------------QFSNQLAAAVRS--INWSYAIFWSISTSRPGVLTWKDGFYNGEIktRKVtSsaditadqlvlqrseqlrelyesllsgqcDhrarrpaaalSPEDlGDAEWYYTVCMGYAFRPGQ-G-LPGRSFASNEHVWLCNAQCADTKTFQRALLAKllltnimmstmygahacylcrlnqTASIQTVACIPLMGGVLELGTTNTVLEDKGMVNWIGTSFWELKfptcskseepNsipsvddtgdADIvfdvlnhntmammipgelelgeveclSddnleritkeingfyglydeldvgaleenwtmggyfeimsSpeVppapaatngitngavtlSSvEPSrsscftawkrswDSaEDmatlvarEtQKLLKKalAggawenNGgndtaRaqEstNTKNHVISERRRREKLNEMFLILKSLVPSIHKVDKASILAETITYLRELEQKVEELGSNRAARttavRKRHevggkKVlARSkRKASelgGDDterVlPKDDGLSSVINVTVTDNE-VLLEVQCRWKELLMTQVFDAIKSLRLDVLSVRASTPDDLLALKIRAQFA---------------------- -------------------------------NLRKQLAVAVRSI--QWSYAIFWSLSATQQGVLQWGEGYYNGDIktRKTVqvmelkadkiglqrseqlrelyesllegeiDqtkrpsaalSPEDlSDAEWYYLVCMSFVFNHGQ-G-LPGRAFANGETIWLCNAQYADSKIFSRSLLAKSASIQTVVCFPYLGGVIELGVTELVPEDPSLLQHIKASLLDFSKpvcseksssaphNadddrdpacvrvdheivDlldlenlyspteeikfdqekfnelheninenFniSspdecsngceqnhqmedsfmledvngvasqvqswhfmdddfsngvqiSINSsdcvseafanqekaaisspkqgsvNHshfkefqegnhtklSsfdlgvDDDlhyrrtlsailgtsnwliesqGfhtcgykssfiswRkgeKanfHRPrvqqnifKKilfavplmhSgsslmsqkenGGkhclgklendDDDEKGYLLPEKRR-E--EEKFLVLRSMVPSISEIDKASILKDTIKYLKELEARVEELESCMDSVdfearPRRNcldamkqasdnhenrKVENvkkSwiNKRKACDIdeshetGseqSrvipRDGLTSDVKVSIKELE-VIIEIRCPSREFLLLDIMDAINNLHLDAHTVQSSTLEDVVIVTMKSKFRGA-AIAPAGMIKQALQRV---- -------------------------------DLQSRLLDLVEGPPdrpcLGWNYAIFWQISRAKsgDLVLGWGDGSCRDLRdgeeaaaaaavaRSPGddesqqkmrravlqklhvyfggsDddNyalrLDQvTDAEMFFLVSMYFSFPRGK-G-APGRALAAGKHLWILS----SSDYCYRGFLAASAGFRTIVVVPFDTGVLELGSVRSLAESPNSLQTIKSVFSGTTPagmpqsrekyerNgseacpkifgkDLnlgtsnvndkplvtkvedsswdtqpkrgsgdwvlfpnvrkgmqsfswnhvrgpSShqqqfgngavItSSevgDHSdgvrgdtllgqlqiqknqhkpqqslqppprqidfsggtsragtliahvgalegdhaDIEvsCkdervgppDERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITELQKRLKEMESERERFLESNVM---DH-------STRVHQPEVDVQALEDE-VIVQVSSPLNTHPVSKVFQALKEVQVNVAESKEVkLIDGLTL------------------------------ -------------------------------GLKEMLQSAVQSV--QWTYIIFWKFCHK-KRVLVWGDGCYNGPIktRKTVapvevsteeaaesrseqlrelydslasgeqqvtEnqqavtrrpsvalSPEDlTEFEWFYLMCVSFTYPPGV-G-LVGGAYAKQQHQWLTGANEADSKVFSRTILAKPKtsILQTVICIPLLNGVVELGTTDKVEETIEFIQHVKLFFLK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLRQRLQAAVQSI--QWTYAVFWKPCPPPQGELVWSDGYYNGSVktRKTIivsrerspeehglqrsdqlrelfenlsasgDgsqsstatrrptaalSPEDlTDTEWFYLVCMSCTFDPGT-G-IPGQAFSKGRPVWLCKANEATTKVFSRALLAK-----TVVCIPMAEGVLELGSTELSW---KEFQRQASISSSQ-------VKS---QCQAmlKNvlfRVPhiqSKsvsRKEDDVNTAHAMLERRRREKLNDRFLMLRNMVPFVTKMDKVSILGDAIEYLRQLQRQVADLEQRNKPE---DSFPM---STTYK-LGPDSSSYKAEIQMQDDF-TALEIECSFRQGILLDILAALDKLNLDVSTVEARTPDQ--------------------------------- -------------------------------NLRTHLALAVQSF--QWSYAIFWSVSCIQPGMLEWCEGYYNGDIktRKTVqvaevdmdqlglqrsdqlrelyvslslgDtkpqakrpttalSPEDlTDAEWYFLVCMSFVFNANQ-G-LPGRTLAANQMIWLCNAHRADTKVFSRSLLAKSASIKTIVCFPHSGGVVELGTTELVPEDPSLIRHISSFLESPSVavplipnlvfdssscnpNglnlerldhahmledgldrlmddpymemcspynssdDFannllreeSnlvegvggeasklqswpvmedavsnclnnSVNSsdcvsqtegelekviPHSDGNkekkscvqecnqktpsegqgndvhyhsvlsyllksshqlilgpyirngsteSsfvfwrkvgvpgpqrgttPQKLLKKvlfevArlhqscrgesdkhricpKSDEADRNHVLSERKRREKINERFMILGSLVPSGGKADKVSVLDHTIEHLRKLERRVEELESYKEAMEREStthsksqdAIERTsDnyrdDNNSkrPAMnkrkaghrdkTGPrlrdSSPTDNITISVSNKV-VLIEMRCLFKEHVLFEVMEMLSKIHLETQTIQSSTIDGTLSITVNAKCE-GLKSPSAVVIKEALQKIIS-- -------------------------------NSHHKLQFLLQTQPYPWAFAIFWKTTYNHdygrPWTLTWADGYFLQNPNKPAfkEiqtlvGPDNtDGAEWFYVVSLARSFGIGD-ESAPSNSFTSNSVIWLTGAHSLISFNCERAKEAYIHGLETLVYIPTTNGVVELGSYHVINHtESDLAHRVKSLFSASSSSssSFlspSsnlinqpndyliSfgemvsrLpqDEESkdiFDLGTttfgqqskklgkvvEntnnkgQKKSQKKKGHDPPLNHVEAERKRLTNLNQRFYALRSVVPYVSKMDKTSLLEDAVCYINELKNKVEELEAQLQAMNNQPKlkkikVKAPDvtfvrNSQGANIyNNgnrtKTNGTLEVEVRMVGDN-AMIRIQSGNADWPSAKLMDALREMEAKVHQASMSCINDVTLQDVVARVQE--------------------- ----------------------------PSTRLQSMLQTAVQTV--QWTYSLFWQLCPQ-QGILVWGDGYYNGAIktRKTVqpmevsaeeaslqrsqqlrelyDslsagesnqqtrrpcaalSPEDlTESEWFYLI-------------LPGKAYAKRQHVWLTGANEVDSKVFSRAILAK-----TVVCIPLLDGVVELGTTEKVQEDIGFVQHVKSFFVDHHTpqppkpalsehstsNpatssDharfhspplpaamyaavdppaianqIdeeeeeeeeeeeeeeegesdseagteaqnplvlpqgvavahhaaaepselmqlemsedirlGSpddgsnnLDSefqllaasqagnpadqhrradsyraesirrwpvlqdplssslqaqppsggpaleelnqEdthysqtvstilqHqssrwsessssatgylmyssesafskwmlrpSDHqhhhhvaavDGtsqwllkyillsvpflhtkcrDENSPKSrdaadsasrfRKGtpqDELSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKKIQDLEARARQNendqrSRSssdpqrtSslSLkEQrSgsgvtaltDrtrvgsdKrklriveGTSGGklkaVDSpppaelppppPpppppqpmEGVTMQVQVSIIESD-ALVELQCPHREGLLLDVMVVLRELRVEVTAVQSSLTNGVFVAEMRAKVKE--------------------- -------------------------------------SFMIQSQQDLWAYAIFWQTLNDDlgRLFLAWGDSYLQCTKdmspklssnvhgsqndrRKVmkgTqaligDNhdidmsmLDGtdiTDVEWFYMMSMTRSFSAGD-G-IPGKALSTGSLVWLTG------------------------------------SSEMIRENWGLVQQVKSLLGSDLiglvpkqsNPnltpgliqfldrnisfaDIgiiagiqedddaSpdiktkqennnksnqtkkdSlklgqpsyADSEHSDSDFpllamnnvEKRTPKKrgrkpGLGRETPLNHVEAERQRREKLNHRFYTLRAVVPYVSRMDKVSLLSDAVSYINKLKVKIEELESQLQRECKKVKVETVdntmdNQSTTTskeqatrpSdSSSgtgtGtdGTSGLELDVKIMGND-AMIRVQSENVNNPAARLMCVLRDLEFQFHHASMSCVNDVMLQDIVVRVPDG--LRIDEGLKSALVSRLDQQ -------------------------------ELQARLQDLVERPDaaaGVWTYGIFWQESR---AVLGWGDGHCRDGGaspHGAsaaSaaessvarkrallrlhalygggDdDegadyalrLDQvTGAEMYFLASMYFSFPSGA-G-GPGYALASGRHAWVTVedPHHPPPGWFVRGSLAQSAGLRTVVFLPCKGGVLELGSDVPVRETPDALRAIQSALAVPPPApaareecmrifgkDLSptgrtprpppqtmmglgltgdnnwahqqlggqataSTPTkkeaakaKPSslpepakmsiDFtkpgkpelQaggGEERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPKISKMDKASLLSDAIAYIQELEDRLRGGGG----------------A-----ARGAEESPAVEVKAMQDE-VVLRVTTPLCAHPVSRVFHAIRDAQLSVAASDVAVADDAVTHTLVLRSAG-PEQLTAETVLAAMSR----- MEELIISSSSSS-------SLSSENPA-P--TLQQRLQFILQNRPEWWAYAIFWQASNDDngSLFLSWGDGHFQGTKptskRSNKkkvldDgvdPvDGDvTDAEWFYVMSLTRSFSVGD-GanNVPGKSFSSGAFVWLTGDHQLQFYNCERAKEAQMHGIQTLVCIPTSNGVLELGSSDVIKENWNLVQQVKSLFSSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------GSWKYAIFWRAVSSKsgGPALIWGDGHCRDTKgggagdvnssRDSSleamqkkkevkkwvleklhacfgglngDNyarrLDGvLDVEMFHLTSMCYAFQLDSIshC-GPGESYKSGKSIWVSDAGSCLHHYQSRSFLARLAGFQTVVFVPMKSGVVELGSVKSTPEEQSYVDTVRSAFGESIKlfpqmNrmmvdGFNvqTrVsSSELlkdeSSaqIDeGKpRKRGRKpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQKKMRVMETEKQMVNNK--------G-------KQLPVPEIDFQERLED-AVVRMNCPLDSHPVSEVFRTLRE------------------------------------------------ -------------------------------NLRKQLAVAVRSI--QWSYAIFWSLSATQ-GELQWGDGYYNGDIktRKTVqafelkadkiglqrseqlkelyesllegDsdqtkrssaalSPEDlSDTEWYYLVCMSFVFDTGQ-G-LPGKALASGETIWLCNAQHADSKVFSRSLLAK-----TVVCFPYLGGVIELGVTELVLEDANLLQHIKASLLDFSKpvcseksssvshNsdddkdpicaeinhgivDlldlenlysptkkikfdheefnefresinedfdIvSadewsnggeqnhqmddSfmvedvkgvasqvqswhfVDgdfgiqekaaisspkleSvSHsrfkelhegnqtiSslDLEvdDdlhykrtvsavlrssnwsiespgfrtcgykssfvgwKKewmtnfYRPrvqqnifKKilfavplmhggnflwsvkENGRkdclgkpekdENAIRCALPERTREE---EKFRLLGSMVPSISEVDKESILKDTIKYLKELEERIEELEYCKNSMefearlRRNCldAVEQTsdnyetrtvDNAkkswinerKACdfdeSlqeTgsdlkrSTPkDGLAPDVRVSIKELE-VIIDIRCPSREFLFLDIMEAINNLHLDAHTVQSRTLDGLVTLTLKSKFRGA-AIAPAGMIKQALQR----- MYNLtFSPSLSSSP-----LSFTQQTPAivssSPAdLALQQKLRFVVETSPDRWAYIIFWHKMFDEpsnRSYLVWVDGHFCGNKnNKSQenyttnsiEcElmMDGgDDLELFYATS----FYSED-G-SPRKEIFDESLVWLTGLDKLRFSNYERAKEAGFHGVHTLVSIPINNGIIELGSSDSIIQHRNFINRVQSIFGSGKTPehtnQTGSdpkpAESDHSEIGNrqsgsERKRRRKletmdvAVAAeekhhPPVLSHVEAERQRREKLNHRFYALRAIVPKVSRMDKASLLSDAVSYIESLKSKINDLETEIKKLKTTMTTETdkLdNNSSntSpSSVeyqNNqkpsesNRVSDLEVQVKVVGYE-AIIRVQTENVNHPTSALMSALVEMDCRVQHANASRLSQVMVQDVVVLVPEG--LRSEDRLRAS-------- -------------------------------QLSYHLAAAVRS--INWTYAIFWSISTGPAGVLAWKEGFYNGEIktRKMtSstttteprsqqlrelyEsllsggnsdrrarlSPEDlGDAEWYYTISMSYTFRPGQ-G-LPGKSFASNQHVWVYNAQSADTKTFERALLAKTVPIKTVVCIPFMGGVLELGTSDPVLEDSNMVHQIGTSFWELHlpsfpacskseepcsNpslaNetseagimleDldhnaIegmiselreveclSdvnlecvtkemdefqflleGLDScalednwvmdrsfefissPQtvSsmDypctedvivtlsssvqgtrpscfiawrrslelkdmvvrvtdTEESQKLLKKivAggawtnNGdggsmardREsNIKNHVISERRRRERLNEMFMVLKSLVPSIHKVDKASILLQTIAYLKELEQRVKELESNRA------------------------------------------------------------------------------------------------------------- -------------------------------TLQQRLHAVVKVTHEAWCYAIFWKPSYHDisgEPVLKWGYGVYKGEDetdktrrrRKTNaeeklqrnkvlrelsstisgvsfpvkDeDDDVelTDMEWFYLVSMTCSFRSGS-G-LAGKAFATYNPVWITGLDMINGSGCSRANQGGDLGLQTIVCIPSDNGVLELGSTELIRENTGFFRKIRFLFNFEGYRDFsgdmnssscqlfSSpVyppiqnhiitstatssTsttvrssfaedikledSDHFNIDVKamlkRKRQKKpTHGREEPMNHVEAERLRREKLNQRFYALRALVPNITGMDKASDLEDTVRYINELKLNAENAESKKGAVqiqLNKLNEEIAEgphiRNSTLRAFAAGEKEVdlilPGTARLrvqlgvnMPAQ-AHHKLHQDQEESGTVELFEVYdvvvymgmIDIlqEYNMKKRMEHTCKSIQYDPMSISAIEP--TYYAKRFTDFLLKVFP-- ------------------------------------------------------------TRSLEWNDGYYNGDIktRKTTqqtecrvdemglqrteqlrelyeslcngDcnqqtrpsaslSPEDlTDKEWYYLVCMSFTFNFGQ-D-LPGKAYELNESIWLNNAHFAENSCFCRSLLAKSASIQTVVCLPFMDGVLELGTTELVMEEPGFLLNITSSFWELQLpgfsehstsssplerkeeeDDvclisnhevqgtimsenpaliieddshlfpfsvdsyapdInsdlihykeiiginipnepsqvhirhlmadefnnglnSSLNlsecvspqnipcspkgerlkgyvfnhSredNHSklgslgieedgshyfsslsailgDLEQgrsspgfpfqnrhidssfrvwEegsksskifirfpQRMLKKilfGrnwiNGdewvksheenvprnkafkseaDDANSNHVLSERRRREKLNEKFVTLRSLVPSISKVDKASVLADTIEYLKDLEKRVEELEFCREERdtdmRepRKhPDItERTsdnygNNefiisqkSSSNkrkacEMddSDaqlnlilSNNGLFDINVTMIDRE-VLIELHCPWRDFLLLDIIEALCNLRLDPHSVRSSTPDPTTVIALRAKIMSTT-VTSPGMIKRSLQRVLG-- -------------------------------LLRKQLAVALRSV--QWSYAIFWSSSLTQPGVLEWEEGCYNGDIkkRKKSyeaahykyalqrsnqlrklylcmlegdsnttistthdvDdygddeehNcnsatsmmlsPDDlSDEEWYYIVSMSYVFSPSQ-C-LPGRALVTGETIWLCNAQYADNKLFSRSLLAR-----TVVCFPYLGGVIELGVTELISEDHSLLQHIKSCLLETSKPDCasynfsarqdsddeknqtkiktSdgnsnSVlqgnhqiqsdedvhykrtvstllkyaadkDIHHlqpdlvsSNIESsflrwKQReqpnsilfqehsnlqtlsqnVLRK-ILQDVPLMHsLDTKRtlpsktfglnqddpWDTRKENEKFSVLKAMVPTVNQVDKEEILNNTIKYLQELEERVEELESCMGSVnfaerQRKSvndsvLIEETSgNyDDSTKIdgNSGEteqvtivRDETHLRVKLKETE-VVMEVRCSYRDYIVADIMETLSKLHMDAFSVRSYTLNGFLTLNLKAKFRGA-AVASVGMIKRELRR----- -------------------------------DMKKQLALAVRSI--QWSYAIYWSASATQPGVLGWGEGYYNGDIktRKTSqgvelnadqiglqrseqlrdlyeslataEsnpqtkrpsvslSPEDlTDSEWYYLVCMSFIFNIGQ-G-LPGRTLANGQPIWLYNAHCADSRVFIRSLLAK-----TVVCFPFLDGVLELGTTDLVSEDPSLIQRIRTSFLDI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------LLSKQLAVAVKSV--QWSYAIFWSSSPTQSGVLEWGEGCYNGEMkkRKKRyevhykhvlqrsnqlrklylcmregdstntistthDddgyhNcnsktsmllsPDDlSDEEWYYVVSMSYVFSPSQ-C-LPGRALATGETIWLCNAQYADSKLFSRSLLARSASIQTVVCFPYLGGVIELGVTELISEDPSLLQHIKSCLLETSKpdcpsNNFsahqdndddkknqmkikisevNSalqenqqiqfgisdlmLDEdlhykrtvstllkyaadkskmknsHHrqpelvsSNSGSsflrwKQpesnlllkHsnsqnVLRK-ILHDVPLMHSVDtkrmstnkmfglnqdDPSVKRKENEKFSVLRAMVPTVNEVDKEEILNNTIKYLQELEERVEELESCMGSVnfvgkqRKTKkSlndsvlIEETSgNyDDSTKIdgNSGEteqvtvlRDETHLRVKLKETE-VVMEVRCSYRDYIVADIMETLSKLHMDAFSVRSHTLNGFLTLNLKAKLRGA-AVASVGMIKRELRR----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKKPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLQTLESDKEELEKQVdsmKkeLEsKSGFSGPPpppdkdlKMSSgvtRKSIELEIDVKIIGWD-AMIRIQCGKKNHPAARLMAALKELDLEVHHASVSVVNDLMIQQATVKMGSR--FYTHEQLKSALMSKVGD- -------------------------------RLQSMLQTAVQSV--QWTYSLFWQLCPQ-QGILVWGDGYYNGAIktRKTVqpmevsaeeaslqrsqqlrelyDslsagetnqqtrrpcaalSPEDlTESEWFYLMCVSFSFPPGV-G-LPGKAYARRQHVWLTGANEVDSKVFSRAILAKSARVQTVVCIPLLDGVVELGTTEKVQEDLGFVQHVKSFFIDH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKKIQDLESRNRQMesEQRsrsaPEPQRkeqrSGvtvmarvGPPgSDKrklriVegSSGcarpkppqpvASeTVTNVQVSIIESD-ALLELQCPYREGLLLDVMQMLRELRIEVTAVQSSLNNGVFVAELRAKVKENVngKKVSIVEVKRAIHQIIP-- -------------------------------SLQTRLKFILQNRPERWLYAIFWQASKDIngRLVLLWADDYFRGNDVDwipSSnEhmNpmfgCEEvCNAQWLIMSSVGMGFLAGY-D-VVGQSYSSGSCLWLAGDMDLKNYNTKRTEEVRVHGIKSLVCIPTSNGVVELGSCDLVKQDAGLIQLTKSVFDTDSSffnvNlanlgvegEIpnqGPqnqanIEegqeevmStkkmkmSSSDSDPfeinssspstntitnpPKRRGRRAKGvvaasTEvmTHGYHVEAERQRREKLNHRFYALRSVVPYVSKMDKASLLADAVTYIKELKSRIETLEKSAGSESspisSRNKMTQLNskdydYSNIdNSrlsFnghpTNNqvEVGQIDVEVKSLGTE-VMVRVQSADVNYPAAKLMDALRSLELRVQYASDGPLSSFLY------------------------------ -------------------------------NLKKQLAVSVRSI--QWSYAIFWSVSTRQPGVLEWGDGYYNGDIktRKTVqamelkadqlglqrseqlrelyeslsegEssqqavtrrrsaaalSPEDlTDAEWYYLVCMSFVFNIGE-G-LPGRALANGEPIWLCNAHYADSKVFSRSLLAKSASIQTVVCFPFLGGVIEFGTTELVPEDHNVIQCVKTSFLEAP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------TDTEWFFLVFMTQSFINGG-G-LPGQALSTNNPVWVTGSDRLAGSLCERARQGQVFGLQTIVCIPSANGVVELGSTETIYQSSDLMHKVRVLFNFG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANDREEPLNHVQAERQRREKLNQRFYALRSVVPNVSKMDKASLLGDAIAYINELQEKLQIAEMQIKDLQSQARasTSRHeclsiGpsrDhlqysPqTNGtrSASSyiySGDQKPNIAVHILGEE-AMIRVNCLRESYPTVNMMMALQELRLEVQHSNTSTMEDRILHIVIAKMSPK-ERYTQEQLRCILERSF--- ---------------------------------------------------------------------------------PEDlTETEWFYLMCASYCFPPGI-G-LPGEAFARRGYVWLCGANKVDSKVFSRAILAR-----TVACIPVNdDGVLEIGTTEKVAEDSGLIQYARSIFMDQHGipimptlsghststqsThinhqpfqikmekyagGinvqpntlnpedehieteeeddrIdsetntengsrrhlppdnmgneqarpkvwSSdlmqietseslrdgctnhVDDEismlmvcqnaaqdqaalaenahyiqavltilrrnacwraqaapniraylalskNSsfsrwnpkgtnDLqrmlisDGsPQRMLKsilfigaparyshqrhrgKvqspepsrddGegtsrsrrgQGqAELSASHVLKERQRREKLNERFVVLRSLVPFVTKMDRASILGDTIEYVKQLRRRIQDLESRARLPidgghltapaPKRAhQsAssaaalaETGsNKmraveaSSSCSTSGgavrpaaSSAASTEVQVSIIGSD-ALVELRCPRRDGLLLRVMLTLHwELGLEVASVQASSAGDVLLVELRAKVREMHGRKSIDEVKRAIHLI---- -------------------------------TLQQRLQALIEGSRESWTYAIFWQSSYDFsgASVLGWGDGYYKGEEdkgkKKqKaSpssvaeqehrkrvlrelnslisggaaptDEaVDeEvTDTEWFFLVSMTQSFVNGS-G-LPGQAFFNSSPVWVAGSDRLESSGCERAKQAQVFGLQTMVCIPSANGVVELGSTELIFQSSDLMNKVRVLFNFNN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------DLQNKLQNLVEAesQSFRWNYAIFWQLSRTKsgDIVLSWGDGSCREPH-DSemgSdapiiiddvspvtkqrmrkrvlqrlhaafggageEDyapgIDQvTDTEIFFLTSMYFAFPRQV-G-GPGKVYASGAPLWIPNNERkiSPANYCCRGFLANAAGFRTIVLLPFETGVLELGSMKNVPESVEALETIRSVFAGACinraaivkhdeNGsvqasasqglakifgkNlsFsqpsaskgvdasnvegSSwhpqksdsgesmlfpnlrkglqkftwsqargLNsheqkfsndvlvvaSEtaHcsngatqgpgvspfqflkpqqiltqpppqpraprqidfsvgSssrssvltsqktmwDEENgsvhglckderDDRQLRKrgrrpTNGRQEPLSHVEAERQRREKLNKRFCALRAVVPNISKVDKASILEDAIAHIADLKKKLTELEAEKEKFVGRG-M---GDT-----M-EQASRPEVDIQVLKGE-ILVRVVSRMENHPIKKVLQAFEAAEVKV------------------------------------------- -------------------------------AVQQRLQFILQSRPEWWVYAIFWQATKDSdsRLKLEYGDGYFRGKEEKE-EEqTRNvNDIEWFYRMSQTRSYVAGD-G-VVGCAYSSGVDVWLSGVNEFELNDCDdRVREARSHGIHTLVCVYVPGGILELGSCHVFTLGYGLLEMAKSVFEESQNQnPLNnPmgmndataakVDGsstDSSDADADATFPmtRRGGGraREaLPMNHVEAERQRREKLNQRFYTLRSAVPNVSKMDKASAFGR--------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLQRRLQALIEGARESWTYAIFWQYSSDFsgQSLLGWGDGYYKGEEedktnGKASkptssaeqehrkkvlrElnslisgapsssdDdVdEEvTDTEWFFLVSMTQSFVNGS-G-LPGQAFFTSNPVWAAGADRLSASPCERARQGQEFGLQTMVCIPSANGVVELGSTDLIFQSSDLMNKVRVLFNFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLQNKLSDLVERPNasnFSWNYAIFWQISRSKsgDLVLGWGDGCCREPM-EGeeSeatqilnfmlqdegqqkmrkrvlqklhklfggsDddNyalqLDRvTDMEMFFLASMYFSFPRGE-G-GPGQCHASGKHVWMSSALTSNSDYCVRSFLAKSAGIQTVVLVPTDNGVVELGSVNSIPESLDMVQMVKFSFSSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAILYINELKAKLENNEGNKDELRNQIdalKKELSNKvsaqenMKMSSItTRGPPADLDVDVKVIGWD-AMIRVQCNKKSHPAARLMTAMMELDLEVHHASVSVVNELMIQQATVKMGSR--FYTEEQLRAMLISEIND- -------------------------------NLMERLRPLVGSK--GWDYCVVWKLSDDQ-RFIEWMGCCCSGGE-NVKEgGEEllfpvSplpcRDV-MFqhprtkaceALAQLPSSIPLDS-G-IHGEVLISNQPRWLNFSNSSDSNSS-------EETVGTRVLIPVPGGLIELFAAKQVPEDQQVIDFVTAQCNISleqeamsaNmsfsNqsnlgnekdlnhfqpaenlNlpyDIsldrirlcPSmnflqqFSyqssnsndsfegssdgsnpsSEHngfQDSDasqsmmsneqlmeSieqqgnDkdsikqengrsdsgsdcsdqnddedDAKYRRRTGKGPQSKNLVAERKRRKKLNDRLYALRSLVPKISKMDRASILGDAIEYIKELQKQVKELQDELEENSEDegncnnkNNAqEeilQgIpklDdKPpngfhvgSSGngSVskqnqdSSssNdKgqQMEPQVEVAQIdGNE-FFVKVFCEHKPGGFVRLMEALDSLGLEVTNANVTTFRGLVLNVFKVEKRD-SEMVQADHVRDSLLELTR-- -------------------------------RLKAMLQAAVQSV--QWTYSLFWQLCPQQ-GILVWGEGYYNGAIktRKTVqpmevsaeeaalqrsqqlrelyDslsagetnqpgssttasrrpcaalSPEDlTESEWFYLMCVSFSFPPGV-G-LPGKAYARRQHVWLTGANEVDSKVFTRAILAKSARIQTVVCIPLLDGVVELGTTEKVEEDNGLIQHVKGFFMDH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRGRKpNTGRDTPLNHVEAERQRREKLNHRFYALRSVVPNVSRMDKASLLSDAVSYINELKSKVEELEHQLRSEKQKTTATSDvpSQTTCtTSedqvrpsrTSyNSAATPMEVEVKIMGSD-AMIRVQSPNVNYPAARLMNALRDLELQVHHASISCVNDLMLQDVVVRVPDG--FRTEEALKNALLRRLEL- -------------------------------DLRNQLAVAVRTI--QWSYAIFWSISSRQPGVLEWGDGYYNGDIktRKTVqavefnadqlglqrseqlrelyeslstgEsspqarrpsaalSPEDlTDTEWYYLVCMSFVFNIGQ-G-LPGRTLANGQPIWLCNAHYADSKVFSRSLLAK-----TVVCFPFLGGVVELGVTDLILEDPGFIQHIKTSFLEIP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------RLQSMLQTAVQSV--QWTYSLFWQLCPQ-QVILVWGDGYYNGAIktRKTVqpmevsteeaslqrsqqlrelyDslsagetnqptrrpcaalSPEDlTESEWFYLMCVSFSFPPGV-G-LPGKAYARRQHVWLTGANEVDSKTFSRAILAKSARIQTVVCIPLLDGVVEFGTTDKVQEDLNFIQHVKSFFVDH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLRKQLAAAVRSI--QWSYAIFWSISTTQPGVLEWGDGYYNGDIktRKTVqsaelnadqlglqrseqlrelyesllsgEsdpqakrpsaalSPEDlTDTEWYYLVCMSFVFNPGQ-G-LPGRAFASNQPIWLCNAHLADSKVFSRSLLAKSASIQTVVCFPHLGGVIELGTTDP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------VISGSVVWLIGAHELQFYDCERVKEARMHGIQTFVCVSTPSGVLELGSPDLISEDWALVQLAKSIFGADINAgsfpkqlnqesqpQipnrtvsnfldFgmfSSPqkerttslenqkesdtrkepsgqgrsssDSGRSDSDAgftennigFKKRGRKPGGKELPLNHVEAERQRRERLNHRFYALRSVVPNVSKMDKASLLADAATYIKELKSKVNELEG---------------------------------------------------------------------------------------------------------------- -------------------------------TLQQRLQALIEGARESWTYAIFWQSSYDYsssASVLGWGDGYYKGEDdEskskaknKTSssaaeqehrkkvlrElnslisgsatpatdDaiDEEvTDTEWFFLVSMTQSFVNGG-G-LPGQAFFNSSPIWVTGADRLVSSPCDRARQGQVFGLQTMVCIPSANGVVELGSTEVIFQSSDLMNKVRVLFNFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------RLQSMLQAAVQSV--QWTYSLFWQLCPQ-QVILVWGDGYYNGAIktRKTVqpmevsaeeaslqrsqqlrelyEslsagetnpptrrpcaalSPEDlTESEWFYLMCVSFSFPPGV-G-LPGKAYARRQHVWLTGANEVDSKTFSRAILAKSARIQTVVCIPLLDGVVEFGTTDKVQEDLNFIHHVKSFFTDH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------QFSYQLAAAVRS--INWSYAIFWSISTSRPGVLTWKDGFYNGEIktRKVtSsadltadqlllqrseqlrelyqsllsgqcDhrgrrpaaalSPEDlGDAEWYYAVCMSYAFRPGQ-G-LPGRSFASNEPVWLCNAQCADTKTFQRSLLAKTTSIQTVACIPLMGGVLELGTTDTV-------------------------------------------------------------------------------NRTSFWDETIPYSRPKEQSSPSADSNREADiaFQKLhhnsgkKMIPGSLRkaseECcDDterIlpkDDGfYNICDEVNVTVTDKN-WILEVQCRWFEVMSSQVFPPIKSLMVDSLSVRASTPDGLLALKIRAQFA---------------------- -------------------------------TWQQRLQFIIQSRPEWWVYSIFWQASRDArdHVVLSWGDGYFRGTR-DFtcksSnmlsqqrkrsgkevqgffnEvmdmDrmvdGDgDfTDYEWYYTISMTLSFTVGD-G-ILGKAFGSSSHIWLRDHEPI-----TRSLT------------P----------ADQI----------------------------------REHKPR--SGKESPIDHVEAERQRREKLNHRFYALRSVVPKISKMDKASLLSDAVTYIKELQSKIDKLETELL------------------------------------------------------------------------------------------------------------- MIDAfLNSSSDIWP-----LSPANRTL--ET-TLQQRLHAVVKVTHEAWCYAIFWKPSYHDisgEPVLKWGYGVYKGEDetdktrRrrKTNaeeklqrnkvlrelsstisGvsfpvkDeDDDvelTDMEWFYLVSMTCSFRSGS-G-LAGKAFATYNPVWITGLDMINGSGCSRANQGGDLGLQTIVCIPSDNGVLELGSTELIRENTGFFRKIRFLFNFE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLRFQMATAVRNI--QWSYSIFWSFPVPQPGILEWSDGYYNGDIktRKIVqamevnqdemheqrteqlrklysslstreseeDlqpqvkrpssalSPEDlTDTEWYFLVCMSFVFNHSQ-G-LPGKILARNNPMWLCNAHQAHSRIFSRSLLAKSSSIQTVICFPYTDGVIEFGVTELVHEDRNLIQQIKNSFVEA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLRKQLALAVRGI--QWSYAIFWSTPVTQPGVLEWSDGYYNGDIktRKTVqaeevnedelglqrteqlrklysslltgeseEdlqpqvkrpsaalSPEDlTDTECLKFInNAPFSFVLSVDRKLPGKTLATNETIWLCNAHQAESRVFSRSLLAK------------ARGVIELGVTELVLEDPNLIQQIKNSFLEADQsviskrpnyvsNdrnivsqklfynilenDvypveInnssphdssngfvanqeaedslmvvdvigetSqaqswkfmddnmsngandSLNSsdcisqnnanceklsplssgekdtkpcpldrqEHdqkklhpSDHqgdDAqyqavlstllkssdqltlgphfrnsnkkssfvgwKnniqtprigtaQKLLKRvllevprmhggvvhkiskENRrknnllrpevDDIDKNRVISERRRREKINERFMHLASMLPTSSKVDKVSLLDETIEYVKELERRVQDLEARSARRSND-TAEQTsDNcgtskfndikvslpkkRKACDmdeIepeNcNGllKGsSADSIVINMIDKE-VSIKMRCLWSEGLLLKIMEALTNLQMNCHTVQSSNIEGILSIAIESKSA-GSKKVAVGTIREALQRV---- -------------------------------KLRKQLAIAVRSV--QWSYAIFWSLSARQQGVLEWGDGYYNGDIktRKVQatelkadkiglqrseqlqelyksllggDagqqakrsspalSPEDlSDEEWYYLVCMSFVFNPGE-G-LPGRALANKQTIWLCNAQYADSKVFSRSLLAK-----TVVCFPYLEGVIELGVTELVTEDPSLIQHIKASLLDF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------EWLRPLVDSK--NWDYCVVWKLGDDPSRFIEWVGCCCSGANgvdVNVKkENggqeqhLTPlcRDSQIQHpirtkaceaLAHFPSSIPLYS-G-IHGEVVISNEPKWINHAEASNSNLSH-------ELKGTQVLIPVAGGLVELYSSKLIPKDQKTIEFIINRFKLGSEeansSqkedqvlDffpyeklnfcapplqypssapqLsqvsqsssnpsiegSSTGSIPsneltlchspsdhlsrniplsqssdgyfehSELQCsgnLSrmpssSfpwnqenyiiagDAFtMgkKRQRGqYQSKNLVTERKRRNRIKDGLFALRALVPKISKMDKASILGDAIDYINELQENVKELEDELNEIEAEVcrnnessEVVLSDmtemsKVtgPTNektqSCNTTKRTRMevQVEVNQIGAREFLLKVSGSHKRGGFTRLMEAMDSLGLEVVNANVTTSGGEVLSIFIAEANVDR-VVDAQKLRSSLIELT--- -------------------------------NLMERLRPLVGL--KGWDYCVLWKLSEDQR-FIEWVDCCCGGAE-SI----E-SGGELQFPVtsvlpcrdvmfqhpktrscellaHLPSCMPLNS-G-IYVQALISNQPKWLNFSNNSDSNVLE-------EIVGTRILIPVAEGLIELFVAKQVPEDQHVIDFVMAQCNISWEqeammnssnmdtsfhlNlnalnefqgkpfssngndqkdsnnhfqppvtttcdnlnlpwDIsvdqirlcnSpmnffqqfnyssenrpkndiffegSHDSIHSDKpinpfkssaengfqemdalhqsmmtnssnmhpsfmessvtkeqgnekdsikqengrsdsisDCsdqnddeDDA--KYvgRTGKRPQSKNLVAERKRRKKLNDRLYALRSLVPKISKMDRASILGDAIEFVKELQKQVKDLQDELEEHSDEdngaKNtgnngnnnnfqSEILnnngipvgsnpehDKSpngsHmgcsSNgSIskanqqnhdTcNDKTqqMEVQVEVAQIDGNEFFLKVFCEHKPGGFVRLMEALNSLGLEVTNANVTTFRGLVLNVFKVEKRDS-EMVQADHVRDSLLELT--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNHVEAERQRREKLNHRFYALRAVVPNVSRMDKASLLSDAVCYINELKAKVDELESQLHREkSKKVKMEMADstdnQSTTTSTdhvdqSndNtAGALALEVEVKIVGND-AMIRVQSENMNHPSARLMNALRDLELQVHHASMSSVNDLMLQDVVVRVPDG--LRSEEGLKAALLKRLYQ- ---------------------------------------------------------------------------------LDRvTDTEMFFLASMYFSFPRGE-G-GPGKCFGSGKHMWLSDALKSSSDYCVRSFLAKSAGMQTIVLISTDVGVVELGSVRRIPESLELLQSIRSCFSSSSFvslirdkpgapipavsgtnegvgerPdgnpkifgqDLnssrsqyreklavrkveekpwevyqngnrmpfqntqnvfhpsnwtqfHsvrqgspveiyspqtpptnnlqngvredfrlnqyhpqmqidfggatsrpsvisrpiSAESEHSDVEAsckeeravpaDEKRPRKrwrkpSNRREEPSNHCEAERQRREKINQRFYALRAVVPNISKMDKASLLEEAQG------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYITELKSKLQTLESDKDGLEKQldslkKdldNVKKEASSAPPPlpdkelrMSSnnlvggGKLIDLDIDVKIIGWD-AMIRIQCSKKNHPAARLMAALMELDLDVHHASVSVVNDLMIQQATVKMGSR--FYTQEQLRSALTSKVG-- ------------------------------------------------------------------------------------TDTEWFYLVSMSYFFSHGV-G-TPGQALASGEYVWLLEANKAPSHVCTRADLAK-----TIACIPTKNGVVELGSTELIFESWEVINNIKEFFSEG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQKFYALRAVVPNVSKMDKASLLGDAISYINELRTKVQDADSEKEEMQKQLdEMKKQlsSKeScsTAPPppDqdrnMSNKLIELDIDVKIIGWD-AMIRIQCSKKNHPAARLMTALKELDLDVHHASVSVVNDLMIQQASVKMGSR--FYTQEQLRIALASKVG-- ------------------------------------------------------------------------------------HDSDRFYFYgvSLTQSFAAGQ-AskNILGRAFCSGGFVWLAGGHELQMYECERVKEARMHGIQTLVCITTSCGVLELASLDVIMQDWGLVHLSKSLFGSDQKNnkfkllvpdPLekiGflsggqkeftiqegganepiihtdgsStgssYdsFGNFTPANTenpqSKKRGRSsssnhgATSREsQLLNHVEAEKQRRDKLNHRICLLRSIVPNVSEMDRSSLLADAVAYMNQLKGKVDELEAKIQA------------------------------------------------------------------------------------------------------------ -------------------------------QLGKMLAASVRS--FQWSYAIFWSPSTKQEGVLEWSDGYFNVDKvdlKKSEklremyerlslgetkEqakiasttslSPEDlSDVEWYYVVCMSFAFAPGE-G-LPGRAFLNGEHIWLCNAQHADSKIFNRSLLAKSASIQTVVCFPVSGGVVELGVTHMVIEDIGLVQQMKAFFLDFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------VKEFLRPLVDSR--AWDFCVIWKLGDDPSRFIEWVGCCCSGSYidkniKHEkVEeerqNMSSiCRDEHNKhhirtlaceaLSRFPLFMPLYP-G-IHGEVVMSKSPKWLVNSGPG----------SKQDIFSTRVLVPVRDGLVELFSFIMKPVDESMVDLIISHCNTFFEpypeQTLPriiskSEESLLMHKEEDvvMQNDDKkPAKENFKSKNLHSERKRRERINQRIYALRALVPNITKMNKNGTLSDAVDYINELLVEKQKLEDELSGINEeecrKaAEEESAiANPLieANKVSSrlNkkVNNEVQLEVHETGERDFLIRVCQEHKRDGFKRLMEAVDSCGLEIIDVNFTRLDLRVMTILNVKATKD--GITPENLRDLLIK----- -------------------------------NIRLLLQAVVRST--QWTYSIFWRFSPS-RGLLVWREGFYNGDVeRSLqlrelfhSlksEeeinqpsskqcvalSPEDlTDTDWFFLVSMSFDFAPVK-C-LPGRALANRCPVWLCRANEVEARVFSRALLAKSAGIQTVACIPLMDGVLELGVTKL-------------------------------------------------------------------------------TNKESILGEAIEYLKHLQRRVLELEAHKKQTEvdhngfqEQnPidgaiidkqdeelsdekhfsRVKKlrdANDQlKSlrmDkrkvrvvegSATSpmetGEGSMAEIEVSINDEK-ALLQLKCCWKKGLLLQILQTLSSFHLEIYESQSSRVQHnYFVATIK-------------------------- -------------------------------RLQKMLQAAVQSVE--WTYSLFWQICPQ-QGILIWSDGYYNGAIktRKTVqpmevsteeaslqrsqqlrelyDslssgdtnqparrpsaalSPEDlTESEWFYLMCVSFSFPPGV-G-LPGKAYARRQHVWLTGANEVDSKTFSRAILAK-----TVLCIPILDGVVELGTTEKVQEDLGLVQHVKTFFNDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIKNHVMSERKRREKLNEMFLILKSLVPSIHKVDKASVLAETIAYLKELQRRVQELESSRELTSRPfettRPITKArgNecvskklcagsKRKSPDFGGdvekehpwvlPKDGTSNVTVAVSDRD-VLLEVQCRWEELLMTRVFDAIKSLHLDVLSVQASAPDGFMGLKIRAQFAG--------------------- -------------------------------SLQQRLQTLIDGAREAWTYGIFWQSDVVDfasPLVLRWGNGYYNGEEdKnkcKTtSfspyfiaeqehrkkvlrevnslisgtqtsgENdvVDEevTDTEWFFLISMSQSFVNGS-G-LPGLAMHNSSPIWVTGTERLAASNCERARQAQGYGLQTMVCIPSANGVVELGSTELISQSSDLMDKVKVLFNFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------LSTQLAVAIRSI--QWSYGIFWASSTTQEGILEWRDGYYNGDIktRKTVqtmiesnadqirlqrseqlkelykfiligesDsqtkrpyaslSPEDlSDSEWYYLVCMSYVFNSKQ-S-LPGKALESGETIWLCNAQHADNNVFSRSLLAKSASIQTVVCFPYLGGVIEIGTTELLQDDPNLIQHVKACFLEIS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRSVVPNISKMDKASLLGDAISYINELQAKLKDMEAERERLGYSSR-PT-SCLEINSNTQMENQAPEVDVQTANDE-VIVRVSCPLDSHPASRIIQAFKDAKVTVIDSKLASGTDTVFHTFVIKSQG-SEQLTKEKLMAAFSR----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESEHSDVEAsckeeqpglaDDRRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYINELQAKLKDMESERERQGGTSR-DP-SALETNPNSeEMQSQAPDIDIQAVNNE-VIVRVSCPLNSHPASRIIQAFKEAEITVVESKLAAGNDTVLHTFVIKSQ-GSEQLTKEKLIAAFSC----- --------------------------------------------SINWSYSLFWSISSTQrPRVLTWTDGFYNGEVktRKIShsveltadqllmqrseqlrelyealqsgecDrraarpvgslSPEDlGDTEWYYVICMTYAFLPGQ-G-LPGRSSASNEHVWLCNAHLAGSKDFPRALLAKSASIQTIVCIPLMGGVLELGTTDKVPEDPDLVSRATAAFWEPQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------TLQQRLQAIIEGSRETWTYAIFWQSSTDAgASHLGWGDGYYKGCDdadKRRqqpTpasaaeqehrkrvlrElnsliagggaaapdEaVEeEvTDTEWFFLVSMTQSFPNGM-G-LPGQALFACQPTWIATG--LASAPCERARQAYTFGLRTMVCIPLGTGVLELGATEVIFQTNDSMGRIRSLFNFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------RLQQMLQAVVQSV--HWTYSLFWQVCPQ-QVILVWGDGYYNGSIktRKTVqpvevsteeaslqrsqqlrelyeslssgEanlparrpcaalSPEDlTEAEWFYLMCISFSFPPGV-G-LPGKAFARQRHVWLTRANEVDSKTFSRAILAK-----TVVCIPLMDGVLELGNIEKYSM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------ASGCERAREAHLHGIETLVCVPVPGGVLELGSADLIPENWVLVQQANSILSSDAPHhhlaaaDpslraapllpkkegaaaagLsSSLDSEHSDSDAagllqgERRRgAKKrgrrpGTGRETPVNHVEAERQRREKLNHRFYALRSVVPNVSRMDKASLLADAVAYIKELRAKVDDLEADAK------------------------------------------------------------------------------------------------------------- -------------------------------TLKQRLQTVVESKP-GLLYAIFWQMKSTNkkinhKRVLTCSDGYLKNSM-NVGE-HNEiVVPGWFYAVSLTKLLDIDDNNLIIGQAMKSSSYMWLINADrNANFSGLERAKEAIQYDIRTLVFVPLthLGGVIEIGSLDEIDEDKSLIELTHFIFGSNID--------DNSDLTSsrsESRTAADVPAKMQRSNHVEAERHRRDKLNQRFYALRSVVPYVSKMDKASLLSDAVTYINELKAQL--------------------------------------------------------------------------------------------------------------------- -------------------------------HLRKQLAATVRKI--QWSYAIFWSTSTGQPGVLAWSDGYYNGDIktRKMTqpmelkadqmglqrskqlrelygslsagDNnpqsrrpsaslsPEDlTDTEWYYLVCMTFTFAPGQ-G-LPGRAFANNQHIWLNNAPFADSKIFSRSLLAKCIYS-DSGLHPFAGGVLELGTTEQVLEDPALVKQITSFFREMP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------ELRLQLQAATRA--VKWTYFTFWKPAPGDQKKLVWGDGYFNGTIktRKTIDgkeltpeefglqrshqlrDlYETlSNTELRHAIAnkpvalKPEDFAEEE-W-LMGRAAASGRYKWMCGANGMTTXVFTRCLISKSASIQTVICVPLKDGFREFGTTQNVPVDSKMVQHLLSFLEQPKHNrsqsslvigqsarnpkraklsnpprtkveDkmslnnvnIStrlsrqgprtcvhifqrlqcvseklnwrSAqGSasrrngEqfpeGSkrtsPASAfviwKNslTPPRKyrkagnrqwilkevlfhvtqlfngtlkeinvevesslvttekvGedrraseleshkpvpSIEETNASHVLAERRRREKLNERLLSLRALVPNVSKMDKASILGDAIEYVKELQSRLQAFQI---------------------------------------------------------------------------------------------------------------- -------------------------------EVQRSLQAVAQGL--RWTYAILWQLCPDQ-GALVWAEGHYNGAIktRKTVqpavaqaqaqapaaeaadqarsrqlrelfDslareaaagggpgfrdvhGcaqearrpsaalaPEDlTETEWFYLMSASYSFPPGV-G-LPGRAFARGGHVWLSRANEVDSKAFSRAILARVAGIKYAVKMLIVDGVLEIGTTKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------MSERFYTTSLHKFLDIEDTNSVIGQLMSSGTHLWLVDVdGKLNYSRCERAWEARQNNIQTLVFLPISpGGVIEVGSLDVIKEDRSLIDLTYSIFGAGGDGNMN-ITSRNS-----NRRS--APATaVPRSSPAEAERKRRDRLSQRLCTLRAVVPNVSKMDRASLLSDAVDYINKLKSRVSLLEDNLGVLQNRiPtvahlqdqNlhqPERQNNPAvnsllynqhlqqpgDqNpTVpvPqlaamVNTNMQLKVEVKLLGAE-MIVQAQSSGLDYPAAKLMNVLRDLNLVISNATISNVDvdGFVLQNVVVKRPPeGNGfIGTQEGLTNAILQRLQ-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQKKLKEMESEKEMFKNS---------------STRVCCPEFDVQMGHEE-VIVQVSCPLNTHPVSRVIQTFKEHQIDVQESKVSTENDTVIHTFSIWTQSGSAEMTMEKFFSPLS------ ---------------------------------------------------------------------------------PEDiADTEWYYVVCMTYAFRPGQ-G-LPGRSYASNRSVWLCNAQSADSKTFLRALLAK-----TIVCIPFMSGVLELGTTDPVSEDPNLVNRIVAYLKELQfpiclevpsstpSPdetedaDtvFdglieedqmvilqgedelgdvvvaecetNganpetitmetdefySlceeLDldlgSyqlvptsarEtmaaaaaaANDVDGvayshascfvswkranpaekvvavpmtagiEsQKLLKKavGGgtawmsnidGRgsvaitttpgSSIKSHVMSERRRREKLNEMFLILKSLLPSVRKVDKASILAETITYLKVLEKRVKELESS--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRPHQSKNLVAERKRRKKLSDRLYKLRALVPNISKMDRASILGDAIEFVKELQKQVKDLQDELEEPSgdhdqhlqddynerRKnnkqQQISSclqlqhdhHQngtSgGpTANDvydhdhqtvaAttaarcSStWdqqtQQMEPQVEVNQIDRNEFFLKVFCEHKPGGFVRLMEAMNSLGLEVTNANVTTFRSLVLNVFKVEKRDNDEMVQADHVRDSLLEIT--- MEDAISPFQSLSL------NLQPKIS--ST-SHQHCLQIIVKSKP-GWLYAIYWQLSSisnDSaynnRRVLACSDGYLMHSSKPGNlqqqEvshiqEVDEmVMSERFYTASLHKFLDIEDTNSVIGRLMSSGTHLWLVDVDgKLNYSRCERAREARLNNIQTLVFLPIsPNGVIEVGSLDVIKEDRSLIDLTYSMFGARGDGNMN-ITSRN-----SKRR--TAPATAvPQSSPVEAERKRRERLNQRFCTLRAVVPNVSKMDRASLLSDAVVYINKLKSRVSLLEDNLRV------------------------------------------------------------------------------------------------------------ -------------------------------ALQQMLQASVQSL--QWTYSLLWQMCPQ-QGVLVWTDGYYNGAIktRKMVqsveatadeaclqrsqqlrelyeslsmgEanqparrpcaalSPEDlTESEWFYLMCISFFFPPGV-G-LPGKAFERQKYVWLSGASEVDSKVFSRAILAKGAQIQTVVCIPLADGVLEIGTTNKVVEDPALIHHVKGFFTGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------PDSALQKRLQAVLDGTQEAWTYAIFWTPSYYDfsgDSVLKWGDGIYKGEEadktRrrrRTVaenehrstilrelssmisDeallvmgDEDDlevSDPSWFYLTSMTVSFGSGS-G-LPGKAFATYKPVWVTGSDHIMGSGCDRAKKGGDLGLQTIVCIPLDNGVLELGSTAEIQQTPDLFNKIRVVFSFEG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------NLQNKLSDLVERPNasnFSWNYAIFWQISQSKsgDWVLGWGDGSCREPKegeeSEAtrnlNlrledetqqrmrkrvlqklhtlfggsDedNyafgLDRvTDTEMFFLASMYFSFPRGE-G-GPGKCFASGKHLWLSDALKSSSDYCVRSFLAKSVGFQTIVLVPTDLGVVELGSVRMVDESFELLQTVKSVFSTQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------VLRWYDGYYNGDIktRKTVqsmesntdqasfqrsdqlrelyeslcngEtNhqtrrpcaalsPEDlSNSEWFFVICMSFSFHPNQ-E-LPGRTFARNQHFWLCNAHEVDSKTFFRSILAKSAHIQTVVCFPHLEGVVELGTTDKMDEDMNFIQHIKSFFIRQQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAITYITDLQMKIRVLETEKEMVNNK----------------QQCTPPEIDFQARHED-AVVRVSCPLDAHPVSRVIKTFREHQITAQESNVSMTEnGEVVHTFSIRTQGG----AAEQLKEKLVAAL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQDHVIAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKQLQERVKTLEEQAAKKTVESvvFVKKSqlsaDDdSSSSDENsDgcSDQPLPEIEARVSDKD-VLIRIHCEKQKGCLVKILSEIEKLHLSVVNSSVLPFGNSTLdITIVAQMDDEFSMTVKdlvKNLRLALLKFMS-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQRFYSLRAVVPNVSKMDKASLLGDAISYINELRSKLQTAESNREDLQKELegmkselAIEDSRPALTSldDprMldDNGNMIELDVDVKIIGWD-AMIRIQCSKRNHPAARLMAALKELDLDVHHASVSVVNDLMIQQATVKIG---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHIIAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKQLQEKVKTLEEQTRKKTMESvvFVKKSqlsadgDNSSSDeNFSSGpfDEPLPEIEARFCDKN-VLIRIHCEKRKGVLEKTIAEIEKLHLTVINSSVMTFGSSAlDITIIAQMDEEFCMTVKdlvKNLRSAFKSFM--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTQDHIMAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYVKQLQERLKTLEEQLPKKRMRSvsKVKSSSPSTSNSedTssyhvvDEDDGSQPEIEARMIDKN-VLIRVHCEKRKGLLVKSLAELEKLQLSVLNANILSFSATTlDLTFTAQMEEGC-ELTADEIVRALQDFFK-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELESTPPGSSLpPSSsfHplTPTPPTlpcrVkeelcpSslpSPKNQPARVEVRVREGRAVNIHMFCARRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEqCREGQ-DVLPEQIKAVLLDS---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVEAERMRREKLNQRFYASRCVVPNVSKMDKASLLGDAISYINELRSKLQALESDKEGLQSQIeslKEESAGSSrsrpppNNGSreheltVmNgGGRCSGVEIEVKILGSE-AMIRVQCMKRNHPAARLMAALKELDLEVYYASVSVVKDLMIQQATVKMSSR--YYTQEQLRSDLDSRDA-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQDHIIAERKRREKLTQRFIALSATIPGLKKMDKASVLGDAIKYVKQLQERVKELEEQKKERTMESvvLVKKsqlclDDnNQSSSSSSCeddcSSsDILPEIEARVSGKD-VLIKIHCEKQKGIELKILAEIEKLHLSVTNSSVLPFGNStLDITIIAQMEEEFDMTVNdlvKNLRQALSKF---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQKINDLHNELESTPSGSSLPttPTsfHplTPTPPtlpsRIkeelcpSslpSPNGQPARIEVRLREGRAVNIHMFCSRRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEQcKEGQ-DVHPDQIKAVLLESA--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNQEHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYLKQLQEKVKSLEEQVAKRTVESAvlVKKSqlcadDDSSScDSNSDSGESLPEIEARVSGKS-VLIKIHCEKHKGVLVKALSEIEKLHLSVQNTSVMPFGNSSLdITVMAQMEEEFSMTAKDlvkKLRSALRQ----- -------------------------------ALQHKLTFLVDNSSlCCWTYAIVWQLSSADgQMILSWGDGYFSTNEnstqRNEAkqfdadqilrrkvlrelhDlchpeeDyreVDHvTDQEWFYLLSMSWNFACGE-G-IPGRAFQFGQHIWICDTVKPINFQCARLELAKSAGIQTIVCVPTRNGVVELGSTEIVNECSRTLQDIRRYFEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------QRVLEWGEGYYNGHIktRKSVhnkdvdnhklglerseqlrklyeallEgeseqgakklslalSLEDlSDLEWYYLVSMSFTFKVGQ-S-LPGRALATGQHIWLYDTQSADSKLFTRSLLAK-----TVVCFPHKGGVIELGVTDLVLEDISFIQHIKTALVQPIEPdcspkassvsqkedsdkdhvianitenedemvDilpFSSLhnsaeqikfdedienglyqsvleefigspgdcsnDSSHHAEEsfysCtstfmpwkkeltadnfrmqEsQNTLKKvlfrvpliktnrsNSGRvnedemqdypmspqtydvykldfalqETTANLLLSELE-EKKDNPLYMVQESMIPSITEMDEAFILTDSTKYLAG----VEELETSIDLegTgtAKDLdMLEQNqqaydiySKSMASeinEIdpnSNkaiqTeilQPLDIDIEVSIEELE-VLITMKCPWRECLLIRIMEVLSNLNLETHSVQSSTLNGILSV----------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHIIAERKRREKLNQRFIALSTIIPGLKKTDKASVLGDAIKYIKQLQEKVKTLEEQNAKKTVesvvlvkKSKISV-DDSSSDeDSdSSpSEKPLPEIEAKLSGKN-VLVRIHCEKRKGVLVKVLSEIEKLHLTVINTSVMPFGSSsLNITVTAQMEEEFSMTVKdlvRKLRSALSQFM--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQEHVLAERKRREKLSQRFIALSAIIPGLKKMDKASILEDAIKYMKQLQERVKALEEEVAIKTVESVviVKKSqvtaDDDTSSsDEnSCNqiDQQLPEIEARVSGKC-VLIKIHCEKRKGFTTKILGEIEKLNLSVVNSSVLPFGSSILDvTIVAQMDVGFSMKMGdlvRNLRQALLDLM--- ---------------------------------------------------------------------------------------QLLFLIMMHHCGAGGRSssfyG-LPGRAFARGGHVWLSRANEVDSKAFSRAILARSAGIKTVVCIPIVDGVLEIGTTEKVEEDIGLVQYAMAIFMDQQEthmtpsichsNqtshidqqsfqtqgkthtgqpkpepnkftpeyddDemeyddneIdtecasgsetntgrghcrhgppniasnddhathnvgrSselmqvemservrdgcsSnLgdeiqmlmvcqNSgDHsnlhgqdepwhflyeelcsgypqssgedqamaenahyahtvslilhrnnalrqSDGpntrsylavshqssfsrwDAgihgravaEgttrQKMLKSvllffnaacnkppgdlrcddAGaRREvdFGASHVMQERKRREKL---------------KMDKASILGDTIEYVKQLTKRIQDLESSVARQQVhgdllvpKGSSERrAlmgmEGPSSSSGSsSSAPVATDVQVSIIESD-ALLELRCPDRRGLLVTIMQALQEqLRLEVTSVQASSDRGVLLAEMRAKVREVHgRRSSISQVKRAIHLII--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVMAERKRREKLSQRFIALSAIIPGLKKMDKASVLGDAIKYLKQLQERVKDLEEQNKKKKVESVvfVKRSilfaDDDSSSCDENSDQCLPEIEARVSGKD-VLIRIHCEKQKGIAAKILSELEKHNLSVVNSSFLPFGNSAlDITIVAQMNKEFCL-TVKDLVKNLRQ----- ----------------------------------------------------------------------------------------------------------LPGKSFASNEYVWLSNAQSADRKLFHRALIAK-----TIVCVPFiMHGVLELGTTDPVSEDPALVDRITASLWDTPPraafsseagvADIvvfedldhgnaaveatttmvpgepephavaggevaecesnahndleqitmddiGelySlceeldvLDddSsswvadpwssfqlvptaEATdvddavvaalgaidgscrpspssfvawkrtpDSDEvqavplisgepPQKLLKKavAgagawmnNadGsaatmttdqGSSIKNHVMSERRRREKLKEMFLILKSVVPSIHKVDKASILAETIAYLKELEKRVEELESSSQPSPRPmettrrcckstgKKVSAGarAKRKAPapEDTDGerRHCVSNVNVTIMDNKELLLELQCQWKELLMTRVFDAIKGVSLDVLSVQASTSDGLLGLKIQAKV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQDHIIAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKQLQERVKTLEEQSKKKTVESvvFVKKSqlsadDDgSSSSDEnfdGASNESLPEIEARVSDKN-VLIRIHCEKQKGVLVKILSEIEKLHLSVINSSVLPFGSSTLdITIIAQMEDEFSMTVKdlvKNLRQALLQFM--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTQDHVMAERKRREKLNQRFIALSAVVPGLKKMDKASVLGDAVKYLKQLQEKVKTLEEQTTKKTVESviFVKKTqisaDdnDSSSSEensVagSTYDEPLPEIEARVSHKN-VLIRIHCEKRTGVFVKILSQIEKLHLSIISSNAIPFDDSSlAITITAQMNAEYSMTVKdlvKSLRSAVLKAM--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKKIQDLETRNRQMESDSQqrnsSSKQQRSgvTVrGPdkrkmrIveGGtkpktvepPGEAETSVEVSIIESD-ALLELQCGYREGLLLDVMQMLRELRIEITAVQSSLNNGVFVAELRAKVKENVngKKVSIMEVKRAINQIIP-- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELESTPPGSSLTPStsfHplTPTPPTlpcrIkeelcpsslPSPNGQPARVEVRVREGRAVNIHMFCGRRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDIFRAEQcKEGQ-DVHPEQIKAVLLDS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNQDHILAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYLKTLQEKVKTLEEQAAKKTVESavLVKKSqlstdddDDSSSSDeNFDGgQSSLPEIEVKLSDKT-VLIKIHCEKRKGVLVRALSEIEKLQLTVVSTSAMPFAASSLdITVMAQIEEGFSMTVKDlvkKLSSAFRQFM--- -------------------------------HLRKQIAATVRKI--QWSYAIFWSISTRQPGVLAWSDGYYNGDIktRKMTqpielkadqiglqrseqlrelyeslsagDsnqqtrrpsaslSPEDlTDAEWYYLVCMTFKFTLGQ-G-LPGKALANKQHIWLNNAQFADSKIFSRSLLAK-----TVVCIPFMGGVLELGTTELILEDVDLVKQITSFFWELPNPicseqsisspqlaergegiicpDIdngidnsipsehhhliadrqtplesdpthfpfpihsyvpaehtesvkveelhqniceepdtcspddSSnecclthqledllgadglngmsrthslqlVDdefsngllhgslsSdEHatmsfvdaqravssatreptrnqmlgglqegshgkhiSlDLDGddshyaEtvatilrtsKlvnpvlcflkvsfrssfvvwRRgfnaPksfigtpqkllKKiLMDRAwWRGNHVLSERRRRDKLNEKFLALRSLVPTGGKIDKASILDDTTQYLKHLERRVQELESGTAVLgttdrRKNPDVaERTsDnylgNEITnewkppgNkrkacDMDEgeaehhfvlSKHGPVHVTVTVKEKE-VLVDLRCPWRECLLLEVVESMSNLHLDPISVQSSTVDGMLALTVKSKLRSSN-VASPGMIKRSLQRVI--- -------------------------------------ASAAPGGGESWTYAIFWQSSLDAatgEMLLGWGDGYYKGGEgdRTTrgsStaasvaeqehrkqvlrelnsliscgasgtsaEDvVDEevTDGEWFFLVSMTQSFVNGV-G-LPGQAFLTGATSWISGGQRLAVVPCERAHQALKFGILTMVCIPVSGGVVELGSTEFVCQSAEIMNKVKVLFSFNG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELESTPPGSSLPPTTssfhplTPTPPTlpsrVkeelcpSslpSPNGQPARVEVRLREGRAVNIHMFCARRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEQcKEGQ-DVLPEQIKAVLLDS---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANDREEPLNHVQAERQRREKLNQKFYALRSVVPNVSKMDKASLLEDAITYINELQEKLQKAEAELKV------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELESTPSSSSLPATTttsfHpltPTPPTlpcrVkeelcpsslPSPNSQPARVEVRVREGRAVNIHMFCARRPGLLLSTMRALDGLGLDIQQAVISCFNGFALDVFRAEqCKEGP-GVLPEEIKAVLLHS---- -------------------------------TLQQRLQSIIEGSRDTWTYAIFWQSSLDVvppgASLLGWGDGYYKGCDedkRKQrSatpaaaaeqehrkrvlrElnsliagagaapdEavEEEvTDTEWFFLVSMTQSFHNGM-G-LPGQAFFASQPTWIATG--LSTAPCERARQAYTFGLRTMVCLPLASGVLELGSTDVIFQTGDSLPRIRALFNLS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLIDRLRPLVGL--KGWDYCVLWKLSEDQ-RFIEWMDCCCSGTDGNTqtNggqEllfpvypvlpcrDiMHHSRTNsCDLLAQLPSSLPLES-G-IYAQAIISNQIIWLNSTKR---------DLSHMERDETRVLVPSGGGLIELFVSRDVTEDQQVIDFITAQCNISHeqdillsascnastNtsftvdinnmsNDIrpkaflvddnggndhlnnnhsfqqqpvfpamaldhnSnlpcdiSVDqirlcstspmnflqnSnnnnvynfdqgSHeslgemglqADTnaqnlhnniqvnEGieniEQqvvddqdsiKHegGRtadhsasdcsdqfdddggtnyrRRTGKKPQSKNLVAERKRRKKLNERLYHLRSLVPNISKMDKASILGDAIEFVKELQRQEKELQEELEQHSddggsKKRKSNNicgnhtnfqpeTlsqNgNTTANkqendelpngfrvgtagDignISkqknqdSditkDRGQemEPQVGVTQLDGNEFFVTVFCEHKPGGFVRLMEALDSLGLEVTNANVTSFRSLVSNVFKVEKKDT-EIVQADHVRDSLLEI---- MEELISPSSSSSP-TPPPfYSIQPQpltispgNSLeaLPTLGLQYILQCLLHSRSEWWTYAIFWRVSPDH-TLLSFGDGHFRGKLVsATADGSNDgDDAEWFYAVSLTRSFIIGE-LTMPSRAYGSLAPVWLTGSHALQTCGCDRSREAEMHGIETLVCIPSSTGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRRERLTQRFIALSTLIPNLKKLDKASVLGDAIKYIKQLEEQVKTLEEKAKKCSEEPvvAVKRPrllssyDNSSSsDENSNvsTDRSLPEIEVRASDGN-VLIRIYCKKQAGIIKEIFSEVEKLHLSIISSSVMPFGyNTTHITIIAQMDHQLSMTANdvaNRIRASIMKLI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESAPSSSLVGPSSasfHPSTPtlqTfpgrVkeelcpssfPSPSGQQATVEVRMREGRAVNIHMFCARRPGILLSTMRALDSLGLDIEQAVISCFNGFAMDVFRAEqCRDGP-GLLPEEIKAVLLHS---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPSSSSLPPSsSfHpltPTPQTlpcrVkeelcpSslpSPKGQPARVEVRTREGKAVNIHMFCGRRPGLLLSTMRALDNLGLDVQQAVISCFNGFALDVFRAEQCkEGQ-DVLPEEIKAVLLHT---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EESGNHVLAERRRREKLNERFMILRSLVPTVNKVDKISILDDTIEYVKELERRVQELESRKHTEgnkdatmqRKESqdKGERTSdncgnsetnDGKSGsakkrkafDAdekineEcpcTSkDECTDNVVISMIDKE-VLIELRCPWREGLLLEIMEALSDLNLDSHSVQSSTNDGILSLTIRSKVKGS-KVASIGEIKQALQRIV--- ----------------------------------------------------------------------------------------------------------LPGRSFASNEHVCLCNAHLAGSKAFPRAILSK-----SIVCIPVMGGVLELGTTDTVPEDPDLVSRATAAFLEPQCptylqepssNpsaseageaavivvfeDLghnametmtaagghgqelgeaeslfNaSLehitkeiDdfySlweemdvvpeatavpgattnnaaDTSssapvDgsratsfkawtrsqscSDEvavpviqePQKLLKKvvAgggawaNcgGRgttataqEisGIRNHVMSQRKSREKLNEMFLVLKSLVPSIHKVDKASILAETIAYLKELQRRVEELQPSRELLSRPSEtTERptttrprGigNEsvrkklsagskRKSPEFGGdvekehpwvfPKDGTSNVTVTVSDRD-VLLEVQCRWEELLMTRVFDAIKSLHLDVHSVQASAPDGFMGLKIRAQFAGSG-VVVPWMISEALLKTIG-- -------------------------------EIQGLLKAVVQSV--GWTYSLFWQLCPQ-RRKLVWSSGFYNGAIktRKTTqpaeimaeeaalersqqlmelyqtlfagEssmearactalSPEDlTDTEWFYVLCLTYSFEPPS-G-MPGKAYARRKQVWMSGVNEVDSKIFSRAISAKSAKIQTVVCIPVLDGVLEIGTTNKVKENEEFVEHMKSFFQNHP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQKFYELRAVVPNVSKMDKASLLADAVTYINDLSSRQQSLELERDELRTqigaakkELLVlPsKfGNKEPSghTNMdlkgSSgGKFPGLDSEVRILGQE-AMIKIQCAKHNHPVARLMTALQELEMEVLHASISTIKDaLMIQTVIAKMTRV--LYTEQQLHALLCKKVA-- -------------------------------QFRKQLAAAVRSI--SWTYAIFWSISTTRPGVLTWKDGFYNGEVktRKIGsstmeltaeqlllqrseqlrelyssllsgecaDqqrrrpvtalSPEDlGNMEWFYMVCMTYAFRPGQ-------WYASLIIAWLCNASSADSKAFPRKLLAK-----TIVCVPFMNGVLELGTTDPK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------EQLRELVRSM--GWSYAVLWSIPPLM-TELVWTDGWYEASNLKV-------NVERMFNSSyKTCSFAPGY-G-YVGKVFTQGQHIWVNGDAvHRQSTTSGQATFFSSAGIQTLLCFPWFNGVVELGAEGLVPQNDDLLQQIRRFLSN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLQQTLQFFVESRPEQWAYAIFWQKSKDVngGLVLAWGDGHFCGTK-DTitkqpNtqvnnntfgvgleqkkalkglisDylleatDwsMEgDvTDIEWFYTMSLTRSFAVGD-D-IPASAYGSSNYVWLTGLQELQQYNSERTKEAQMHGIQTLVCIPTLSGTIEIT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------PFQRRFQMIFEGARERWIYAIYWEYSPA-DSLLCWGDGYYNGNGKaqKTtSpteqaqrksvirllnllvsgpsathGDcDEDvTDPEWFFLLSMAHTFVNGS-G-MSGQAFFNGALVWVTGPDRLSESACQRARQLQQFGLQTMVCIPCPNGVVELASSEVVLPNPDLMIKVRDFINFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQDHIMAERKRREKLSQSFIALSALIPGLKKMDKASVLGEAIKYVKQLKERVKVLEEQNKKKKVESVvvLKKSqlcsDeDSSScDEsINSdSkSESLPEVEARVSGKE-VLIRIHCEKQKGILVKIMSEIQNLHLSVVNSSVLPFGTSTlDITIIAQMGEEYNLTVKelvKNLRQALLKFM--- --------------------------------------------------------------------------------------------------------G-LPGQALFAGQATWIAT--GLASAPCERARQAYTFGLRTMVCIPLGTGVLELGATEVIFQTNDSLGRIRSLFNLNGGGggsgswppiapppqeaetDpsvlwladapagdMkeSppSVEisvSKppppqppqihHfengStsTLtENpslsvhAQQPPpQQaaaAaqrqNQHqqqlqhqhQLQLQHQHNQGPFRRELNFsDFASnasvtvtppffkpesengvRrAHEVPNVSKMDKASLLGDAISYINELRGKMTVLESDKETLHSQieaLKKERDARPaaPSSGMhdNGARCHAVEIEAKILGLE-AMIRVQCHKRNHPAAKLMTALRELDLDVYHASVSVVKDIMIQQVAVKMATR--VYSQDQLNAALYGRLA-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRGRRpTHGREEPMNHVEAERLRREKLNQRFYALRALLPNVTKREKASILEDTVTYINELKLNAENAESEKNAIEIqlnELkeKIAGRRNGS-SSVcSGGektPEIEVKIDVKVMDRD-ALIRLESSKNNHPGARLMNAFMDLEVEVNHASISVMNDLMIQQVTVKMGSR--VYKQEQLRDLLLSKI--- -------------------------------LLQERLQILLQR--LNWSYVALWTLNPR-TRVLEWRRGHFNVNSTAgtTSSGPREvWNAQLFYSTYKSCSFAPGN-G-SVGRAYAEGRNIWLNGDSVHQnAGSMEQSQFLRHAKIQTVMCIPWSDSVLELGTTEHVAENFQLMDQIREFLSE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHSKNLVAERKRRKKLNDRLYALRSLVPKITKMDRASILGDAIEYVKELQKQVKELQEELEKNTEEedeAgVVPDGmiDrgtTPSSDedNdeeqsVflgatehSSSmRPGEPQVEVKQLTANEFFLKVLCEHKQGGFARLMEAMSALGLEVTNANVTTYRSLVLNVFRVEKRDNE-VVRAEQVRDSLLEL---- --------------------------------MMDRLRSIVG--PESWDYCVLWKPCKEQ-RVIEWIDCCCSGSNaaRHgIGnDDqqqqlvfqcKDvafhhPtTDTC--NLLSlLPSSMPFDS-G-LYGQTMISNQPRWLNFSNSSNSGYSE-------ENLGTKVLIPVPIGLVELFVSKQISEDQSIIDFVTTMFNMSLeqpmlnpNNnidssfsvnmdslddgeskDyiaqvlddqkdqnnhfqppISpatmlenlnlspnniSdnhmhpMnflqqfnygEsrntnnifmegtSEpmmnHdgpfdpnSeDNvgfdhEidmalqGqmmsEnmgkahlmeplENTPKKqgndmnrsdsvsdcsdqndedddpkcrrKNGK-GQSKNLMAERKRRKKLNDRLYTLRSLVPKITKLDRASILKDAIEYVMELKRQVEDLQNELEENSDDegttnnqStIVEQEvihgNGsnskrrynhGPglfvnGpqleaySgvgNIevSkqnqdvegASeKGQqmEPQVEVASLDGNEFFVKVFSEHKPGGFVRLMEAFNALGLEVTNVNVTSFRCLVLNVFKVERKDS-EMVQADHVRESLLEI---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQKINDLQNELESSPSTSSLPPTptsFHPLTPtlptlpSrVkeelcpsalPSPTGQQPRVEVRLREGRAVNIHMFCARRPGLLLSAMKAIEGLGLDVQQAVISCFNGFTLDVFKAEQcKDGP-GLQPEEIKAVLLQS---- ------------------------------------------------------------SNVLEWCGGFYNGQIktRKTIqlreleadqmslqrseqlrDlyeslssgnsnqqmrracaalSPEDlTDAEWYYLICMSFAFNIGQ-G-LPGKAFVDNQHIWLNGAQFADCKIFSRSLLAK-------------------------------------------------------------------------------------------------------VDKASVLGNTIDYLKDLEKRVLELESCQEPAehetaesRKHPDVaERSsdncrNKqivnGeKSlakkrkvCDVdrSNaehlwilTKDGPIEVNVAMKDKE-VLVEVHCPWRESLLFEIVESISNLHLDPLSVQSSTVDGMLSLAIKSKFRSTS-VASPGMIKQSLQRVMG-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKGPQSKNLMAERKRRKKLNDRLYNLRSLVPKISKLDRASILGDAIEYVKELQKQVKELQDELEEHSDDdgdnSnCInpnnlshnngtKNGpkhehGKssngfhvGTSsNGIVnknqqedesTtDkKTqqMEPQVEVAQIDGNEFFVKVFCEHKPGGFVKLMEALNSLGLEVTNANVTSHTGLVSNVFKVEKKDS-EMVQADDVRDSLLEL---- ---------------------------------------------------MYWQVSSLKsgGPALIWGDGYCRDPK--I----------------------GGA-G-VDGKSEGVEK---INEvRKQVLQKLHSRSFLAKSAGLQIVVFVPVKSGVVDLGSIKLIHEEQNIVEMVQIKFIGNSSNGCqsegnaklfpqllvGGLNaqarisgMEHPkdDSPslSDERKPRKrgtkpANGREEPLNHIEAERQRREKLNQRS--------LISKMDKASLLGDAITYINDLQMKIRVLETEKET------------------------------------------------------------------------------------------------------------ -------------------------------GVQQALCQIVEGS--NWSYAIFWQVSSLKsgGSILIWGDGHCRDPKGsgvgdqNSSsdgklqgvekkderkkwvlqklhacfggseeDNyaakLDRvSDMEMFYLTSMYFIFRCDK-SYGPSESYKSGRSIWASDTNSCFDHYQSRSFLARSAGLQTVVFVPVKSGVVEFGSIKSIPEEQNFIEMVKTVYGGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------DGVLEWCGGFYNGQIktRKMIqpieleadqmslqrseqlrelyeslpsgDsnqqmrracaalSPEDlTDAEWYYLICMSFAFNIGQ-G-LPGKAFADNQHIWLNGAQFANCKMFSRSLLAK-----TVVCIPIMDGVLELGTTDL-------------------------------------------------------------------------------VDKASVLGNTIDYLKDLERRVLELESCQE------------------------------------------------------------------------------------------------------------- ---------------------------------------------VQWSYAIFWSSSPTQSGVLEWGEGCYNGEMkkRKKRyeahykhvlqrsnqlrklylcmvegdsttaistthDdddddNhncnstsvmlsPDDlSDEEWYYLVSMSYVSPSQW-F-FARKSSGDGETIWLCNAQYADSKLFSRSLLAR-----TVVCFPYLGGVIELGVTELISEDPSLLQHIKSFLLEAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QEHVMAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYVKELQEKVKTLEEQNSKRSVEErksQISANdDDSSSGDenFSEGseGQSLPEIEARLSDKT-VLLKIHCENRKGVLVKVLSEIEKLHLSIMNTSVVPFTASsLDITITAQMEEGFSM-TVKELVKKLN------ --------------------------------LSKQLAVTVKSI--KWSYAIFWSFSTREqggkslrldetlFRVLEWGAGYYNGDIKtkKIVhsmelEtNktglqrsvqLrELymsLSEEWYYLVCMSFVFKPGQ-S-LPSTALEKGQPIWLCNAQYADSNVFSRSLLAKSASIQTVVCFPHMGGVIEFGITDLPKG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLRKQLAVAVRKI--QWSYAIFWS--------LQWS-GYYNGDIktRKMTqpmelkadkiglqrseqlrelynsllegEndpqsrrpsaalSPEDlFDTEWYYLVCMTFVFDPGQ-G-LPGRALANNETIWLCNAQYADSKIFSRSLLAK------------------------VPEDPNLHQHIKAFLLEFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------DLQNKLQELVESESpgTSWNYAIFWQLSRTKsgDLVLGWGDGWCGEPR-DGelgaaaSagsddskqrmrkrvlqrlhiafgvaDeeDyspgIDQvTDTEMFFLASMYFAFPRHA-G-GPGQAFAAGIPSGFPIRHEAERS----PGLAKIFGKDLNLGRPSVGLAVGLSNSKVDERTWEQrsavggtslLPSVQkglQNFSwSQArglnshqqkfgngvlivsNNegahrnngavDspsaaqFqlrkapqlqklSvvqktpqlvnqqPmqahvprqIDfsagssSKPgvlvtragvLDgesaeVDGlckeegpppvmEDrwprKRGRKpANGREEPLNHVEAEHQRREKLNQRFYALRAVRRFCSTMgmtnQAVNAAKEAVQRSEDEDIRIIRLYE---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTYDHIIAERKRREQLSQRFVALSAIVPGLKKMDKTSVLGDAIKYLKHLQERVKTLEEQAAKQTMESvvLVKKSqllveDEGSSDEnMGGsNEQPLPEIEAKVCNKN-VLLRIHCEKHKGVLVKILSEVEKLNLAVVNTSVAPFGSLALDiTIIAEMEKEF------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YKSKNLEAERRRRGKLNQKLFALRALVPNITKMSKESTLTDAIDYIKQLQKQVLDLQDELSDMPDEEGEKQGSASSTESFAPPEniQYQGQVELSPLGGNKFHLKIFCEKKRGGFTKLLEALSSLGLEVTNVNSVSFSGVSESVFCIEVKDEQ-DVVMDELRKLLSSIVE-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIIAERKRREKINQRFIELSTVIPGLKKMDKATILSDAVRYVKELQEKVKALEEDGNHRsgsvesavlVKKPCIAAPpDEGeGSPSaGApSTGSQLPEIEARLSEKN-VMVRIHCENGKGLLVRVLAEVEGLHLSITHTNVMPFPAcTVIITITAKVEEGF-NVTAEEIVGRLNSVLH-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKNHVMSERKRREKLNEMFLILKSLVPSIHKVDKASILAETIAYLKELQRRVQELESSRELTSRPSettrpitrqhgNkesVRKklcaGSKRKSPEFggdaekehDPwvlPKDGTSNVTVAVSDRD-VLLEVQCRWEELLMTRVFDAIKGLHLDVLSVQASAPDGFMGLKIRAQFAG--------------------- ------------------------------------------------------------AEFIEWMDCCCAGIE-MTNinggEElhfpvspvlpcRDviiqHPRTESCELLSqLPSSFPLDS-GINHAQTLISNHPSWINFSNSSHGDVM-------KETVWTRVLIPVVGGLVELLATKEVPEDPHVIDFITTQCSISMGqeaamvttsnmdANFSSpVNNvhengrsdsisDCSDqidDEDDAKYRR-RTGKGPQAKNLVAERKRRKKLNDRLYALRALVPKISKMDKASILGDAIDFIKDLLKEIKELQDELEENSDdegsaKNnntsmNVnhnivKpeifsQSGgfhlgATASgNSstlpkVqnqdleiTNDKTQQMevQVEVAPLDGNEFFVKVFCEYKPAGFVKLMEALNSLGLEVTNANITRFRGLVSNVFKVKKMDN-EIVQADHLRDSLLEL---- -------------------------------KFGYHLAAAVRS--INWTYGIFWSISASPrpghSSVLTWKDGFYNGEIktRKITgsttpeftpdervmhrskqlrqlyesllpgnsDqrarrcaaslSPEDlGDGEWYYTISMTYKFHLNQ-G-LPGKSFASNQYVWLCNAQNASTRTFPRALLAK-----TIVCIPFMGGVLELGTLDQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------TFQQHLHDLIDNSRQPWTYAIFWQSSSivDYsnksVMVLGWGDGYYRGEFRKPkttSssvtsfaeqehrkrvirelDsmisgseletDaIDEvTDTEWFFLISMTQSFFNGN-G-LPSQATLSNQPGWITGQKQVLASRCEHARQGQAFRLQKMVCIPFRRGVVELGSTELIFQSSGVMNQVRVLFDITN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEKRPKKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLEDAISYIRELQERVKIIEAVGVR-----TVE---------------SQEVVEIQAREEE-VVVRVISPLETHPASRIIQAMRNSEVSVMESKLSSAEETVFHTFVVKSSNGSDPLTREKLIAAISA----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTYDHIIAERKRREQLSQRFVALSTIVPGLKKMDKTSVLGDAIKYLKHLQERVKTLEEQATKQTMESVvlVKKSqllveDEGSSDESGSDEQPLPEIEARVCNNH-ILLRIHCEKHKGVLVKILSEVEKLNLAVVNTNVTPFGNLALDiTIIAEMEKEFSLTVKelvKNLRSALQH----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIKNHVMSERRRREKLNEMFLVLKSLVPTIHKMDKASILAETIAYLKELERRVNEMESRRET------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPLSHVEAERQRRDKMNQRFYALRSVVPNVSRMDKASLLADAVDYIKELRSRIDALESKLVKYErsspKRLKSDRAvaDVSetTsllSNnssTMaSTtlavPRLSEMAVEVKVLGSE-AVILVRSPNVGHPCARLMDVLEELGLAVRHASMSCVKGMMLQDVVIRTPVEC-LVSDHSMRDAIRNKLC-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGKKaTMGQEKLMNHVEAERQRRDKLNHGFYKLRSVVPNVSKMDRASLLSDAVAYIEELKAKIKILEANVGQRKHKPCVmDRHGNYQST--ST---WSGEVGVKILGSE-ALIRVQCADVNFPSARLMGVMRDLELQIHHASVSKVKEVMLQDVVVRVPHG--FTTEEALRTAILTRFQ-- --------------------------------LSKQLAVTVKSI--KWSYAIFWSFSTREqggkslrldetlFRVLEWGAGYYNGDIKtkKIVhsmelEtNktglqrsvqLrELymsLSEEWYYLVCMSFVFKPGQ-S-LPSTALEKGQPIWLCNAQYADSNVFSRSLLAKSASIQTVVCFPHMGGVIEFGITDLPKG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------IDYEWFYTVSVTRSFAVED-G-ILGRTFGSGAFIWLTGNHELQMFGCERVKEARMHGIQTLASSQNET------SEKQIEGDKkkDVTGQVRS-----------SSDSGRSDSDG--------N---FAAGITDRFKKRAKK--------------LQTMDKASLLADAVTYIKELKAKVDELESKLQAVTKKSKNTNvTDNQSTDSlidqIrdPSiYKTKAMELEVKIVGSE-AMIRFLSPDINYPAARLMDVLREIEFKVHHASMSSIKEMVLQDVVARVPDG--LTNEEVVRSTILQRMQN- -------------------------------QLRNHLAAAVRS--INWTYALFWSISSTQPGFLTWTDGFYNGEVktRKIVnsaeltadqlvmqrseqlrelyeallsgecDrraarpvaslSPEDlGDTELYYVVCMTYAFRPGQ-G-LPGRSFASNERVWMWNSHLADSKAFPRALLAKSTSIQTIVCIPLMSGVLELGTTDATT--LPVMGCRRILFEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTYDHIMAERKRREQLSQRFVALSALVPGLKKMDKTSVLGDAINYLKHLQERVKTLEEQVAKQTIESIvlVKRSqllvaDDGSSDEMGCpDEQPLPEIEAKVCNKN-VLLRIHCENHRGVLVKILSKVEKLNLSVVNTSVAPFGSLALdITIIAEMDKE-------------------- -------------------------------QQQQQLQTLMEGAHENWTYAILWESMYDYsgSLILGWANGYYKDKYkittataveqklRKEAlnnlDsmicgsnvytlgdDiflSQDvPDTEWFFILSMFYSFVKGG-G-LPSHAFFHSSPVWVAGADRLAGLPCDRARWGQSLGLQTMVCIPWANGVVELGSTELIFHglhELDLIKQVRDLFKFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------LAVEMFYLTSMYFTFRCDSSNCGLGELYAFGKSIWVSDMPSCLHHYQQRSFLARLAGFQTAVFVPVKYGVAELGSIKAVPEEQNIVDMVKTTFGESNSVqskvfpkifghelslggtksrsvNInfSpkvehdvgfisktfkvqaigtnhvygnSSngcqgdDNEeKgfpqlnqmavgafnpqnvvSSLEmsrdelssqPDERKPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAT-------------------------NISKMDKESELGDNIYY---------------ITPAPEFDFQDKQDD-SVVTISCPLDAHPISGVIKVFREKQIVAEETNVSMDNDKVFHTFS-------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIVSERNRRKKLNERLFALRSVVPNISKMDKASIIKDAIDYIQELQEQERRIQAEISELesgRlkKNPgyDFDQDlpvllrSkKkRTdqsYDSGGSrsSPIEVLELRVSYMGEKTLVVSLTCSKRTDTMVKLCEVFESLNLKIITANITSFSGRLLKTLFIEADEE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNQDHILAERKRREKLSQRFIALSKIVPGLKKMDKASVLGDAIKYVKQLQDQVKGLEDEARRRPVESavLVKKSqlsadDdDGSScDENfdGQeAAGTLPEIEARVSDRT-VLVKIHCENRKGVLIAALSEVERLGLTIMNTNVLPFTTSSLdITIMATAGEDF------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQEHVIAERKRREKLSQSFISLSALIPGLKKKDKASVLGDAIEYLKQLQERVAVLEEQVAKRTVESviFVKKTqfyaDdDETSSyDenFDTqSKNPFPEIEARVSDKD-VLIRIHCEKNKGCISNIINEVEKLHLSVLNSNALPFGQATlYITIVAQMEDEFSMTLKdlvKTLREGLLK----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKQHCSKNLFAERKRRKKLNDRLYALRALVPKITKMDRASILGDAIEYVMDLQKQVKDLQDELEETNQDgdghdKqigsNIHNSnsqmdvpipNgwmdhdDSGNNPrmVaaaddnkpSSDKGqqMEPQVEVRQLEANEFFLKVLCEHKQGGFARLMEAMSSLGLEVTNASVTTYGSLVLNVFRVERRDD-EVVQADQVRDSLLEV---- -------------------------------TMQHHLQTLIEGAHENWTYAILWEPLYDYsgSLILGWSNGYYRGNNNsngkaKTTtvvveqelrkkalgklysvicggsdmsngDDeivlEDDvPNIEWFFNSSMFYSsIVRGG-D-LPSHAFFNSSPIWVVGSDQLAGLPCGRARQGQSLGLQTMVCIPWANGVVELGSTDAIFHcedQMDLIKKVRVLFNSN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KERPTKSLIAERRRRKKLSDRMHKLRSIVPKISKMDKASILGDAADYLKELQQKINDLQSELESSSPGSFMPPPmTSTTStlpvpvkeelchSNVSSPKNQSTKVEVRVREGGTVDIHVSCTHKPGVLLSTMKALDSLGLDVHQAVINCFNGFSLDVFKAEQyKEGQ-KVLPEQIKAVLLNTLS-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNRRFISLSALLPNLKKMDKASVLEDATNYIKELQDRVKELEGLSSTKRKNmqesvisikrSRLSGSDDdySSSDETnseeSTsPSKSSPEIEVRMSGSS-VLVRIYCQKNSSSLVKVLSEMQKLGLSIISSSAMPFANtTLLITIVAQIEDDFCMTAT-------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNNVEAERQRRKKLNQRFYPLRAVVPNISKMDKASLLGDAITYITDLQMKIRVMETEKQMVNSS---------------QMQFPVPEIDFQERHED-AVVRMNCPLDSHPVSDVFRTLKNI----------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSYDHIMAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKQLEEKVKILEEQTAKKTVESvvfvnkrsRLSADDDSSSSYFDDqSNNSLPEIEAKVSDKN-VLIRIHCEKHKGSLVKILAEVEKYHLTVVNSNVMVFGDSALDiTIHAKLDMKFCMEIKdlvRNLRSEFLRFM--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERINKLQEEIEVGSNQLNLLSIfKDLKPNEMLVRNSPKFDVERR--NGD-TRIEICCAAKPGLLLSTVNTLEALGLEIQQCVISCFNDFAMQASCSEEMEQRTMISSEDIKQALFRN---- ---------------------------------------------------------------------------------PDDlSDEEWYYIVSMSYVFSPSQ-C-LPGRALAMGETIWLCNAQYAENKLFSRSLLARSASIQTVVCFPYLGGVIELGVTELISEDHSLLQHVKSCLVET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERIKNLQEEIEAGPNQLNLMSIfKELKPNEMLVRNSPKFDVERR--NGD-TRIEICCAAKPGLLLSTVSTLEALGLEIQQCVISCFSDFSMQASCSEEMEQRQVISSEDIKQALFRN---- ---------------------------------------------------------------------------------PEDlSDSEWYYLVCMSFVFYPNQ-S-LPGKALETGETVWLCNAQQADSKFFSRSLLAKSASIQTVVCFPYLGGVIEIGTTELVSEDPNLIQHVKACFLEIS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------ENLRPLVETK--KWDFCVVWKLGDDPSRFIEWMGCCCAGGYGehlnvKEergGEkhllafcrDayiqhPIRTKA-CKTLAQFPSSMPLYS-G-IHGEVVLSNQPRWLSHGYTSNSNN-------EHESMGTQVLIPVVGGLIELFSVKHIPKDQKIIEFMMAQYDISMEqeamtahnyTNIfpkypkpAPilaLkDHlqvlivhqGrcHrTnQLEnmpCakipiamrlilscsvPITRPEKdnfkvrkRTEREqYHSKNLVTERNRRNRIKDGLFTLRSLVPKISKMDRASILGDAVDYMEELQKRVKKLQDELKEMEEEdskeNnaKLdiKElkgVGKTysPATPrtqgFSSAdeqKEAEVQVEVNQIGTNDFLLKFCCEQKRGGFARLMEAMNSLGIQVVDANVTTFNGKVLNILKAKKSE----VQRKNLKDSLIK----- ------------------------------------------------NYGIYWQVSSLKsgGSILIWGDGHCRDPKlcgagvdvRSEgVekinevrkqvlqklhvgfggseEDsyvakLNGiSDMEMFFSPQGTLNFIVI-----HRMVLEnpTSQQINLDLRFKFLFKsLSIKIILARSAGLQTVAFVPVKSGVVELGSFKLIPEEQNIVETVSIVFRGFSSVqtktipkifghELSlggsksqSItvNfSPKTEDESgfmlesyDaQPlGPnhfmviplmdVKVKGTQ-SCSHIyLLEVGMHKQEFLRFYALRAVVPNISKMDKASLLGDSITYITDLQMKIRVLETEKETVNHPQ---------------KQLPMPDIDFQQRHED-AVVTMRYPLDAHPVSRVLKALKENQITAHESDVSTTdNDKIVHTFTIGASSGGAELLKEKLMEALSK----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQKINDLHNELESTPSTSSLPPSSTATTpTsfhpltptlptlpSrVkeelcpSSlpsPNSQSARVEVKLREGRAVNVHMFCARRPGLLLSAMRALDGLGLDIQQAVISCFNGFAMDIFRAEQcKDGP-GVLPEEIKAVLLQS---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIVSERNRRKKLNERLFALRAVVPNISKMDKASIIKDAIDYIQELHEQERRIQAEIMELesgklKKNPgfDFDQelpslrskkkrLDQIFDSSGSrSSPIEVLELRVTYMGEKTMVVSLTCSKRTDTMVKLCEVFESLKLKIITANITAVSGRLLKTVFIEADEE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETLDHIMAERKRRQELTQKFIALSATIPGLKKMDKASILREAINYVKQLQERVTELEED-NKRGKESViiINKSHvcIDDTNSDEcYGpNEMLPEVEARVLENE-VLIKIHCEKQKGILLKILSQLENLHLCVTSSSVLPFGNsTLDITIIAQMGDAYKMTVKdlvKNLRQVLMN----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RALNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAIAYITELQKKLKEMESEKEQMLDSN-MT--DPR-----EGGNHHQPQVDVQEIQDE-LIVRVSSPIETHPVGKVFRAFEEAQVNVADSKVAAANGKLVHTIVIKSA-GFEQQMKEKLISALSHVMS-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RETQINRVEAERLRREKLNHRFNELRSVVPNVSKMDRASVLTDAVAYIKQLKAQREELEAQVRVESQTA-AKACVGSSSIAGGHhAVPSLGEVEVMIVGSE-AMIRVQCVDVNYPCARLMEALRELEIEVYHASMTKVKEIMLQDVVVRPPRG--LTsDPEALTTAIQRRFQ-- ------------------------------------------------------------SNVLEWCGGFYNGQIktRKTIqlreleadqmslqrseqlrDlyeslssgnsnqqmrracaalSPEDlTDAEWYYLICMSFAFNIGQ-G-LPGKAFVDNQHIWLNGAQFADCKIFSRSLLAK-------------------------------------------------------------------------------------------------------VDKASVLGNTIDYLKDLEKRVLELESCQEPAehetaesRKHPDVaERSsdncrNKQivngeKSlAkkrkvcDVdrSNaehlwilTKDGPIEVNVAMKDKE-VLVEVHCPWRESLLFEIVESISNLHLDPLSVQSSTVDGMLSLAIKSK------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAISYITELQKKLKEMESEKDVQ---------------------QNSPDVDVQMGNNE-VIVHVSTPLETHPVSTVINVFKETQVDVVDSKFSASNNTVFHTFVVKTQSGS------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQWFYALRAVVPNISKMDKASLLGDAIAYINELQAKLKTMEARW-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAERQRREKLNQRFYALRSVVPNISKMDKASLLGDAISYIKELQDKVKIMEAADQGLKTESDLA---ES--N--TRTVEKSPEVDVRATKEE-VVVRVVSPLDSHPASRIIQAMRNAEVSVMESKLSSTQDTVFHTFVIKSN----SLTKEKLMAA-------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLEKINHLQEEDEVDSNMMsIFKDLK---PNEILVRNSPKFDVERR--NAD-TRVEICCAAKPGLLLSTVSTLEALGLDIQQCVISCFNDFAMQASCSEEMEQRTLISSEDIKQALFRN---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQRFYALRAVVPNISKMDKASLLGDAISYINELQAKLKMMESEREQ------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFFSLRAVVPNVSKMDKASLLGDAISYINELKSKLQNTESDKEDLKSQIedlKKESrrPGPPPpPNQdlkMSShtgGKIVDVDIDVKIIGWD-AMIRIQCNKKNHPAK-------------------------------------------------------- -------------------------------QQQQQLQTLMEGAHENWTYAILWESMYDYsgSLILGWANGYYKDKYKiTTataVeqklrnealnnlDsmicgsnvytlgdDiflSQDvPDTEWFFILSMFYSFVKGG-G-LPSHAFFHSSPVWVAGADRLAGLPCDRARWGQSLGLQTMVCIPWANGVVELGSTELIFHglhELDLIKQVRDLFKFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIIAERKRREKINQRFIELSTVIPGLKKMDKATILSDATRYVKELQEKLKALEAAGSNGrsietvvlVKRPCLHAaAapDEdGSPSSASSgtpaARKPLPEIEARFSEKS-VMVRIHCEDGKGVAVKVLAEVEELHLSIIHANVMPFSAcTLIITITAKVEEGF-TVTAEEIVGRLNS----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQERKRREKVNERFIMLRSLVPFVTKMDKASILGDTIEYVKQLRKKIQDLEARNRQMEDDqrSRSsgDSqrSSsskKSRsgltvvkrsrSaPPVAdkrkmrrvEESGGQTDVEVSIIESD-ALLELRCPYREGLLLDIMQMLRELRIETTTVQSSLNNGVFVAELRAKVKENvnGKKISISEVKRAIHQIIP-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPKISKMDKASLLSDAIAYIQELEARLRGDA----------PVP------------ARAEGPAVEVKAMQDE-VVLRVTTPLDEHPISRVFHAMRESQLSVVASDVAVSDDAVTHTLMVRSAG-PEQLTAETVLAAMSR----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTVSHVEAERQRRDKLNRRFCDLRAAVPTVSRMDKASLLADAAAYIAELRGRVEQLEAEARQAAAAR--EASAAAA-A-SGGSAGlGEEKLEVRMVGRDAAALRLTTA-ARHAPARLMGALRSLDLPVQHACVCRVGGVTVQDVVVDVPAA--LRDEDGLRAALLHRLQD- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAVSYINELQSRVQEIEAEKKE------------------------------------------------------------------------------------------------------------ ------------------------------------MEALIKGARESWTYAIFWQSSYDMpgASMLGWGEGFYKDERdKvktkpKTttSlveqeyrkkvlrDlnslisgadtsadNavIDHevTDAEWFFLVSMTQNFVNGS-G-LPSQAFFHSNPVWVAMQDRLAASSCERARQGQVFGLQTMVCVPTTNDVVELGSGG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------AKHFLRALLAMVYFFQTVVCIPFMGGVLELGTSDPVSEDPNMVHWISTSFWELHlpsfpacleseepSsNpsladeteeaDimfddldhnvIegmiSelrevecesdvnletitketdefhSlleeLDldarednwimdgsfefvsSpqmvpamaapctEdvnvtLSSSvAgtrpsCfiawrrsneakkvvapmtatieSQKLLKKivAggawtnNGdggsvaraPEsNIKSHVISERRRRERLNEMFLVLKSLVPSIHKVDKASILAETIAYLKELEQRVKELESSRA------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNQEHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYVKQLEQKVKTLEEQAAKRTVESAvlVKKSklsadDDGSSSGGSSAdyGKSLPEIEAMISEKT-VLIKIHCENRKGVLVRALSEIEKLHLTITNTSVLPFPSSSlDITITAKASE--------------------- -------------------------------SVQQGLCKIVEGS--DWTYAIFWQVSGSKsgRSALIWGDGHCREPKgsevedRNCSgdqkleegdlkkrvllklhacfgrsEeDnyaanLDLvSDVDMFYLTSMYHSFPFDK-PSSPAQSFNSGRSIWVSDTKSCLEHYQSRSYLAKSAQFRTLVFVPVKSGVVEIGSVKSVPEEQGVIQMVKTIFGGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------TDTEWFFLISMTQSFSSGE-D-LPGQAYLGSNPIWAAGSDRLKSSPCNRARQGACFALQTMVCIPVLNGVVEVGSTEMIFQSPNLMNKVRVLFSGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQTQDHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYLKQLQERVKTLEEETKKKTMESvvIVKKSqllfceDESSsSDETfSKGpvDEPLPEIEARICDKQ-VLIRIHCEKRKGVLEKTVAEIEKLHLTVVNSSVLTFGSSALdVTIIAQMDMEFGM-SVKDLVKNLHS----- -------------------------------QLQAALQKLIEEVRHSWTYAIMWGSSYDHsgMPILRWADGYYKGNDdyhvetndRTEkplSvvlEeqeilasatDEEDvTNTEWFFLKSKTQCFLNGS-G-LPGQAFVTSRLVWVAGLDHLATSTCNRARMGQASGLQTMVWLPSANGIVELGSTMLIFQSTDMINKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------YLIHRLRSLVGL--KGWDCCVLWKLSEDQR-FIELIDCCCAGTEISQSDagqNlpfppvlacrdtiLQHpRTTSCDLLAQIPSSMPLDS-G-IYAETLISNQTSWLNF--------CNNTFLSTlGETIGTRVVIPIPGGIIELLVTKQVFEDQHVIDFVAAQYNISLEeealTnitgtrkmsevgskrfldhlsfkttsenlnlhpyDVsmertsnspmnfsqqftnynsrnltknnidiSSaenefqemeamqrsITSErqqHMDMqqymealvpnidqqEGNEKRDsntheaegqagdfmsdcsdqidededtKYqrRTGKRPQAKNLIAERRRRKKLNDRLYALRSLVPIISKLDRASILGDAIEYVKQLQKQAKQLQDELDDHAEddaatnnvKSEiqsrsgVnhirPKTddhqDdhKASdgshfgtPGdcSVSkqsrdysYtvhdhkTEQMEPQVEVAQLDGNQFFVKVFCEQKPGGFVRLMEALSSLSLEVTNANVTTFRCLVSNVFLVEKKDT-DMVEADDVRDSLLEL---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPPNHVVAERLRREKLKQRFCALRAMVPNVSNMDKASLLGDAVSYINHLRGKLTALKSYQDALHAEmeaLKKER-DALPAPHDAGPRCHAVEIDAKIVGME-ATIRVQSHKRNHPSARLMEALRELDLDVYHASVSVVKDLMIQQVSVKMASR--AYSQEQLNAALYSRLA-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AHDREEPLNHVQAERQRREKLNQRFYALRSVVPNVSKMDKASLLGDAIAYIQELQQKLQIMELKCQSVPSsgRPSTSnhRGsrshlDYSaQTGNTrSlHSyiyiLDQKPNVDVELLGME-VMVRVNHLSEAYPTSQLMFALQDLQLEVQHANISTVEDRIFHLVIAKPA---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIKNHVMSERRRREKLNEMFLILKSLVPSINKVDKASILAETIAYLKELERRVQELESSRKPSRPakrKPCSEEiIGGGGGggaGRvkghhhwVlSEeQEGTPSDVRViVVDKKE-LHLEVQCRWKELMMTRVFDAIKSLRLDVLSVQASAPDGLLGLKIRAKYA---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELSASHVLAERRRREKLNERFVILRSLVPFVTKMDKASILGDTIEYVKQLRKKVQELEGRTKSGeeRDKRKlqvIEESssGNEMRVKKTAaQLQQSNMLEVSIIESD-VLVELQCPYKEGLLLDVMIKLRDMRLEVTTVLSSLNNGLLATELRAKVKENvnGKKPSIIEVKRAVNQKIP-- --------------------------------FQQQVEAEIEQAQERWTYAIYWELSRPSsssLGTFSPAKGFYNVEDQKF---NNKnMNTSFFFLMSSWQCFIFGS-V-L-GQVFSTSSPIWVVGKDCLASSKYYRAREGQQYGLQTMVWIRVADGVMEFGSTELIHPSTDLINKLRMMN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------DLQNKLQNLVEAdgQSLRWNYAIFWQLSRTKsgAVVLGWGDGSCREPHdGEigfaTSfgagdassvtrqkirkrvlqrlhsafagaDeeDyapgIDQvTDTEIFFLASMHFSFPHHV-G-GPGKVFAAGRPLWIPNNDLkvTPANYCYRGFLANAAGFKTIVLLPFKAGVLEVGSIQNVPESAEALQTIRSMFLGT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRPRKrgrkpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAVSYINELQSRVQEIEAEKKE------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSGTNHVLSERRRREKENERFMVLKSMVPSISKVDKVSILDDTIEYLKELERRVEELESCMETTearsRRKFqdTVEKTsDNcgnTkmnngkkpivnkrKACDIdetepeINrdvSkDSSADNVKVSMNEKE-VLIEMKCPWREGLLLEIMDAISNLHLDAHSVQSSTLDGILSLTIKSKFRGS-AIASVGMIKQALQRVA--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQAMDHIIAERKRREKLSQRFIALSAVIPGLKKMDKASVLGDAIKYVKQMQEKVKKLEEEAKKKSVESAvfVKRSyvsaeENTTddqlSakSAVtdaAGscCEGSLPEIEVRFSDKD-VLITVHCEQKKGMFEKLISQFEKLNLAVISSSSLAFGGSALaVTITAQMESDY-SLTAKDLVRHLHSTL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQCKNLEAERKRRKKLNDRLYKLRSLVPNITKMDRASILGDAIDYIVGLQNQVKALQDELEDPADgaKaPDvlLDHpppaSlvgleNdDSPRTSlqqppavTagsrraSAaaeedkGHDMEPQVEVRQVEANEFFVQVLWEHKPGRFVRLMDAMNALGLEVTNVNVTSYKTLVLNVFRVMRRDNEVAVQADRVRDSLLEVT--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIIAERKRREKINQRFIELSTVIPGLKKMDKATILSDAVRYVRELQEKLKALEDGGSGNdrsieswvlVKKPcSVVAGDDAGSaSWDsgGAspGTNQLPEIEARFSNKN-VMVRIHCENGKGLLVRVLAEVEELHLSITHTNVMPFPAcTAIITIMAKVEFGF-SATIPDIVRSIHCVLHQ- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKFSQLFISLSKIVPGLKKLDKASILEDAIKYIKELQERVKTLEEAIKKNKNLIsstsMVQKQ-ISCSSNVSSfkSqvLESIPEIKVRILDKN-VLINIHCNKQmRGIFSIIAGEMEKLHLTIHDIRIMPFGHTLLdISILAEMDNGF-DITVQDIVKAFQLNI--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRPaKKKKGKNLAMNHVEAERLRRENLNKRFYALRSVVPNVSKMDKASLLADAVCYINELKQKVDELEAGGPKLK-KVKVEMGAKNT--------YNKNKVDVKMVGED-AMIRVQSANTDMPTSKLMSALRKMEAVVHHASMSCVXCV--QYVVAKIPAG---ATEDQIEACVLSRLN-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SALKNIEMERNRRRKLNERLYALRSVVPNITKMDKASIIKDAIDYIQELQEQERRLLEELSHLQATaDKKESAagiigaDDfglsrgrkRMKSTApSSAPVEIVQLGVSEVGEKIMVVSITCQKRKDTVAKLCEVLESLNLKIITANITSVSGSLLHTLFVESEE--------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHTELESTPPSSSgLhPLTptPQTlsyrvkeelcPSSSLPSPKGQQARVEVRLREGKAVNIHMFCGRRPGLLLSTMRALDNLGLDVQQAVISCFNGFALDVFRAEQcQEGHE-MLPEQIKAVLLDT---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKRPQCKNLMAERKRRKKLNERLYHLRSLVPNISKMDRASILGDAIKYVQELQNQEKDLQYQLSRNSDDeehcndLNidyhqhhqmnqspqIQNAqNirfgmefdHEktrNSfqmgpgNpEslkrshdIESNndKAqqMEPQVEVAQVEGNDFFVKVFCEQKRGGFVRLMEAMNCLGLEIINVNMTSCISLVSYVFIVKMRDS-ENVQAEYVRDSLLEAMRN- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKITKMDRASILGDAIDYLKDLLQQIDDLHRELKSPTSmdSPPIpciPKAgmpSQSPSTlAcrVkeefPSAmpdqDPPTPKVEVNMKEGRALNIHMFCSRQPGLLLSTMRALDGLGLEVQQAVVSCFNGFALDIFRAEQLSEL-NFGPEEIRSALLQALGA- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APPDHIIAERKRREKINQRFIELSAVIPNLKKMDKATILGDAVKYVRELQDKVKTMEDDDSAAATttttiRSAvlVSKPCKAVADddDESPaTGGGLPEIEVRVSQEKNVLVRIHCKNAKGLLVRVLAEVEELRLAITHTSVMPFPaDTAIITITAKASYQ-------------------- ---------------------------------LEWLRPVVETM--AWDYCIVWQFGDDPSRYVEWTGCCCNGSSsvcRNVKeeiDGskhhLSSlcRDTyikhsantkTCVKLANIPFHLPLYS-G-IHGEVAMSAQPSWSHDT------------------LGTQVLIPVNGGMIELYISKQVTRDQEMIEVLTARFNIFSRhfeqlktggsPNCsnpwsenSSLvsaGSTqVSptqsiDMpinlLGyaISDQPKEhtKNrqntSKdHYQSKNLLTERNRRNRIKDGLFALRALVPKISKMDRASIVGDAIDYIKELQANVQELKKELERLEEDdsqSHVdeiEvcKPRKPheLSpikgHNlVSTtpDRKTQVQVEVHQIGAKNFLLKLVYGKQRGAFLRIIKTVNSLGLQVLDVNVTTCYGKVLNILKVEAKEK--DFAAKSLKDSLLD----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLDKIHKLREEDEEDeIKDIKFMGNFKElKPNEALVRNPPKFDVERR--NED-TRIEICCAAKPGLLLSTVSTLEALGLDVQQCVISCFNDFSLQASCSEAVEHRTILSSEDVKQALFKN---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEICGNHVLSKRKRREKLNQRFMILKSLVPSNNKviklpfpvvvtqeffcvfgglwfdihvteyvehkclssvallnslaffmhADKVSILDDTIKYLQDLERRVEELITCIE------------------------------------------------------------------------------------------------------------- ------------------------------TSLQQTLQAVVQSV--QWTYSLFWQPCPR-QGILVWGDGYYNGSIktRKTVqpvevsteeaslqrsqqlrelyeslslgEanvparrpcaalSPEDlTEAEWFYLMCISFSFPPGV-GYhaiihhplyqqywisssprcmLPGKAFARQRHVWLTRANEVDSKVFSRAILAKVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIMAERKRREKINRRFIELSTVIPGLKKMDKATILSDAVRYVKEQQEKLRALEDRNRRSAavdsvvlvKKPPaaVpEDDDVGGCcpsPSagaVaGsttatTTGSALPEIEARISESD-VMVRIHCEDAKGVLVRLLAEVEGLHLSITHANAIPFPAcTLIITVTAKVEEGFQ-VTAEEIVS--------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANKNIVMERDRRRRLNEKLYALRSVVPNITKMDKASIIRDAIAYIEQLQEEerrmlaeISALESAAAAVKAaaggedaeddgvgfprRKKMRRAPSASSDAItSPAtpPVEILELRVSEVGEKVAVVSVRCSKGRDAMAKVCRALESLRLRVITASITAVAGCLVHTMFVEVE---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSKNLMSERKRRKKLNERLYSLRAIVPNISKMDKASIVSDAIDYIRELQKQVCDIECDIVNLKSqKENIAAGDSrlldmKlHMRPSANlkkkvkQEHWIVELEVSQMEEHIYHLRIHCKKSPGVLIQLSRALESLELEIVNANLTAVDDHILNTVVVEVKNGWCMKTEE-LRNMAL------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRISDLHSELESAPSSAALGgpSTANSflpSTPTlqpfpgrIkeercppapfPSPSGQQATVEVRMREGQAVNIHMFCARRPGILLSTMRALDSLGLDIEQAVISCFDGFAMDVFRAEV----------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETPPNHVEAEKQRRQKLNSLFYVLRGIVPNVSKMDRASLLADAVAYIKELQENVGELEAKLICaKSQETKISfpnKhDNQSTSitrvdhchsrsTSLSgNGnGIMPAEVDVKVKGSE-AVIRVQCMDVNYPVARLMDAIRVLECHVRHASISKVKELVFQQVVVdQVPDG--LRSEAALKIAIGRRF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSRNLVSERRRRKKLNEKLYSLRALVPKISKMDKASIVSDAIDYVRELQKQVESIQADIHALQCckdGSqqQLSCImiDGRgSAKRSkkNSlMEHQILELEVADMEEQTFQLRIHCKNGPGALVQLTKALEALDFEIVNANLTVVNDHILNNVVVKASIGK-VMTCDELKKLILEIIP-- -------------------------------HFQAGLKKLIEEARQSWTYAIMWGLSYDHsgSSMLRWADGYYKGEN-ELNsvitrsnVDDKDvSNTEWFFLKSKMQCFLNGS-G-HPGQAFVTSRLVWVAGLERLGSSSCNRARMGQVSGLQTMVWIPSANGIVELGSTELIFQSTDLINKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIVSERNRRKKLNERLYALRSVVPNITKMDKASIIKDAIDYIQELQEQERRIQAEISELEsgksEKNpgsDFDQDlpsllrsKKrrteQAYDSSGsrsSSPIEVLEVRVTHMGEKTVVVSVTCSKRQDTMVKVCEVFESLCLKIITANITSFSGRLLKTMFIETNGE-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQHSCKNLVAERKRREKLKDRLYILRALVPKISKMDRASILGDAIEFVKDLQNQVKRLQEQLEETNPEEdGGEQGGAGaLCNGDNSDENGLPQVEVSQVGSNRFFLKVFCEHRRGGFVRLMEAMTSLGLDIVNVNVTTSEPLVLNVFEVEVI---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFKSKNLEAERRRREKLSDRLLALRSLVPIITNMNKATIIEDAITYIEELQKNVKNLSDQLLEMEASSeeEAKPkKEEIDAAEEMKKWGIEEEVQVTQIDGNKLWIKIIFEKKRGGFTKLMEAMNYLGFELIDTSVTTSKGAMLITSCVEGIYGE-TLDVEQTKELLLEII--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKVDRASILGDA-EYLKELLQKINDLQNELESTPSCSSLSPlSnfyplTPTTpalpcrikeelCPSAfasplSSPTGQPARVEVRLREGRAVNIHMFCGRRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDIFRAEQcKEGQ-DIPPEHIKAVLLDS---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRPaKKKKGKNLAMNHVEAERLRRENLNKRFYALRSVVPNVSKMDKASLLADAVCYINELKQKVDELEAGGPKLK-KVKVEMGAKNT--------YNKNKVDVKMVGED-AMIRVQSANTDMPTSKLMSALRKMEAVVHHASMSCVV---------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLEKIKNLQEEMDQGGPnQSNLMGIfKELKPNEMLVRNSPKFDVERR--NND-TRIEICCAGKPGLLLSTVSTLEALGLEIQQCVISCFNDFSMQASCSEEMEQRTLISSEDIKQALFRN---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESMPSSSSVPGSNTTTptpsfhplTpTpqTlpsrVkeelcpSSlpsPTSQPARVEVRVREGRAVNIHMFCSRRPGLLLSTMRALDNLGLDVQQAVISCFNGFAMDVFRAEQcRDGP-GVLPEEIKAVLMH----- --------------------------------------------------------------------------------------SSFFRAYSLTRSFVVRD-GFVPNKAFSSRTSIWLSRAHELQFNNCERAKEAQIHWIETLICIPTFDGVLEMGSSGLIRENWGLIQQAKSLFRSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKERRDKLNQRFYALRSVVPYVSKMDKASLLADAVTYIGELKSKIETLTKKAESLH---LIADDGASMTQSHLSTDcmVTESQVEVRIVGSQ-AVIRVQSSEVNHPAARLMDAMKNLEIKVHHASAANIGNLMIQDVVAQIPEG--FPNDEGLLQTI------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLSERRRREKLNQKFIALSSIIPGLKKMDKASVLGDAIEYIKQLKEREKILEEQVAMKRKESAVlKRrTtlfaDNDNSPSDEVSGQPLAEIEARVLGKN-VFIRIQCEKHEGCEAKILRELENLHLTVQSSSILPFGDAtLCITIIAQMDDEHSM----------------- ----------------------------------------------------------------------------------------------------------IHTEVVISTEPSWISQIDAMDSNA------SNMDSVGTRVFIPIMGGLIELYAIKHIPKDQKTLELIMgqsNLFWEQEAmierncThksldeqmlspahdgdgylhgDylcfmskhqFGSvrpendsfhegsstgsIPSeEpqsfgsrsalgsrqmvalmeQSDRittqDSltessvyreigynncfliEQdmeivsghlmggKDKLKacrRLGGEqYQSKNLITERNRRNKIKSKLFALRALVPKITKMDRMSILGDAIEYIQELQNNVKNLQDELMCSQekdeSKSNiqlnIPNrrGGatekirrqvHGTScSSsTreNhdfstvNDmGRQPMEVEVHQIDPNEFFVRLCCEHRRGWFRRLMETMNSLGLQVTDVNVTTFKGMVLcNLKSTEVNHG--ELQAQHVKELLLKKIC-- -------------------------------TLQSRLQSLIDQSTDHWTYAIFWQSTLPPSSHLLWGDGYYKCSQDETqaqiatTpaeqshrkrvlrElnalvsgssssDEDDvTDTEWFYLVSMTQSYDPHI--------LIAGEPLWYAGSDQLVKVQCERVREAHVLGIRTVAFIPVIgAGVVELG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDHIIAERKRREKLSQRFVALSAILPGLKKVDKASILEQAIRHVKELKEKVQLLEEEKKTRSQESvmfvnksQLEM-DDSSSEENNSCSDLDADIEVRFSDKN-VLIRITCARRNAFVLNIHNEIEKLHLTIVQSCMMPFGKQaIDITLVAQMEESFCMTLKD------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AHDHIIAERMRREKISQHFIALSALIPGLKKMDKASVLGDAIKHVKQLQEQVKVLEEESKRKSAESvvYVEKSevvsvSDTwsnSGGDGnssyevSKavSRSVLPEVEARVSEKN-VLIRIHCEKQKGVLVHIIKEIEKLHLSVLNTTSLPFGTSILdITIIAEMDDEFSLSAKelaRNLRVGLLQS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIKNHVMSERRRREKLNEMFLILKSVVPSIHKVDKASILAETIAYLKELEKRVEELESSSQPSpcpletRRRKCREITgKKVSAGakrkasaPeVaSDdcTDgehhCVPSNVNVTIMDKE-VLLEVQCQWKELLMTRVFDAIKGVSLDVLSVQASTSDGLLGLKIQAKFASSAavepGMIT-EALRKAIAS----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPPGSLLPPStsfHplTPTPPTlpcrVkeelcpSslpSPKNQPAKVEVRVREGRAVNIHMFCARRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEQCmENQ-DFLPEQIKAVLL------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KARDHIIAERKRREKLNQRFIALSAIVPGLKKMDKASVLGETISYLKQLQVQVKTLEEQTAKQTVESVvfIQKSqlladDDTSSSNgNFDgySKMPLPEIEARVSDKT-VLIRIYCEKRKGVLVKALTEIEKLDLTVVNSSVIPFGSSAIdITIMAQMDVKFCMTVKdlvRNLGSAYGQFMRK- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHVMAERKRREKLSQRFIALSAVIPGLKKMDKASVLGDAIKYVKNLQERVKTLEDRSAMKSMESvvFVKKSkvyvDeESSSStdEINSEeiYDQLPEIEARISDKD-VLIKIHCEKQKGCLMKILYALEKFHLDVINSSVIPFGNSTIdVTIIAQMDGEFSM----------------- ---------------------------------------------KNWTYSAFWKPAFvNQKKILVWGDGYYNGVIKtyKTIhgmeltpkefglqrsqqlrdlcltlDsrtrDqhaskpfalkVDDlADPEWFFLLSMIYDFAENE-G-MVGKTAARGQYTWLRQAHEQETAVFTRSLPAKSSNIQTVVCIPLKNGVLEFGTSEDVPDDSKLVQSILAFFMEP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTQDHIMAERKRREKLNQLFIALSAIIPDLKKMDKASVLGDAITYLKELQERVKKLEEQTANKTKKSVvlVSKSkffdeDNASSDESfTDfADKGLPEIEARVSDKN-VLIRIHCEKHSGIFLEIYKTIEKLNLTIVNSSAMPFGDLALDiTIVAQMDVEFC-LTVNELVKNLQS----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKNLISERKRRKKLNERLYGLRALVPNISKMDKASIVSDAINHVRDLQMQVKKVQEDILALRsqKEGSVTTlgPcaAERDQDNKmqkkqkqNTMLHQLLQIEVSQMEANIYHLRIHCNKSPGVLVQLTRALEALDSKILNANLSSVDDHILNTVVIE------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THGREEPMNHVEVERLRREKLNQRFYALRAVVPNITGMDKASLLEDTVRYINELKLNAENAESK--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIASERNRRKKLNQRLYALRSVVPNITKMDKASIIKDAIEYIKSLQEEERRLLAEITELEsgmsSPSnsTVLDFDyaeaATycskpkrarmeHcHDSAgsrlvSSSPIEVLELRVSDMGEKTIVVSLECRRRRDTMVKLCEAFESLKLKIITANITAFSGRLLKTIFLEG----------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQPQDHIIAERKRREKLSQRFIALSALVPGLKKMDKVSVLGDAIKYLKQLQDQVKNLEEQTRKKSMESvvfvkKYELCaDgESSSSEenFSGSpiDEPLPEIEARFSDKE-VLIRVHCERKKGILDKIVAEIEKLHLTVVNSSAMSFGDSAIdITIIAQMDEK--FTTPlkdfmKNLRSALL------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYQDHILAERKRREILSQRFIALSALLPNLKKMDKASVLGDAIEYMKTLQEKVRTLEEQTPKRSNrKsVSFEMVNDgGeISSSdekISCLSEQLPEIEARFSGKD-VLIRVHCEKKPGVVEKTLAEIEKLHLSVINSNAIIFANSALHiTVIAQMDKD-------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPYPSKNLITERNRRNRIKDRLFTLRALVPKITKMDNASILGDAIDYIEELQGTVKRLQDELKELEEKqdnkSSlhlqIPNStglrvqdNDhqShGSSSVKVmGrphQFSTVEVEVKKIGAKEFNVRVCCEQRKGGFGRLMEAMNGLGFLITDVNVVTLRGKVSSVLNAEAKSE--EIQAHQVREMLLK----- --------------------------------VAESLRPLVESK--QWDYCVVWKLGDDPSRFIEMMGCCCGGGYeYDCvNvkeeegephsaklcrDGflkhPIRtKACEA--LAQLPSSMPLYS-G-IHTEVIISAQPRWLSGHVNASGSNP-----SQSHDfVGTRVLIPVLSDLIELFSTKNIPENQKMLELFMAPFNNSLKqepmatHDyanvnlnasaslneFhvdplpeecpekllpslnlanfiprpqvfpSSvsqttscpilegssSGsnpsSEHpllssrsrkskrGDNllqqQAglasgsgsvvEKhkaKVTRK-TGsGQYQSKNLFAERNRRSRIKDGHFALRALVPKISKMDIPAIIGDAVEYIEELKKKVKELEDELREIEEeedltknKADVKilASDmrkEGSicliSTEhkqGSSSfvqkSPTAVQVEVNQIGKRDCLIKLFYEQSRGGFASLMENMDSLGLQVVDANVTTFDGNVLNILKVQA----------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAVDYLKELLQRINNLHNELESTPPGSLLQPSaSAsfhpltPTPPTlpcrVkedlypgdlLSPKNQSPKVEVRVREGRAVNIHMFCTRRPGLLLSTMRALDNLGLDVQQAVISCFNGFALDVFRAEQqcREGQ-DVPPEQIKAVLLDS---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGREeQPLSHVEAERQRREKLNKRFCALRAIVPNITKMDKASILEDAVTHITDLKKKLEKMEAEREKLLELGKVD---S-------NEQTTMPEVDIQVVHGE-ILVRVVSQIDNHPIKKVLQAFEEAEVRIGESKVTTNDGTVVHSFVIKSPSSE-QHTRNKLLASI------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEAQDHIKAERNRREKLNQRFIALSAVIPGLTKMDKATVLEDATKYVKQLQEQIKTLEKQTKSGTMiESavVVKKTllviNDdnkPGfSNETSfiErtlPDESLPEIEVRFCDKK-VLIRVHCDRKKGVAEKILSEIAKLHMTVLNSSVLAFGSSAIDvTVIAKVNFECSMA---------------- ---------------------------------VEWLRPLVKTK--AWDYSIIWKLGDDPSRFIKWGACCCSGANgghfKmKeeTGlEkhliieckDtrnkhPVRTKA-CRALAQFPSSIGLYS-G-IHGEVVISKQPKWLTLANASISNS-------LSEPVGTQVLIPVAGGLIELFSKSLVPKNQEIIDFIFSRFTSSAEQEimseksyinfnhqidwppslhylnlnpeIsqlnidSSfegssiistLSNEHQsfnihDDHvfGkmlpEKssgkyseipssnlNLKRKqnadentnlkdlqRGGKEhYQSKNLITERNRRKRIKDGLFALRSLVPLISKMDRASILGDAIRYIKELQETIEKYQDELREM----------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKDHVLAERKRREKLSQRFIALSALLPGLKKMDKASILGDAIKYIKQLQERVESLEEMGKNSNIESaiLIKKShlcNNmNDCcDDIdgeehNhkTgfSDQKLVEIEAKISDKH-VLVRIHCEKHEGLLAKLLEEMEKLNFKIINANVFPFGSST------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKITKMDRASILGDAIEYLKELLQRINELHSELEGPADGGsmGIPpqqQSgallSpQSfapcvkeecPASSISplpllpGppTDLQPAKVEVRTRDGKGINIHMFCARTPGLLLSTMRALDDLGLDVQQAVISCFNGFVLDVFRAEQQCSDAEIAPEEIKAVLLQT---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQDHVIAERKRREKLSQRFISLSALIPGLKKMDKASVLGDAIKYLKQLQEKVKTLEEQTAKKAVESviFVKKTqiyavDETSSSEeNfdSQSNKPFPEIEARVSDKD-VLIRIHCEKNKGFVSNILNEVEKLHLSVLNTNVLSFGQATLdITIVAQMETEF------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALPNNIIMERERRKKLNRKLYNLRSVVPNITKMSKASIIFDAINYIQQLQDQERSLLDEISEQeshEKRVaPVDGQlcraqakkwrtAPRSSCSWSFslpmPSVEAMEVSVREMGNGTSVINITCSKKRHAMVRVCEVVESLDLRIIAANITSRSGIVFHTLMVEDDGGQSAQLKEKIEAAFEHLG--- ---------------------------------VEWLRPFVDSK--GWDFCVVWKLGDDPSSacfnvkvekdesqKPFCRDGHFQHSIRSK-------ACEA--LSHFPFAISLYA-G-IHGEVAMSNQPSWVNHGNPSGSQS------SNVEMTGTRVLIPVFSGLIELFTSEHMPKDQNLIELVTSQCNAVLKqeittgenyakAnldkwyNlpFsislStfvprielippisdsnshhSLDGshsgsspsiEHppfaSDSAyisqDEQfkqligtyygtKRLrcsknvpeqqarfapdgNKsikdkmrtTKqpAKEkFHSKNLVMERNRRKKINDQLFKLRALVPKISKMDRTAILTDAIEYIGDLLEEKKKLENELMKIDEenceKSNLelKSTllDkspkDNMSavkpNQVSSSlaemAKMEVHVEVNQLTKREFLIKLYYEHKRGSFAKLMEGIDSLGLQVIDANVTTFNGKVLSMFKVEANRD-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARDHLVAERKRREKLGQLFISLSKVVPGLKKLDKASLLEDAINYIKALQERVRVLEEEEMEKRSEDIdNsyESSNiiDDSTNE-LSISAASPEIKARISNRH-VLIKILCKKQKGLMSRIPSEMEKMHLNVVDMRVMPFGGDALdITILAQMQSE-------------------- ----------------------------------------------------------------------------------------------MSFVYNIGQ-G-LPGRCLADGKPIWICNANQADSRVFCRSLLAKSASIQTVVCFPFLGGVVELGATDMVQEDIQLIQYVQASLLGNHDSltssRIdTSITSeaengsEfcstqHliEDgydLhyhsvlSSlfKsnhhltLKPPinfRKqscfrswKNdGTITIGVHHKAKNQSPQKM------LKKILFETPRMHNfSSIHKDNI------------LELQLDGGtiSFPPRVH--NFSSVNKelekrVEVLNVNQENVTVSLINKN-VLIDIRCQWKDRLLLDILHSLTNLALDPHSFEASTIHGILHLVVQSKMKESM-GLSAGIIRQLLQKA---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIEYHIMSERKRRQDIAEKFIALSATIPGLKKIDKASVLGEAINYMRQLQQRIAVLEKGSNNKSTKSIIiTKSHQCSpSCEANSSNEVLPEVEAIGLEKE-VLIRIYCEKRKGILLKLLTLLKNVHLSITSSSVLPFGNSTLNiIIIAQMSEEYN-LTVEDLVKTLKQ----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SETLDHIMTERKRRRELTERFIALSATIPGLKKIDKATILSEAITHVKQLKERVRELEEQCKKISVESvsFIhQKSniisDdKGTTsGAMNSddcfRtNEALPTVEARVLKKD-VLIRIHCKKQSGILLKILDHLNSLDLSTISNSVLPFGNSTLdITIIAQMGDKFN-VTMndlvKNLRLALLQ----- -------------------------------NIQKRLKSVIQDARQGWTYAIFWRVSEAldPmnPLLLSWCDGYFSEEAgqitnfRAMPppcvgelehrksvfrqitsllcEgvaEPEEevTDSLWFFLVSATQFFVGGA-G-LPGRAFETSTAIWVTGTQKLAGLDCTHADEARKYGIQTLVNTPVEDGVVELGSTIHVLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRRHLSKNLVAERKRRKKLNERLYSLRALVPKITKMDRASILGDAIEYVKELQNQVKVLQEELLETKEEdiehnPaSfIqpEGGhlideNGndirpdeGQySlkTDhikIpsdSNEkrledLSQPMQVEVSKLDGQLFSLRIFCEKRPGVFVKLMQALDVLGLDVLHANITTFRGLVLNVFNAETRDKD-LMQAEQVKESLLEM---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQEHVMAERKRREKINRRFIELSTVIPGLKKMDKATILSDAVRYVKEQQEKLKALQDRDVRSidsvvlVKRPCISNSDDGcPSppPSAaagggpPTTRIPLPEIEARISESN-VMVRIHCQDGKGVLVTLLAEVEGLHLSITHTNVVSFPAsTLIINLMAKVDEGF-TVTADDIVWKLD------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQARDHIMAERRRREKLSQRFIALSTIVPGLKKTDKASVLGGTIKYLKHLQDRVRFLEEQASQRTIESVVY-LNKSrLSVADTElECIALPEIEARSSGKN-VLIRVHCERRKGVVEITMAEIEKLKLTVINSSVITFGSSSLHlTIISQMGEGFNITT--------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNQDHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYLKQLQERVKTLEEQEKKKSVESvVFVkKCeiygegDNSSSDeNFSGGpyDEPLPEIEVRFCDKN-VLIRIHCERRKGVVEKTMAEIEKLHLSIINSSVIAFGSSALD----------------------------- ------------------------------------------------------QASNDDqgRLFLAWGDGHFQDTKdtspklRanKISniqglqderrkvmegiqdlvgDNhdidmsmIDGtniSDAEWFYMLSLTRSFSAAE-G-IPGKSLTTGSLVWLTDARELQFYNCERAKETQLNGIETMVCIPTSCSVLELGSSEIIKENWGLVQQVKYLFESD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLQQLLGTLIEGARESWSYAIFWLSTYDYsgASILRWGDGYYNFYKfeedkaKgkapKTtSssaeqahrkkvirelhslfsepsasatDDLDEevPDIEWFFQDSITHSFVNAS-G-LPGHAFFNSGPVWVTGSDRLSELACKRARQGQVSGLRTLVCIPFENGVVELASTKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVPAESIRRRRLNDRLYAIRSVVPNITKMDKASIIKDAIEYVQQLQEQERQLLAEMSILESaapatHGQllatAERGaqavvlrdscaamppmkkmrsFMSSSTasNmVSSsRRIEALEVRVSGVGDKVLVVSVACRHRKDAIAKVCLALEGLRLRIISANVTSTSGTLKYTALVQKEE--------------------- --------------------------------VKELLRPFVDSK--DWDFCIIWKLGDDPSRFMEWVDCCCSGGYsgeHiKHenVEeEGEGGEGEQKKgvsmcrdehkkhplrtLpcevLSRFPLFmPLYP-G-IHGEVVMSKLSRWLLNNQGNGSGLGSSNPL--QDVFRTRVLVPVNDGLVELFSTKLKPVDQAVVDSIISSCNAFLSDlriglkprplfepfleqtvqgsantgvNIsfdgSSSGSNPSsETqpplpnhlELlyKQepppclllsSKSKKdiAgrdNGfksikkvvKEmGKSKNIITERNRRYRINQGIYALRALVPKITKMDKAGTLSDAINYINELHEEKRKLEDELKHMNDMEYIesvaeeimaKKPdeDPSMAaDPatyqVSSelnRKQNEVNLEVHKISEREFLIRVSHENKRDGFKRVIEALNSTGLEIINVNFTRLNESVMNILNVKARKD--GIEARKLRDVLFM----- -------------------------------TLQRRLQWLIEDDvHMKWTYAVFWKLLHDYsgESILAWDFGYYQGNKdnlKaKTtSeveqEhvkkvlvnlsllNsgfVDEqelTDTKWFFLASKMLSFVNGS-D-LPGKAFTTSNPVWVAGESSLASLPYDRARQGQHSGLQTMMYVPFKIGVVELGSTELLLQEEN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSQDHIIAERKRREKINQRFIELSTVIPGLKKMDKATILSDATRYVRELQEKLKALQQDGGGGggrgmesavlaSKKPRIAAPdDdeDGGaHPYAaagpaATRNNALPEIEVRISEGNVVMVRIHCRDAKGVVVRLLAEVEGLHLSITHTNVVQFSAsVLIINIMAKVSQGF-NSTADDIVG--------- -----------------------------------------------------------------------------------------------------------------------------------------------TRVLIPVPGALVELFAAKQVFEDQQVVDFVMSHCSNQlelqaffnsgLpSSthgahDngYgmeammthdGSdLprepsgghskdlnekDSvkpEmgRSDSisDCsdqiddEdDAGCRKRNGKRPQAKNLEAERRRRKKLNERLYNLRSLVPIISKLDKASILVDAITYVKDLKKQEKELQDELEELSNDEdvrnngtaNIEAPtdfmsypDNlNAPNnllfgaidSMqpctlitrtheAATeddKvqQMEPQVEVTLINANKFFIKVFCEHKPGRLVRLLEFLNSLGLEVTNVNVTSCKKLVSNLFEVELKRDS-EVVADDLKNSLLEL---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSASLENLMAERRRRKKLNNCLYMLRSVVPKISKMDRASILGDAIDYMTELLHRINDLYAELESAASSALAAGpAaaSfHPSAPTlqpfpgrMnPSPSGQQGTVEVRAVEGQAVNIHMFCARRPGILLSTMRALNSLGIDIEQAVISCFNGFAMDIFRGKQYRGP-GLLPEEIKAVLLY----- ---------------------------------------------KNWTYSAFWKPAFvNQKKILVWGDGYYNGVIKtyKTIhgmeltpkefglqrsqqlrdlcltlDsrtrDqhaskpfalkVDDlADPEWFFLLSMIYDFAENE-G-MVGKTAARGQYTWLRQAHEQETAVFTRSLPAKVErsnnstyrycgDGQTVVCIPLKNGVLEFGTSEDVPDDSKLVQSILAFFMEP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAQDHIMAERKRREKLSQRFIALSAILPGLKKMDKASVLGDAIRYVKELQERVEVLEEQTKKRTVESVvyVKKsqlvvsgTDDeSSScDDnseISTSDGTLPEIEARVSDKD-VLIRIHCEKQKGLLPKLISQLEMLHLSITNTSVLPFGNSTL------------------------------ -------------------------------MLQQRLQAIIEGSiDEAWTCAIFWQSSVDAitgSSCLSWDDGYYKGCDRDekgpskrqpTTpavqaeqehrkrvlrelhslicgndqnaastptpasqeeevsdelwsnltsvmqsfvdisgvrgqeqqhrknvlrelssllsgypaacDlnkDpdMEDvTDTEWFFLVSMSQFLPASS-S-LPGNALLAARPIWITTAL--SDAPCQRACQAYTFGLRTMVCIPIGTGVLELDSTNFIFQTTESIPRILSLFNQA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGREEPMNHVEAERQRPKKLNQRFYALRAVVPNISKMDKASLLEDTIRYINELKSNVENTESKK-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNGREEPLNHVEAERQRREKLNQRFYALRAVVPNILKMDKASLLCDVITHITDLQMKIRVIETEKQMVNNK--------G-------KQLPVPEIDFQERHGD-AVVRMNFPLDSHPVL-------------------------------------------------------- ------------------------------------------------------------DLVLGWGDGYCREPDDDaTGahdeglqrmrkrvlqrlhaafgggatDdeNyalrLDRvTDAEMFFLASMYFSFPRGD-G-APGRAFSSGKHVWILDP----SDYCVRAFLARSAGFRTIVLLPFETGVLELGSVKVIRESLEGLRAIRSVFTPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPPGSVPpPSTsfHplTPTPSTlpcrVkeelcpSslpSPKNQTARVEVRVREGRAVNIHMFCARRPGLLLSTMRALDNLGLDVQQAVISCFNGFALDVFRAEqCREGQ-DVVPEQIKAVLLD----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPSGNHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKRVQDLETR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTYDHIIAERRRREQLSQLFVALSAIVPGLKKMDKSSILEDAIKYLKHLKERVEKLEQNAEKMAMESIvlVKKSqmfeEDNEEEQISSCfeEQSLPEIEARVCNNH-ILIRVHCEKQKGVLVNLLCKVESLNMIVVNTNATPFGNVSLdITIIAEMEKEF------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTQDHIIAERKRREKLSQRFIALSAMVPGLKKMDKASVLGDAIKYIKQLQDKKENMESVVFVKKTQL-FANDDNSSSEeNNSSGpfEETLPEIEARFCDNN-VMIRIHCEKRKGVVEKTIAEVEKLQLKFINSSVLTFGGCALDvTIIAQME---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSASHVLAERRRREKLNERFIILRTLVPLVTKMDKASILGDTIEYVKQLRKKIQDLEARCRSGKR--KIRRSGGGG----M--AAVAVAVEVSIIEND-ALVEVQCGNREGLLLDVMKKLRELGVEITTVQSCVEGGLFSAELRAKVK---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSQDHIIAERKRREKLSQRFIALSAVVPGLKKMDKASVLGDAIKYLKQLQERVKTLEEQTKRKTMESVviVRKShvyvDEggeNSSSDVSKGpiHETLPELEARFCDKH-VLIRIHCKKNKGVLEKTVAEVEKLHLSVINSSVLTFGTSAL------------------------------ ---------------------------------------------------------------------------------PEDlTDTEWYFLVCMTFEFNYGQ-G-LPGRTLAKNTTIWLSDAHFADSKVFIRSLLAKSASIQTVVCFPYLEGIVEFGVTE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVQDHIIAERKRRELLSQMFISLSAIVPGLKKIDKTSVLGEAIKHMKQLQEKVKVLESVAAKRTvesvvvvKKSKlmVDdNGssDDnVSSSTvddncgsgSgssgddgGgNnnAnnlNDSLPEIEVKISGKT-LLLRVYCEQQKGILAKLFAEVDKHDLSITNCSVIPFENLALdITIVAQMEEGF------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTEFKSKNLEAERRRREKLSERLLALRALVPNITNMNKATIIEDAITYITELQKHVNSLSDQLFEMEaseEETEPKKEEIDAAEE-MEKFGIQAEVKVTQIDGNKLWVKIICEKKRGGFTKLMEAMTGFGFELTDTNVTTSKGAMLVSSCVEVTCAT-L-EVEQTKELMLEI---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLQNELESTPSSSSLPTTNATslhpLTPtlpTlpcrlkdelkhCSSslpsPNSQPARVEVKAREDRAVDIHMFCARRPGLLLSALRSLDSLGLDIQQAVISCFNGFALDIFRAEQCKDP-GVLPEEIKAVLLHS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLAMLRSVVPKISKMDRTSILGDTIEYMKELMQKIQELQQQTETTTSDCHLRPSKSSKPNEIAAKNSPKFDVETR--KSD-TRIEICCGGKEGLLLSTVTTLEGLGLEIQHCVASCFDDFALQASCF------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTQDHIMAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYVKSLQDRVQKLEEQAPKKNVSSiAvVKNGkDsKGSGSDgeTgaeSEvvESGETPDIEARVNDKN-VLIKMHCEMKIGSVAKCISELEKLHLIVLNANILSFTNTsVDLTLSAQTEDGH-EVTADEIVAALQSFFK-- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMAERRRRKKLNDLLYMVRNYVYNVEKMDRASILGDAIEYLKELLQKINDLHNELESTPSSSSLPPTptsfHPltPTLptlpSRVkeelcpsslPSPNGQQARVEVRMREGRAVNIHMFCARRPGLLLSTMRALDGLGLDIQQAVISCFNGFALDVFRAEVCKEGPGLLPEQIKAVLLHS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSQDHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYVKQLQERVKAMEDETAKRTVESvvLVKRShvqvDdDTSScDeNfdVGpdgrpAGgGETFPEIEAKLSDRS-VLVRVHCEKRKGVLVKVLAEVEKLHLTVVSTSVMPFAGSAL------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSKNIVSERNRRNKLNQRLFALRAVVPNISKMDKASIIKDAIEYIQHLHEQEKKIEAEIMELqsgmPNNInpnydfdqelpvllrsKKKRTDQFyDSLNSTNSPIELLELRVTYMGENTIVVSLTCSKRTDTMVKLCEVFESLNLKIITANIICFSGKLLKTVFIQANEE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAQDHILAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYLKQLQEKVKILEEQTRRKDIESvvFVKKSrvfGDGNNT--SKmEDEPLPEIEARSCDKN-ILIRIHCVKNKDVIEKTIAEIEKLHLTIVNSSVMSFGSLALdITIIAQMDNEF-RLSLKDLVKNLQST---- -------------------------------TMQHHLQTLIEGAHENWTYAILWEPLYDYsgSFILGWSNGYYRGNNsngKaktkKVVveqelrkkalgklysvicggsDmsngdDeivlEDDvPNIEWFFNSSMFYSSIIRG-GDLPSHAFFNSSPIWVVGSDQLAGLPCGRASRGQSLGLQTMVCIPWANGVVELGSTDAIFHcedQMDLIKKVRVLFNSN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKRGRKpANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKLKLQNIK----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KHVMSERRRREKLNEMFLILKSLVPSIHKVDKASILAETIAYLKELQRRVQELESSREPSSRPSetrkRSddDEiVGKkvsaGakrKpSPEVGSdvrehptKDGTVSNVTVTVMDKE-VLLEVQCRWKELLMTRVFDA--------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKRPRKrgrkpANGREEPLNHVEAERQRRENLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLSELESEKGE------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQEHVIAERKRREKMQQQFVALATIVPDLTKTDKISLLGSTIDYVKQLEEKVKALEEQGSRRTSEPTvfeskcrISADDnDASGPSGSAfgAGGSSPTVEASIHGDT-VLLKICCKERRGVLVMIISELENQGLSIINTSVVPFTDSClNITITAKIEEG-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEDHIIAERKRREKLTQRFIALSAMVPGLKKMDKASVLGDAINYLKQLEEKVKILEDQAAKRTVESAvlVKKSrvrVDGDSSSHDESLDGLPQIEAKMSGKT-VLVKIHCDNRKGVLVKLLSEIENLHLSVANTSAMSFVGSS------------------------------- -------------------------------CLQSTLQAAVQSV--KWTYSLFWQICPQ-------------------------------------------Q-G-LPGKAYSRRQHVWLTGANEVDSKTFSRAILAKSARIQTVVCIPLLDGVVELGTTEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------TDTEWFFLVSMTQSFVNGG-G-LPGQAFFHSTPVWVAGLDRLAASPCERARQGQVFGLQTMVCVPTANGVVELGSTELIYQSSDLMNKVRVLFDFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLQQRLHAVVKVTHEAWCYAIFWKPSYHDisgEPVLKWGYGVYKGEDetdktrrrRKTNaeeklqrnkvlrElsstisgvsfpvkDeDDDvelTDMEWFYLVSMTCSFRSGS-G-LAGKAFATYNPVWYTGLDMINGSGCSRANQGGDLGLQTIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSLDHILAERRRREKLSQRFVALAAIIPGLKKMDKASVLGDAVKHIKELEERVKNLEEDKiERKAVEIstmNMKPChdhsNDceSPiSsvenNNIiNnnSShqKLHPHEIKIKICDKA-VLVNIHCENHKGVLAKLVSDIEELHLMVSNFSAVPFMGSSFLDITvaAQVEEGC-FITLEDIAKKL------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAHVLAERKRRDKLNQRFVALSAILPGVTKMDKASILGDAIKYVKQLEEHLKELEERKARTL---SAESF---YTTNIDRESIELVAIEARAFGND-VLIRVHCNKIKNIIVRCLEVLDRMPISIVHANVLSFSDSaMDLTFSAQIEQGS-DLSAKDIVEALQCFF--- -------------------------------NLQNKLSDLVDHPNasnFSWNYAIFWQISYSKsgDWVLGWGDGSCREPR-EGeeSEatrilNlrFEDeTQQRMRKR--VLQKLHTLS-G-GPGKCFASGKHVWVADALKSGNDYCVRSFLAKSAGIQTIVLVATDVGVVELGSVRP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELSANHVLAERRRREKLNERFIILRSLVPFVTKMDKASILGDTIEYVKQLRKKIQELEGCTKSGderyKRKVQvVEES--SSVSEIrakkTvAQSQQSNMLEVSIIESD-ALVELQCPYKEGLLLDVMITLRDMCLEVTTVLSSLNNGLLAAELRAKVKENVngKKPSIIEVKRAVNQKV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGLPAKNLMAERRRRKKLNDRLYTLRSIVPKISKMDRTSILGDAIDYLKELQQRIETVYTDLQSPvmsfaSKqKLLFEEELQ-------TSVTFPMEVDVQTSGANAISIHMFCEQRPGLLLSTMRALDGLGVDVQEADIKFTNGFQL-EIYAEQS-TKKLASPEEIKAVLMH----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHEHVVAERLRRQRLNKLFIGLSATIPGLKKMDKATVLKDAIDYVKRLQERVRELENEEGKRKRRGGGG--EKCWCCR-AQEAVEVPEMEVRVLENE-VLVRVQCEGRRDMMRKTVELLEHVHLPVICCNSLAFGNSAlSITIVAQMKDQ-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPSKNLMAERWRRKRLNDRLSMLRSIVPKIIKMDRTSILGDTIDYVNELTERIKTLEEEIGASPEELNLLNTSKsRPSKKlyeMMMRNSTKFVIEKQ--GNGETRIGICCPTSPGVLISTVSALEVLGLKIEQCVVSCFSDFTMQASCSQEEGGSRVTSTDEIKQALFKS---- -----------------------------------FVRSYIPSM--TWDLCVIWKLGDDPSRFIEWVGCCCSGCYidKniKLenSEeaterkkkaSfcRDEhNKHHIRTLACealshFPLFMPLYP-G-IHGEVVMSKSPKWLVNSG------------SKMDMFSTRVLVPVSDGLVELFSFDMKPFDESMVHLIMSRcttfFEPFPEQRlqfrIipraeesmSsgvnlsfegggssSVSnpsSETqnlfgnyPNARCveilrEEQGPclvmnkekdvvvqnandSKANKrlpKEnFKSKNLHSERKRRDRINQAMYGLRAVVPKITKLNKIGIFSDAVDYINELLVEKQKLEDELKGINEmeckEIaaEEESAiADPEAEKVSsksNKkvKKNEVKLEVHEIGERDFLIRVVQEHKQDGFKRLIEAVDLCELEIIDVNFTRLDLTVMTILNVKANKD--GISSGILRDLLLKMM--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPPAKNLMAERRRRKKLNDRLYTLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELEGSSNPNttcgssapAlLPAggfpppTlnslncNNQPSpfmplvkledcsSSIpgqlhlqtmPNaapvpDPSQPPKIEVRQREGRSMNIHMFCGRHPGLLLATMRALDGLGLDVQQAVISCFNGFALDVFRAEQSQDD-DVGVEEIRRVLLHTV--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPPGSLLPPSssfHplTPTPPTlpcrVkeelfpgslPSPKNQPARVEVRLREGRAVNIHMFCARRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAE------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQKINDLHGELTGTPSSSPLPAAalRASTvdSDTAhpppprQGGALPEPaaEPSSQLPKKE-RACRQhphVLPPKAGLLLATMRALENLGLDVQQAVISCFNGFALDIFRAEPCNDSPRVRAEEIKAVLLHS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAVRNVAMERIRRKKLDDRLYALRSVVPNITKMDKASIIKDAIDYIQELQDEERQLLADVSDLElkQelasmDDDLAHEnlhfsqrkKKRTLSCPslPSSSPEIIELRVSEVGEKTIGINITCNKKSDTMIKLCELFESLNLKIITANITSFSGSLFYTLFIEVDD--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQEHVMAERKRREKLTQRFIALSAVVPGLKKMDKASVLGDAIKYLKQLQEKVKSLEDQVAKRNTESAVL--AKRSYDERQRWESLPVEIEARVCQKS-ILIKIHCENQKGVLVKALSEIEKLHLSVICTSAMSFAI--------------------------------- ---------------------------------------------------------------------------------PEDlTDAEWYYLLCMSFVFNLGE-G-LPGRALANGKSIWLCNAQYADSKVFSRSLLAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTVDHIMAERRRRQELTERFIALSATIPGLNKTDKASVLRAAIDYVKELKEQIQELEKQDKTR---SLLKKRD----------PSNIPEIEARVLGKE-VLIEIHCEKQNGIQFILLDHLENLHLTVTASSVLPFGNSaLSITITAQMGEAYKM-TVDDLVKNIRQ----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CQAKNLVTERKRRTRIKEGLYTLRSLVPKISKMDMTSILGDAAEYIKELQAEVRKLKEELEALEVEDcrnkdTLSKSlarevGHtrSKSlaRqqdNQeSSRldlkTQMKAQVEVNQIGKGDFLVKINMEQKQGWFSKMMEGIHSLGYTVVSANMTTLNGKVLANLTLELTDD--GILPKNLRESLMQL---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPRISKMDRASILGDAIEYLKELLQRINDLHNELEATPPGSLLQPAtsfNPLTPtlpyrvkdelgpSSLPSPKNQPARVEVRLREGRTVNIHMFCGSRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFKAEV----------------------- -------------------------------------------------------------------------------------------------SIPLYS-G-VHGEAVLSTEPKWLSCTKDSDSNQS-----HKSN--GTQVLIPVVGGLIELFSTKHLPRDQKIIAFIVSQYNNTMEqdsitakscsnmrfnvqsHDtlpgahypvnnLpalfeakkffprlpflppvsqlnlhptlegSSTGSnpsnEHSisfnsgsvhvspnvsvngtfgeDPTnDKsnKcRnlSPKQdhlvetdklkSKQrmeKEqYHSKNLVTERNRRRRIKDGLFALRALVPKISKMDRAAIVGDAIEYIEELHKNVKELKAELAEMEeverKKKNdelvIPKLNtkKGtKTSTTTADEkeKMEVQVEVHQIGTRDFFVKLLCTQKTGGFARLMEAMHSIGLQVVDANVTTHNGKVLNILKVEMA---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSKNLMAERRRRKRLNDRLSMLRSVVPKISKMDRTSILGDTIDYMKELLERIRRLQEEMDGPEAAAaaaPLLSVfRELNPNEMLARNTPKFEVERKEGEEGDTRVEIYCAAKPGLLLSTVSTLDTLGLDIQQCVVSCFNDFAMHASCSEMQRE--MMSADAIKQELFKN---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSNVVVTERRRRRRLNDKLYALRSVVPNITKMDKASILRDAIEYILQLQQQERQMLAEISLLesaaevhHhaqllvgTQPVlpngcaghamppTKKTrrNPSFSStPapASamAVASPPVeALEVRVsgAGDKVLVVSVACRHRRDAMAKVCRALEGLRLRVISANVTVASGTVTHTALVQRQ---------------------- -------------------------------KLRNQLASAVRS--INWSYALFWSISSTQPgsshdpscTGKPWTNGFYNDEVktRKIanSteltanqlvmqrseqlrelyeallsgecDrrmarpiaslSPEDlGDTEWYYVLCMTYTFQPGQ-G-LPGRSFASNEHIWLCNAHLADSKAFPRALLAK------------------------VLEDPDLVSRATASFWEM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRRSKNLISERKRRMKLNESLYGLRAIVPNITKMDKASIVGDAINYVKDLQMQVKTMQEDILALrcSKKGSLKtlspcaaeRDqdNKMQKKQAQNtIVHSVLQINVSNMEANTHQLRILCNNAPGILVRLSRALESLDSKIVNANLTAIGDHFRNVITIKTSRDG-TKRPEDVGDLLAKRFS-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSKNLVSERKRRKKLNEGLYTLRALVPRISKMDKASIIGDAIDYVRELQKEVDDLQTAISEVeasRKSGNldTEEMsqNaqimeNSMvTEDfekasrnNTPgsnddttTEQKILKLDVAKMEEKSYHLRIFCTKGPGVFVLLMRSLEALGMEVLSANLTSFEENILNTFIAEIKDLE-AMKTEEVKAAILDV---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQVYEHILAERRRREQLSQLFIALSAIVPGLKKTDKTSILGDAIEYLKNLKQRVQNLEQKSARKQAmDSgvTVKKSqlfveDEEES---KSGGSDEPEIEVRVVNNN-ILIRIHCGKQKGILANLLAKVESLNMVVVNTNVTPFGNSALdITIIAEV----------------------- -------------------------------ELNTTLWDLLQTI--QWSYAALWTLTPDR-RMLKWQEGWFNLKA--AGDsNgsDSDnKNAELFYFLYNQLTFAPGV-G-FAGHALQhmGDRILWLAGDMALGSIpnpVEKQSFFIKAAGIQTTICIPLEDKVLELGTINLVPENDEIAHCIKKIM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLKQRLKELIDNANENWTYAIFWESSIVdDtnSFTLKWGFGYYQEVIDKPnriSwtTSVEVSDIGLftFYLI--RKSLDNNN-G-LPGQVMLSNQPVWLAGREQLSASHCEWAQQGQGLGLQMMVCIPSRDGVVELGSSELIFQSSNLNNQVRALFDFNN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQTQDHIMAERKRREKLSQRFIALSALVPDLKRMDKASVLGDTIKYLKQLQERVNTLEEQTRKKTTESvvFVKKSqlfDDvRSCsPseNSSSdlSlSEALPEIEARVSAQD-VLIKIHCEKRKGVVEKIVAEVEKLHLTVTNISSMTFGSFALDiTIISQMNPD-------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQKINDLHNELESTPSSSSptpslnfypVTPTGPRVSSlvkeelcpqatlpnPVSIPTGQPAKVEVRLREGRAVNIHMFCGRRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDIFRAEQcKQGQ-DLHPDQIKAILLD----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGPQSKNLVAKRKRRKKLNDRLYALRVLVPKISKMDKASILGDAIDFTKELLKRQTAASG-NDST--LPKVQ--NQDL--GITNDKTQQmeVQVEVAPLDGNEFFVKVFCEHKPGGFVKLMEALNSLGLEVTNANITHFRGLVSNVFKVKKKC-SEMVRADHVKDSLLEL---- -------------------------------RVQQMLQAAVQSV--QWTYSLFWQLCPQQ-GILVWGDGYYNGAIktRKTVqpmeaasseeeaslqrsqqlrelyDslsagevnpptrrpcaalSPEDlTETEWFYLMCVSFSFPPGV-G-LVSFSLSSSSFVWQN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSKNLMAERRRRKRLNDRLSMLRSVVPRISKMDRASILGDTIDYMRELLGRINNLQEETHLFK-DVKP---NE-----ILLRNS--PKFQVERGNPD-TRIEICCGGKPGLLLSTVTTLEALGVEIQQCVISCFNDFALQASCSEC----------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLISERRRRGRMKEKLYALRSLVPNITKMDKASIVGDAVLYVQDLQMQAKKLKAEIAGLEASLNgSEryqGSiENPkKIqvARNNHPiCKKIIQMDVFQVEERGFYVRLVCNKGEGVAASLYKALESLtSFNVQSSNLATVSDRFVLTFTLNVRE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETQDHIIAERKRRQELTGSIIALSATIPGLKKMDKAYVLREAVNYTKQLQERVKELENQNKRVDSAIFIRKSqaSSNKSLSISSenNKESLFEVEARVLEKE-VLIGIHCEKQKDIVLKIHALLEKLHLSITSSSVLPFGTStLIINIIAQMDEECSM-TMDELVKNLR------ -------------------------------NLQNKLSDLVERPNaSNFSWNYAWQISRSDsgELVLGWGDGHCIETGneeeeegcgsRRNplNgahqkmrkrvlqklhtlfggsDeeNyalgLDRvTDTEMFFLASTYYLLPKGE-G-GPGKCFASGKH--------------------------TIILWNFDFGVVELGSVTSVLESLELLQSIRSSFSTK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIKNHVMSERRRRGKLNEMFLILKSLVPAINKMDKASILAGAIAYLKELERKVQELESIRGGISRshgKTMlrchgneVigmslSAANKRkKasepSGGMeerehhweLSKDGSSNVINVSIMGTD-VIVQVQCRWKELLMARVFDAIKNLHLDVLSVQASTPDGLFGLNIKAQCQ---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERKRREKLSQRFIALSAVVPGLKKTDKASVLGDAVEYLKRLQEKVKYLEDRVSKRNVEAAvlVKRS-Q-LCA--GQGGQSLPEIEARVCEKA-VLIKIHCENRKGVLVKALSEIEKLHLRVMNTSVVPFSGSSL------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKTLVSERKRRGRMKEKLYELRSLVPNITKMDKASIIADAVVYVQDLQSQAKKLEEEISMLESSSKEDqvlQNpiRNSSNAiQKdptASpFGGKILQVNAHEVGEGRFYVRVECSKGDGVASSLYSAIESLScFHLESSNFSLSSERFVLTLTLNVGG--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPSKSLIAEKKRRQKLSDNMHKLRSVVPKITKMDKISILGDAVDYLKELKKQISDLQSEIESSSPRSFVPPPagtriKTSTMSTlpVqmkeklcpnnVSGlKNQPTKFDVRVREGGIVNIHMVCSYKPDVLASTMKALDSLGLDVHRANISCFNGFSLDVFKAEQHNKDQELTPEQIEAVLLKALG-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVRDHIMAERKRREKLSQSFIALSALLPGLKKMDKASVLGDAIKYVKEMKEKLTMLEEQNKKRRVmESvvTVKKSpicggDdDSSSSeeNVINgvGeAESLPEVEVRVSDKD-VLLRIHCQKHKGILVKILAEIQNLDLFVVNSSVLPFGDSNIdVTIIAQMGEGY------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKHFATERQRREQLNDKYQALRSLIPNPTKNDRASIVGDAIEYIKELLRTVNELKLLVEKKRcgrersKRHKTEDDaaGDmeSSNmkplgDPqDqsyngslrSSWlqrKSKDTEVDVRIIDDE-VTIKLVQRKKINCLLFVSKVLDELQLDLHHVAGGHIGDHYSFLFNTKICEGS------------------- -------------------------------------------------------------------------------------------THSLTRSFAVGD-GSFPGKAFGSGTSIWLSGAHELQFNNCERAKEAQIHGIETLICIPTSDGVLEMGSSGLIRENWGLIQQAQSLFGSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LASKNLVSERKRRKKLNDGLYSLRSLVPKISKMDKASIVGDSIVYVKELQQQIQSIESEIAEMEEKLlsstGVaAEcsggsrdstsleskepaAGSSSscekgteeamlgvelNDNtVlaasektsSsadsQGpsQEhspvvqrKILNMEVAKLEDQTYQLRITCQKGPGILVQLTRALESLDVDILTAHHTSFQENMLDTFIVEMRSLD-VKEAEHVRKALLDAVA-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNQDHILAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDAIKYLKTLQDKVRTLEEQAAKRTVEtavlvkkSHIsaEEENEASSSDeNFAGdGSRLPEIEVKLSGKS-LLIKIHCENIRGVLVRALLEIQKLQLALVSVSSVAFAASsLDITVMAQIEDGFSMT-VKDLVRKL------- ----------------------------------------------------------------------------------------------MSFVFNPAE-G-LPGRALANKQTIWLCNAQYADSKVFSRSLLAKSASIQTVVCFPYLEGVIELGVTELV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSVVPKISKMDRTSILGDTIDYMKELLDRIQILREEMVEHGDDSYPSSEGPPAAGllRLlkdrlSHDevlIRNTPKFNVERRETD-TRVEMCCAARAGLLLSTVNSLEALGLEIQQCVVSCFNDFGMHASCSEDAKQRTMVSTEEIKQTLFRN---- -------------------------------SLRKQLALAVRNI--QWNYGIFWSISASQPGVLEWGDGYYNGDIrtRKTVqplElKADQlglQRSEQ--LRELYESLSAGE-GSpqarRPSAALS---PEDLTDA------YMQRVRWCRSLVAKTVVCFPFAGGVIELGVVDLVPEDLSLIHRVKSLFLDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQDHIMAERKRREKLTQRFVALSALVPGLKKMDKASVLGDALKHIKYLQERVGELEEQKREKRLESvvlvnksKLilDDNNQSSSSSCcedGSSGLELPEIEVRFSDND-VLIKILCEKQKGHVAKIMAEIEKFNFSITNSSVLPFGPTLDITIIAKKENDF------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAICRARRRKK-LNQYFRELSTIVPANKKRDKLSVLGDAIKYVKELKERVKTLEEQAMKKKMESvvMIKKSqisDdDSSSsNENfiSCTSDPLPEIEARVSDNN-ILIRIYCKKRKGVLQKTLTEIEKLHLTVVNGSAISFGESALnITIVAKMDVDFSMEVKD-LVKNLCS----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKTLISERRRRGRMKEKLYALRSLVPNITKMDKASIIGDAVSYVHDLQAQAKKLKAEVAGLEASLLVSENyqgsiNNPKKVQVsnNShPiCKKIIQMDMFQVEERGFYVKIVCNKGEGVAASLYKALESLtGFNVQNSNLATVSDSFLLTFTLNVKG--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNQVEAERRRREKPNQRYYALRAVVPNISKMDKASLLGDAITYISRMQ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAKNHVVAERKRREKLNQKLIALSALIPGLKKMDKASILVDATNYIKQLGERVQTLEREAKKIilvePTKPSVKRfrlssTDiNGTClsDdNIdgnSNNINQSPEIEARVSDKH-VLVRIHCKKQDGLIAKILSELDKFCLDVISSSTMPFGDTALdITIIAQMGD--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQDHVIAERKRREKLSQRFIALSAVIPSLKKMDKATVLGDAVKYIKQLKGRLEKLEEELSRKT----VE-----------------SVVVVK---KS----QVHCERRQGCISKILNLIEKMNLSVLSNSVIPFGSSILdITIVAQMEGELPMTIEdltKNLRQNLLNLI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAKDHVIAERKRREKLNQRFIALSALVPGLKKTDKASILGDSIKYLKQLQERVKALEEQTSKKTVESMiiVKKSqmiytDDETSpTDINfdaQSNQYLPEIEVRVSDRD-VLIRIHCEKNnnKGHLANILSEIENVhHLSVLSCNVLPFGNSTVdITVVAQMD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQDHIMAERKRREKLTQNFIALAALVPNLKKVDKYSVLVDTIKYLKELKKRLEVLEEQNEKTKIESVVilTkPGicnNDNSSScdeSIDCVVDLPFQVEARVLGKY-MLIRIQCQEHKGLIVKIMVEIQRFQLFVVNNSVLPFGDSILDiTIIAQLDEGYN------------------ -------------------------------SLMERLRPLVGSK--SWDYCVLWKLSEDQR-FLEWMGCCCGGSE-NIQ----ESGEELLFpcrdvmfqhprtkscdlLAELPSSIPLDS-G-IYAQTLMSNQAKWLNFSNNSDSN-------ASEETIGTRVLIPIPGGLVELFAAKQVAEDQQVIDYVMAQCN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNIESERKRRKKLTERLHALRAVVPNISKMDKASIIKDAIDYIQELHNQervvqaeISELESKRSIFldfDeeiscnSKPkrsRFEQT----CDSVGSrsSLIEVLELRVSHIGEKTIVVSLVCSKRTDTIVKICEVFESLNLKIITANITAFSGRLLNTVFLEANEE-------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DASSMGRRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINELHNELESAPSSSLAGPTSTsfhPSTPilqtfpgrvkeelcptSFPSPSGQQATVEVRMREGHAVNIHMFCARRPGILMSTLRALDKLGLGIEQAVISCFNGFAMDVFRAEQcRDGP-GLGPEEIKAVLLHS---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKDHVIAERKRREKLNQRFIALSAVVPGLRKMDKASVLGEAVKYLKQLQERVRILEEHAAKKTMESVvfVRKTrlsaNDDTSSSDKSSDQPLPEIEARVSDKN-VLIRVHCEKSKGCAAKILNEIEKLHLTIVTSSLLPFGNSTVH----------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQGHIMAERKRREKLGQRFIALSALIPGLKKMDKASVLTDAIKHLKQLQERVKILEAEIQKKKSmEsvvlvkkKKYQEGrGEEDDDdRISftVEEETLPEIEIKRCSEN-VLIKIHCEKKKGILEKVIAEIQKFNLSFVNSNVLTFGETIL------------------------------ ---------------------------------------------------------------------------------LDRvTDTEMFFLASMYFSFPKGY-G-GPGKCFASAKHFWFKS----VSDYCVRSFLAKSAGIQTVVLVPTDFGVLELGSVRMLPENFELLN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------DLDEHLQNLIERSPMNWTYAILWRCSSP-RSLLSFHRGYCRTTGkpRHLrilgSriTAAESlSDAEWFFRISAAQSFRVDE-D-LPGHALWGSSPVWVSAGDS-EGPRWERAAWGKQFGIRTFLCVPLKeRDVLELASTQIVASPLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELESTPPGSLLQPASAsfhpltPTPPTlpcrVkeelypSslpSPKNQSPKVIFVC-----LNANLFCSRRPGLLLSTMRALE------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNIVSERNRRKKLNERLFSLRAVVPNISKMDKASIIKDAIDYIQELHEQERRIQAEILElesgkLKKNPGyeFDQElpvllrSkKTKLENIfdSggSrtSPIEVLELKVTHMGEKTVVVSITCSKRTDTMVKLCEVFESLKLKIITANITAVSGRLLKTVFIEVS---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERIGKLQEERTEEGIdQMNLLgNTKDLKPNEVMVRN--SPKFDVEKREQD-TKISICCATRTGLLLSTVNTLEALGLEIQQCVISSFNDFSMQASCSEVGERRTSISPEEIKQALFR----- -------------------------------NFKEQLALSVRSI--QWSYAIFWSTSSTQPGVLSWGEGYYNGDIktRKTSqgvelnfdqiglqrseqlrelykslkavEaspqtkrrsaalSPEDlTDTEgWYVEVCMSnnkhtLAFSVGC-S-LPLKAYTHETLVELGQ-------KGVRSLLAVPVS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASRNTVSERNRRKKLNDKLFALREAVPQISKLDKASIIKDAIDYIQDLQQQEARLQAEIMELESER-FEDElpvfLTSGSYRhLADPrsdPIEVHQLNVSYMGERTVFVSLKCSKARETMVKLCEVFESLKLKIITANITTFSGMLKKTLFIEADV--------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPPGSlTLPPSsNfHpltPTPQSlpcrlkeelcPSslpSPKGQPARVEVRLREGRAVNIHMFCGRRPGLLLSTMRALDNLGLDVQQHK--------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMKNLMAERHRRKKLNDRLYMLRSIVPKISKMDRASILGDSIDYLKELLQRSNDLHNE--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------HRHEWFFLVSMTQSFFNGA-D-LPGHVFITGAAAWLAGAS-------RRVRQALTFGIQTIVCAPVAGGVVEFGSTDLIYQNPNIMDKVRFLFNHG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAKSISMERNRRKKLNEKLYALRSVVPNITKMDKASIIKDAIDYIVQLQDQERQMQAEISALEslnQDRaSSDHDldfyDdlqliqkkkKrRRTP--ASEPIQVIELTVSDVGEKTMVISITCNKNRDTMIKLCELFESLHLKIITANITCVSGSLLHTLFVEGD---------------------- ---------------------------------------------------------------------------------VDHvTDQEWFYLLSKSWNFACGE-G-IPGRAFQFGQHIWICDTVKPINFHCARLELAKSAGIQTIVCVPTRNGVVEASSTEIVNECSRTSQDIRRYFEEQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APKNIVSERNRRKKLNDRLYALRAVVPNITKMDKASIIKDAISYIQELQEQEKILGGEITQleyslatKNKKSLdeLNQAaaDmamPSTVSkkkrtDkqqlfdESgSSrvlasLVPVTELNVSYVGRRTVLVSIKCTNQRNTMVKLCKAFESLKLKSITANITSSSGILVKTVFIEL----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNRHFISLSAIIPNLTKMDKASVLEDASKYIKELQDRVKELEESPSIKRNhvhESviSVKRSrlsasDDEyySSNDTNSeestaPYMTSPEIEVRMSGSS-VLVSIKCQNNISSFTKALDHMEKLGLSIISCSSMPFAKtNLLIGITAQVG---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERIKTLQEEIESGSDELNMAHIfKDVKPNEILVRNTPKFEVERR--NVD-TRIEICCTGKPGLLLSTVTTLEALGLEIEQCVISCFNDFAMQASCSEDLEQRTIMSSEDIKQALFRN---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGTPSKNLMAERRRRKRLNDRLSMLRSTVPKISKMDRTATLGDTIDYVKELTERIKTVEEEMGTTPEELNLLKNFSSGGNEeTPTRSSTKvcANVENRG-GGD-TKIEICCSTNPGALIATVTALDVLGLEIEQCVVSCFSDFAMQASCSQAEGKRQVISTDEIKQALLRSA--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNQEHVIAERKRREKLNLQFIALSAIIPGLKKTDKASVLGDAVKYVKQLQERVKMLEEQTTKKMVESvvTVKKYqlsDDETSLSyhdsDSSSNQPLLEIEARVSNKD-VLIRIHCQKEKGFAVKILGEVEKLHLTVINSSFMPFGDYTMdITIVA------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMMAERKRREKLNDRFVTLRSLVPYVSKQDKVSLLGDAIDFIKDLQRQVEELESRRKI----S--E-------------NPSKPRVEITVENNR-AVFEISSPWRQDLLIAILETFVGTHMQVEDVAAKVSKDTFKATLKAKVTSSgiddddddEDKKSIKQIRETLLSVV--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAQGHIMAERRRREKLSQRFIALSAIVPGLKKTDKASVLGDTIKYLRQMEERVKSLEEEAKQKTVhsmvlqvkKPQLLPSrDEAPSSepetdSFhTSFNDALPEIEARICDKS-VLIRIVCEKRQGGvVEQVLAEVEKLHLTIINSSVLSFGASSLNIiIVAQVIGG-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RCVASKNLVSERKRRKKLNEGLFQLRAVVPKISKMDKASIIGDAIAYVRELQKELEEIESEIDDLEQKCtgsvgdetgSVEEAgtgeNfsSPTsSNpaSgveiqgaepgvdsnVdkvSAdaTqvqlparlAQKILEVDVARLEEQTYHFRIFCQRGPGVLVQLVQAVESLGVQVINAHHTAFQENILNSFIAEMKDPK-MET-EDVRRTIFSA---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPFKNLITERKRRMKLNERLYCLRAVVPNITKMDKASIVGDAINYVKDLQAQVKIMQEDIHALRagKEAPLEALsscaAERGHDRekhpkeMQNAfQYRVLQISVSSMEPNTHQLRILCKNAPGILVRLARALESLNSEIVSANLTAVGDHIMNAIIIKMGSDG-VKRPEDVRELLVQTF--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQSKNLVAERKRRKKLNERLYALRSLVPKISKMDRASILGDAIEFVKELQNQVKELQDELEEH----------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMPQDHILAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKSLKEKVKTLEEEAKKRDQAVVVFT-SDA--D--GDGDEQLPQVEATFSGKH-ILIRLHCQKKPGVVEETLTLIGKLHLSLINITVITFATYSlDITIVAQMDEEFAM----------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPNISKMDRTSILGDAIDYMKELLDKINKLQDEEQELGVSnsshhSKLFGDIKDLNT--NEPlVRNSPKFEVDRRDQD-TRVEICCSPKPGLLLSTVNTLETLGLEIEQCVISCFSDFSLHASCSEAAQQRDFINSEDIKQALFRN---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGRKpANGRDEPLNHVEAERQRREKLNERFYALRMVVPNISKMDKASLLGDAITHITDLQTKIRVLEAEKA------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VASKNIVSERNRRKKLNERLFALRAVVPNISKMDKASIIKDAIEYIQHLHEQEKRIEAEILDLEsgklKNPtyEFEHdlpillrSkKKRTeqlFDSATsrNSPIQLIELRVAYMGDKTFVVSLTCSKRIDTMVKLCEVFESLNLKVITANITSFSGTLLKTVFIEADEE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VASKNIVSERNRRKKLNDRLFALRAVVPNITKMDKASIIKDAIEYIQHLHDQEKRIQAEILDLEsgnklKNPTyeFDQDlpillrSkkKRTeqlFDSVSSrnSPIEIIDLRVTYMGEKTFVVSLTCSKRTDTMVKLCAVFESLKLKVITANITSFSGTLLKTVFIQADEP-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------LGTQVLIPVNGGMIELYISKQVTRDQEMIEVLTARFNIFSRhfeqlktggsPNCsnpwsenSSLvsaGSTqVSptqsiDMpinlLGyaISDQPKEhtKNrqntSKdHYQSKNLLTERNRRNRIKDGLFALRALVPKISKMDRASIVGDAIDYIKELQANVQELKKELERLEEDdsqSHVdeiEvcKPRKPheLSpikgHNlVSTtpDRKTQVQVEVHQIGAKNFLLKLVYSKQRGAFLRIIKTVNSLGLQVLDVNVTTCYGKVLNILKVEAKEK--DFAAKSLKDSLLD----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLVTERNRRTRIKTGLFSLSARVPKISKMDKAAILGDAIDYISELLKDVKNLRDEIKNAEEEecraSnmelktsKLETCQKGcmSSTKVNqdpSGfvkkERTEVQLEVDQIGKRHFLLKFLCEKKRGGFGRLMETIHSLGLQIHDANITTFNGKFLNILKIESTSV--EVDLDMLRRSLISL---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNLVSERKRRKKLNERLYSLRAIVPKISKMDKASIVADAIDYVQELQGKVQELQEDVSSLeaaeRREvelgslfhrhrPALRQVAQPrlpQSSRGSSlsfvSiyKFVLLQLEVSKLEEQVFYLRINCGNSDGVLIQLAKAFESIGLEFSSASLSSFQGKII------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRRERLTQYFVTLSTLIPDLKKLDKASILGDAIKYIKQLEEQVKSLEEETKKYNEEPvaAVKRprvltSyDNSTIS-NENSNKSVPNIEVRANSDGNVLIRIYCKKQARIVKEIFSQVEMLHLTITSSSVIPFGyNTTDITIVAQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNQEHILAERKRREKISQRFIALAAIVPGLKKMDKASVLGDAIKHLKQLQEKVRSLEDQVAKKSIESAvlLNKSthlisnvNDDD-TSFAdEShGESLPQIEVRVCDKS-ILIKLQCENRKGALVRAISEIEKLHLSVVSTSVMVFSGSSL-DITV------------------------- ------------------------------------------------------------------------------------TDTEWYFLISMMQSFVNGS-G-LPGQAFFTTNLIWIAGNDRLASSSCDRAKQAQVLGLQTMVCIPLSTGVVELGSTNLIFQSSDLMNKVRVLFNFNN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYKSKNLDAERNRRQRIKDGLYTLRALVPKISKMDHASIVGDAVDYIIDLQKNIKDLQDELKELEEQD-CE----------VNDDEVEVEVEVHEIGAREFLLKLMCSYKPGQFLRIMETVDSLGLEVIDINITTCNASVLNVLNLKV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FKSKNLEAERRRRKKLNDRLLELRSLVPIITNMNKATIITDAIAYIEELKNRVEELTDQILQMEAteeERNTKKEDINIADD-MHNMGIEPEVKVNHICGNKLWIKIIFQKKRGRLTKLMEAMNVLGFVLTDISITTSKGAILFTSSAEVMHGG-MQGTEEIKELLLEII--- -------------------------------LLQDRLKYLVESC-LGWVYAIFWQTFKDTynNLYLSFGDCYFRGLE-NFqqSQGTSSlnTASE-LIIGSASRSFVLGE-D-IVGGTFGTGSFVWLAGDNALQMNGSQRAKEVSLHGIRTLVCVGTSWGVVEFGSLEVWKEDWGIVQLTKSLFMSES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLFAESRKRNKLRDKLYTLRSLVHKTSKMDKSATVGDAIEYIGELQQELKKLNEELKEIEEEECKE--NAEL-----KSSKLEALVEVNQIGERDFLIKYICEKKWGGFGRLMEAIHSLGLQIVEVNVTTFNGMVLNILKVESQKE--GIQPCNLRDSLI------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRRHLSKNLVAERKRRKKLNERLYALRALVPKITKMDRASILGDAIEYVRELQARVDCLQKELLDDEEILNvdaiLEDGNRegcfediKTSEPrldIiPEeqqieNLVQPMEVYVHKLDEAVFTVRIISEKSEGMFLGVLRIMDEYGFDILHANIITHRGIALHVFRAEIRDKK-TPTIEQVKESLLQL---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SASKNLVSERKRRKKLNERLYSLRAIVPKISKMDKASIVADAIDYVQELQGKVQELQEDVSSLeaaeRREVElgsvVDAwnemivSDHRGcsySTDIdqhyaklrNQDSRKAVELEVSKLEEQVFYLRINCGNSDGVLIQLAKAFESIGLEFSSASLSSFQGKIINSFIAKMEEWK-SLHTDEVKKILLE----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSRNGVAERQRRNKMNQQFYALRPVVPTISRMHKASLLADAMDYIKELQSRIAALESKLVKSelssPKRLKSNRTvasfsDVSKITSlsskNSSttlavPGWREMVVDVKMVRQE-AVIRVWSPNLDHPCARLMDMLKELEFKVQDANMSCMKG--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGPQSKNLQAERKRRKKLNDRLYTLRSLVPIITKLDRASILGDAIEFVKELLKQVSDLQLELEEQSGDdegtenngrSeilnaglKREheNTlvggNNmGAAsyGSVaeptnrkhdSDAydhKshQMEPQVEVAQIDENEFFVKVFCEHRSGGFVRLMEALNSLGLEVTNVNVTSCRSLVSNVFQVKKMDS-EMVQADYVRDSLLEI---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKNHVR----REKNLNKQFYSLLSVVPKVSKMDKASLLGDAVCYINELKQKVEELESELEMRDS-TKVN-----------CEKKKKKNIQVKMVGEY-AIIRVQSANSDWPELKLMSALGKMEAKIQHATMSCVNDVMFQDFVAKIP-G---ATEDEVKAYLHTRLN-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHIIAERKRREKLSQKFIALSAI------MDKASVLGDAIKYVKQLQERVVALEDQSTRRTVESAvlVRRSqlslDDGISSSdeNfDgpTAGTPLPEIEVKLCEKS-VLVRVHCEKRKGVLSRLLDEIEKLHLTVVNTSS-------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNIVSERNRRKKLNDRLFALRAVVPKISKMDKASIIKDAIEYIQKLHEEERNIQAEIIELesnHNKGSHNnnnnnnnKnlggnydhfdqelpillrskkkkIDQQlyDSNGSrcSGsiSPIEDLELRVTYMGEKTLVVSLTCSKRTDTMVKLCEVFESLKLKIITANITAFSGRLSKTVFIEADED-------------------- -------------------------------NFKEQLALSVRSI--QWSYAIFWSTSSTQPGVLSWGEGYYNGDIktRKTSqgvelnsdqiglqrseqlrelykslkavEaspqtkrpsaalSPEDlTDTEWYYLVCMSFVFNIGS-R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVISERKRREKLSHRFIALSALVPGLKKTDKASVLGETIKYLKQLQERVKILEEQTAKKKTmESmiIVKKShmaSDGeTISSVddnfdSQSyQLYLPHVEARVSDKD-VLIRIHCENEKGSLVNILSEIQKLPLTVLNSNALTFGNSTLdITVIAQMD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQENVLAERKRREKISKLVIALAAIIPNLKKMDKASILEDAIRYLKELQQRVKALEEEAAVKTEESviIVKKSpltryDDTASSSdeNSCSqidqQLSLPEIKARISGNC-ILVKIHCARRKGFISKMIGEIEKLNLTVVNSCVLPFGSSILdVTIFAQMDVGFSLkmGDfVRNLRQALLDL---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTAAKNLVSERKRRRKLNERLYALRSLVPYITKMDKASIIGDAIKYIKDLQKQAKDIQAEIAALQSNNdssssTLTSaTadvDDNcndQTQDVkserlnhihvAafdrgGSchADRTLQIDISKIEERTFHIRLFCKREPRVLIHLTKALESVQlLEVQTCNLTCFDGHIINTVIAKTKELQ-EIEADALKHII------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESGGSYLLSERR-REKLNEKFVVPRSLFPSISKVDKASILDDTPRYLKQLERRV--LESCRETAelsgrdRRKqhPDVsERTsdnyihkeitDGRKAsANkrkardMDeaEAehEHHCVEVSVTMKEKE-VLVKMHCPWREYLLLEIVESMSNLHLDPLSVQSSTVDGMLAMTVKSKFRSTT-VASPGMIKRSLQEVIG-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPAKNLMAERRRRKKLNDRLYKLRSVVPKITKMDRASILSDAIAYLKELHERIQGLENEIGSSPLNsPSiVPgltsQTNDfklPTIRskrSASNYNPKQSSVEVRVGKGDAVNIHMHSVQKPGLLAATMQTIDNMGLDVQQAAISCLNGFTLDIFRAEQSkkDGT-AVRSDDIKTSLLKS---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTKHFATERQRRVQLNDKFDALRNLVPNPTKNDRASVVGDAIDYIKELLRTVNELKLLVEKKRcgrersKRHKTEEDGdegDmeSCkplgepdqsYNNGslrSSWlqrKSKDTEVDVRIIDDE-VTIKLVQRKKINCLLFVSKVLDELQLDLHHVAGGHIGDYYSFLFNTKIYEGS------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLHAERRRRKKLNDRLYLLRSVVPKISKMDRASILGDAIDYLKDLLQQISVLQMELKSPAGsDSSLapclPSIafDTLhGSDThVkeefpgfMeDTELQPPRVEVCAQEDGSLNIHMVCSKQPGLLLAAVRKLDELGVDVQQAVFSCFNGFSFDVLQAEQLSQ-KAVQPEEIKSALLQT---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLMTERNRRKRIKDGMFALRALVPKISKMDRVSTLGDAAEYIKELQETIDGYQDELQAMEENEcKnvIAKPNPTMSIkECSEkKASIEARVEVNQLGNKEFLVKVVCMQKRGGFSRLIEALDSLGLWITDANATTFNSAVLNVLKVENGGGAEyseafTVPAGELRRLIE------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDAIDYMKELLDKINKLQDEEQELGNSdnSHHSKLfGDLKDLNANESlVRNSPKFEIDRRDED-TRVDICCSPKPGLLLSTVNTLETLGLEIEQCVISCFSDFSLQASCSEGAEQRDFITSEDIKQALFRN---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKRPRKrgrkpANGREEPLNHVEAERQRRENLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLSELESEKGE------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHVLAERRRREKLNQRFVALSAILPGLKKVDKASILGDAIKYVKQLEEHLKQVETQHSCS--K------NNT------DESIQPADIEARAFGNN-VLIHVHCNKIKNILVRCLELLDKMPLLIINANVLSFSDTALdLTVIAQIEQDS-DLTANDIVEALQTFFS-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHPSKNLVSERKRRMKLNERLYSLRSIIPKISKMDKASIVGDAITYLQDLQKRVKDLQDEIIALEEDNKrgdGEETydlHHPVPeSAVGSSlSCYKILLNVSAIDSKMFTVRVSCPRTDvRMLVQLTKALEAIDLAIVNANVITVNDHILNTIVVRIHQAE-ACDAERLKELIQCSLA-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLVSERKRRGRMKEKLYALRALVPNITKMDKASIVGDAVLYVQDLQMQARKLRSEIAGLESSLtgggrnRQGIVeNRKNIQFVSPnhPiCKKIMQMDMFQVEERGFYVRVECNRGQGVAVSLYKALESLtRFNVQSSNLATLSERFILTFTLKVRDC-------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQTLDHIMAERKRRQELTERFIALSATIPALKKTDKSSILREAINYVKQLQERVTELEQQNKRGKDSIiILKRTdlyaNNedNTSSETNSedccrTSEMLPDIEARMMENE-VLIEIHCEKEDGVELKILEQLENLHLSVTGSSVLPFGNSTlGITIIAQMGDA-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERIGKLQEEEGTSQ--INLLGISREQ----LKPNEAIFDVER--RDQD-TRISICCATKPGLLLSTVNTLEAIGLEIQQCVVSSFNDFSVEASCSEVAEQRDCIHPEEIKQALFRN---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTVSHVEAERQRREKLNRRFCDLRAAVPTVSRMDKASLLADAAAYIAELRARIARLEAESRRAAA-ARWEPVAAATACGAhegrQGAGGADEVVEVRMLGPDAAAVRATSA-APHAPARLMSALRSLELHVQHACVTRVNGMTVQDVVVDVATP--MQDdDNGLRAALLQRMQD- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAERQRRDKLNRRFCDPRAVVPNVSRMDKASLLADAATYIAELRSRVASLEEETNKALEESP---TAASRGG--PASKflQVDETVEVRMMGRD-AAAVMT-TAASHAPARLMGALQSLDLQVQHGCLSRVQGVTMQDVLVDVPAS--VEDADGIRSALLQALQD- ----------------------------------------------------------------------------------------------------------LPGRALAMGETIWLCNAQYAENKLFTRSLLARSASIQTVVCFPYLGGVIELGVTELISEDHSLLQHIKSCLVETS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKGHIQAERKRREKLNQRFIALSAILPGLKKMDKVSVLGTAIKYVKQLEEQLKLLEDTTVKQiVKSTGCENLNNGhnATSGMDNtflCTRQQPDIEARAAGKT-VLIRVHCDKIRNILLRCLEELERMPLSIMNANVMSFSTTsVDLTITAQIQQDQ-PLYDDCIKNNFFNFI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVQEHVIAERKRREKMHHQFATLASIIPDITKTDKVSVLGSTIEYVHHLRGRLKALQEEQQSSTG-STAESPplDARCcIGSEDDGnaSEVEPKIEADVRGTT-VLLRVVCREKKGVLIMVLTELEKHGLSIINTNVVPFADSSlNITITAQIEDGSS-TTVelvNNLNSALRNF---- ---------------------------------EQRLAALVNY--IGWSYIVVWSLPQ---RDLVWQQGLWPAGS-S-------FQQALFYTAYKSCQFPFGH-G-HAGIAAIRREHVWVTGVNVTNTSVLEQRDFLQATIIQSLLCIPLLDGVLEIGSTETILETDSLLQTIRTFLYAAPValpvstehpsTstsSiFSqspseaSLDipglhhqsyttSdwttiyqatsslgtqfDTSsatafrkwDplqqksmaipttSQAmikrmllalaqiEEvrKRARGlAqgptqtmSGGEdarTRTVHIDAERNRRRRHKDSISRLRSLIPFKTK-DKLSVLQGAIDHMQYLQRRVAQLENSKATTEETagPGAEI-GAIK-TELTT-SDDRDELSVNALDDEgTFAIRIHRrrPQRQDVMLQLLNYLWSLGLSVTSIDSAVTENSFRAALVAKLRN--------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERINNLQQEIEADPDQLNVMSLfKDIKPNEMLVRN--SPKFDVQRRNVD-TKIDICCTGKPGLLLSTVSTLEALGLQIQQCVISCFNEFAMQASCSEDFDQRTMVTSEDIKQALYRN---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKNFAMYWDRQRYLNMENTLLQ---PNINQMDKASIIKDAIEYIQQLQDEERRIQAEIRELESTtgsPDfssdFDRdllkserSKkmKRadSVPSRSAsPPIEVLELRVSEVGEKTLVVSVTCSKRRDTMVKVCEVFESLRLKIITANITSFSGCLMHTVFVEADEE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAVNHVEAERQRREKMNNRFYALRSVVPTVSRMDKASLLADAVAYITELKGKVDSLESQLQIM----------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKRQQCKNLIAERKRRKKLNNRLYTLRSLVPNITKMDRASILGDAIDYIVGLQKQVL---------------------------------------------------CSHKSGRFVRIMDEIAALGLQITSVNVTSYNKLVLNVFRAVMKDNEAAVPADRVRDSLLEV---- -------------------------------EIQGLLKAVVQSV--GWTYSLFWQLCPQ-RRKLVWSSGFYNGAIktRKTTqpaeitaeeaalersqqlmelyqtlfagEssmearactalSPEDlTDTEWFYVLCLTYSFEPPS-G-MPGKAYARRKQVWMSGVNEVDSKIFSRAISAKSY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------DLGEDLKNLIEGSPqSCWTYAILWRCSSP-QSVLTFHDGYCTATESKPKElrilgssvtVTEDvTDAEWFFRISAAQSFGINE-D-LPGHAFCGSGPVWVTAED-SDARRWERATWGYQFGIRTVLCIPLKeKGVLELASTEIVPYELKMMEEMV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RENHILAERQRREEMNEKFSALRAMIPKATKKDKASIVGDTIDYVLELEKRLKQLQACKDTAsgtgffkslKRKSPygsrgggedgaLESPkpgGsSSetthqrdpGSPSpiresrdsaVSSpsdqiteesklpGktKGGVAEVDVQMLGKQ-AVVKVVCSRQPGHVLRVLNALEECKVEVLQSNVMTVADNSIHFITVQLEEGA-SISSEELVSAILQA---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYMQMDKASILGDAIKYVKQLQERLKELEEDNKKNGVESSmvVTNkPqicsDNESNcEeNAcdgYGNNESLPEVEARVLGKE-VLIRIHCQKQKGILLKILAEIQSLHLFVVNSSVLPFGNSiLDITIIAQMGDGYN------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATAKNIVSERVRRKKLNDRLYQLRSVVPIISKMDKASIIKDAIAYIQSLQQQEREILAEISQLesqKcKNPscladRVDKPteSRPikkmRTDSIqavhiaapTSNyPPRVTSLEILEMGEKTFVVRISCLKGRNAMANLFRAFESLKLRIITASTTAMHGHIFKTVFVEVEDGE------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTYDHIIAERKRREKLSQSLIALAALIPDLKKVDKASVLGNAIKYIKELKERVSNLEEESKKTRVvvlkDPELNGDNyDSSSCeegSIenSCGsESLLLQVEARMSGQE-VLLRIHCQKKNNILVRILA------LYVVHSSVLPFGDYSLdITFIAQMGEGYN-LTVEDLVKNI------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TARNIVMERNRRKKLNDRLYALRSVVPNITKMDKASIIKDAIDYIQQLQREEKRLLDDVRMAetwmgEKKLAVDGIpRQGSfdtATrkkrRMspeSPGsvSIEFMELNVCELGDKTLVVSITCSKKRHTMMKVCELFESLKLKIVTASFTSVSGNLLHTLFVENEEE--MA-AEELKERI------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGTSLKSFATERQRRVHLNDKFKALRNLIPNPTKNDRASVVGDAIDYINELIRTVNELKQLVEKKRCkkRrtkrHKIEGVndvktepvvDESqNShsyNDSslrSSWlqrKSKDTEVDVRIVDDE-VTIKVVQRKKINCLLFVSKVLDELQLDLHHVAGGHIGDHYSFLFNTKICEGS------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANSRKEPLDHVEAERQRREKLNQRFYFLRSVVPNVSKMDKASLLADAVTYINELRSKTQALESDNQ------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlGEAEWY-----TYSFRPGQ-G-LPGKSFASNEHVWLYNAQYADTKTFQRALLAKTAPIQTVVCIPFMGGVLELGTPDFV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DENQMMAERMMMRLLNDNLYKLRCLIPNISKLDRKSIMSDAIDYIKKLQKEVKELQEELEKNSDTEdGSDqhrQCGGmSSINGAdnelmMKGgGVFEPQVEVamvKVDGSYEFSVKVICEYKPGGFTKLMEALDSLELVVINANTTRSLDLVSNVFMAERKDGE-MVQVDHVKDSQMQ----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGQPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYVKELLDKIQKARDEVLDEdSqNQVNIIRdClNKEiKPDNDSQvRNPPKFDVERR--KQD-TKLEICCAPKPGLLLSTLGTLDALGLDIQQCVISCFADFSLQASCLEVAEHRTLVSPEDVKQALFRS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPKKSITQERERRKRFNEKLYALRSLVPSITKMDKASIVKDAIDYILQLQEDERKLLAEVAVLeqgsgKRKPDVEGGelAQserkkRRTESPTGSSIDVTELVVREVGDGTSIVSITCSRKKDTMARLCQGLEPLHLNILAANITSCSGNLLHTLFIEAPE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQLEHVVAERKRREKINQRFMELSAVIPKLKKMDKATILSDAASYIRELQEKLKALEEQAAARVTEAAMA--TPSPAR-AMNHLPVPPEIEVRCSPtNNVVMVRIHCENGEGVIVRILAEVEEIHLRIINANVMPFLDqgaTMIITIAAKASSSL-LYKAEEIVGRL------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPAKNLMAERRRREKLSDRLLLLXSIVPKISKMDRTSILQDAVSYMMELLQRVEVEERE------------------------------------GRN-LNIRMCCPTRPGLLLSTMRHLDGLGIDIKQAFISCSNEFFLDVFHAEPIEG--RVAPEDIKALLLHN---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSQDHIIAERQRREKLSQNFIALSAIIPGLKKIDKASVLGEATKYMKQLQERVKTLEEQTVKKTVESVvvLKKSqllvDDSTSPfdENleGCSDDQLPEIEARVSEKN-ILIRIHCEKGKGILVKTLAEIEKLHLMVVNSSLVLFGSSALdITIVAQL----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNIVSERNRRKKLNERLFALRAVVPNISKMDKASIIKDAIDYIQDLHEQERRIQAEISELesgkSKKSppGyeFDQEipvlvSKSkkkrTQHCyDSGgSrvsPIEVLELRVVYMGEKTVVVSLTCSKRTDTMVKLCEVFESLKLKIITANITAFSGRLLKTVFVEIP---------------------- ----------------------------------------------------------------------------------------------------------GPGGSFTFGKSIWVSDSV-------------------------------------SLPEDQGALDLVRTAFGK-------------------------SNGKEEPLNHVEAERQRRKKLNQWFYALRAVVPNISKMDRASLLGDEQ------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKEHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDTIRYLKELDEKLSADDDSS--FCDDENFEY-G-------QRRfGESLPEIEAKMSDKS-ILIKIHCENGKGVLVKALSEVEKFHLSVVSSSVMPFAGSSLdITIMAQIEDGFNMT---------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTQQHIMAERKRREKISTLLIELSAMVPGLKKMDKLSIIGKTIDYVKYLQNRIKDLQEQNSKMESiTCcRNNKSNVNISENSNNGlddRLTFPKVDVSVSGKD-VIIRVICEKREHIVTKLLSMLASHNLSVVCSSVLPFGSSTLNiSIIAKVQ---------------------- -----------------------------------------------------------------------------------------------------------TGGALGNGEPIWLCNAHTADSKVFTRSLLAKSASLLTVVCFPFLGGVLEIGTTEHITEDLNVIQCVKTLFLEA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlGDTEWYYVICMTYAFRPGQ-G-LPGRSFASNEHVWLRNAHLADSKAFPRALLAKSIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKEHVLAERKRRQKLNERLIALSALLPGLKKADKASVLEDAIKHLKRLQERVKKLEEERVGTKKMdqSviLVKRSqvyveDDSSSysStcSAasppSSSldevsilKQTMPMIEARVSDRD-LLIRIHCEKNKGCLVKILSSLEKFRLEVVNSFTLPFGSkTLVITILSKMDNK-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRASHIMAERKRRQQLTQSFIALSATIPGLNKKDKSSMLGKAIDYVKQLQERVTELEQRKKRGKESMiILKKSE-ANSEDCCRANKMLPDVEARVTENE-VLIEIHCEKEDGLeLIKILDHLENLHLCVTASSVLPFRNsTLSITIIAQMGDAYKMKVNdlvKKLRQVLLN----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESVNHIMAERKRRQELTERFIALSATIPGLKKIDKASILSEAITYVKQLKKRVEDLEEQRCCK--KIRVEsvsfinKTnfyNDeGSvSGDkktnFDDThelNVSLPEVEARVLEKE-VLIRIHCKNQNGTIIKILTHLKSLHLSTISNSVLPFGNSFL------------------------------ ----------------------------------------------------LWNIISPDCPAIGWDDMYYNGPCCKSShasvpfskqwnqrrqwrkmpEeaqRsPRSrvtqCFDEWYYEIPSHFE---KD-R-TPGKMLMTGGYEWICDGEEVNGALFSRTALCK-----TVLCLAVSGGVVEIGTTALIDQNLQLVQFVRNMFQR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REMAMdVHVEAERKRREKLNHRFYALRSVVPYVSKMDKASLLGDAVTYINELKAKIK-------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNQHFISLSALLPNLKKMDKASVLEDASNHIKQLQDRVKELEGLLGNKRKDGqecviSMKRSriinsDDEySSSeEAdsreStNPpCKSFPETEVRVSGTS-VLVRIQCQKNISSMVNTLTQMQKLGLSIISSSSMPFAKnTVLIIVVAEIKDDLCMTTKE------------- -------------------------------RLQIMLQAAAQNV--QWTYSIFWQLCPQ-QGILVWSDGYYNGAIktRKTVqpmevsaeeatlqrsqqlrelyeslsagDtnpqtrrpcaslSPEDlTESEWFYLMCVSFSFPPGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISKSLVSERTRRQKLNEKLYTLRALVPNISKMDKASIIGDAIDYVRDLKEQVKDMKLDIVKLEasKDdianglpPRfLEyKgVRQRGSNyQTkeASkPLHQILELDVTQMEEKIFQFRIHCKKTPGVVLQLARALEALDIDIVNGSLSAINDHILHILVIEVGGA-HLIGSEDLRARAL------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSKNLMAERRRRKRLNDRLSMLRSVVPKISKMDRTSILGDTIDYMKDLLERIKLLREEMEVGGSGLQSDNLlNifKElETNEVLVRN--SPKFDVERRERD-TRIEICCAAKSGLLLSTVSTLEALGLEIQQCVVSCFNDFGMQASCS------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCKNLVSERNRRKRLSQQLLALRALVPNITKMDKRSVLVDALSYLRNIHEETAKLQKELKEQQqRQPKlndlRETSpDNpSdtlgiprTTSaPVIAskPKAQIIEIDTEKIEDKRFIVKITCKGGNGVGGDVLRVMESLGFEITYTALDQIKPqHVLVTVFIRVRKQG-KMTEEKLKDCIT------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTHVLAERRRREKVNKRFAALSAILPGLKKMDKASILGDAIKYVKQLEEHLKQVEAQHSCSR--------NNS------DESIQPADIEAWAFGNN-VLIHVHCNKIKNILVRCLELLDKMPLLIVNANVLSFSDTALdLTFIAQIE---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLHAERRRRKKLNERLYLLRSVVPKISKMDRASILGDAIDYLKDLLQQINDLQRELKSPmTMETapphHFPNLglGHAPSgSGIsvkeeySVpaeGhEMASPKVEVNAKDGKAFDIHMACATQPGLLLATVKKLDELGLDIQQAVVSCFNGFSLDIFRAEQALDK-NSHPEDIKKALLQTLS-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERDRRKRLNEKLYALRAVVPKISKMDKASIVRDAIAHIEKLQEEERRLLDEISALQSavdptAvafPRMKKPRsTPPLdNggALRSAPSPPLqILQVSNIGEKTVAISIQCVKTKGAITKMCRDVESLRLKVVSANVTAVDGSIVHTMLVEISS--------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPNCENLAAEMRIRKKLNERVYTLRSLVPNISKLDRASILVEAIEYVKDLQRQVKELQDELKEDSNNDGLKNngTNETSGnGSIskqnqdwdtTNGKapQMEPQVEVAQIaGIE-FFVKVFREHEPGRLVRLMEALNSQALEVTNANVTTFKNLVSNVLRVEKDSK-VVVQADQLRDFLRE----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNRQFISMSALLPNLKKMDKASVLEDATNYIRELQDRVKELEALSDLMRKDTkdilvalkryRLSRDeeDDSSlneTNSGdhSAGvpSESSAEIEVRISGGS-VLVRIYSHKTYSLAVKVLSQMQSLGINIISSSTMPFANTiTVITIVAQMD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AHDHIIAERKRREKISQSFIALAALVPGLKKMDKASVLGDSIRYVKELKERLAVLEEESKKTKAK-KAEQLhGHGAAvfSSLceETIDGSLPQVEAREWGQQ-VLLRIHCWKEEGILVRILSEIQSLQLMLLNSSVLSFGDSILdITIIVQAGEGY------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTLDHIMAERKRRQELTQKFIALSATIPGLKKTDKSSILGEAIDYVKQLQERVTELEQRNMRG-KESMiiLKKSevcNSSETNSEDCcrASEMLPDVEARVMENE-VLIEIHCEKEDGVELKILDHLENLQLCVTASSVLPFGNSTLgITIIAQAP---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAASHVESERQRREKLNRRFCELRAAVPTVSRMDKASLLADAARYIAELRARVAQLEADADARHHAAlaRWEPASAG-GD--DAGAAVGGELYVRKVGRDAAVVRVTSGARH-APAWLMGALRSLELQVQHACVSRVHGVTTQDVLVNLPDGAAaLQDHDGLRGALLQK---- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPSKNLMAERRRRKRLNDRLSMLRSVVPKISKvscllraallllllprtdrtsrirqMDRTSILGDTIDYMKELLERIKRLQEEIGVGPEQANLLSIfKESNSNEILV--RNSPKFDVERRDDD-TRIEICCAAKPGLLLSTVSTLEALGLEIQQCVASCFNDFGMQASC-------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AHEHIIAERKRREKLSQRFIALAAVIPGLKKADKASILGDAVKYVTELEQTLKSLQDQKTKKIVESvAINKdhtlsTNnnDSSTgGSslVicsrSdekpnqNpSGDLSPEIQIRFYQKN-VPLRIHCENQKSLLLKILSEVEKIHVTVTNFNSMPFCPHFLQ----------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQCHNHIIAERQRRQTLSERFIALSALIPGLKKIDKTSVLGAAIIHMQQLKERIKILEEGNAKKQMESIvvlkqphiiLENSecNSSTCNhNLSSkfSDEQLPDIEARFSNDN-VLIKVHCEMQKGILIKIMSELEKLQLLVTTTNAMPFNGRTLdITIMTQMEEDFNMRPQD-VVQNLR------ ------------------------------------------------------------HRVLTWKDGFYNGEIktRKVtSsadltpdqlvlqrseqlrelyesllsgqcDhrarrpaaalSPEDlGDAEWYYIVCMGYAFRPGQ-G-LPGRSFASNEHVWLCNAPCADTKTFQRALLAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDTKHFATEKHRRQQLNGKFDALKNLVPNPTKADRASVVGDAIEYINELKRTVEELKILVERKRcnrgrmKKHKTEDDstldvesiytrpNGGGdhdqqayngnSTStMrSSWlqrKSKNTEVDVRIIDDE-VTIKLVQQKRINCLLLVSKVLDELQLDLHHVAGGLIGDFYSYLFNTKICEGS------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNLVSERKRRMKLNERLYALRSIVPKISKMDKASIVADAIKYVQDLQNKVKTMHDEVVALQSDNTDEdrQSDCGLADEVvddpSGcikrtAhCFRIMELDVLKIEPKVFSLRVLCRRDNGVLVQLSKAMETLNLSTVYANFSTVNDHMLNTIVVQVR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YKSKNMHAPRLYREKLSSRLLTLRALVPILGQMNKATIIEDAITYIEELQKKVEELSDQLLEMEATSeeELETKsDEIIdAAEEMKKWGIEEEVQVTHIDGNKLWIKIVFEKKRGGFTKLMEAMSSLGFELTDTSVTTSKGAMLVTSCVEGTHGE-VLEVEQTKELLLEIIR-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKNILMERDRRRKLNDKLYALRSVVPNITKaraslllaltmdtvtfllgsqMDKASIIKDAIEYIQQLQEEERQVLQEVRAMdptarvDKKPKRARSTPSFVVDGGAPpppppPVEVLELRVSEVGDRVLVVSVTCSKRRDAMARVCRAIEGLRLHVITATITSVAGCLMHTVFVEVH---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPAKNLMAERRRRKRLNDKLYLLRSIVPNISKMDRASILGDAINYVYELERKVNDLRNDLRSLSPTPTptsTPsSSdfNAGSSsvnNseppppfhsSgqIkdeitfSTpqSHNqlPTIDITVKEENGK-LNIHIYSGVLklpPTFLPSTMQALDDMDLDIQQAVINCHNGFVLDIYRAQKCNS--WVRPNDIKARLLD----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERERRKRLNDRLSMLRSIVPKISKMDRTSILGDTVDYMKDLLERINNLQEEIEVGSSNdeLKLVNIlKDLKPNEVLGRNSPKFDVERR--NME-TMIEICCTPKPNLLLSTVATLETLGLEIQHCVISCFHDFSMEASCSDSEEleQRAFIGSEEVKQALFRN---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYVKELTERIKVLEEEIGASPEDLDLLNTlkDSSTCSNeMMVRNSTKFDVE--KRGNGSTRIEICCPTNPGVLLSTVSALEVLGLEIEQCVVSCFSDFAMQASCSQ------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRRRKKLNDRLYMLRSVVPKITKMDRASILGDAIKYLKELQQDINELHNELEST----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALDHIMSERKRRQQMAEKFIALAAAIPGLKKIDKASILQEAINYVKELQERIALLEKESNNKEQ-LIVKNsqfccsSlpcDKNNNNnNIGGNEMVLPEVEARLLEKE-VLIRIHCEKRNGIMLELLAFLENNNLSLACSSFLPFGNSTLNVIII------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGKSLVAERQRRQKLNEKLYSLRSLVPYISKMDKASIVADAIHYLKDLKKRIHEVEECIAHLEAcKDQVANGlSsslkrQRVCNKhINKpiSiSHHIHKLDVKQVDRGLFQLEIHCKKSPDTLVQLVRALEALDLHIKNAITTSIGGKVLNTVMVQVDGE-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKEHIIAERKRREKLSQRFIALSAIVPGLKKMDKASVLGDTIRYLKELDEKVKVLEEQAAKRTVESSvlVKKSqlsadDDSSfCDDenFeyGQRrfGESLPEIEAKMSEKS-ILIKIHCENGKGVLVKALSEVEKCHLSVVSGSVIPFAGSSLdITIMAQIEQGFNM----------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKRRRKLARQFIELSSMIPGLKKMDKASIVDDAINYVKQLQDRVNRLEKQTKKN----SVEKTRASAGEGTSSSTEELPEIDVKVQEKN-VLIKIYCKNQKGYLSKILCEIEKLHLKIVTFSALPFADCFLDtTVSTQMGDSFCM-TIEDLKRDLRLAL--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKENEKFSVLRSMVPSMNEIDKESILNDTIKYLKELEARIEELESCMNSVEpspRRNfldRVEKTsdnyndtgnikkfsiNKRKACDIdetNSelnrqvPkFRLEPHVRVKIKEQE-VVIEMRCPYREYILLDFMETINNLYLDAHSVQSSTLNNFLTLNLKSKFRGD-AIAPVGMIKQALWRVA--- -------------------------------LLRKQLAVAVRSV--QWSYAIFWSSSSTQSGALEWGEGCYNGDLkkRKKRheahykyglqrskqlrklymcmlegdnsttirtthdiDdhsddddhNcistsmmlsPDDlSDEEWYYIVSMSYVFSPSQ-C-LPGRALA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPISHVEAERQRRDKLNRRFCELRAAVPTVSRMDKASVLADAAAYISELRDRVEQLEAEAKQAAA-VAVVALAH-------SSPGVLEKLEVRMVvGQEAAALRLTTTAARHAPARLMLALRSLDLPVLHACVCHVvGGVTVQDAVVDVPAAT-LRDERRLHHALLCRLQQ- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKRQRELTERFLALSATIPGFKKMDKTSILDKASNYVKQLQQRVRELEQEVQSNICSNSTSSCEvNSNYY-CGTNNEILPEVKVRVLQKD-VLIIIHCEKQKGIMLKILSHLENLHLSVVNSSVLRFGKSTlDITIVAQMGDGYNM-TVDELVKTL------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGGWKNEKQRRVNLNNKYKALKNLVPNPTKPDRASIVGDAINYIKELLRTVDELKLLVEKKRRCRrrsRMkhETGQDSDCPkqlynNGslrSSWlqrKSKDTEVDVRIIDDE-VTIKLSQHKKIDCLLFVSKVLDELHLDLHHVAGGHIGDLYSFLFNTKIHEGS------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFKSKNLEAERRRRHKLNDRLIALRASVPIITNLNKATIIDDAITYITGLKKHVDGLTNQLLEMEAPPppQSEDVvEKMVAQE-ADKLEIKAEVKVSLMDESKLWIEIVCENKRGQFVKVTEAIGSLCFEIINMNVTTSKGVTLITFCVKVNGE--MVLVEQVKGFLEQMM--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGIPAKNLMAERRRRKKLNDRMYMLRSIVPNISKMDRASILGDAVEYLKELQQRINDLHNELEST----------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSKNLDYERQRRKKLNANLYTLRALVPNISKMDKASIVSDAIDYVQSLQKQVKHVEEEIIALTLwghvvQKNIAKAASTLTSSIEQIDQKIVEVDVNKVEGEVYQLKILCLNGHRVIGKLTKALDTLQFDIVNANVATVNDYVLCTIFLEEKNGV-GLKPLELKDMILK----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GASKNIVSERNRRKKLNDRLLALRAVVPNISKLDKASIIKDAISYIQDLQEQEKILQAEITqlessraEKNKKSAAEMelpvllrskrTKyDQLFDhSGSRSkPIQVHQLSVSYMGEKTVFVSLKCSKQRDTMVKLCEVFESLKLKIITANITSVSGMLKKTVFIE------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMERRRRRRLNDRLYALRSVVPNITKMDKASIIKDAIEYVLQLQQLERQLLAEVALLDtaaNAhhlpagcantPSTEDGfaGHaavSVSPtkkmkrnpSFSShhsrSSSPpvdALEVRVSGAGDKVLVVSVACTHRRDAVAKVCRALDGLRLRVIAANVTAASGTVMHTALVKE----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANKNILMERDRRRKLNEKLYALRSVVPNITKMDKASIIKDAIEYIEHLQAEerrmlqeVRELEAAGfgaEERYEgyeydEgLVLEAVrtAkrmKRSAPEAaggaraAApAPVEVLELRVSEVGERVLVVSVTCGKGRDAMARVCRAVEELRLRVITASITSVAGCLMHTIFV------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASKNIVSERNRRKKLNERLYNLRAVVPNISKMDKASIIKDAINYIKELHEQERRIKSDISDLeyrRSKNGIDntcsmmdyeqelpgllikskkkRTDHRKQHyDFNGccrTSINDLEVRVSYVGERTIVVSLTCSKREGTMVKLCEMFESLKLKIITAHITAFAGRLLKTVFLEAD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STHHSLAERKRREKLSQRFAALSALIPGLKKMDKASILGDAIEHMKGLEERVKGLEERARKRSMIePVVFNVKKEE----GGDDDDFPVIRARFCDKE-LLVSVHCRRGRGVFEKIVGEVENMQFCVVNSSLMSYGDScLSITLTAEKNDEEDNMNIEKLVENLRG----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNLISERKRRKKLNESLYELRSLVPNITKLDKASIIGDAINYIKELHQEVETIELEISKKENASMvegsgrsmasdsgenaVKSGaitetGAvttvnytidSQPNhqyfgieyveNfsedIdqdqSPaaidqeqSpavvdQQKMVEINIDKGDQKSYLLRVFCQYESSILIQLMDSLESLNANFLSANCTTLEESMMNTFVIEMQEA-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTIDHIMAERKRRQELTERFIALSATIPGLNKTDKASVLRAAIDYVKQLKEKVEELEKQNRKSVAETviLVNKTDSngneDTTNPTETNCSILPEMEARVLGKE-VLIEIHCEKEYGVELKILDHLENIHLCVTGSSVLPFGNSaLCITITAQMGEEYEM----------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAKEHVIAERKRREKLSEKFIALSALLPGLKKADKITVLDDAISRVKQLQEQIRKLNEEKEARREmesmilvkKSKVlfDEEpYLSSSSSSSShAkfDQLLPEIEAKVVQKE-VLIRIHCEKRKGCMINILNTIENLHLRIENSIVLPFGDSTLdITVLAQMGKD-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARDHVVAERKRRENLSQLFIGLSKVVPGLKKLDKASVLEDAIDHLKELQERVRVLEEEMSVTNfiNTPtnDyYSSsSNEDkfteNSNSGrASSESGAAEIKARINSDnQHVLINIQCKKQKGLMSRVPRQLEKMHLSVVDMRIMPFGGQALLhiTLLAQMQSE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STTEHALAERVRREKLSKHFTALSSLVPGLTKMDKASVLGTAIKYLKKLEERAKMLEEKTTKKKMESvaFIKKS-KKI---VNGWyDEPLPEIEAKVFANN-VFIRIHCEKHKGLLVKILAEIENFQLTVVNSSIMPFGRFAV------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERNRRQKLNDQLYALRSVVPTITKLDKASIIKDAIDYIQKLQEQEKRVLLEMSEMKTEregqelvstgmdfinnvnpffnrRKKKRTmqfSGSSSDSpGSSSlspAIEIIELRVCKFGDGCVVISITCTKKRDTMIKVCEAFDSLNLKVISANFTSLSGSLLHTLFVEIDD--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDHIMAERKRREKLSQRFIALSAIVPGLKKMDKASILGDAIKYVKQLQERMKTLEECAHKPV-SVAHQKCSAS--GSVqnSDiSGYKQPDIEVRLVAKN-ALIHVHCEKRKSLLLKMLGELEKLQLMIVNASVLSFTAtSMDLTITAEVEENV-DLTADCIVKALHAFF--- ---------------------------------------------------------------------------------PEDlTETEWFYLMSASYSFPPGV-G-LPGRAFARGGHVWLSRANEVDSKAFSRAILAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISKNLVTERNRRNRIKDGLFTLRSLVPKITKMDRGAILGDAIDYIKELQEQIKGLEDETRDLGEEeddyekstTKLRrqiqKEeGrtrNPPLNElIrSCcTiktqMEVQVQVEVNQIGRREYFIKLHYEKKRGGFARLMEAIHSFGLQVVDANIHTFDGKVLSILTVEANRQ--DIDPKRLREYLT------ MVELiISPSSTSSL--------NAPAA--A--DLQYRLQSFLIARSEWWAYAIFWRASPDH-RVLSFGDGHFRGGR-KSR-GSDDsvDDGEWFYVVSLSRSFVVDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAHKLAERTRREKSNKKLDTLISIVPIITKKDKVSVLTSTIEYIGQLTSRISNLEKEEEAAagPTgAPKEattsvakfRRGKElGsFSDEIgagpSSSTTTPVVVE-GILDGETMNIKVEANNHARSLIQLLNILQELDLGIITVDYVCTNGRFRAAVCVKNSRKS-RTTPDVLQATLLRVLE-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DHAEAK-RRREKLNHHFSSLRSLLPNASNSDNseAAVLSDAVSYINELQVKMEDLESHLDVKKSNP--ED--EATSG--AKKSVMEVEVEVKIIGLDRAVVRIQTKNMSYAVARLMEALRDLELKVHHATMCNSNDITCQDLVIGLPPQ-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSQDHIIAERQRREKLSQNFIALSAIIPGLKKIDKASVLGEATKYMKQLQERVKTLEEQTVKKTVESVvvLKKSqllvDDSTSPfdENleGCSDDQLPEIEARVSEKN-ILIRIHCEKGKGILVKTLAEIEKLHLMVVNSSLVLFGSSALdITIVAQL----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKDHVISERKRRASLNQRFIALSAMLPGLQKLDKASIIGGAIKYIKQLEGHANKLEEEVGEKPEEAilSVKRfwlsGeDDASPlDdNFeyCSSNHLFPVMEVRVCDSN-VLLRIHCDKHNGCIAKVYTEMQKLRLIILNSSVMPFGQSNlAITITAQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGVNHFATERQRREYLNEKYQTLRSLVPNPTKADRASIVADAIEYVKELKRTVQELQLLVQEKRraagdssggKRRRLSldDAdnyaGSctteNASNGhlvmqkgndTfsrdgsqlrSSWlqrtSQNGTHVDVRIVHDE-VTIKVNQRrGKNCLVFDVIAVLQELQLDLLQASGATIGEH-------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GETLDHIMTERKRRRELTERFIALSATIPGLKKIDKATILCEAITYVKRLKERVRELEEQCKRTRVESvSFVhqrSnvicSdDKGTTSGAtkSDecykTNEALPTVEARVFKKD-VLIRIHCKIQNGILIKILDYLNTLDLSTTSNSVMPFGSSTL------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGISHVEAERQRREKLNRRFCDLRAAVATVSRMDKASLLADAAAYIAELRGRVEQLEAEAKQQVAARKLGG-NPAMCP---ASGGFEEKLEVRMVGRHGAAVRLTTASTRHAPALLMGALRSLDLPVQNACVSRVGGSA------------------------------- --------------------------------------------------SFFWEL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKGAEsRGINHFATERQRREYLNEKYQTLRSLVPNPSKPDRASIVADAIDYVKELKRTVQELQLLVEEKRRGsnKRCKASpddpsctDmESTTamqqpggTrvsketTfpgDnsqlrSSWiqrTSqMGTHIDVRIVDDE-VNIKLTQrRRRNYVLLFVSRSLDELRLDLNHANGASIGEHHIFMFNTKV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMKELLERIGKLQEEeVEEGSSQINLLGIsrDQLKPNE--AIVRNSPKFDVERRDQD-TRISICCATKPGLLLSTVNTLEALGLEIQQCVVSSFNDFSVEASCS------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERRRRKKLNDRLYMlLRSVVPNISKMDRASILGDAIEYLKELLQRISELRNELEST----------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLNQDHILAERKRRENISEQLFTLSMIIPGLKKRDKLSILMHTIDYLKQMEEKVKTLEEQASKETVEPSVSTTkSQlSVASdegeeSVPSAHSTLPEIEAKISATA-VFIRIHCKNRRGVTLKVLGEIEKLHLSVINSSSLPFSDHFLdINVTAQVEEGFAMT---------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSQDHVLAERKRREKLSQLFVTLSTTIPGHKKSDKHTLLGNTVDYIKELKSKVKILEEVIETPVESAvLVEKSslmNNGESslSSNgSlSREKPPLKIEAKINGKS-VMIKVQCENHKGLVVKALLEIEKLPMTITNTSIMPFGDSSLDiVIMAEVEDGVSMK---------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPSKNLMAERRRRKRLNDRLSMLRSVVPKISKMDRTAILADTIDYMKELLEKLKDLQADADADVDPN---QANDLLGLGMMQFNSSNILFEVERRDAD-TRIGICCGMKPGLLVSTLSTMEALGLEVEQCVVSCFSDFGMRASCSDHDNGnRERFSSEDIKQELFRA---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YKSKNLHAERRRRQKLSDRLLELRSL------MNKATIITDAITYIQELQKCVQDLSEQLLEMEATSEEEgKTkIDEIdAAEEMKKWGIEPEVQVTHIDGTKLWIKIVYEKKRGGFTKLMEAMSVLGFELTDTSVTTSKGAFLISSCVE------------------------ -------------------------------TLQHRLQALIEGARENWTYAIFWKSTTNDfpggpGPVLGWGDGYYKGEEdkgkRKTAstlaeeqahrkivlrelnslisgaypsENdaVDEevTDTEWFFLVSMTQSWKHR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSIPILDQMDKASVLGDAIRYLKYLQERVKTLEEQAANQTRESTvvVKKSqlvvDDEGSS--SDEEQSLPEIEARVCNKN-VLLRIHCEKHKGLLVKILSEVEKLNLAVVNTSVAPFGSLALDiTIIAEMEKEFS-LTVKEIVQALRSVL--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENLMVERRRRKKLNDRLYMLRSVVPKISKMDRASILGnaiDAIDYLKELLQRIIDLHNELQSMPSGSS------PPST--AN-FHPL--L---TTPPP-VNIHMFCARRPSLVLSTMRALDGLGLDIQQAIISYLNGFALDVFQA------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPQSNFEAEMKRRNKINDIFHILRTLLPNNTGMDRASVIGDTIAYVSKLQRQVKELQKELECNSNGGGKETSyicgNNGNlQSeflrqmeTIiAnTPenEKMEPQVEVTELDVNEFSVTVLCEHKPGGFVRLMEALDTLGLEVTYANVTNFKTLIFNVFKVQKNDStSKIVQADHVKDSLLEI---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESHILAERQRREEMNDKFSSLRAMLPKSSKKDKASIVGDTINYVVDLEKTLKRLQACRAKRKGCHiPKEKSlKSSpSSDPkleASKtdTvQRLPVQVEVQALGEQ-AVVKLVCGKSPKLVLRILTALEQCKVEVLQSNVTTLGDIAVHFFTIELTPGV-SATTEELIAALEA----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASLLGDAIAYITELQDKLRGMESEKEMTGGPA--------------RAQAQNPAVDVQAMQDD-VVVRVSCPLDAHPVSKVIHAFREAQMSVVESDVSVADDSVLHTFVVRSAG-PERLTKETVIAAISRGMN-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKRKTRKKLIRQYKELSAILPSCSkKRDKASIMEDALAYLKQLQERVNTLEEETNNTSA---------VFGP-QTCEEAAIVKIDAIAEGKN-VLIRIECVKQKGCITKIVTEIEKLHLTIGSFNSLPFGNNLlAITISAQMDDEFCMTTNDlltNLRRCICEKM--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQARDHIMAERRRREKLSQRFIALSTIVPGLKKTDKASVLGGTIKYLKHLQDRVRFLEEQASQRTIESVVY-LNKSGL-SVADTeleCIALPEIEARSSGIN-VLVRVHCERRKGVVEITMAEIEKLKLTVINSSVITFGSSSLHlTIISQV----------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRNVMSERSRRHKLNEKLYSLRALVPNISKMDKASIVADAIDYVKDLQRQCLAAKNNLlqlAEVRDRRRRGPSRLTSSNcPTTSARYQVMKLSVSQLEARTYHVELDCKGSQDVLIKLTKAIEALGGDILGSNISTFNDRLLSTSVIQVKDDN-LIGQQEMRNK-------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDHLNSLRSLMPPsyIQRGDQASIIGGAIDFVKELEQLLQSLEAQKRMRKTEEGSTSIGissNSlfTSPEssVsseegNCeeevkaeNKSEAAEIEVTVIQNH-VNLKIQCPRRQGQLLKAIVALEDLRLTVLHLNITSSQASVLYSFNLKIEDDCKLGSADEIAAAVHQIF--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNQDHIMAERKRREKLSQRFIALSKIVPGLKKMDKASVLSDAIKYVKQLQDQVKGLEDEARK------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------MDMEWFFLMSMMQSFDNGV-W-LPSQAFYNSTPIWISGADQMSASPCEWARQGRVFGLQTMVCIPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSIVATERRRRRRLNDRLYALRSVVPNITKMDKASILRDAIEYILQLQQLERQLLDELGLLEAgagahhllvgTpmPsagAAEDDDDraghaavsptrrmkrnpSLSTPApSSRhcpSSppvDALQVRVSGAGDKVLVVSVACRHRRDAVAKLCRALEGLRLRVIAANVTAASGTVTHTALVQ------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKRKRREKLSQRFIALLAIVPGLKKMDKASVLGDAIKYLKQLQERVKILEEQTVKKRVESVvlVKRSqisadNDNSSSdENnlGGGrsddEAALSEIEARVSDKD-VLIRVHCEKQKGT---------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNISSERRRRLKLNEKLYCLRALVPSISKMDKASILADAVQYVRELKQKVDNMEEEIASLEEyKMKIVRTpqrhhaamDGSrKrYAQFSTkSrnlaHHIVHELDVEKMNDALFYIQIHCMKSSGVLLQLARAIEALDVKIVNASSMSKNDHLINTLMIEVH---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRFYALRATVPNVSKMDKASLLGDAEEIAGR--NAISS-------------VRR-GGG-----NAPEIETANIDVKILGCD-AMVRLESSKRNHPAARLMSAFMDLDLELNHASISVIHDLMIQQATVKMGSR--MYTQEQLRDMLVSKI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSKNLMAERRRRKRLNDRLSMLRSVVPKISKMDRTSILGDTIDYMKELLERIRRLQEEMD------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQHIVVERKRRREINQRFLALSKVVPGNKKKDRASILGEAVKYMKDLQERIKKLEEKNKKKVVESVvfVKRSSSSscpsSGNnqyycnpsyeepnrNddsLSNRnkrrwsllAEEEIIIEAKVIERS-LLIRVHCGNHNAILPTLLAAISEFHLIVLTANAIPFGKHIDITVIAQMGVNFYMKTKdivDRLRVAL------- ------------------------------------------------------------------------------------------YLILTHVSFLLFF-R-LPGKAFADNQHIWLNGSQFANCKMFSRSLLAKSASIQTVVCIPIMDGVLELGTTDLVS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNEKQRRERLGKKFEDLKSLIPNPTKPDRASIVADTIDYIKELLRTVDELKILVEKKRSKRarsiKLEIDDeahgDmeSSSIkSvidesdhpLngslrSSWiqrRSKETFVDVRIIDDE-VNIKLTQRKRPNCLLIVAKVLDELQLELLHLSGGNVGDSHIFMLNTKIHEGS------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQAQDHIIAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKQLQHKVKALEEEQ-------------------------------------------------------------------------------------------------------------- -------------------------------RLRNILQTAVQSV--QWTYSIFWQICPQ-QGILVWSDGYYNGAIktRKTVqpmevtseeaslqrsqqlrelyDslsagemnqpirrpcaalSPEDlTESEWFYLMCVSFSFPPGV-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSKNLLSERKRRQKLNEKLYSLRALVPKITKMDKASIMADAIGYVEELKSQVSAMRREISAIEEDhrsPNssLTTASPaSPSPSLeddhhSGDrrdhKLASLQIDVEKLDEcnRMCLVRFRCC--PTVLADIVGALESLDLEVLGASVNTFQGQIFTTCMAKVRDE-------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPRRFQMDKISILGEAINYVKQLQERVKELEQQNKSNTCSS-TCKIK-SNASNNGTSSNSLPEVKARVLDKE-VLIIIHCEKQNGVVLKILSELENLHLSITNSSVLPFGKSnLNITIVAQMGDGYSI-TVDDLVKNLQE----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKNVVSERNRRKQLKDRIHGLRAIVPNISKMDKASTIKDAIDYIKELQEEERRIKEDIAKLelRKQNnNnessswcstivLEQElstlltNKSNNDhdkrcydSNNSGcRsflVEDLKVGVSYAGGRTIIVSLSCSNRNGIMVKLCELFECLKLKVITANITVVGGRILKTIYVEV----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPKNIMAERERRKKFNKTLYDLRSVVPNITKMSKASIILDAINYIQELQEQemslvaeISELESQKQITAPPHGIKDEDllHAhMQrRRVaSMSPIEAMEVSVSEMGNGISLVSITCNKKRNATGMVLEVIESLDLRIITANITSSFGKVFHSLVIQVS---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQEHVIAERKRREKLQQQFVALATIVPGLKKTDKISLLGSTIDYVKQLEEKVKALEEGSRRTAEpttafesKCRItvDDDDGGSASSgtdDGSSSSSSPTVEASIHGNT-VLLKICCKERRGLLVMILSELEKQGLSIINTSVVPFTDSCLnITITAKA----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMDKASVLGEAIKYMKQLQERVKELEEQNRKKSEESVvfVKKSqlcdNDDmsSsSINSgDGyRcDEPLPEVEARVLEKE-VLIRIHCEKQKGIIEKIMSLLENLHLSVISSSVLPFGNSTLdITIIAQMDMEFCMTVKgivKNLRSASLS----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGDPARNLLAERRRREKLNERLLALRSLVPNITKMDRASILGDAIAYLKDLSEKINKLELELNP------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADEICGNHVLSERKRREKLNQQFMILKSLVPSNNKclssvallnslaffmnADKVSILNDTIKYLQDLERRVEELVTCSElmeleTRTKrQPrdGVERTSDNyGSNkNIANRKkkymnkRKASDIGEAS-KDNVVVIQFRCPWRDG-----LDALSNLNLDCHSVQSSTTLTSLTH-YKIQRS-N--VASARRIKEALKGLF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASRNTVSERNRRKKLNDKLYALREAVPRISKLDKASIIKDAIDYIQDLQEQETRLQAEimeleseRSEKDKGFEFERElpvlltSKKTrYDHISDhrvPrsdPIEVHQLRVSSMGEKTLFVSLTCSQAREAMVKICEVFESLKLKIITASVTTVSGMVKKTLLIEAD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMDKATILEDASKYIKELQERVKELENAKGKNViqesvvlvKRSKFSNGDDDnagSSSDTnsgSSFTKPTPEIEARISENS-VMVRIHCQKNKGVLVKALTEMEKLGLSIISSSVMPFSTATLITIIAQTSDEFS-ITARYLVKCLLSSL--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSKNIAMERDRRKRLNEKLFALRAVVPKITKMDKASIVRDAIAHIEKLQEEERQLLDEISVLQSaaavaatavEdvddsgvtmpsmKKLRSTpplDGGggalrvaSSPPlqileVetketedfyglilqtSQSWPSDPQLQVSKVGEKTVAVSIRCAKTRGAMAKVCHAVESLHLKVVSASVAAVDGTIVHTMFVETEQ---MSGAQEMKQRIQSS---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTQEHVIAERKRREKMQQQFVALATIVPDLTKTDKISLLGSTIEYVKQLEEKVKTLERQNMRRTSEPTvFESkCristDSSDASSSreSTfGaGRFSPTVEASIHGDT-ILLKICCKERRGVLVTLISELENQGLSIINTSVLPFTDSCLnITITAKIGEGF------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKTIVSERKRRVRMKEKLYELRSLVPNITKMDKASIIADAVVYVKNLQAHARKLKEEVAALEarpRSPaAgqqQQQHGRRAaaagrrrgqDaDGsRrsaGsAGhGARVTHVGAAQVGEGRFFVTVECERRDGVAAPLCAAVESLaCFRVESSSLGrSGPDRVVSTLTLKVSE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FAKEHVIAERKRREKLSEKFIALSALLPGLKKADKITVLDDAISRLKQLQEQIRKLKEEKEATRHmESMilVNKSkvflDEGtflSSSSSSSDheqfDQPLPEIEAKVAQNE-VLIRIHCEKSKGSMIDILNTIENFQLRVENSIVLPFGESIL------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSRNLFSERKRRKKMNDGLYSLRSIVPNISKMDKASIIGDAIKYVMELERQVKELEGEMELdeQRK-NKINSSsdtlgslaatgvqhgGDAAAqNDkdVdwnkNSgGnvskldtkDQPNVTLELSKMKTGMYNLRMFYQQQPGIFMHMTQAIESLDLNILNSHVSTCDGYVVHSMIAK------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTSKNLMAERRRRKRLNDRLSMLRSIMPKITKMDRTSILGDTIDYVNELTERIKTLEEEIGATPEELnllnnsyrvsvmNMDRTsilgdtidyvNElteriktleeeiGATPedlnllnTtknLSSGssEEmpmrnsTKFVIE-KQGDGE-TRIDICCATSPGVLISTVSALEGLGLEIEQCVVSCFGDFAMQASCSQEEGRSQVTSTDEIKQALFT----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LMDRASILGDAIEYVKELQKQVKELQDELEDNHdhdKPPDVlidhplvglDNDDASPpnshQqqdplapSGSrskkTnlgSDKGhqMEPQVEVRQVQGNEFFLKVFCEHKPGGFVRLMEAMNSLGLEVTNVNVTTYRTLVLNVFKVEKRDN-EMVQAERVRDSLLEVT--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRRERELTEKLLALSATIPGLKKMmDNTSILDKASNYVKQLQERVRELEQEVGSQSCKNN-E---TSSCIEVnsdyygePNDNIILPEVKVRVLHKE-VLIIIHCEKQKSIMLKILSHLENLHLSMVNNSVLPFGKSTlDITIIAQMGDGYNMTTDE-LVKSL------- -------------------------------ALQQKLQLLVESSTVNWTYAIFWQLSNSSsgEMMLGWGDGYFKVPKEsEVNdlkhlergdreedqqlrrkvlrelqalvcsteDDaaasagLDYvTDTEWFYLVSMSCFFGHGV-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQAHEHLLAERKRRKKISKLFVSLASLIPGLNKMDKASILEGAATLIRQLGERAKTMDHHQST------IDM---------MKKNSLLPEVEIKSLEKE-LLITILLYKnqQKGNIDEILSVIQRLHLTIKTTNFMPFGTTsMHITVIAQMNDEFCETTdflAEKLRSSIIKVL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDHLNALRSLMPPsyIQRGDQASIIGGAIDFVKELEQLLQSLEAQKRMRKSEESGGSSSSSfmsspsnSIsSSsqyrsGSeegNcgeevkaeNKSEAADIEVTVIQTH-VNLKIQCPRRPGQLLKAIVALEDLRLTVLHLNITSSQASVLYSFNLKIEDDCKLGSADEIAAAVHQIFS-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHQHVIAERKRREKLTQKLIALSAIIPGLKRRDKVSILTAAISYMKQMEQKLKSLEERVPSANS--------QQLSC--SSGeETVPAEIEVRVSGSKTFLIKIQCETRKGALVKAITEIESLHLHAITTSAFPFSNRFLhITVMAQVEEGF------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPKNIMAERERRKKFNKTLYDLRSVVPNITKMNKTSVILDAINYIQELQEQERSLVEEISELESPKQitapphgIKDEDllHAQMQrrrAASMSPIEAMEVSVAEMGNGISLVSITCNKKWNAIVMVLELIESLDLRIITANITSSFGKVFLSLVIQAD---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRSKTLVSERKRRGRMKEKLYSLRALVPNITKMDKASIVGDAVLYVQDLQMQTKKLKAEIANLESSTtKTnntnnERNDQrSKyeGSTIflggkstnfTNqlPiLKKIIKMDVFQVEERGFYVRIVSSKGKGVAVSLYKAVESLaTFNISSSNLATASHNYIFTFTLNVREG-------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNKEGRSRNLVFERKRRKRLNQQLMTLRSLVPNITKMDKRSILIDALAYLQNVlQETEKEMEKLNLPSS--SSFSSSsGEESCSTIvedeapplmthTQeydryAsLPTISKMEAYMLEEERFILKICCNKAVGAVGLVQRAIEMLGLQVTCASIDELDHaHMLTTTFLRVKKKG-GFTQEKL----------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERRRRKRLNDRLSMLRSVVPKISKMDRTSILGDTIDYMKELLERINKLQEEIDV------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAKDHTIAERRRREKINQRLMELSTLIPGIKKMNKATIIGDALKHVRELQEKVKILENNNRHAATttiSStvFVHK-NRPflsgLTSNyrdDDAGepshlGTWLPEIKVRLSDKI-VLVQIHCENTNGLLVRVLGEVEVLRLAITHTSSMPFlADTTIINITAKA----------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRRLSCKNLMAERKRRKKLNDRLYALRALVPKISKMDRASILGDAIEFVMDLQNQVKKLQDQLEE------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHNMAERKRRLELSQRLIALSAIIPGLNKIDKGSILKEAVSYVKQLQIRVNELEEEQRAND--LHMDKDiAPNyKMNPDDCHklNVALPEVKARVMEKE-VFIRIHCEKNYGVLLKTLSHIKSLHLSIVSHSVLPFGKFS------------------------------- ---------------------------------------------------------------------------------LDRvTGAEMYFLASMYFSFPEGS-G-GPGRTLASGRHAWAEVDPHPSgsasaPGWYVRSSLAQSAGLRTIVFLPCKGGVLELGSVVAIRETPEILRAVQSALRAE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------LPGKAFADNQHIWLNGSQFANCKMFSRSLLAKSASIQTVVCIPIMDGVLELGTTDLILEDPAIIEKITRSLWELP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSSKNLDYERQRRRKINENLYALRSLVPKISKMDKASVVSDAISYVQSLQRQVEEVNKEVQALKSWeNIINKNVLSTAPTLTStmkRvQHKILEVNVIEVEKAIYQLEIICSDGQGVIANLTKAIEMLGINILNAKLTKIDDHILNTIFVEASDGL-RIEPKEFKDMLLR----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETLDHIMTERKRRRELTERFIALSATIPGLKKIDKATILCEAITYVKRLKERVRELEEQCKRTRVESvsFVHQrSnvicsdDKGTTSGAtkSDecykTNEALPTVEARVFKKD-VLIRIHCKIQNGILIKILDYLNTLDLSTTSNSVMPFGSSTLdISIVAQMGEKFNAtmNDlVKNLRVVLLQ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRDHLVAERRRRQKMTQHLISLAALLPHLKRMDKSSILGEAVEYVKQLQERVEVLEADNARNVEESSlveFEEDNISCCGDnneeIhRSKQGQLPEIEARLCNEN-VVVRIQCERQVAILVKILSALEKLRLSIITVHAFPFGE--------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQPQDHIIAERKRREKLSQRFIALSALVPGLQKTDKASVLGDAIKYLKQLPEKVKALEEE--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKTGSRNLISERRRRRNLNDKLFSLRALVPNISKLDKASIVADAIEYVRDLQRQVEEVSGEVSQLvaTKEV-AQQTndglykNTSTSTntntDINsiglNpclkcpsqSyQYTIVKIGVTFMEGKMYHAQLQCKKGHGVLVKLTQAIEALEVDIISANFSVVNDHILNTLMIEVKEDR------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKDHILAERKRGEKLNEHFMAHSKITPKLKKMNKASLLSDTIKYVKHLQEHVKRLEEQARKPRVQVavLVKKSqlSpraDGSSRDeCVEGlQAMLPEIKVRVSECT-VLIKIQCANSKGALINALSLVESIGFTIITTNVLPFTTSQEITITAMVSEDF-FLSCHEILRK-------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTRNMDMERTRRRKLNERLYALRSVVPNITKMDKASIVRDAIAHIEHLQEQERRLLAEISVLQSSddgtaaaaaVKTEDAaatGgaaydvdsvpwrkKPravplpsvyftdnPTSSISSSpPVRILEVQVSQAGERVAVVSLWCSRGRDAVGKICLALEPLRLRVVTATITARGDTVFHTLFVEV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAQDHIMAERKRREKTNQRFIELSAVIPGLKKMDKGTILTNATSYVKELQEKVKSLEEAGRNHrSVETMvlVrEPSRHAaqNCDegSrLfyatdrTPArSQLLPEIEAKLSGNK-VMLSIHCEInGKGLVARVLVELEELHLCIVHNNVMPFTEStVIITTMAKVEEGF-TINAEEIVGRL------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIVEERVRRRRLNEKLYAIRGVVPNITKMDKASIIQDAVAYIEELQEQErrilaevSDLEAGGCTAVVKSaastgseGVEDAgvgfsprkkmrrTASSSSSIndvvTSPatHPVLLELEVIPIAEKLAVVSMRHDNAQHVMAKIYKALDSLRLKVINSSVTVVDGRTVHTMFIETEE--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLIMERMRRSRMKEKLYALRSLVPNITKMDKASIVGDAVLYVQDLQTQAKKLKAEIAGLEASLNgseRYQGiheNPNKTQVAkSNpSiSKKIIQMDMFQVEEKGFYVKLVCNKGEGVAASLYKALESLsSFQVQSSNLATVSDTFVLTFTLNVRE--------------------- ------------------------------------------------------------------------------------SDLEMYYLTSMYYLFPFDK-PSSPSQSFNTSRSVWVSDSRSCEEHYQSRAFLAKLARFQTLVLVPVKRGVLELGSFKSILEEQSLVAMVKTLFNGC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------GVWRWKCQVLEGS--KWNYAIFWQVAGLKysGSALIWGDSQCCDPKggEAgegGSegnwsgvskgdeeelqkkvlqklDayfacyvskeaNyarLDRvSELHMFYLASKYYIWGFDS-PCGPGGSFK----------------FESRSFLGRSVGLQTVVFVPLKVGVVEFGSVETMPEDQGVLDLVKIAFYA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVSHVEAERQRRDKLNRRFCDLRAAVPTVSRMDKASLLADAAAYIAELRARVARLEDESKQAAAA-RWDTRSASLGGGGGSiQhfPAGDETLEVRMMGRDAAAVRVTT---------------------------------------------------------------- ---------------------------------------------------------------------------------LNGvSDLEMFYITSMYFTFRCDS-SRGLGESYTSGKSIWASDLPSCLRHYQQRSFLARSAGFQTVVFVPVKSGVVEFGSTKSIPEEQNTVDMVKKIFGES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAHEHVIAERKRREKLQRQFVSLATIVPaGVRKADKISLLGSAIDYVKQLEEKVKALGEQGLLKSPEctlfeSKcsISAAdkDDSAgpSGSGSsSGDSSPVDVEASTRGNT-VLLKICCKERRGVLVMVLSELENQGLSIITTNVLPFTDSCLnITITAKAS---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRNMAMERTRRRKLNERLYALRSVVPNITKMDKASIVRDAIAHIEHLQEQERRLLAEISVLQSSddgaaaaasVKTEDAaatGGaaydvdSvpwrkKPravplPSvyftdnltssISSSpPVRILEVQVSQAGERVAVVSLWCSRGRNAVGKICLALEPLRLRVVTATIAASGDTVFHTLFVEVI---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQYHAITKRRRRDKLNQRFIALAKVIPCFDKMDKTSVLEEAIKYVKQLEERVKDLEEQAKPRMVESAmlVKRTRET-VD-LESKKIAFPEIEAKVSNKD-VLVRIYCKKQYGLLllERILKEMDKVHLSINGTGLLSFGNH-------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQERVLAERKRREKLAQRFMSLSSLLPDLKKTDKATVLEDAANYIKELQNRVKELEGIKKKSMQESvitgkrsRLSSSDDNvSCSNEAnleeSSKPLNPEIQVSMSGCS-LLVEIYCWRNNISLLKVLNELKKLGLSIISCSTVPFSDTtLLVTIVAQMNEDF------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RENHILAERQRREEMNEKFTALKALLPKSTKKDKASIVGETINYVLELEKKLKELQSTANSKTshrhKRRALPAeTNpeRriATSSNADQGenlSVKPADIELQSIGGQ-AIIKMVCMRSPGLALRILATLESCQAQVIQSNIATLGSHAILFFTVELSSS--NTSTEELIATL------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNKNFITLSNVLPKLTKMDKASMLEDASNYIKELEGRVKELEGTLENNKRENvdqesviSVKRYRPSSSNDdlrdepAtsgeSTApCKTTPEIKACRLGNT-LTVSIQCQINHSSFVKALTQMQKLGLSIISSSSMPFAKtHLLITIVAQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRLMNEHLAALRSLMPPsfVQRGDQASIVGGAIDFIKELEQMLQSLQAEKRMRSSPSSGEDSwspsaatvssffvspqYQdTTGSSTsystslpredeEGagDKTSVADVEVTVVQGH-VNLKVLGRRRPGQLVRAIAAMEELRLTVLHLNITSLDASVLYSLNLKMEEDCKLGSADEIASAVHQIFS-- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAKNLMAERRCQKKLRDRLYMLQSVVPKISKMDRASILGDAIEYLKELLQRINDLRTELES------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TREFKSKNLETERRRREKLSSRLLMLRAIVPIITNMNKATIIEDAITYIEKLQDKVQSLSQELHQMETTS--EETGNTKTDEIdaaqdMKDLGIQEEVRVAQIDGNKLWVKIIIEKRKGRFRKLMEALNNFSIELIDTNLTTTKGAFLISSCIQMNRG-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSKNLDYERQRRRKINANIYALRSLVPKISKMDKASVVSDAIAYVQSLQKQVGEVKKEIQALKSWENISNKNVSSrAPTLTSTmkqvQHKILEVNVIEVEKAIYQLEIICSNGQGVIENLTKAIEMLGINILNAKIIKINDHILNTIFVEAIDGL-GIEPRELKDMLLR----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQDHILAERKRRQKLSSHIAALSAVVPDLKKLDKASVLGGAVKHIKQLDKRVKFFEKEEKKRNQleEllaSAMKKprPnNdNSSSSaeNVSnnSScdhhSSSSVEVQVTSSGGD-MLIKIECKNHEGILLGFSSLMKRIHLNITSSSFMQFGHgMLFIGAVAQVDEKFC-VTAeflaNSIRQALLKL---- ------------------------------------------------------------------------------------SGTIWFVCLSSS--TLV---K-VECIAFANGEPIWLCNAHTADSKVFSRSLLAKSAAVKTVVCFPFLGGVVEIGTTEHITEDMNVIQCVKTSFLEAP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSGREERLNHAEVERQRRAKLNQQFNALRAVVPNISKKDKVSLLGDAIAHITDMQKKIRTWK----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RENHILAERQRREEMNEKFSALRAMIPKATKKDKASIVGDTIAYVLELEKTLKQLKACKDSRkgfsfkllKKKSssKVlEDNdrstsDtapdtaapeemkpgPGCSNStrfedivlkeckereeptISSsdnisrdcshNhhknmsIpnaldidiSSSSQVEVQNLGEQ-AVIKIVCARSRGLVLRIIQALEECKTEILQSNVTTVSQHSVHFITVQINSGL-SCSIEQMVQALLKA---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSQYHAIAERRRRDKLSQRFIALAKVIPCFEKKDKRSVLEEAIKYVKQLQERVKDLEEKAKPQNVESAmlVKRKHKNK-E---TVDLQFPEIEAKVSNKD-VLLRIYCKNQHGLLETILNEMEKVNLSINGTSFLSFGNHdMDITTIAKMNENF-GITAKELVQKL------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNIVSKRNRRKKLNERLFALRVVVPNISKMDKASIIKDVIDYIQELHDQESRIQAE--------------------------------------------------------------------------------------------------------------- -------------------------------ILHEHLKNLIEGSPIRWTYAILWRCYTSPKLSLRFREGYHRGTGtvKEVrilgScvSAAEEvtdAESEWFFKISKGQTFAFHE-D-LLGHAFLSYDPVWITAADTDDS-SWKRVTWGHQFGIQTFLCLPLReAGVLELASTEIIPRNLEAIEDMV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFKSKNLEAERKRRRKLSDRLLELRSLVPNITNMNKATIITDAIDYIEELQNTVRDLSDQLCQMDItlKEDLESQNKYVTDPAkeMKNWGIETEVKVTRLNGAKLWIQVVFQKKIGGFTKLMEAISVIGYDPKDVSVTTVKGALCVTSCVEF----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHLVAEKKRRENLRQLFIGLSKVVPGIKKLDKASLLEDAINHLKSLQERVRVLEEEQIKN----------GSNAT---AQLSSAPEIKVRIWNKQ-VLIKICCENRTGIMSKIPCEIEKINFNVMDMRFMVFGGATLY----------------------------- -------------------------------ALQQKLQLLVESSTVNWTYAIFWQLSNSSsgEMMLGWGDGYFKVPKEsEVNdlkhlergdreedqqlrrkvlrelqalvcsteDDaaasagLDYvTDTEWFYLVSMSCFFGHGV-G-MLG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EASKNILSERNRRKKLNDRLLALRAVVPNITKMDKASIIKDAIEYIQELRSEENRIETEI-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNLHTERKRRKKLNDTLYTLRSVVPKISKMDKQSIIGDAISYVLDLQKTIREIEGEIEGLCSSNKgdhtqrTPQTmNPLTnANcalgkrSIeSGdkkksvDklkHGKVLQVEICNAGEGgIYHVRIEGKKETGGLVKLTRALESLPLQIMNSNICCFDEAIHYSLTVNVK---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAFKNMHSERKRRKKLNDALYTLRSVVPKISKMDKQSIIGDAISHVLDLQTKIQEIQGEIEGLCSSNKgedhtqispdmmkpnLEKRfTESGdAkKSVDNfKHGKVLegkIVEICNEGKDGiYHVRIECKKDVGVLVDLMRALESFPLEIVNSNVCCFHESIHCTLYVCSPQN---VEADKLEDMIRQIM--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTNHVLAERRRREKVNERFSTLRSLIPSVSKVDKISILD---------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHEHVVAERLRRQRLNKLFIGLSATIPGLKKLDKASILKDAIEYIKRLEEQSKALEEEAGKQLGKPKHPnRIDTS--D-Y-HSSALISDIQARFCEGE-ILIKIHCKQPKQVTHKLLGELEKLHLTIINCSVIPFDESHDITIIAQVL---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASVLGDALKYVKQLMENLKTLEEQATKKTVESvvLVKRSqvsdDEdSSSSDhNHdScSDQLLPEIEARVSGKD-VLIRIHCEKSKGCLVNILNEIEKLHLTIVNSSVLPFGNsTLHITIVAQMEKEFCM----------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKNLDAERRRRNKLNGKLLALRALVPNITKaitlhevvlqMSKESTLTDAISYIKQLQQQVLELQIELSKIPDEDGEKQ-GSASSTETMAPlETiqLQEKVELNPIGKTKYHLEMIYKNITGTFTRLLEALHRMGAEVTTVSSVAFSDFSETVFCLEVKD--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIQYHIMSERKRRHEMAERFIELSSIIPGLKKIDKASVLGEAINHVKQLKQRISMLEQQSYEK--K-------------------MLHEVEAICIesEKE-LLIRIHCEKLNGILLKLLALLESMDLSVSTSNMLPIGNNTLhITIIAKMGKE-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPNDHILAERKRREKLSHRL------------MDKASVLGDAIEYMKQLQEKVKALEEKKTT-----VV------------LSGDPLPEIEARICDKD-VLISIHCEKRKGILEKTV----------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETADHIMSERNRRQELSRKFIALSATIPGLKKTEKAHVLEEAIKYMKELEERVKVLEEDGEISITRSHV-------C---GCGHETLPEVEARVFGKQ-VLIKIHCVTQCGVLIQIFSQLQLLHLSISSSNVLPFGNTLDITIIAHMGH--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATPNRVMAERKRREQLSQRFISLASLIPGLKKMDKASILQDAMKYTEELNEKIKSLECCLKKEEEEEEMSDEN-RLA-VVHHQPNNYMEMRFKESNKN-ILIRIYCQNGkevDDIASKMLSYLKTIQLTILNTCFLPFGQHAF------------------------------ ------------------------------------------------------------------------------------TDREWFFFISMTHSFINGN-G-LVGQTMLSNEAIWICGREGLLVSNCDYARQGESFGLQKMVCIPSTNGVVEFGSTELIRWSWNIIKEIGVLFNSP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHIVAERKRREKLNQRFIELSAAIPGLKKMDKASILEDAVKYVKELSEKVKTLEDQS-------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERQRKKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLRELLQWINDLYNELEST----------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPXKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELEAT----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSVVPKISKMDRTSILGDTIDYMKELREKINNLQEEME------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTDKASVLGDAIKYLKQLQEKVRALEEEQNMKKNvESvvIVKKSqlsNDVNNSSLeSHsqFDEALPEIEARFCERN-VLIRIHCEKSKGVVEKTIQEIEKLHLTVTNSSAMIFGNCSLdITIIAQMDMEFCMT-VKDLVRNL------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STHHSLAEKKRREKLSQRFVALSALIPGLKKMDKASILGDAIEHMKGLEERVKGLEERARKRR---RIEPVvfNVKKEE--GGDDDDFPVIRARFCDKE-LLVSVHCRRGRGVFEKIVGEVENMQFCVVNSSLMSYGDSCLsITLTAEV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASERNRRKKLDDKLFALREAVPKISKLDKASIIKDAIDYIQDLQEEETRLQAEIMGLeserlEKERgyEFERErpallrsKKTKYDQISDhrapisDPIEVHQLRVLSVGEKTLFVSLICSKAKEAMIRICEVFESLQLKIITASVTTFSGMVKKTVLIEADG--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHILAERKRREKLSQRFIALSALVPGLKKilklMDKASVLGDAIKYMKQLQEKVKALEEKAK------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPDFANERQRREWMNVAFWALRILLPDPTKDDRVSIVEDAIEYIKELNRTVKELKILVEQKRhgtnrkKMIKMEDeaTsDmENSSTkPvrdeqdneldgaIrSSwvqRKSKEARVDVHIVENA-INIKLTQRKKANSLLHAAKVLDELHLELLSVVGQIVGDHRIFIFNTKVSEGS------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPTKNLMAERRQRKKLNDRLYMLRSVVPKINKMDRASILGDAIEYLKELLQRIMXLNXQ--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlTESEWFYLMCISFSFPPGV-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIEYHIISERKRRQDIAEKFIALSATIPGLKKIDKASILGEAIKYMRQLQQRIAVLEKGSNSNSVKSFmIAKSHLCSAScEAKSSVEMLPEVEASGLENE-VLIRIYCEKRKDMMLNLMTLLKHVHLSVTSSSVLPFGNSLLNIIIV------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMKNLMAERWRRKMLNDRLYMLRSIVPKISKMDRTSILGDAIDYLRELLQWINDLHNELES------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKDHTMAERKRREKLNQMFIALSALVPGLKKMDRATVLGDAVKYIKQLQEKVKTPEEQAR------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIDYLKELLQRINDLHNEWESTPPGSSLQPSasfHplTPTPPtlpchvkeelcpsNLPSPKGQAPRVEVRVREGRAVNIHMFCERKPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEQcKEGQ-DVLPEQIKAVLLDS---- ------------------------------AELQARLHDLVEQKGGTWTYDIFWQESRRSganggRAVLGWGDGYCRDGAagaetgevgaaeRsmarKRVllrlhalygggDDegadyalrLDRvTGAEIYFLSSMYFSFPEGA-G-GPGRALASGRHAWAEVDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPPAKNLMAERRRRKKLNDRLYTLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNDLEA------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAQDRILAERKRREKLSQRLIALSAIIPGLKKMDKASVLGDAIKYVKQLQEHEESSS-----------CEENSDGQ-----SSDVALPEIEARFSDDD-VLIRIHCEKQQGM---------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKSRTFPTERERRVQFNDRFFALKKLIPNPTKGDRASIVGDAIDYINELRRTVSELKSLVEKKRCgreRSKIDSRNteietvfskmqcnndEEnmkkKNNsSSldrCSWlqrKSKVTEVDVRIIDDE-VTIKVVQRKKINCLLFVSRVLDQLQLDVCHVGGG------------------------------------- -------------------------------GLRQLLQSLCTNSP--WKYAVFWKLGHQSPMSLTWEDEYCVYPIpSESMesissdvySNseiIPsqfeSSiNDSCEFSIdlvvaHMsHLKYTLGE-G-VVGKVAHTGKHYWISYDNIFTskfnStmvDECPEEWLFqFAAGIKTILLIPVLpHGVVQLGSLEMVAEDSSIVAYIKDRFSCNSIhlelpsspisslpenleesstsasmnplnsEDqpntvdtvndYtfhivpgtylysildieceNrinvnnasffSffpkgcelhkallgppFrrqsnESlweneglfsglepgsmlaEGSEPdylleavvghvyegsfnmpnrsntqlptssqPQtvesdyygETQKGPKqssiKKRRAKPGDNPKARPRDRQLIQDRLKELRELVPNGSKCSIDGLLDRTIKHMMFLRSvtnQAEKLQQWAhrEVTSRKNirssETKENYQLETSwGFeIGDEPNVYPIVVEDLpyPGH-MLIEMLCNDY-GLFLEIAQVIRSLNLTILKGVMESYANEKWAHFIVEVSRG-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLDAERRRRAKLNDRLLQLRALVPIITNMTKAYIIKDAITYIEELDSHVSELKDELLELGDSfPPREETKSANIDvvkNIIAPkemkfYGIEPEVKVSPIDDNKVWIKVVYEKKMGGFTKLVEAITRLGLEFNDTNFTTSNGAAVISSCL------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EELNHVVAKRRRREKLNERFITLRSLVPFVTKMDKVSILGDTIEYVNHLSKRIHELESTHHEPNqKRMRI---GK---------GRTWEEVEVSIIESD-VLL-------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIQDHIMAERKRRQVISERFIALSATIPGLKKTDKIYILEETINYVKQLQEKIKELDNQNTMKNKDSEilIKKSqacTKENDNDEhkDYSKKELPKVKARVINKE-VMIGIHCEKQKNIMVKIMGLLQSLHLSLASSSILPFGTSTLkVTIIAQV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSHDHVFAERKRREKLSKLFLNLSTTIPANKKSDKDSLLGNTVNYIKELQSKVKALEQAIETPTesallvnKKPPlMDMNENSMFlNESSSrSEQVPLKIEAKLNGKS-VILNIQCENHKGLIVKAMLEIEKLPMTITNTSILPFGDSLLDIvIMAQVDDG-------------------- ---------------------------------------------------------------------------------PEDlTDPEWFYVLCFTYSFEPPS-G-MPGKAYARRKHIWLSGANEVDNKIFSRAISAK------------------------VKESEEFVDHIKSFFHNY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLSVLRSLMPPsyVQRGDQASIIGGAINFVKELEQQLQSLGSQKQTKNSPsppnNNISSPfSefftfpQySTSSTtsnnLTMnEqiQSAIADIEVTMVDSH-ANLKIRSKKQPKQLLKIVSGLHSLRLTVLHLNVTTADQMVLYSFSVKVEEDCQLNSVDEIAAAVYQLL--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLISERRRRGRMKEKLYNLRSLVPNITKMDKASIVGDAVLYVQELQKQAKKLRAEIAGLESSLKGGsLGyqdlvDQNpKKTQlVPeNkhPiCKKIVQMDVFQVEERGFYVRLVCNKGEGVVAALYMALESLpCFDVQSSNFATVSERFVLTCTLN------------------------ ------------------------------------LQSIMQSF--HCTYICLWSYLPHPSNCLLNLDGLYDEDD-KK--QPSSslgsFARRLFNAYRQL-VFNVEnS-L-VPGHAFKNNIPfleLDESVLQTHSSSQIQRQ-FYQEAGIKTVVFMGCSNGEIELGFSTSPQ--VNMVEEMKQgndFMAWSeVSsmilpPNlsspssssssLRsiSAGSpessslflptdisqqpqqPslPPSsslsggHrgsafkaydpnkaasaEADanrkgQSMMKKginfyrkinsMRmrerlqreRRptSAQLHHMISERRRREKLNESFHALRSLLPPGTKKDKASVLATTREYLTSLKAQVSELSHRN-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLHHMISERRRREKLNESFQALRSLLPPGSKKDKASVLANTREYLKTLKAQISELEERNRILEAQLLNkKEADQFQ-----DDSSGRVQVQIktgssestsqaQQIDLR-VTVRGECDIID-LVLHVLECLKGMR---------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSPNLEAERRRREKLHCRLMALRSHVPIVTNMTKASIVEDAITYIGELQNNVKNLLETFhemEEAPPEIDEEQTDPmikPevETSDLNEEmKklGIEENVQLCKIGERKFWLKIITEKRDGIFTKIMEVMRFLGFEIIDISLTTSNGAILISASVQTQE---LCDVEQTKDFLLEVMR-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKISHITVERNRRKQMNEHLSVLRSLMPCfyVKRGDQASIIGGVVDYINELQQVLQSLEAKKQRKAysevlsprvvsspRpsplsprKPPLsmslpisPRTpqpsspykpRlHqqQqgylnpslpspvepsPCNsstsSsINdavnelvaNSKSAVAEVEVKFSGPN-LLLKTVSHRIPGQAVKIISALEELALEILHVSISTVDETMLNSFTIKIGIEC-QLSAEELAQQIQQTFC-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLSVLRSLMPDsyVQRGDQASIIGGAINFVKELEQRLQSLEAQKEMEQKSDgSsvssLpfSefftfpQYSTSSGhcENsAAmSekvgEsQSAIADIEVTMVESH-ANLKIRSKKRPKQLLKMVSGLQSLRLTILHLNVTTVDQIVLYSLSVKVEDDCKLTSVDEIAAAVYQMLG-- -------------------------------TLQQRLQALIEGARESWTYAIFWQSSVDAsgASLLGWGDGYYKGCE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APSKNLMAERRRRKRLNNRLSMLRSVVPRISKMDRTSILGDTIGYVKELMDRIENLQDD--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETADHIMSERNRRQELSRKFIALSATIPGLKK---AHVLEEAIKYVKELEERVKVLEEDGEISITRSRVC----------GCGDETLPEVEARVFGKQ-LLIKIHCATQCGVLIQIFSQLQLLHLSISSSNVLPFGNTLDITIIAHMGH--------------------- -----------------------------------------------------------------------------------------------------GS-G-LPGQAYFNSTPVWLTGVENLALSACERARQGQEHGLQTLACVPSAHGVLELGSTELIYQNNDLMNKVKMLFNFNN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQDHIIAERRRREKINQRFIELSTVIPNLKKMDKATILGDAVKYVRELQDKVKTMEDD--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPPsyVQRGDQASIVGGAINFVKELEQLLQSLEAHKRTKQQNSAAGSsssPfadfftfpqySTRSSNSAsdSAaAenRSAAADIEVTMVESH-ANLKILSRRRPRQLLKMVAGLQSLRLTILHLNVTTVDQMVLYSFSVKVEDGCQLNSVDEIAAAVNQMLG-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRRERLTQRFIALSTLIPNLKKLDKATVLGDAIQYIKQLEEQVKTLEEKN-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPGsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlyGDApPrPVGDsSmPpiqQPqppffppLplPNDqMklvdleTglreetAeNKSCLADVEVKLLGFD-AMIKILSRRRPGQLIKTIAALEDLQLNILHTNITTIEQTVLYSFNVKIASES-RFTAEDIASSVQQIF--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEICGHHFLTERQRREYLNEKYQVLRSLIPNPTKADRASIVQDAIDYVNELKQLTDQLQCKRGLAdQKRQKVVDScldrvvdvgNTqSckgkhlSSTSkVGQegtlcqlShktSRYGTEVDVRVFDDE-ATIKViQHQPQRSLLLDAVSMLNEAELELLYANGARIGNCHAYMLNVKIQETK-AMQANQIAKQLLDHI--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFKSKNLHAERRRRQKLSDRLLSLRSIVPIITNMNKATIIEDAITYIQELQKTSEVLSGQLLQMEGsseEegkPiRIEI-DAAE-D--PKKCGIKEEVKVTNIDGNKLLIKIILEKKRGCFTKLIEAMNYLGFELSETNVTTFKGAMRISSCVQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVQDHILAERKRRELLSHLFISLSAIVPGLKKIDKTSVLGEAIKHMKQLQEKVKVLEQVAAKRTvgsvvvvKRSKVimvDDNgssdNNgnvSSStvddsctsaTSgrsangggggVSAgvggGgggDdnvSSFPEIEVKICGNT-MLLRVYCEQQKGILTKLFAEVDNHDLRITNSSVVPFEDFAL-DITI------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERQRKKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLRELLQWINDLYNELEST----------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLMQADQVSLLDDTIRYLKQLERRVQELESCRETAelsgrdRRKQhpDvSERTSDnyihReITDGkkasAnkrkardMdEaeaeHEHHCVEVSVTMKEKE-VVVKMHCPWREYLLPEIVESMSDLHLDPHSVQSSTVDGMLAMTVKSKLRST-TVASPVMVQQALQR----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVQDHIIAERKRRELLSHMMISLSAMIPGLKKIDKTSVLGAAIKHMKELQEKVKVLESVIAKRTvvvvNKSKLKADNDSSDDNVSSS-TVNDCSGVKVMGKA-LLLRIFCEKQKGIFVKLFVEAQKHGLSITNFNVAPLSDIAL------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNAQDHILAERKRREKLTERFVALSALIPGLKKMDKASVLGDALKHIKYLQERVGEFEEQKK------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTVDYMKDLLERINNF------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLHAERRRREKLSDRLLTLRASVPIITNMNKATIIEDAITYIEILQRNVKDLSEELLEIealSSEedPKPEI-NAG--EE-MKKWVVKEDVKVTNMDGNKLWIKILLEKRRGRFTKLVEAMNFLGYEFTDIHVTSFRGAILISCCVEGNYG-DMLTADQASDLLLEII--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGAEnRGINHFATERQRREYLNEKYQTLRSLVPNPSKADRASIVADAIEYVKELKRTVQELQLLVEEKRRgsnKRrcKASPDNPseggGatdmeSSSAiqpggtrVskettflgdgsqlrSSWlqrtSQMGTQIDVRIVDDE-VNIKLtQRRRRNYVLLAVLRSLNELHLDLLHANGASIGEHHIFMFNTKIMEG-------------------- ------------------------------------------------------------------------------------TDTEWFFFLSIAHDFVNSS-G-LLGQAFFNSNPVWATRPNLLSEPACQRARRLHEFGLQTMVCISCPNGVVELASIDVVLPNPDLMIKVRDLIIF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------NDTEMFFLASMYFLF--------PGKCFAAGKHVWILDALKSGVKF-------KHLNIE----APCK-------------E------------------------EKVSV--ANERRPRKrgrnpANGREEALNHVGAERNRSEKLNQRFSALRAVIPIISIMDS--------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIEYVKELQMLVKALQEELDETTEEEqqqqQQGNNGdgvapvatTPSSdsNNhggfsvmeerVeeSsstthhllhipninNDQQQQMEvqVEVNQVDAHEFNLKIFCEKSSGGFARLMEAMDALGLEVIHVNITTYMSLVLNVFKVEDNE---AIQIEHVRDSLLEL---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNSNMSPERCQRPPSNSSSCCSQHYQPNNFQMDKASTIKDAISYIHELQEQERRIKEDIANFDRRRCNNNGdNNSTSSTidfeqefsflsnknsTdhdrqqydfNNCcRssiIDDLKITVSYVGGRIVIVSLSCVNKKGILVKLCEMLESLKLKVTTAHITVVGPKILKTVYVEADE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTEQHIMAERKRREKISTMMIELSAMLPGLKKLDKISIVGKTIDYVKHLQNRVNDLQEQKRKTES-VKCCK-NNGS-N-V-NISENFPKVDASV--SD-VRIRVICDRREHIVTKLFSKLESHHLSIVCSSVLPLGSSALNiSIICQVE---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPPsyVQRGDQASIVGGAINFVKELEQLLQSLEAQKRLKQQSsENgFSSsPfadfftfpqySTSQSpcNnsSSTSsSaAekrSAIADIEVTMVESH-ANLKILSRRRPRQLLKLVAGLQSLRLTILHLNVTTVDPMVLYSFSVKVEEGCQLTSVDEIAAAVHQMLR-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIEYLKELLQRINDLHNELEST----------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------KTFGRSLLAKSASIQTVVCFAVSGGVVELGVTNMVMEDLNLLQQMKSFFLDFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STHHSLAEKKRREKLSQRFVALSALIPGLKKMDKASILGDAIEHMKGLEERVKGLEERA-------------------------------------------------------------------------------------------------------------- -------------------------------DLHQILRSLCFNT--GWKYAVFWKLKHRARMVLTWEDAYYDqhDSSEnKCFGKtLENlHD----YSHDPlglavakmsYHVYSLGE-G-IVGQVAVTGKHQWIFSDKHVNnSCssfeFCD-GWQSQfSAGIKTIAVVAVvPHGVVQLGSLNKVPEDLKLVNHIRDVFL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLISERRRRGRMKEKLYNLRSLVPNITKMDKASIVGDAVLYVQELQKQAKKLRAEIAGLESSLKGgSQGyqdlvDQNpKKTQlVPeNkhPiCKKIVQMDVFQVEERGFYVRLVCNKGEGVVAALYMALESLpCFDVQSSNFATVSERFVLTCTLNVRD--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASRNTVSERNRRKKLNDKLFALREAVPKISKLDKASIIKDAIDYIQDLQQQETRLQAEIRELEserlendKGYEFERDLPVllTSKKIPDPrsdPIEVHQLRVTSMGEKTLFVSLTCSQARGAMTRICEVFESLKVKIITASVTTVSGMVKTTILIEAD---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EELNHVVAMRRRREKLNERFITLRSLVPFVTKMDKVSILGDTIEYVNHLSKRIHELEST--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------SDYEWYYTVSMTRSFAAGD-G-ILGRAFGSGSYVWLSGDEPFQLYECERVKDARTRGIQTLVYLSTSFGIVELGSSETIEED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQCKNFAAELKRRNKVNDRFKKLCSLVPNITRMDRASILGDTIDYIVRLQKQVKELQDET-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTALAERKRREKLSQKFIALSALVPGLKKMDKATVLGDAINAH----------------------F--------------DVLLPEIEARHCDKS-VLIRIYCEKRKGFPEKIIYEIEKCQLTVTSSNVMTFGSSAVHiTIVAQMDVEF------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPAKDHTIAERRRRQKINQRLMELSTLIPGLKKqMNKATIIGDAVKHVRELQEKVNILENNNRHAATTtvcSTvlIHKNrpclGDLTSNygDdyVGQpSqlGTWLPEIKVRFSDKS-VLVQIHCENTNGLLVRVLAEVEVLRLAITHTSSMPClADTTIINITAKAS---------------------- -------------------------------TLQQTLQFFVESRPEQWAYAIFWQKSKDVngGLVLAWGDGHFCGTK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKMSHIAVERNRRRQMNEHLKVLRSLTPCfyIKRGDQASIIGGVIEFIKELQQVLQSLEAKKRRKvySevlsPSPgpspRpLqlPISpRTPqpssPFpgiEpNssstssVkelGAcCNSPVADVEAKISGSN-VLLKTVSRRIPGQIVKIISVLEKLSFEILHLNISSMEDTVLYSFVIKIGLEC-QLSVEELAQEVQQS---- ----------------------------------------------------------------------------------------------KSCQFPFGH-G-HAGIAAIRREHVWVTGVNVTNTSVLEQRDFLQATIIQSLLCIPLLDGVLEIGSTETILETDSLLQTIRTFLYAAPValpvstehpsTstsSiFSqspseaSLDipglhhqsyttSdwttiyqatsslgtqfDTSsatafrkwDplqqksmaipttSQAmikrmllalaqiEEvrKRARGlAQgptqtmsGGEdarTRTIHIDAERNRRRRHKDSISRLRSLIPFKTK-DKLSVLQGAIDHRQYLQTRVAQLENSKATTEETagPGAEI-GAIKTELTTSDDRDELSVNALDVEGT-FAIRIyrRRPQRQDVMLQLLNYLWSLGLSVTSIDSAVTENSFRAALVAKPR---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQRRKKLNDRLYMLRSIFPKISKMDRASILGDAIDYLKELLQRINDLHNELEST----------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------ALFYTAYKSCQFPFGH-G-HAGIAAIRREHVWVTGVNVTNTSVLEQRDFLQATIIQSLLCIPLLDGVLEIGFTDTILETDSLLQTIRTFLYAVPVslpvstehpsTstssifsqspseaslDIpglhhqsyttsdwttiyqatSSLGTggqfDTSsasafrkwDplqqksmaipttSQAmikrmllalaqiEEvrKRARSlAQgptqtmsGGEdarTRTIHIDAERNRRRRHKDSISRLRSLIPFKTK-DKLSVLQGAIDHMQYLQTRVAQLENSKATTEETagPGAEI-GAIK-TELTT-SDDRDELSVNALDDEgTFAIRIHRrrPQRQDVMLQLLNYLWSLGLSVTSIDSAVTENSFRAALVAKPR---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQYKKNLLAEKRRRETLNKQFIALSTLLPGITKTDRISIMGEALKYINQLKEENNKLKQYNPNQavvVKKSQVhEEQNSCSIHKSSsvCSDEQLPEIEVRMYEKK-ILLTIRCEKEKDVLANILSEIEKLNLTVISGNIMPFVGITYEIIiVAEMDT--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQEHLLAERKRRDKISQRFACLSALVPGLKKLDKSSVIEGTIKHLKELQERLKALEEGRNREhgqesvvyQKKPCIRF-HQEAS--LSSFDQSLTNLEVRILKGN-VLVKACCRRRSGFTDAFLHAMEKLDLVIESCSFMPFADNLLAiSAAAKMNDGF-SMTEENLAN--------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVPGLKKMDKASVLGDAIIYLKALQDKVKVLEEQAAKRTvvtsvlvKRCRlsaVEDENDASSTdEthegaaIDSGdSMSLPEIEVKLSEKS-LLIKIHCDSRKGILVHALQEIEKLHLTVVSTSLMPFAASSlDITVMAQIEEGFCMTTKE------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKTDRSKRIVSERRRRGRMKDNLHALRSLVPSITKMDRASIVGDAILYVQSLQSKANRLKVEIAELEASAasqGLYATEHSNfhiATSSankrSTPPVPryIKQMDACQVGEGEFYVKLVSNKGEEIAACLHKAIESLrdGFTLQSSNLSLVSDDYALTFTLRVKDGGEEMNLPNLKMWLSRALH-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMTHIAVERNRRKQMNEHLAVLRSLMPHSYmqKGDQASIIGGAINFVKELEQLLQSLEAQKRQNEQKPeaGSSSSSSppfadfftfpqySTSSfgdNSdsvEsEvgeSKSAIADIEVTMVESH-ANLKILSRRRPKQLLKMVAGLQSLRLTVLHLNVTTVDQMVLYSFSVKVEDDCQLRSVDEIAAAVHQML--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGPPAKNIDAERRRRKRFNGRLYDLRALVPKISNLNKASILGDAIEFVKVLQKQAKELKDELEE------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVVPNISKMDKASLLGDAIAYITELQKKVKEMESEGILLC---------QS------TIGVQCPDIDVEAVQDE-VLVRVSCPLDsQIPVSRVIQAFRESEINVTESR--------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIHSEAEKRRRERINAHLATLRRMIPDSDKMDKAALLGRVVDQVKDLKRKASEISKSSA-IPAE--T---N-------------EVTVECDtgdaadsAGsDEN-IYIKasVCCDDRPDLFAELTQAFHGLRLRTVRADMTSLGGRVQHVFVLCRKEGgsggVCLNSlKESLRQALARV---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQDHVIAERKRREKLSQRFIALSAVVPSLKKvaMDDYSSTS--------------------------------DESSC---DQPNQELPEIEARVSEKH-VLVKVHCERRQGCISKILNLIEKTNLIVLSNSVIPFGSSILdITIVAQMEGEL-PMTIEDLVKNLCR----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSANHVENERQRREKMNRRFCELRAAVPTVSRMDKTSLLADATAYINQLRARVAQLEAQQA------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAHVLAERKRREKLNQRFVALSVVLPGLTKMDQASLLGDTIKYVKQLEERLKELEERK-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNSRAERRRMDKLNQSIYALRSLVPNITKMSKQSITPPTISYISNSEKERVDLQIELSGVQDEEGEKPGyFSPTRTTKPLQDAVPfkGMVQLCSFGKNKFHLKVTMEKRIGDFRNFWKRESQSGWRFTEVTTVSFSDIYQRALCLEVR---------------------- -------------------------------ALRQLLKSLCSNS--PWKYAVFWKLKHQSPMILTWEDGYCDYPKpREPVesisDDiyfngsneifsfsceSSIhDGSSGGYpiglaVADMScLQYSLGE-G-VVGEVAYTGNHCWVSSDDIftgeFNSKLvpeCPDEWLLQfAAGIKTILLVPVlPHGVLQLGSLEMVAEDLALVAYIKDRFN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKNLDAERRRRTKLNQQLFSLRALVPKITKMSKESTLTDAIDYIKQLQKQVVDLQIELS------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTKNVVWERNRRRKLNGKLYALRSVVPNITKMDKATIIRDAIAYIEQLQEQERRLLAEIS------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLSVLRSLMPEsyVQRGDQASIIGGAINFVKELEHRLQLLSAKKEVKERSNgsrSscsspfaefftFPQYSTSSsqGdnNSisMNEsmpveTQSAIADIEVTMVESH-ANLKIRSKKRPAQLLKLVSGLNSMRLSILHLNVTTVDQTVLYSLSVKVEDDCKLTSVDDIATAVNQLLG-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSPNLEAERRRREKLHGRLMALRSHVPIVTNMTKASIVEDAITYIGELQKIVQNLTEKLHEMEETPlEiYEQqTvHtiKPEVEAIdlkveMKKMGIEENVQFCKIGKRKFWLKITTEKRPGIFTKFMEVMCLLGFEIIDITLATSNGAIIICSSVQILQGLcdgDSVDPEQTKDFLLEVMR-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLAVLRSLMPesYVQRGDQASIVGGAIEFVKELEHLLQSLEAQKLALLQQQqARTAgpNdDsaTStTNstepdgPPfaqffsypqytwsqLPNkytskSKAAIADIEVTLIETH-ANLRILSRRRPRQLSKMVAGFQSLRLTVLHLNVTTLDSLVLYSISAKVEEGCQLNSADDIAGAVHHML--- -------------------------------TLQQRLQALIEGTRESWTYAIFWQSSYDYsGTVLGWGDGYYKGEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLHHMISERKRREKLNESFEALRSLLPPGSKKDKASVLSNTREYLNSLKAQISELEERNR------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IASKNIVSERRRRQKLSDKLLALREAVPKISKLDKASVIKDAIDYIQDLQEQERRLQADIRELEsrrleKNhtPYIEDElpvllrSKRTkYEHVydhwlarSTCPIQVHELSVTSMGEKTLFVSLTCSTTTDAMIRICDVFESLKLKIITANITTLSGMVKKTVLIEVDEE-------------------- --------------------------------IIQLLQGLCSDG--LWRYGIFWSFKSEmNGWILTWGDGYVDKMIedRQMGDlsagptvskNqiiPSSccnksypfCPIEAALMRMPSHLYPLGE-G-IIGKVALTGQHCWISANE-LCStsmhKYQEDWQLQFAAGIKTVLLVPVvPHGVLQLGSLDMVFESAALVALIKDMFHEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMSHITVERNRRKQMNEHLSVLRSLMPCfyVKRGDQASIIGGVVDYIKELQQVLQSLEAKKQRKvysevlspRlvssprpsplspRKPplspRLnlpiSpRTpqpgspyKprlqQpgylSptmapslepsPSsSSsssIndnvnelvANSKSAIADVEVKFSGPN-VLLKTVSPRIPGQALKIISALEDLSLEILHVSISTVDETMLNSFTIKIGIEC-QLSAEELAQQIQQTF--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIDYLKELLQRINDLHNELESAPPGSLLPPSssFQpltPTPPTlpcrVkeelcpSsfpSPKGQPAKVEVRVREGRTVNIHMFCARRPGLLLSAMRALDNLGLDIQQAVISCFNGFALDVFRAEQcRES--QFLPEQIKAVLLD----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RENHILAERQRREEMNQKFCLLRTLVNKAPKRDKASIVKDAIDYIMELEARVKLLQKRslLKrtheaatleEeeqqKRKEiPncpntnsisDIKSSacmstqctpfdmhafNPtsafhaSvgqrScnvgnwmyaanrlvkcededvnidadyenrlspiiSSatapSMassapsSSsvlpkyaknercaseemeGNNDDSQVDVQSLGSQ-AVIKVVCSRSRGLFLRVLQALEECKVDILQSNVTTVGEQVIHFLTIEMSPG-------------------- -------------------------------GLKHLLRLLAEA--GDWVYAAFWKLAD-NGRTLSWSSGYYNGPQmmgKDGNaggavletlkeafesrrqalDqltemtltkkkpGteaasmlTAGlMETEWFYVNNTGMQFPLGS-G-VVGRCALSGKYAWLCEADKMDSATFTRAADAKEAKeakevereeeeaedggksgpeqvgratsrggagggrvggagagagggagaggaetaaggwvreagargartagwqargegaggggkrRGTILCVPVQGGVVELGTTKLAQEETLLVKMVQTMFSTH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------RLQQILRSLCFNT--GWKYAVFWKLKHRARMMLTWEDAYYDNNEyhdKKEnkcfNStqgNlNEGpysHDPLGLAVAKMSYhVYSLGE-G-IVGQVAVSGKHQWIFADKHVSdsssSSEYCDGWQSQfSAGIKTIVVVAVvPHGVVQLGSLHKVAEDLKLVDHIRDVFCA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKEHVLAERKRRQKLNERLIALSALLPGLKKADKASVLEDAIKHLKQLQERVKKLEEERV------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCYHASFLTCRRKSMNEHLSVLRSLMPCfyAKRGDQASIIGGVVDYIKELQQVLQSLEAKKQRKVYsEvlsPrPLSspRPsplSPRpppLSPRiIselaANSKSPVADVEVKFSGPN-VILKTASHRIPGQVLKIIAALEGLALEILHVSISTTDDTMLNSFTIKVM---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFKSKNLEAERKRRRKLSDRLLELRSLVPNITNMNKATIITDAIDYIEELQSTVRDLSDQLC------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINAHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQTSEIAEES-PLPT----E--------------SDELTVDASSDEDGRFVVRasLCCDDRSDLLPDLIKALKALRLRTLKAEITTLGGRVKNVLVITGD---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQLHHMISERKRREKLNESFQALRSLLPPGTKKDKASVLSSTREYLSSLKAQVEELSRRN-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KATEHFATEKQRREQLNGKYKILRSLIPNPTKIDRASVLGDAIEYIRELVRTKNELTLLVERKRhgremsKRLKTEDDAAESCNikpfgdadgSIrTSWlqrKSKDSAVXVRIIDND-VTIKLIQRKKVNCLLFVSKVLDELQLELYHVAGGFVGEYFSFLLKSKVIEGS------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLHHMISERKRREKLNESFHALRMLLPPGSKKDKASVLSNTKNYLNTLKAQISELEERN-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETKHFATERQRRVHLNDKYKALRSMVPNPSKNDRASIVKDAIDYINELKRGVNELKLMVEKKRcsKDrikrQKKEDGtsldglDAkqmdeveqSYnGNSLrSSWlqrRSKNTEVDVRIVDDE-VTVKLVQQKRINCLLFASKVLDELQLDLHHVAGGLIGDYYSFLFNSKISEGS------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAKNLITERNRRNRIKKGLFILRSLVPNITKMDRAAILDDAIEYIKELQRQKIELQEKVDVLDvedcKKNTLQmsvQGDKeqPLSelNQSSSySirkTEMELQVEVNHVGETSLMIKLCCEMKRG----------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKDHSIAERRRREKLSQRFIALSAMVPGLKKMDKASVLGDAVSYVKKLQERVRTLEDQAVMKTGRiggpPqEVPAGGgrhRSSSDgNFeSpATAGGLPEIDDRRlraegPGED--TLRE----EERRPAEGSGEMEKLQLSVLNASVIPFAGSsFLHHIMAQ------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSHSEAERRRRERINAHLATLRSMVPCTDKMDKAALLAEVINHVKKLKSNAAEISKG-------CTVP-----------S-DADEVRVEVEgdPSnGGG-FLIKasLCCDDRPDLFADLKQALQSLRLKTVGSEISTLGGRVKNVFVMSCEGNggdvERHLFATSVHQALKSVLD-- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPVKNLMAERWHRKKLNDRLYMFRSIVPKISKMDRASILGDAINCLRELLQQINDLHNELEST----------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPEHFATERHRRQHLNEKYQALRSFVPNPTKTDRASIVGDAIEYIKELLRTVNELKILVDKKRcsrersKRHKTEDDtaGDVeSSNmkplgdhqdqsynGTsalrSSWlqrKSKDTEIDVRIIDDE-VTIKLVQRKKINCLLFVSKALDELQLDLHHVAWW------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESHILAERQRREEMNDKFTILRSMIPKLTKKDKASIVTDTINYIKELEREVSFLQGRRKKVPRRThnhlgiiqpypsKgsSKGTtllDTPSseriknndeiledhlkSreymynkdeNdegsyllSISGdpfnrhqGfCGkdmrriSIGQVEIESFENQ-AIIKVLSQRVKVTSRHKQDPLEECKVDVIQSNVTTIGNNMVHYFTIGLHPGI-SKTLDELKATLQV----- ----------------------------------------------------------------------------------------------------------LPGRAFARRGHVWLTGANEVDSKVFLRAILAK-----TVVCIPVVDGVLEIGTTEKVEEDMGLIQYARGIFMDQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTKHFATERQRREHLNGKYAALRNLVPNPSKNDRASVVGEAIDYIKELLRTVQELKLLVEKKRcgRerikRRKTEEDggvdvlDNSNikvepdqSaySNGslrSSWlqrKSKDTEVDVRLIEDE-VTIKLIQRKKVNCLLYVSKVLDELQLDLHHAAGGLIGDYYSFLFNTKINEGS------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERKRREKLSPRFMALSVIVPGLKKMNKASVLGDAIKHVKQLQERVKVLEERS-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASLLADAAAYIAELRARVEQLEAEAKQAAA-ATWA----AISHSFGGgGLALEEKLEVRMVGRDAAALRLTTA-ARHAPARLMDALRSLDLPVQHACVSRVGGVTVQDAVVDVPAA--LRDERGLRAALLHKLQR- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFPTEKQRRAQINEKYDILKLLVPNPTKADRASVVSDTIDYINELKRTIEELTILVENKKhgrsKRRKTEdaAAaaaaDmESSSlrPlaaDVdlpfagslrSSWlqrRSKETFVDVRIVDDE-VNVKVTRRKKPNCLLLASRAIDDLRLDLLHASGGHIGDCYVFMFNTKISEG-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKNHSEAERRRRERINAHLDTLRGLVPCTEKMDKATLLAEVISQVKELKKNAAEASKGL-------LIP--------------MDDDEVRVEPQEdggDGSFSIRasLCCDYRPELLSDLRQALDALHLKIVKAEISTLGGRMKNVFVFT------------------------ -------------------------------SLRQLLKSFCNNSP--WKYAVFWKLRHQNPMLLTWEDGYCDYPKpREPmesiSsDfylNssneisssacetsmQNGssSGCPIElAVANMSClQYALGE-G-VVGEVACTGKHSWVFVDNFfaseFSSNlvpEYPeEWLLQFALGIKTILLVPVlPHGVLQLGSLEMVAEDASVVAFIKDRFNGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASKNIVSERNRRKKVNERLFALRAVVPNISKMDKASIIKDAIDYIQNLHEQERRIRAE--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHIVAERKRREKLNQRFIELSAAIPGLKKMDKASILEDAVKYVKELSEKVKTLEDQS-------------------------------------------------------------------------------------------------------------- -------------------------------ELQTKLQEVVEGPSgRPWTYAIFWQATRARtgEALLVWGDGHCRDAEprRrGSSivarageaereeerrqrmikrvlqklDavygcgdeNaairLDRvTDAEAYFLISMYFSFPSGG-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEIGGNWGEMERKERR---------------VKKMDRASILGDAIDYLKELLQRINDLHNELESTPPGPLLPQ----------S--TSIHPVEVRVREGRAVNIHMFCARRPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEV----------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIQYIVELQQEVKKLQDEVNMEQEDCNmkdaeLKRSSrysPATTEhNrGSSSirekkqiESQRVQVEVKLIGTREFLLKLLCEQKRGGFARLMEAINVLGLQVVDANITTFNGNVLNIFRVEARE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TASKTIVSERKRRRKLNDKLLELRGAVPKISKLDKASTLKDAIVYIQDLQEQERRLQAEMMELEskslkKDPGfdFEQElpvllRPKKTryDQIyDhrapiSYPIKVHELRVNSMGEKTLLVSLTCSKTRDAMIKICEIFESMKLKIITASVAIVSGMVKKTVLIEVC---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASRNHSEAEKRRRDRINSHLATLRKLVPNSDKMDKATLLAKVIEQVKELKQEAMESSKFQD-IPT----EA-DEVT--------VEPYTISDDF-ESDTIIFKasFCCEDQPEAISEIKRALTKLQLETVQAEIICLGGRMKNNFILKDC---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATRNVVTERGRRRRLNEKLYALRSVVPNITKMDKASIVRDAIAYVEHLQEQE--------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEQHIMAERKRREKISTMMIELSTMLPGLKKLDKISIVGKTIDYVKHLENRVNDLQEQKRKTES-VKCCK-NKGS-N-V-NISEKFPKVDASVSGKD-VRIRVICDRRENIVTKLFSKLESHHLSIVCSSVLPLGSSAL------------------------------ ---------------------------------REIVQEIVER--IGWVCTSLWQTLPTDNSLVGWADGYYNGHVSEnseAplpsSaqwnkikrvEElqsvpeiclTDrlDlSNIEWFYLISFKFKFPFGTDG-SSGKMLLTGGFEWICDGEEANGALFSHTALCKATGMKMVLCLT-VSGVVDIGTTALI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IASKNIVSERSRRQKLSDKLLALREAVPKISKLDKASVIKDAIDYIQDLQEQERRLQADIRELEsrrleKNhtPDIEDElpvllrSKRtKYDQVydhwlarSTCPIQVHELSVTSMREKTLSVSLTCSKTTDAMIRICEVFESLKLKIITANITALSGMVKKTVLIEVDEE-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIVSERNRRKKLNEHLFALRAVIPNISKMHKASIIKDAIDYIQELHDQ---------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDYLAVLRSLMPPsyAQRGDQASIVGGAINFVKELEQLVQTLEANKQIKQSSNLFSNffTfPQYSTPSMeaVEAMSAIADIEVTMVESH-ANIKVLSKRQPKQLLKMVAGFQSLRLTILHLNITTVDQMVLYSFSVKVEDECQLSSVNEIATAVHQMV--- -------------------------------ELQARLQHLVERSGGMWTYDIFWKDSRGAggggCAVLGWGDRHCRDGAwgpHDTaaageerSaarkrallrlhglysggDdDegadyalrLDRvTGAEMYFLASMYFSFPEGA-G-GPGHALASGRH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------EISYGDGYYKGEKdkgkRKlkTSsvvveqehrkkvlrklnslifDDaVDEevTDTEWFFLVSMTQSFVNGS-E-LPGQALFNSTPIWVVGSKRLVSLTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRNLVSERNRRKRLNNQLFTLRGLVPCITKMDKRSILVDAQAYLQDILnQTEKELEKEDPSHSiidtaamwPDSLIENIEIDhpPCEhfDVegqpqpkTYPrsavLPAITKMEAEKVDKEIYILKICYNKAMGAMSQVQRSIEMLkGFDITSVSISEYDQH-------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPSsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlyGDghdDSSLeiQQPQQppffaPLPpNdQLlnefeiGlrqeeiaENKSCLADVEVKLLGFD-AMIKILSRRRPGQLIKTIAALEDLQLNILHTNITTIEQTVLYSFNVKIAGET-RFTAEDIANSVQQIF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSKHLAIDRGRRQQLNDKFFTLRSLIPNPTKNDRASIVGDAIGYINELLRTVDELKLLVEKKRcgtersKRHKTEQDggagDEncnAKSephdqsyNNGslrSSWlqrKSKDTEVDIRIIHDE-VTIKLVQRKKINLLLSVSRLLDELQLDLHHVAGGHIGNSYSFLFNTKMYEGS------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTQDHIIAERKRREKLSQRFIALSAIVPGLKKviflfflptinliffssrfyeyvWDKASVLGDAIKYVKQLQDKVKTMEEQT-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMTHIAVERNRRRQMNEHLRVLRSLMPGsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlyGESSlvsggRAPQTDhAAPplplqpsypvfgvdPDdgNLNEplreeiaeNKSPLADIEVRLLGYD-AMIKILSRRRPGQLLKTIAALEDMQLSILHTNITTIEQTVLYSFNVKIGGEC-GLSAEDIANSVQQIL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDHLNALRSLMPTsyIQRGDQASIIGGAIDFVKELEQLLESLQAQKRMRRSEeggdastnsssssPKIAsKGlctqhrfapDESNSAeggrSDeftfTAdNKSAAADIEVTVIQTH-VNLKIQCPRRPGQLLKAIVALEDLSLTVLHLNITSLQSTVLYSFNLKIEDDCKLGSADEVAAAVHQVF--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVEERRKRSRIDEQLELLRAIIPNSCTDEKASILMDAYEYIEKLQRQVQELQYELDPESCFSdDeddvssCEDDlspsfTETvDSNAqseSSSSsccGYSQPMVEVKRTEGG-LEIHIECEKRPGLLVDIMELLESSGINVEQASIACQEQLVFDALGSEV----------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TESLKKERERREKMSESYSVLQSMVPNLfPKATREKIVSETINYIKYLEEEIKRLEGLKKSS-ESVAVGKP--MLSQ---C-TNRNSSVNVTVSGNV-AFFGIQSPVRQGLVTKIFMVFEKHQAEVLAANVAVNHGQLTLTVTAMVGGNG-DNTIEKIKRDILILLK-- ------------------------------------------------------------------------------------TDQEWFYLLSMSWNFPCGE-G-IPGRAFQFGQHIWICDTVKPINFQCARLELAKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CKNLVSERNRRKRLSQQLLALRALVPNITKMDKRSVLVDALSYLKNIHEETERLQKELKEQQPRPKLIdlreSSqDNPSGTlRIprttATVAYHKPKFQITEGNEFFFFVSWSCRVRDGTSSDVIRVFGSLDFEITHTALEQ------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIMAERKRREKINQRFIELSAVIPGLKKVDprlflhidiisKATILSDATRYVKELQEKLKALQQD--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKHLGPEKQRRELIKDNFEALRKLIPNPTKNDRASIMGDAINYINELKKTASELKALLQKKRSEkERVKRANcenISlETDPNScSWlqrKSYNTEVDVRIIMDQ-VTVKLvHHKRIKCCLVLVSKIFDEFQLDLHDVAGGVIGDHYSFLFNSKICEG-------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPAKDHIIAERHRRAKINQRLMELSTLIPGLKKMNKATIIGDAVKHVRELHEKVKILENNNMHASTttiSSAvlVhkKRPclGGRTSNygndDVGDpSqlGTWLPEIKVWFSDKS-VLLHIHCENTNGILVRVLAEVEVVRLAITHTSSMPFLAnTTIINITAKKR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKKHSEAERRRRMRINGQYATLRTILPNLIKMDKASVLAETIRQVKELKKTVSELEAACGGSSDECVFP------------SGADKLSLEYC--NKDEGLVKatFSCEDRPGLMSDITRALRSVKGKVVRAEMVTVGGRTKSVLWVQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNRNFISLSSLIPKLKKMDKESVLEDASIYIKEHQDRVKELEGL--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINTHLATLRSLLPSTTKTDKASLLAEVIDHVKDLKRQAAEIAEGMP-------VPT-D---------VDELTVDTDDSSSDGK-FVIKasLCCEDRPDLLSDLIKALRTLRLRTLKAEITTLGGRVKNVLLV------------------------- --------------------------------QQQRLQALIEGARENWTYAIFWQSSYDMsgDSVLGWGDGFYKDESdkWKArpkkmtSlveqehrkkvlrelnSlisgahttaddeVVDQvTGTEWFFLVSMTHGFLNGG-G-LPGQAFFYSNPVWVTGPDRLAASSCERARQAQVSGLQTMVCVPTSSGAVnEMGSMEFYFFEME------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNEYLAVLRSLMPEsyVQRGDQASIVGGAIDFVKELEQQLQSLEAQKRTLlqQqQdaTPhnRsaspsaCDAaTtSnCSsSvtedaAaDppPFaqfftypqyvwchSPrdspAAaeesraPAVADIEVTLVETH-ASLRVMSPRRPGQLLKMVAGLQALRLTVLHLNVTTLDSLVLYSLSVKVEEGCGLTTVDDIAAAVHHVL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAQDHVLAERKRREKLNRNFISLSSLIPKLKKMDKASVLEDASIYIKQHQDRVKELEGL--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIMAERKRREKINRRFIELSTVIPGLKKMDKATILSDAVKYVKEQQEKLKALEDR--------------------------------------------------------------------------------------------------------------- -------------------------------SLQQALKSLCSKS--GWCYAVFWKLKRRSRMVLTWEDGYYEFSSpsIDANfssmnrgGpggNpLDQggaGDdqiglavARMSY-----QVYSMGE-G-IIGRVAFTGKHQWVFHDGESSLETtsggalNNQAILEKypdgwqnqfAAGIKTIAVIAVPQGVVQLGSTQTIMEDLKWVDHVRSVFGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGQPSKNLMAERRRRKRLNDRLSMLRSIVPKISKMDRTSILGDTIDYMRELLDKIHKLREE--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITEKNRRKRLNETLYNLRSVVPNISKMDKISVLKDAINYIQKLQEDERRILAAAAPPpeERKKKMKAVSRRDPN--APPSIEVLEMQVTDITEEMSFVSIRCQKRKHTMARSAQLKENIEMAI------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARDHVIAERKRRQKLNQKFITLSSILPGLKKMDKATILEDAIIHLNQLKEQVKNLEEQVADK----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDHLNALRSLMPTsyIQRGDQASIIGGAIDFVKELEQLLESLQAQKRMRRSEeggdastnsssssPKIAsKGlctqhrfAPDESNSXeggrsxeftfTAdNKSAAADIEVTVIQTH-VNLKIQCPRRPGQLLKAIVALEDLSLTVLHLNITSLQSTXLYSFNLKIEDDCKLGSADEVAAAVHQ----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTERDRRSQIIIKYDAFfwKQLIPSPTKGDRASIVGDAIDYIKELLRTVDELKLLVEKKRcgrersKRQKTEEDgfDgdgEScntrpLGEphdqSfNngslrSSWlqrKSKVTEVDVRIIDDE-VTIKLVQRKKINCLLFVSKVLDELQLDLHHVAGGQIGEHYSFLFNTKICEGS------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTVSHVEAERQRREKLNRRFCDLRAAVPTVSRMDKASLLADAAAYIAELRARIARLEAES-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKSHSEAERRRRERINNHLAKLRSLLPNTTKTDKASLLAEVIQHVKELKRQTSLIAETS-------PVP------------TEIDELTVDNASDEDGKFVIKasLCCEDRSDLLPDLIKTLKALRLRTLKAEITTLGGRVKNVLFITG----------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKVSVLNKAIEYVKSLEQRVKVLEEENKKRKIESemclKVSKSnmvDYdfSwTSHACydGDdEtSKTLPKVEARVSGKD-VLIRVTCEKQRGIVQNVMAKLEKHNLSVICSNVFPFGSSVL------------------------------ ---------------------------------------------------------------------------------LDRaNDTEMFFLASMYFLFPLGE-G-GPGKCFTSGKHVWILDALKSGSNYCVWSFLIK-----RTECSPLFPDPSELW----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKKHSDAERRRRLRINSQFAALRTILPNLIKQDKASVLGETVRYFNELKKSVKEIPTT-------PSLED-----------------SLRLGQCNnnRDLAKVVFSCSDREGLMSEVAESMKSVKAKAVRAEMMTVGGRTKCVLFVQG----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKTIVSERKRRVRMKEKLYELRSLVPNITKMDKASIIADAVEYVKNLQAHARALKEEVAALEAQPRspagagHEQQNQqqhvgrAAaAgrrqqDRagDSGGrrGghGaRVTCVGAARVGEGRFFVTVECEKKDGVAAPLCAAVESLACRVESSSLVRS----------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSPLNHVEAGGCAEKKLNQRFYALRAVVPNVSKMDKASLLGDAISLHQELG------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRNHCEAERKRRARINAHLDTLRSMVPGANKMDKASLLSEVVSHLQELKRSAAEASEGLL-MP--TDI----------------DEVRVEGQENGLDvgPYLIRvsLSCDYKPGLLSDLRQALDSLHLIVMKAEIATLEGRMK------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TASKNIVSERNRRKKLNQKLYALRSVVPNITKMDKASIIKDAIAYIQSLHDE---------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIPMSTWMYNLMQVDKITILTEAIKHMKQLQEKVKVLEEKAAQKKVsksmvvvkKCQltVDNDndNDSDsaSGdncdsgSggcnsnGgdNnNDnndiinLSSLPEIQVKKLDDT-LLLKVCCEKQKWILPKLYAVVYKHDLSITHSNVIPFERLAIdITIVAQMERGF------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRKENEKFSVLRAMVPTVNEVDKESILNNTIKYLQELEERVEELESCMGSVnfverqRKTTKslndsvlIEETSGNydDNTKIdgNSGETqqvtvfrDETHLRVKLKEAE-VVIEVRCSYRDYIVADVMETLSNLQMDAFSVRSHTANAFLTLNLKAKFR---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASVLGDAIKYLKQLQERVKILEEQTVKKRVESVvlVKRShisadDDNSSDenNLdggrSDDEAALPEIEARVSDKD-VLIRVHCEKQKGVVAKALAEIEKLHLTVVNTQQ-------------------------------------- -------------------------------FLRPFLQNLCFNSP--WNYAVFWKLRAPQhENVLAWEDGFCNIQKQKIpEDIkiedfysTEIlhSDFSPYllsknpcnYtvglaVAEMSrTSHVMGN-G-VVGEVALTRKPRWIYAAQIAADTsktiisqYPDEWQLQIAAGIKTILLFPVvPHGVLQLGSIEMVAEDATILSCVENVFAC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNISSERRRRLKLNEKLYCLRALVPSISKMDKASILADAVQYVRELKQKVDNMEEEIAS------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDYLNSLRSLMPPcyIQRGDQASIIAGAIDFVKELEQLLQSLEAQKRTRKVEeSnnSMSKpAmeihqqeyeNGSEDGhcgeEVkAESKTGAAEVEVNVIHNH-VNLKIQCSRRAGQLIQAIVTLETLRLTVLHLNITTSQASVLYSFNLKMEDDSALRSADEIAAALLE----- ----------------------------------------------------------------------------------------------------------ILGRALFSGGFVWLAGDHEFQLYECERVKEARIHGIQTLACIATLSGVLELAFLDVIQQDWGLVHLTKSLFRSN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQDHIMAERKRREKLTQNFIALAALVPNLKKVDKYSVLVDTIKYLKELKKRLKVLEEQNEK------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINAQLATLRKLIPKSDKMDKAALLGSAIEQVKDLKRKATEISKAFTI-PT--EVDEV---TVDC-DVPED--TNSSTNKSKDN-TFIRasVCCDDRPELFSELIRVLKGLRLSIVRADIASVGGRIKSILVLCNKDSdEEGVSLSTLKQSLNV----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATKNIVMERNRRRKLNDRLYALRSLVPTITKLDKASIIKDAIDYIKVLQGQEKQMLA---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDRASILGDAIEFVKELQKQVKDLQLELEEQSDDEatdnhnngRSESLNQSGthvgskpdhekPPNgfhnnDSetNyDkpRQMEPQVEVAQLDGNEFFVKIFCEHKRGGFVRLMEALNSLGLEVTNVNVTSYRCLVSYVFKVEQRDS-EMVQAQDVRDSLLEI---- ---------------------------------------------------------------------------------PEDlGNMEWFYMVCMTYAFRPGQ-C-LPGKSFASNGCAWLCNAQSADSKAFPRKLLARQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------EWLRSFVYSN--AWDFCVVWKLGDDPSRFIEWKDCCCSGGInVKVEqDklqlqgpplcrDaqfqhSIRsKACEALSHFPFTVSLYAGENR-IHGEVAISSQPKWLNHANISTSLS-------SEETMGTQVLIPVFGGLIELFASKNIPKDQNIIELIRTECNALLKaetttaesyrkAnlhkwylntlqekDlpFSmSlstvnpriqfIPSiGHppfsSASayisQDEqlkqpigtyygTKRlgcsqnvcaqqteiglvlDCKvnsvndkmrtAKQpekVNYHSKNLITERNRRKKIKDGLFKLRALVPKISKEIYRRRKRNS-------------------------------------------------------------------------------------------------------------------------------- -------------------------------TLQQRLQALIEGAHETWTYAIFWQSSYDYsgSSVLGWGDGYYKGDD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRNHSEAERRRRERINGHLSMLRSLIPGTTKMDKASLLAEVISHLKQLRRTATESTKGVLI-PM--D------------------IDEVKVEQQDDnsldgSSYSIraSLCCEYKHEVLSDLKEALDGLHLKTIRAEIATLGSRMMNLFVIT------------------------ ------------------------------------------------------------------------------------------------------------------------------------------QSEQNQMLMFSIPS-YYELGSCSDS---YNL-SIVMDMMSSSPTNSDNG-SLNLSPSSMAE---AK--AVAASKSHKEAERRRRKRINGHIATLRSLLPNTIKTDKASLLGEVVRRVKELKKTAAELTA-IDDDGN-------DNTASWSCM-FPGETDELKLCYCENDSGLIKatLCCEDRPELILDLIQALKSVEAKVVRAEMATVGGRTKSVLWVRSGVGGEGDGLGTLRRALKMVVD-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRLMNDHLAALRSLMPPsfVQRGDQASIIGGAIDFVKELEQLLLSLQAQKRQRAS-AASSRCtasSRASapldgffiSPqytSYSQqqrrrlkedGeEePaeAGVDVEATVVQGH-VNLKVAGRRRPGQLVRAIAALEELRLSVLHLNITSLDpSSVLYSLNLKMEEECKLGSADEIATAVHQIFS-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQTSLIAD----T---SPV------------PTELDELTVDVDASdeDGK-FVIKasLCCEDRSDLLPDLIKTLKSLRLRTLKAEITTLGGRVRNVLFITG----------------------- ------------------------------------------------MYGIFWQESRGSsanggRAVLGWGDGHCRNGAagaRTGevgvaerSmarkrvllrlhalyggrDDegadyalwLDRvTGAEMYFLASMYFSFPESA-G-GPGRALASGRHAWAEVDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKHQSKNLVAERKRRKMLSERLYALRSL------MDRASILGDAIEYVKELQMLVKALQEELDE------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASISHKEAERRRRKRINAHIATLKSILPNTIKTDKASLLGEAVRRVRELKKAAAEHNEGDS-----FLY--------------PSETDELKVCDEERGLIKATVCCEDRPEINLDLIRALKSVEAKVVRAEMSTVGGRTKSVLWVRLNPDE-EAGLGRLRRALKMVMD-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCKNLLSERNRRKRLNQQLLALRSLVPCISKMDKRSILMDAATYLQNLHREIEEVKREIATQETS-DTSTTsSESnlPSPeeTIqcneSSPpQHQILNIDIEEMDERTFAVKVVFQRAQGSRCQVQCMIHSLGLNISNTWTHEIDRhQMITTSFLQVK---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSLRALVPKISKMDRPAILTDAIEYIGDLLEEKKKLEDELVEIEeencKRSDseLRsaKSdklhkeNMSavKPNQVSSSltNmvKMEVHVEVNQITKREFLIKLYYEHKRGSFAKLMEGIDSLGLQVIDANVTTFNEKALSIFKVEVR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPPsyAQRGDQASIVGGAINFVKELEQLLQSLEARKSSRQCAahdaaaaaPPfasfftFPQysmsaTAAPApapvVNEhgrddggAgtaeaeaSGSkPSAVADVEVTMVESH-ANLRVLSRRRPRQLLRLVVALQGHRLTVLHLNMTSAGHMVLYSFSLKVEDDCQLTSVDEIATAAHQIIE-- --------------------------------LKEALKTLCGE--NQWSYAVFWKIGCQNPKLLIWEDCYYEPAPCsgpPgIsgSENSelpfqewEGcwvssesrssqlgcqAEDRVCSLVnkMMAnnQVHVVGE-G-IVGRAAFTGNHQWILSDNYNRdAHPPE--VLNEmhhqfSAGIQTIAVIPVlPHGVVQLGSTLMIMENMGFVNDVKSLILQL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSINLQMDRTSILGDTIDYVNELTERIKTLEEEIGATPEELNLLNTRKNfsSGSSeeMPMRNSTKFVIEKQ-GDGG-TRIDICCATSPGVLISTVSALEVLGLEIEQCVVSCFGDFAMQASCSQEE-GRSRVTRtDEIKQALFT----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SETLDHIITERNRRRELTRKFIELSAFIPGLKKTDKVHVLGEAVKYVAQLQERVKELEEDIKKKGAGSLitITRShllDDNdTAmGEMNTkecyRhNETFPELEVRVLGKE---------------------LQILHLSITTTNVLPFGNTLNITIIAQMGDKYK-LTVEDLVK--------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPSRSLVSERKRRGRMKEKLLALRSLVPNITKMDKASIIGDATAYVQELQKEATKLSEEI-------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIDVKIIGWD-AMIRIQCSKRNHPGAKFMEALKELELEVNHASLSVVNEFMIQQATVKMGNQ--FFTQDQLKVALMEKVE-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNDYLAVLRSLMPDsyVQRGDQASIVGGAINFVKELEQNLQCLSAKKQMTENNensssSSLpfgefftfPQysTddDGPnggaTTSggSISmeqirSehGGGVAADVEVTMVESH-ANVKIRSRRPPKQLSKLVNGLQGLRLTILHLNVTTADGVVLYSFSVKVEDESKLNSVDEIAGAVYQLL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTEKQRRGKMSEKFSLLRSLIPHPRKHDRASIVAEATEYIKELLRTVEELQTLLAARRRRVEeWrNPTaARGGGGhppPRCSWvqrRLRGISVDVRIVEDE-VVVRLLRRGGTHCLLLLSRALLDLQLDLLHLAAGNIGDSHVIVINCKIEEGS------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSSTEKQRRRNFNDKYQHLRSLIPNQTKTDRASIVLDAINHIHELRRTVGELKLLVEKKRisKErrkrHKTETNDTpvggdqhSNGVdgvAavkpdpdedfnGsaaiqlrSSWiqrKCKDSEVDVRIVDDD-VTIKLVQRKKINCLLSVSRTLDELQLDLRHVAGGEVGDYYSYLFNTKICEGS------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVQDHIMAERKRRELLSQLFISLSAIVPGLKKIDKTTVLGEAIKHMRQLQEKVKVLEEIAAKRIVESFvIDysASGGSngggGSGdSGdSGdggySDRSPPAIEVKTTSNF-VKKRICCDKHNGLL--------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKISILGSTIEYVKQLEEKVNSLEEQSAPRTSEPtvferkcRISSDNDASwpNGSTSSGaiSGYMPTIEASIHGDT-VLLKICCRERRGVLVMIFSEVENHGLSIINTSALPYTDScLSVTITAKAR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTISHVEAERQWREKLNRRFGDLRAAVPTVSRMDKASLLGDAAAYITELRG----------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEAAINHMMAERRRRVKQKENFAALRRLVPIISKADKASTLVDAITYLKDLQKEVEELKASKE------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAQEHVIAERKRREKLAQQFIALSAMIPDLKKTDKASLLGGAIDHLKQLEEKVKVLEEQAT------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHIMAERKRRENINQSFIELSALIPGLKKMDKGTILADATIFVKELQERVKYLEAA--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EREnYHSKNLLTERNRRHRINHGLLTLRSLVPNISKMDKASTLGDAYDYIQELQRSVEEYQDKLR------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DENDRNHVLSERKRREKINERFLILGSLIPSDGKVDKVSILDHTIEYLRQLESKVEELRSRKE------------------------------------------------------------------------------------------------------------- -------------------------------ELQARLQHLVERSGGVWTYDIFWQESRGAggggCAVLGWGDGHCRDGAwgphdaaavkeeRsaarKRAllrlhalygggDdDegadytlrLDRfTGAEMYFLASMYFSSPEGA-G-GPGHALAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRIHSEAERRRRERINAHLATLRRILPDAKQMDKATLLASVVNQVKHLKTRATEATTPTAA-----PI--------------PPEANEVTVQCYAGgeHtaaRTYVraTVSCDDRPGLLADIAAAFRRLRLRPLSADMSCLGGRTRHAFVLC------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNLISERRRREKLQKGLITLRELVPMFnQKMDRVSILTDAINHLQDLKRQVEMLESTDSHDEdrrcfdhKtvehtKSssTdVGTSygdNegenqkNSSTDgSfcsefidnsVvrceyetSpsSSrdwDLQQIQLDVVKLDHGVYKLDIICMEQSGILVQLSQAIEAFVIEIVYTSIVVITSaKVTCTFIVKMSSWN-DMTLEEVRADIKKLLG-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHITVERNRRRQMNEHLKALRSLTPSfyVKRGDQASIIGGAVEFIKEMQQLLRALEAKKQRRSVSPRSPPPAQPApAPakSLGAcCNTAVADVEARISGPN-VVLRTLSKRRPGQLVRLVAALERHAFDVLHLSVSSMDDTVLYCFVVKIGLQC-QLSVEELALEIQQSFG-- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYKSKNLETERRRRARIKHQLFTLRSLVPRITKayashiMSKEATITDAVDYIQELERQKERLQKELLGMADETPEKQVSDSrMGAEAASqePvhCKAQEGVEMSTLGKNRFLAGIVCRSRRGGFTRMVEAVGSLGLEVTDASFLSVDGLSQIMLCME------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSQIKDHIMNERKRREKLGQLFIALAAMVPGLKKTDKGSIIVAAIENLKQLKMRETSLRNEVNKIKKKSYtehvtakskegkIQTTNDlkiSSScSStISPattNSTVVLEVDVKYEERK-ILIRLNISRKKLAIANLLNEIESIDLKVTNCYWFPFEDsYLVITIIVEMDAQFSLTTKE-LVTKLHDLI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHMLSERKRREKLNDSFKALKAVLPPGSKKDKTSILIRAREYVNSLESKVSELEEKNR------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEWKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKYLKQLQEKVKSLEEEEA------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINAQLATLRKLIPKSDKMDKAALLGSVIDHVKDLKRKAMEVSKAFT-VPTE--IDEV---TIDC-DHAQDESSTSKVNKSKDN-IFIKasVCCDDRPELFSELIQALKGLKLTTVKADIASVGGRIKSIL--------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEACKSHKEAERRRRQRINAHLSTLRSLLPNTTKTDKASLLAEVVHHVKELRKQAADVARQ-DGD---S----CSGG-SGPEPWPfPGESDEATLSYCDGEgkLVKATVCCEDRPGLNRDLTRAIRSVRARAVRAEMMTVGGRTKSVVVVQWAGGGgGEEEVGALKRALKAVVE-- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TALKSHSEAERRRRERINAHLSTLRSVIPGTDKMDKASLLAEVISYVRELKVSASQICQECM-------IPK------------DNDEVKVEVYGDGSNSfnYSIKasLCCEDRPELLSDIRQTVQSLHLMIIKAEISTLGGRMKNVFVMSC----------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDHELHIWTERERRKKMRDMFANLHALLPHLPpKADKSTIVDEAVKYIKKLQQTLEDLEKQKEQKLKGGnLNaIQSreaflaEQGStSslqNpnPVfSGPefpsifkTWTSPNVVLNVCGID-AHISICSPTKPGLLTAICFVMEKYNLEVVSAHVSSDRNRCMYMIHARAN---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLAVLRSLMPGFyvQRGDQASIIGGVIEFIKELQQLLQSLESQKQRKTyctevlsPRpcssprPPVSprplpaspRTpqpGNPyrpKniqsfmpCTSIdsnfetvkelvANSKSAVADVEVKIAGSN-ALLKTLSHKIPGQILKIVNALENLSLEILHLNISTIDDTVLNSLTLKIGIEC-KLSVEELAQAVQQTF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TERHRRGQMSDKFNALKALIPNPTKSDKASIISDAAVYIKELLRTVEELKTLVLRKrlrgtrggggvRKKQRrnaVCKSvDDVveMDNNVgllrSSWlqrKSKDTTVDIRIVEDE-VNIKVTTRKKPGCLLVISNVIHKLQLQLVHLTSGNIGDYLVFMINTKIQEGS------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCKNLLTERNRRMRLNQQLLALRLLVPCISKMDKRSILIDATEYLQGIHKKIETMEKEMSAGASITCLNS-NLSPSSeGVSQdvhePtiSHNIFEIDIEKLNDRLFTVKVVFKRAKRVQAQIQRALESLGFDISNTMIHPTDQHmMLSTSFIHVKKQ-KHLTEDSLKKQI------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVVVVTERRCRRRLNDRLYALRRVVPNITKMDKASVLKDAIEYILQLQQLERQLLAEL-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNIVEERDRRRRLNEKLYAIRGVVPNITKMDKASIIQDAVAYIEELQEQE--------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRSKTLVSERRRRGRMKEKLYALRSLVPNITKMDKASIVGDAVLYVQDLQNQAKKMKAEIAG------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALRNHSEAERRRRERINGHLTTLRNMIPGTNKMEKASLLAEVVNHLKELRRNATEATTGVL-------IP-----------T-DIDEVKVEQQedGSGGASCAIRasLCCDHKHEIFSDLRQALDALHLETVRAEIATFGGRMI------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSKNLISERNRRKKINEQLLKLRAVVPKKSKMDRPAILTDAIEYVGDLQEEKKKLDQE--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPSsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlygdqGRPMgdsNssssstvlglVQQTpqvQPPlafpPPqhqhqdDDqlrrLvdhqldpmDSgllpeetaeSKSCFADVEVKVLGFD-ALIKILSRRRHGQLIKAIAALEDLHFTILHTNITTIEQTVLYSFNVKVANEA-RFTAEDIASSVQQI---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTERERRVHFNDRFSILKNLIPNPTKSDRASIVGEAIDYIKELLRTIEEFKMLLEKKKleefrsmKKAKTDGeeeeeENNvSyrQQSQVdqscfnkkSlrcSWlkrKSKLTEVDVRIIDDE-VTIKVVQKKKINCLLFTSKALDQLKLDLHHVAGRQIGEHYSFLFNAKICEG-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSKNLMAERRRRKRLNGRLSMLQSVVPKINKMDWTSILGDTIDYMKELLERIKLLQEEIGQ------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THIVVERNRRKQLNEHLCILRSLMPSsyVQRGDQASIIGGAIEFVRELEQLVQCLESQKRRQAPSMlVIPNdqmklVGdyeNGLSEEKAEIKSCLADIEVELLRVD-GSIKILSRNRPGQLIKIIAALEDLQLNIVHTNVTTIEQTVLYSFNFKV----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKRGRKsAGprGPDapPTMNLVEAERQRREKLNHRFYALRYVVPNVSRMDKASLLSC--------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNEKQRRQRFNDKFEILKSLIPNSTKPDKASILSDTIDYIKELSRTVQELRLLVAKKRSKieRgiKPENDdelhgemDSSsiskpSTTTyVesdhglngamrSSrvqRRSKGTFVDVRIVEDE-VYIKLAQRRRVGCPLIVSRVLDELQLEPMHLTGGNIGDILI------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQTSLIAETSL-LPT------------------EADELTVDAAVDEEGRLVIRasLCCEDRPDLLPDLIKALKALRLRTLKAEITTLGGRVRNVLFITG----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLHHMISERRRREKLNESFHDLRMLLPPGSKKDKASVLSYTTEYINTLKAQIEELEEKNR------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------SSSNYSMMQNQVKLGDCNNVEENSNNM-----LFLEGSS-----ANS--NSLRCcTKKRKRTCNNKDQRMIHIAVERNRRKQMNDYLTILRSLMPSsyVQRADQASIIGGAINFVKELEHNLQTLQAQKSLISQleKSDISSSplfaDffsfPrySNCSCESSeavekSRSllMSHDIQVNLVESH-VNLKILSKRRPKQLMKIVVGLQCLWLTILHLNVTTVhDQIVLYSISAKLEEGCQLTTVEEISHAVNQLLD-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPKNIMAERERRNKFNKTLYDLRSVVPIITKvrereagrhacmhscvqsfhpietsefvgfgvqMSKTAIILDAINYIQEQEmslvDEVSELESKKQITAPPhgKKDEDLlhaqmQRRRAA--SMSSMVVMEVSVAEMGDGVSFVSITCNKKRDAIVMVFEVIDSLHLRIITPNVTSSFGKVFHSLVIHVS---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLSVLRSLMPGsyIQRGDQASIIGGAIDFVKELEQLLQSLQAQKRKRECEefgcsPNSPTPfNgfflspqyTSYSaqwNSryaVektsfndtGNeliaeNKSAVADIEVTMIETH-ASIKILSQKRSGQLMKTIDKLQSLHMTILHLNITTIDQTVLYSFNVKIEDECQLTSADEIATAVHEII--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEWRRRKRPNDRLSMLRSVVPSCDKMDRTSILGDTIDYRKELLEKIKHLQELVEASNKANLIMSPLKAiNSNEMV--SSNPPNFEVERRDAD-SRIEVSCVMKS------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HELHIWTERERRKKMRNMFSQLHALLPQLpPKADKSTIVDEAVSYIKSLEQTLQKLEKQKQERlRQLStntgitSIlinpqplaydSReSflaDQGSStNnasldasAtTsfgfPItpsvSPSpvvfqtwTSSNVVLNVCGDE-AQISVCSPKKPGLLTAICFVLEKHKLEVVSAQISSDSNKSMFMIQARA----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEIHIWTERERRKKMRNMFSNLHALLPQLpPKADKSTIVDEAVNYIKTLQNTLQKLEKQKLERlEEYSairlltsqKdnsWEAylADQGSTsNSaitptNhgaspLvpNfPtsfqTWSSPNVVLNVCGED-AHISVCSPKKPGLFTTICYVLEKHKLEVVSAQISSDQF--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRSRERMHIFAERERRRKIKNMFTDLRDLVPSLtNKADKATIVGEAISFIRSLEETVADLERRKRERDslaARCaRlgLGGSsSssapppppppaaadDTAAvmPPapavpppdaaaVTAgPepaPapapGtlmvwSGPSVVLNLCGGDQAFINVSVARRPGVLTMIVDVLERHSIDVVTAQIASDQSRSLFTIHTSV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEMDKTSVLGDAITYLKHLQERVKTLEEQARMQTMESAvlVKRSqvtaeDESCTDGESGsyDEHPLPEIEARVCNNH-ILLRVQCEKHKGVLVDLLSKVEKLNLAILHTNVATFGSLAL-DITI------------------------- -------------------------------ALQQRLQFILQSRQEWWVYAIFWQATKDSdsRDTLEYGDGFFMGTK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKKHSDAERRRRLRINGQYETLRTILPNLIKKDKASVLAETIKYVKELKKKVSELEQDNQSK--DVKFP----SG--------ADSLNLGYCNNNRDLAKAVLSCEDRPGLMSEISRAMKSVKAKAVRAEMVTVGGRTKCVLWVQ------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGKEqYQSKNLVTERNRRHLIKDGLFALRSLVPKISKMDRASIVGDAIEYIKELETNVQD------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINGHLAKLRSMLPNTTKTDKASLLAEVIQHVKELKRQTTEITEESP-LPT--EV----------------DELTVDSTCDEDGKFIVRasLCCEDRPDLLPDLINALKALRLRVLKAEITTVGGRVKNVLAI------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKQRRVVVKGKYEALRALIPTPTKIDRASIVGDAIGYIKELKTTVAELKVLVERKRRAREDEK-GGS----ISSWlhrKTKNTEVDVRIVDDE-ITVKLVQDKRINCLLFASKVLDEMPLDLNHVAGGLIGDYYTYLFNSKICDG-------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASILGDAIDYLKELLQRISDLHNELESTPTPLRsLPPT-PSSFHPLTpTTQTLSFPVEVRLREGRAVNIHMLCGRRPGLLLATMKALDNLGLDVQQAVISCFNGFALDVFRAE------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPSKNLMAERRRRKRLNDRLSLLRSIVPNISKFDVK----------------------------R-R----------------------------NMD-TQIEICCEGKPGLLLSTVTTLEALGIEIQQCVISCFNDFAMQAACSEELEQKTTISSEDIKQALLRN---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEQALEHLLAERKRRKRISKLFVSLASLIPGLNKMDKASILEGAATLIRQLGERAKEDDHHQ--------------STIG-MMTKNNLLPEVEIKSLEKE-LLITILLykNQQKRNIDEILSVIQRLHLTIKTTNFMPFGTTSM------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASILGDTIEYVKQLRKKIQDLEARTHQMeadqrSRaassltlkEqrSGvtvVDRArvgpatDKrklriveASGGAMakaveSPppppPpppplpqpvAGEAVQVQVSIIESD-ALVELNCPYKEGLLLDVMQMLRELRVEITTVQSSLTNGVFVAEMRAKVKENIngKKTSIVEVKRAIHQII--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRNHKEAEKRRRERINSHLDKLRTLLPCNSKTDKASLLAKVVQRVKELKQQTSEITE-LETFPSET--------------------DEITVLssgdySSDGR-LIFKasLCCEDRSDLLPDLIEILKSLHLKTLRAEMATLGGRIRNVLVVAADKDHhSIESVHFLQNALKSLL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPNsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRLIPAEAE--ERA------ESKSCLADVEVKVAGYE-GLIKILSRRREGQLIKTIAALEqDLQLCIVHTNITTIDQTVLYSFNVKVVGGE-EQSAQDLANSIQQI---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSSKNIVSERIRRNKLKEKLFALRALVPKITKMDKASIVKDAIEYIVKLQKQDRRIR----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANDREEPLNHVQAERQRREKLNQRFYALRSVVPNVSK------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETKHFATERQRRVHLNDKYKALRSMVPNPSKNDRASIVKDAIDYINELKRGVNELKLMAEKKRcNKDrikrqKTEGGttismDGSDAkqimDEVeqsyngnslrSSWlqrRSKNTEVDVRIVDDE-VTVKLVQQKRINCLFSASKVLDDLQLDLHHVAGGLI----------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------GTQVLIPVLGGLIELFASNHIPKDHSVIELVTSQCNAVLKPELTSaesytkanLDrcpSiEHppfaSDSAymsqGekfkhligthyGTKRPRCsqnvseqqarfVPDRDESVNNRMrtTEQPEKEKYNSKNFtsPMISLFPNLL-MDKPAILTDAIEFVEDLQQEKKKLEKELMEIEDNIsAVKP-KQ-VSSSVTETVKTEVHVEVNQITKREFLIKLQYEHKRGRFAKLMEGIDSLGLQVIDANVTTFNEKVLSIFKV------------------------- ------------------------------------------------------------CRVLEWGDGYYNGDIktRKTVqsmeinayqlvlqrckqlrelyeslsvgEsspqarrrsislSPEDlSDKEWYYLVCMSFMFNNSQ-G-LLGRTLANVNPY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAQDHVIAERRRRERLNQQFLELSTIIPGLKKfshfivqTDKVSLLGDAINYIRQLEEKVKTLEEKAS------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEKLYELRALVPNIMQMDKASIIADAVAYVKNLQSHARKLKEDVATLEARPsppsrrqqqQQQQGrrqgqhGRNQQdderNSGSSrgGSGaRVTHVSAAQVGEGRFFVTVECERRDGVAAPLCAAVESLaCFRVESSNIGCSSDRVVSTLTLKVC---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQLHHMISERKRREKINESFQALRSLLPPGTKKDKASVLTRTREYLTSLKAQVSELSKRN-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRAAILADAVDYIKELQTQVKQLKDEVRALEvqnsEKntPqlRMplgkEQEGTRSNPlNQSSSectkktQMKQVQAEVHHISKTCFMIKLYCEQKKGGFSKLMEAIHSIGLRVASANMTTFGGKSLNILTVEATKQ--DILPTKLKEYLIQK---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIEYLKELLQRINDIHNELEEAKLEqSrSMPSSptprstHQGYPTAVkeecpvlPNPESQPPRMEVRKREGQALNIHMFCARRRGLLLSTVRALDALDLDVQQAVISCFNGFALDLFRAEG----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTLDHIMAERKRRENLTKMFIALSALIPGLKKVDKVSVLNKAIEYVKCLEQRVKDLEKENK------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMNHIAVERNRRRLMNDHLGVLRSIMPEsyIQKGDQASIVGGAINYVKELEHLLLTLELKKIAVVKEMKssdtREEAneisflNPRFSSsSTQNNRWLSANVDVTLIDSH-ANIRILVEKKRGQLMRIVAGFQALGLAVLHLNVTTLEDPMVAySFSAKLEEGCSLTSADNIAGAVHHVL--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARLMMALKDLDLEVYYASVSVVKDLMIQQATVKMSSR--VYSQEQLNAALCARLT-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNHDHVIAERKRREKLTQRFIALSAIVPGLKKT---SVLGDAIKYLKQLQERVKTLEEQTT------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDQMDKGTILSGATRYVKELQERVNALEAAGGNVRsvetvvlvRKPCYAAPDGESSPRfflaAgTpAVGKQLPEIEAKLSEDN-VMVRIHCEmNGKGLVARVLAEVEELHLRIVHNDVMPFTAsTVIITTMAKVEEGF-TVNTEEIVERL------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FICCVECISHMDRTSILGDTIDYMKELLEKINNLRQEVEVDSNMAGIFK-D-VKPNEILVRNSPKFEVERSV---D-TRVEICCVGKPGLILSTVNTLKALGLEIQQCVISCFNDFTMQASCSEESEQRTMLSFEDIKQALFRS---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDKASILAETIAYLKELEKRVEELESSSQPspcpletRSRRKcheitgkKVSAGAKRKAPapEVasdddTDgeRRHCVSNVNVTIMDNKEVLLELQCQWKELLMTRVFDAIKGVSLDVLSVQASTSDGLLGLKIQAKVV---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REFKSKNLETERRRREKLSSRLLMLRAI------MNKATIIEDAITYIEKLQDKVQSLSQELHQIEAtseEtaeTKIDEIDAA--QD-MKDLGIQEEVRVAQIDGNKLWVKIIIEKRKGRFRKLMEALNNFSIELIDTNLTTTKGAFLITSCIQIK---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APSKNIASERNRRKKLNDRLFALRAVVPNISKMDKISILKDATEYIQQLHEQEKSMKG---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERSRRKLMNEHLSSLRNIIPPyfIQMGDQASIIAGTIEYVKQLEQLLQSLLSERGERDRRhTYFSSTSPPfsqffPSPkyTIHtSRSptTTEVDVAATVVQSH-VNLTVLSRQKPGQLLRAVSELENLHLSVLHLNVTSFDSSVLFSLNLKIEEECKLGSTDEITAVAHQIF--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMIHITAERNRRKQMNEYLSVLHSLMPEsyVQRCDQASIVGGAINFVKELEQRLQFLGAKKESVEGKSdAITSIpfsDfftfpQySTSASCsenSlamNeqvNevKCSIADIEVTMMETH-ANIKIRSKKRPKQLHKIISSLHGMHFTILHLNVHTSGEIVLYCFSVKMEDDCNLRSVDEIAAAVYQMV--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALCPVEAERQRRDKLNRLFCELRAAVPTVSRMDKASVLADATTYIAQLRQRVEQLEVEAKK------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLAALRALMPGsyVQKGDQASIIGGAIEFVKELEHLLHCLQAQKRRRAysdisnlgnpTisRpamPSLDqlhrtqppfsfispQpfMlGSPtTTlgsvgrnsqlqrffPpsqlpppptPLdvpySsTglymplreiyGeaKSDMASVEVKMVGSDQALVKIMAPRRSGQLLRTVVALESLALTVLHTNITTVHHTVLYSFHVQIGLLC-RLNVDEIAAALHQT---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASILGDAIDFIKELLKEIQELQDELEEHSNDEgSPENDtaitaasgNDSTLPKVqnqdleiTNDKTQQMevQVEVAPLDGSEFFVKVFCEHKLGVFVKLME----LGLEVTNANITHFRVLVSNVFKVKKKSS-EIVQADHVKDSLLEQ---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSKNLMAERRRRKRLNDRLSMLRSIALthiCIHKMDRTSILGDTIDYMKELLERIKRLQEEIEV------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLEAERRRRLKLNQRLLTLRSL------MNLATILDDAESYIVELQKNVKALSDQLLETealCeDRPKalVDEIDAA--QD-MEANGIKPDVQVTSIDEHKLWIKIVIPKRRSRFTKLLETLSICGFELTDPSVTAFKGAMLISSCME------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSKNMVSERNRRKRLTKQLLSLRALVPHITKIDKRSVLVDALSYLRNIHEETERLQKELKEQQPGLKLSdlreSSqDNPSGTfripritsaSVAYpkSKVQITEIDVEKIEHKRFIVKVTCKGCAGVGNDVLRVFESLDFEITYTALQQLQPqEVLVTIFVRVRKQG-KMTEQKLKDCIT------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKEFKSKNLEAERRRRGRLNGNIFALRAVVPKITKMSKEATLSDAIEHIKNLQNEVLELQRQLGDSPGEA-WEKQGSASCSeSFvPTeNAHYQGQVELISLGSSKYNLKIFWTKRAGLFTKVLEALCSYKVQVLSLNTISFYGYAESFFTIEVKG--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLQHVLSERKRREKLNDSFKALKTVLPPGSKKDKASILIRARDYVNSLKSRVSELEEKNK------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHIAVERNRRRQMNEHLKVLRSLTPCfyIKRGDQASIIGGVIEFIKELHQVLQALESQKRRKSLSPSpgpSPRTlqpnfhqlDSSSiigPNSFkelGAScNSSVADVEVKISGSN-VILKVISQRIPGQVARIITVLESLSFEVLHLNISSMEETVLYQFVVKH----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNDHIMAERKRREKLSQSFIALAALVPNLKKMDKQSILTDSIKYVKELKQRLEEQN----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDHIIAERKRRQKINQRFIELSTVIPGLKK---------------ELQEKLKALEDGGSGSNdrsieswvlvKKPcSVVPGDDAGSPswdSSgaSPATNQLPEIEARFLNKN-VMVRIHCEDGKGVVVRVLAELEELPLSIVHANVMEVHKC-------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSEDKASVLGDAIVYVKQLQERVNILEEQSKSRTVES-VGRSNNDqDYNhNNNNDnnqtLTLLPEIEARVYEKD-VLIRIHCENHKGIVVKILSEIEKLdhHLSVVNTSVMPFGNCTLdITILAQMEKE-------------------- -------------------------------VLQQTLRGLCHNTP--WSYAVFWKLKERARIVLTWEDGFYDYAKRNQApAGEGDeVDTELLGLAVakMSyHVYSYGE-G-IIGKIAFSGKHQWVFMGASVNtdEKHPVGWENQFMAGVKTIAVIAVPQGVVQLGSTRVVQEDLALVNHVRGLFTT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHISVERNRRRLMNDHLAALRSLMPSmyIHRGDQASVVAGAIEFVKQLEQQLLALQAEMKSRTAP--TAASDFFFSSP-QMTGSGFDESPQSAVQGH-VNLKVASRRWPGQLARAIAAMEELRLTVLHLCVTSLSHnSVFYSFNLKMEEDCRLGSADEVASVVHQIF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CKSHSEAERRRRKRINGHLATLRTLLPNTIKTDKASLLAEVVRHVKELKKTAAELAASESDGDSEFMF--------------PSETDELKVEYCgedGDGSILIKasICCEDRPELLSDLTRALRSVRGKVVRAEMATVGGRTKNVLWVQVklGNgGDEGLL-SSLRRALKAVMD-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THIAVERNRRRQMNEYLAILRSLMPEpyVQRGDQASIVGGAIEFVKELEQQLQSLEAQKRTLLphHKSKcddampthngggsnagggcMESTTTSncSSSvtedaqhvdapPlaqffaypqyvwchsprdsAgataaSSsssSptaglqaehRSGLADIEVSLVETH-ASIRVMSPRRPGQLLKMIAGLQALRLTVLHLNVTTLGSLVLYSLSVKVEEGCNLTTVDDIAAAVHHVL--- ------------------------------------------------------------------------------------------------------------------GKCIWLNEPSKLPSNLCSRAYLAKTGGIQTLVCLPMEHGVVEVGSVEMIRESKHAIDKVRSSFNEN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEMHIWTERERRKKMRNMFSNLHALLPQLpPKADKSTIVDEAVNYIKTLQQTLQKLQKQKlERLQGatpfnyDPSiitpqklaMDSreAfmaDQVSSNnlansnssNsLSVSPrfpvcfqtWTSPNVVLNICGDE-AQISVCSPKKPGLFTAICYVLEKHKIEVVSAHVSSDSN--------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRISHIVVERNRRRQMNEHVNSLRSLLPPsyIQRGDQASIVGGAINYAKVLEQIIQSLESQKKTQQS-SEVEN--R-----VQEDETCVPSIETTVIQNH-VNLRVVCRKRQGGLIRGIISLEKLRLTVLHLNISTLSHFYVsYCFNLKMEDGCELESADEIKKVAHQIF--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDYLAVLRSLMPPSyaQRGDQASIVGGAINFVKELEQLLQFLEAQKwlQANQssSPPSlFDNffTfpqySTYpaATgQNaYSTSqeeRSTAADVEVTLVESH-ANLKVLSRRRPKQLLKAVAGFQSLRLSILHLNITTlVDPSVLYSFSVKVEEECELNTVNEIATAVH------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGFTSLAKVLKPL-EMDRASILGDAIDYLKELLERISDLHNELESTPTPPgSLPPTPSSfhlltPTTQAlSFPvKeelhlpfCLYPQVEVRLREGRKVNIHMFCGRIPGLLLATMKALDNLGLDVQQAVISCFNGFALDVFRSE------------------------ --------------------------------LQHTLRRLCTE--SQWVYAVFWRILPRNypppqwdteggimdrskgnkrNWILVWEDGFCNFSAcaagaakdtRRGSpsfqstqqsprgSDdeCEAMSPELFFKMSHE-VYNYGE-G-LMGKVAADNSHKWVYREPlehEISflspwhgsLDPHPRTWEAQfKSGIQTIAVVAVQEGVLQLGSTKKIMEDLNFVLYMQRKFNYL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSREH-KRAALHEKLQLLRSIT-NSHAVNKTSIIVDASKYIEELKQKVERLNQDIATAQ----------SS-----SDQNPLPMVTVETLEKG-FLINVFSEKnCPGLLVSILEAFEELGLDVLEARVSCTDSFRLEAVGGENEEQGESIDAQVVKQAVLQAI--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSNLVSERKRRKKINEALYALRATVPIVSKMDKVSILKDAIDYTRQLQKHVEDMEDEIRC------------------------------------------------------------------------------------------------------------ -------------------------------TLQQRLHVLIEGEGESWTYAIFWQSSLDAatgEMLLGWGDGYYKGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMDRASILGDAIEYIEALQKTVKELKDKLREMEEEKCNNKSHQHVILD-LNTIKDPLLVEVYQIGTKDFLLKLSCKHKQEGFMGLMEALNSLGLQVINANVSMYSGKVSNILKVEVNIR--EFQPKSLKDSLIKLVR-- ---------------------------------------------------------------------------------PEDlGNVEWYYVVCMTYAFRPGQ-C-VPGKSFASNGCAWLCNAQSADSKAFPRKLLAKNASIQV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEKQRRERLSEKYELLKSLIPNRTKDDRATIISDTMDYIRELGRTVNELKLLVEKKRRKKerGKEVligeelVGDmeSSSvKpFIdegehhasngslrSSWlqrKSKETFVDVRIVEDE-VTIKITQRKRmISCLLTASRILDELQLELLHLSGGIIGDCHIYMFNTKIPEGS------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQAEHIIRERQRRDDMTNKFLMLESLLPPGPKRDRSTVVEDSIQYVKNLHHRVKNLQQKRSEIKSNNasclsetaikhKPKQNspayFHvSSpDlrkqclnvaflkNSIasspseSDamAKSSSIeKIEVHLDLPHQIVIEMTCRPHPHIQSQIMKALERLGMDVSRCSISKLHNRLVCVIIVKPRVVTePPITSDDIIEALKRA---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASLLGDAIAYITDLQKKLKEVESEREMDQKRRA----------------VECPEIEVQTVRDE-VVVTVSCPLETHPVSKVIHVLKEAQMNVVESKLSAGK---------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRSSILGDAIDYLKELLQRISDLHNELESTPTPPGsLP----PTPSSFhlltPTTQALSFPVEVRLREGRKVNIHMFCGRIPGLLLATMKALDNLGLDVQQAVISCFNGFALDVFRS------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRINHIAVERNRRRQMNEHISSLRSLLPPsyIQRGDQASIVGGAINYAKVLEQVIQSLELQKRTKQS-SGVE--N---------RVTCVPRIEATLIQNH-VNLKVECRKKQGQLLKGIVSLEKLRLTVLHLNISSLSCSsVSYCFNLKMEDDCKLESAEEITKVAHQIF--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQLYHMMSERKRREKLNDSFHTLRSLLPPCSKKDKTTVLINAASYLKTLEAQVSELEEKNTKLERH--IPREDGGADAAA-AHRRAKVQIsraasdEQQVVSLT-VMVMVECDIVE-LVLHVLECLRWMsGVSVLSVDADTYSP--------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRLMNDHLASLRSLIPSsyIPRGDQATVVGGAIDYVKQLEQQLVALQAAAAARRGVGGVGTAataaSDGvfVSPqytSYSEArggCGAGVDVEATaAVGGH-VRVRVAGRRWPGRLVRAVAAMEDLRLAVLHLAVTSVGhDAVVYCFNLKMEEGCEVATADEVATVVHQIF--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAHFALDKQRRVQFKDKFQALRKLIPNPTKNDRASIVGDAIDYINELRREVTKLEGLIEKKKKRQN--N-GNSMKERFwFKKTSNGTEVDVHVMDDEdkEVTVKIVQRKGsensscINCLLPVSRVLDELQLGLCHVGGGLIGDC-------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNEYLAVLRSLMPESyaHRGDQASIVGGAIDFVKELEQLLQSLEAQKRTLlaqqqqdHKPPPIRDampspsiTvtaaATtttrSGSGegkqaAatrdgMsppfagffTypqyvcrlpprddAdDHAGAADIEVTLVETH-ASVRVMAPRRPGQLLRMVAGMEALRLTVLHLNVTTLGSLALYSLSVKVEKGCGLQTADDIAAGVHHV---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLEAERRRRHKLNERLINLRLFthYHFLCDYKFATIIDDAITYITGLQKHVKAMGDQIREM----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQCKNLEAERRRRAKLNERLYHL--LVPKITKLGRASILRDAIEYVMELKQQVEDLQSELES------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DETANHAVLEKKRREKLNERFLILRSIIPSINKIDKVSILDDTIE------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------KDVEWFYLMSLAQCFSVGE-G-VVGKCFSSDXFVWLTGDQQFEFCHCERAKEAHyVHGINTF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPGsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRilGEtgNRQIgdmTTTTTSSSspitsvaNpliitgNVteleGgGggglreetaeNKSCLADVEVKLLGFD-AMIKILSRRRPGQLIKTIAALEDLHLSILHTNITTMEQTVLYSFNVKITSET-RFTAEDIASSIQQI---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPGsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlLGEAQARQVgDPSlsvqqppffpplpIPNEqmkIveletglreeTaESKSCLADVEVKLLGFD-AMIKILSRRRPGQLIKTIAALEDLQLIILHTNITTIEQTVLYSFNVKVASDS-RFTAEDIASSVQQI---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPNSIIMERERRRRLNRSLYNLRSVVPNMTNvkstaataamllqlmhlilvfgvqMSKAAIIFDAINYIQQLQEQERSLLEEISEQEshgKRVaPVDGElchapaKKrRTAPrcSCSPepelpmmPSVDAMAVSVRELGNGITVISITCSKKRHAMVRVCKVVESLDLRIISASVDGG----------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AALKSHSEAERRRRERINAHLDTLRGVVPCTEKMDKATLLAEVIRQVKELKKNAAEASKGL--M-----IPMDD------------DEVKVETYDngSNDEPYSIkaSICCDYKPDLLSDIRQALDALHLKMVDAEISTLG---------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHMERNRREKMTEFYTMLQSMVPNLfPKATRTRIVDETISYIKGLEEVIAALEAQKAAREA-S--S---GPSA---L-HSQRSSTVEVTVSGNT-AFFGISFASRPGMVTKVLQVFEKHKAEVLAATVACNEGrSLTVTVTALVMEE---EAIERIKGDLM------ ----------------------------------------------KWTYAIFWKLSHDYsgESILAWDFGYYQGTKdnlKaKTtSeveqEhvkkvlvnlsllNsgsVDEqelTDTKWFFLASKMLSFVNGS-D-LPGKDYH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEKQRRMRLSDKFTALMILIPNRTKEDRATIVGDAIEYIQELGRTVEELSLLVEKKREHQgdVVDASaGESESSvgEaavvpIrSTfiqRKSMETSVDVRIVEDE-VNIRLTNSRSDGCLAAASLALDHLGLDLVHLSGGKIDDCHIYMFNTKIH---------------------- ----------------------------PNSALQKQLQAVLNGTHEAWTYAIFWTPSYYDysgDSVLKWGDGIYKTKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHMISERKRREKLNDSFQALKTVLPPGSKKDKTSILIIAREYVNSLKSKVCELEEKNQ------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGLDKASVLGNAIKYIKELQEHVKKHEDETKKNPVESivCVKKSWLSEEDDFdMSCTQVLPEVAVRVSENY-VIVRIQCEKQNRFIAKIFSEMEKLHLIVINSSVIPFGHSILsTNIIAQMDPRFSMIANdlaKSLRSAIQDV---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AREHALVERKRRQKLSQLFLSLASHIPGLQKGEKqARIVGETTSYIRELKQRVLLLEQQALKRRTQdQTMDSAqschiftDEGSfcssdgnSNNIS-SMNGASDIEVQLSdeNDD-ILIAVHCQKDDDVLPKLLLEMRKLHLTPSNINVMPFGNYMDVTIIAQKQE--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKTLVAER-RRSRMKDKLYALRSLVPNITKMDKASIIGDAIVYVQSLKDEAKKLSDDI-------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSREHKR-AALHEKLQLLRSIT-NSHALSKTSIIVDASKYIEELKQKVERLNQDIACAQ--S-------S------SSQNSLPMVTVETLEKG-FLINVFSEKsCPGLLVSILEAFEELGLNVLEARVSCADTFRLEAVGGENQEE--NIDAQVVKQAVLQAIK-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAEKRRRDRINAQLAALRKLIPKSNKMDKAVLLGSAIEQVKDLKRKAAEINKVF--------ILP-----------TETDEVTVDCDIPEDK-MLMRvsVCCDDRPEVFAELIQVLRGQSLSIVNAEISSVGGRIKSDFIV------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINAHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQMSEIAEESAPLPTES------------------DELSVDAASDDEGKLVVRasLCCDDRSDLLPDLIKTLKALRLRTLKAEITTLGGRVKNVLVVT------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FAKEHVIAERERREKLSEKFIALSALLPGLTKADKITVLDDAISRLKQLQEQIRKLKEEKEA------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIHTCPEKFQREtggrKLNDKLFALREAVPKISKLDKASIIKDAIDYIQDLQQQETRLQAEIRELEserlendKGYEFERDLPVllTSKKIPDPrshPIEVHQLRVTSMGEKTLFVSLTCSQAREAMARICEVFESLKVMIITASVTTVSGMVKTTILIEAD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMDKASVLGDAIKYLKTLQDKVKTLEEQTAKRTVEtavlvkkSHIaaEEENEASSSDeNfGGDQSQLPEIEVKLSDKT-LLIKIHCQNRKGALVCALSEIEKLQLTVLSTSSVPFAASSL-DITVT------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINTHLARLRSLLPSTTKTDKASLLAEVIQHVKELKRQAAEIVEQISVPTE-------------------CDELTVHSANeeEGGK-LVVkaSICCDDRSDLLSEVIKALKALKLRTLKAEITTLGGRVKNVLVVT------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRTLISERRRRGSMKEKLYQLRTLVPNITKMDKASIIGDAALYVQELQMQAKKLKYEIAGLEasltglgKHqATInEKPKKiRIAQN-NNQfCNKILQMEVFQVEERGFYMKLVCNKGEGVAVSLYRALESLTsFLVQSSNLFSASESFILTFTL------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRASILGDAIEFVKELQKQVKDLQDEIEESDGE-DVKNSD--SNNSVQAEmlNPNKVQVDVSLIARNEFFLKVFCDHKPGGFVRLMEALNSLGLEVKKANVTTFKGLVSNVFRI------------------------- -------------------------------TLQRRLQALIEGARESWTYAIFWQCSYDYsngLTLLGWGEGYYKGEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLFTLRYLLPSTTKTDKASLLAEVIQRVKELKQQTAEISEF-G-----P-VP------------SETDELSVDTmencSDEDGK-FLIKasICCEDRPDLLQDLVKTLKSLQLRTLKAEMTTLGGRTKNVLVITIG---------------------- -------------------------------ALRQFLKSLCSNS--HWKYAVFWKLMHHGQLILTWEDGYCDYPKpIEpvenISDDiyfkvvneiwsssceTNTcNDGSGGYPIglavnDMScHHYPMGE-G-VVGEVAFTGSHSWILFENNLTSEfnynlvpECPDEWLlQFAAGIKTILLVPVlPHGVLQLGSLEPQQKDSGCMQPRKGTK--------------PSNV--GKRRARA----------AENQRQrprDRQMIQDRVKELRQLVPNSAKCSIDGLLDRAVKHMLHLRSVTKH------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPSsyVHRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlygdSASSTvlgvVQQTpqlvqpqpqpqpqpEpQPppPSqpppmsmSAIgnheldpmgfAGgllqeetaeSKSCFADVEVKVLGFD-ALIKILSRRRHGQLIKAIAALEDLHFNILHTNITTIEQTVLYSFNVKVASEA-RFTAEDIATSVQQ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEKQRRERLGKKFEDLKSLIPNSTKPYRASIVADTIEYINELLRTVEELKMLAEKKRQRgKKMAAAaaataaGDvESCSSlavaaplaeggpssgMlrSSWiqrKSKETFVDVRIVDDE-VNIKVTRRRRANCLLAVAKALDELHLELMHLSAGNVGGSHIFMLNAKIHDGS------------------- -------------------------------ELRESLRRVCVE--IGWSYAVFWKAIRgiNHQMQLVWGEGYCERVAGVPaiSgfeamdlllkEkvaqrNsreghstemvVARTDDRLntlVYKLMVHQVHVLGE-G-IIGHAALTGNHLWVLQDN-LNdyvsiSKALSEMKQQFWAGVQTVAVIPVlPHGVIQLGSSNMVMEDIDFIRQIRCMFVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ICGNHVLSERKRREKLNQRFMILKTLVPSNNKffcvfgglwfdihvtecvehnclssvaflnslaffmnADKVSILDDTIKYL---ERRVEELVT---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGQKHVMAERKRREKLNRHFIELSTVIPGLKKMDKTTILSDAVRYVKEQHEKLKALQDR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVNHVEAESRRR--LNQQIYALRSVVPNVSKIDKACILADAIYNINELKGKVECLEYQLH------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMNHIAVERNRRRQMNHFLSILKSMMPLSysQRSDQASIIEGTINYLKKQEQLLQSLEAQLKATKPNqsPNIFSDffMfpQySTATaSFSSRhhhNglAVVADVEVTMVERH-ANIKVLTKTRPRLLFKMINEFYSLGLSTLHLNLTTSNDMSLFTFSVKVEEDCQLTpSANEVANAVHE----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFYALRSVVPNISRMDRASILGDTVSYIIELQTKLKVMEAEREQL----------------------------------------------------------------------------------------------------------- --------------------------------------FCVE---IGWSYAVFWRAVGYPsPKHLVWGDGHWFGKLQlSLSDDvnshvnsssefqsLGVgSIDELVNKTMVPQVHVIGV-G-IVGQAACTGNHRWIlrnvTGDNETTLKHFPDVNNQFLAGIQTIVIIPVfPHGVVQFGSTKRVMENLLFVNHARTSLMQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSFATEKQRREHLNDKYNALRSLVPNPTKSDRASVVGDAIEYIRELLRTVNELKLLVRKRD--V-GERGVRG------T--RQR--MSPQA-----IEKKINC------LLFVSKILDELQLDLHHVAGGHVGDYYSFLFNTKIYEG-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKMDKSSVLEDAIKYLKHLKERVKTLEEKTEKRGIESvvFIKKSqifveGEGEDeQSCSFDEQPLPEIEARACENH-MLLRVHCENQKGILAKLLSKVETLNMIVVNTSATPFGNVALDiTIIAELE---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARDHIMAERRRREKLSQRFIALSTIVPGLKKTDKASVLGGTIKYLKHLQDRVRFLEEQAS------------------------------------------------------------------------------------------------------------- --------------------------------LQHTLRSLCIHENSQWVYAVFWRILPRNypppkwdlQggaydrsrgnrrnWILVWEDGFCNFAASaacNSGDcpassvygNcefqHyQGLQPELFFKMSHE-IYNYGE-G-LIGKVAADHSHKWVFKEPQeqeInflSswhnpADSHPRTWEAQfQSGIKTIALIAVREGVVQLGAVHKVAEDLSYVVLLRKKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFTTERERRCHLNERYEALKLLIPSPSKGDRASILQDGIDYINELRRRVSELKYLVERKRcggrhKNNEVDDNnnnknlddhgNedddDDenmekKPeSDVidqcSsnNslrcsWlqrKSKVTEVDVRIVDDE-VTIKVVQKKKINCLLLVSKVLDQLQLDLHHVAGGQIGEH-------------------------------- -------------------------------GLQQMLQLAVQSV--QWTYSIFWRLCPR-QGILVWGDGYYNGVI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGKASILEDAIEYLKELLQKINDLHNEMESTSPSSSLSQTtsfYplTPTApvlpcrikeeldpSSFASPnpspTRQPASLKIKFRDGRSVNIHMFCSRRPWLLLSMMRALNNMGIDIQKVVISCFNGFALDIFRVEV----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERKRRDRINQRMKTLQKLVPNSSKTDKASMLDEVIEYLKQLQAQVQM------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIEYLKELLQRINDIHNELEEAKLEqSrSMPSSptprstHQGYPTAVkeecpvlPNPESQPPRMEVRKREGQALNIHMFCARRRGLLLSTVRALDALDLDVQQAVISCFNGFALDLFRAEVS---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SETQDHIMAERKRRQELTERFIALSATIPGLKKVGYAYIINWFIKRLRQDLLKSHDIQES--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFATEKQRRVQMNGKYDVLKSLIPNLSKTDRASIVMGAIDYIQELQRTVTELKLLIEKKRygrnnKRSKIEMSmdptvitpssNDiieSSsvirhlagSddNNIiinkdllfndtlrSSWlqrESRETFIDVRIVDDE-VNLKMTQKKKMNCLLIAVKALDELQLDIVHVSAGFIGER-------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQLEHVITERKRREKINQRFIELSAVVPTLKKvvqnkshqfhtmkcfrfdplvslsdqMDKATILSDAASYIRELQGKLKAMEPEAT------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRLTHIEVERNRRKQVNEYLSAIRSLMPDSyaDKGDQASIIGGAIKFVKELEQKLQWLESHKHNKNSSPSVPFSNFLTSpNSESSTclRSRAADVEVSMAECF-VNlkIRVITgAVKKPLLPRILQYLDEYKLTVLHLNACGVDRVVLYTICMKVEDECKLTSEDEIAIAMHQVL--- -------------------------------NFKEQHALSVRS--IQWSYAIFWFTSSTQpIRVLSWGEGYYNGDI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSKNIAMERDRRKRLNEKLFALRAVVPKITKMDKASIVRDAIAHIEKLHEEERQLLDEI-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPTNHSAAERRRRDRINDRFDILRRLIPGTQKADKATVLKAVIDYVSRLQAAGADnlLQKEATdEQTAShPqqqaAMSEVYTPTVSarSPgwlSEEeeaTSLQDKIAVDVRDQS-YVVRITCPTRGGLLFDVIATLKQLGLEVTDGELSSCRGRVLHVFYVPIR---------------------- -------------------------------DLHHVLRSLCFNT--EWNYAIFWKLKYRARMVLTWEDAYYDNCEqHDSSEnrcfnkTLDHlcdshysHDPLGLAVAKMSyHVYCLGE-G-IVGQVAVTRKHQWIFADNLFKNncspfQYCDGWQSQFSAGIRTIVVVAVPHGVVQLGSLNKVIENVKLVSHIRDVFSSL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NLQQRLQSSVDSASGNWTFAIFWQLSLDQfssNSFFSWGDGYYRRCD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DHKMHAWTERERRKKMKNKFDTLHALLPNLpEKTDKATIVEATINYIKNLQDKIQKLEMLkMERERAQAlaaASaaaasaSTAATappPemhpsevtTltreSTlaDmvhvweqqaAaggghqamarPSpPPlaplqtWTGPNMTVSLTGDD-AFITLSLPRQQNLVTGALSVLERHHIDVVTATVSTpEQDSNLISLHCHLSPAssssQNLTPEDKYKLAVSEL---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPLHHFATERQRREHLNEKYQTLRSLVPNPTKADRASIVSDAINRIHDLKKEEEGLMDEKKNRqlRRQLRLEMrangkrqrAEESETavkedgESLclkALwSkkvSKHGTEIEVRIVCDE-VDIHIRQKHMPRFLIRVITAVERgLKLEILDGTGGVIHNCDVYRFKLKIQG--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRQTHIAVERNRRKQMNEHLNVLRSLMPGsyVQRGDQASIIGGAIEFVKELEQLLQCLQAQKRRRlysdafSPKPspsAVSSIplppfppyasspapslDNPdpTAaDSSskfvNDnfydckqivaeAKSEVADIEVRMAGSD-AVVKILSQRRPGQLLKTISALESMCMSIVHTNITTIEQTVLYSFTVRIGMES-RLSVDEIAQGIQRIF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAMHSQSEKKRREKINQRMQILQKLVPNCNKIDRASILDDVIEYIKQLQSQVEMMC----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKSLQLQVQIMS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERKRRDRINERMKALQELIPNSNKTDKASMLDEAIEYLKLLQHQLQ-------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDRKVHIITERERRRRMKDMFSNLHGLMPHVpDKVDKATLVGEAIHYIKSLEETKAQLEKRKQEQalARGAaanaGVSsssapQTaqgmaalSppDGwgPvpgqQPpiAApvtaaAAgPvgfqTWSGPNVVLSVSNDD-AYINVCVPRRPGMLTMVMSVLEKHGIDVITSQISSDRARSMFTIYTRVN---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AATNHMYAERRRRKRQRECFAELRTLVPNIRKRDKVTVLEHTIKFIKELQNKVDELERLI-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHVLSERKRREKLNDSFKALRTVLPPASKKDKASILIRAREYVNTLKSRLSELEEKN-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGEEFKSKNLDAERRRRQKLSERLLELRSL------MNKETIIEDAITYIQELQQNVNFLSDQLF------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMSHITVERNRRKQMNHHLSVLRSLMPCfyVKRGDQASIIGGVVDYISELQQLLQSLEAKKQRKvytevlSprglvsPKPPVSprlslpispRTpssGparlimSSSSptSSanscsINdninelvaNSKSHIADVEVKFSGPH-VLLKTISPPIPGQALKIISALEDLALEILHVSITTADETMLNSFTIKR----------------------- --------------------------------LRDALRRLCVE--IGWSYAVFWRSIGSAdPMHLVQEDGHCGHTSCpvgsEPSEslpsdaGcsvPADNRLCSLVhKIMASQVHVVGE-G-MVGRAAFTGNHQWIRRNNIngGDSSSQVLAEMnNQfRAGIQTIAIIPVlPRGVLQLGSAQMVMENINFVNHVKKLFAQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKNHSEAERRRRERINNHLAKLRSLLPSTTKTDKASLLAEVIQHVKELNRQTSQIAQTN------PLIP------------TEINELTVDYCNNeEGN-FMIKasLCCEDRSDLLHDLIKTLKSLRLKTLKAEITTLGGRVRNVLF-------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKMSHITVERNRRKQMNEHLTVLRSLMPCfyVKRGDQASIIGGVVDYIKELQQVLQSLEAKKQRKvysevlSPRpaissprPSVSprplppplsprvglpispRTPQPGSPykpriaqqglylpatmmppSIeSspssehtladlaaNSKSPVAEVEVKFTGPN-VLLKTVSHRIPGQAVKIIAALESLALEVLHVNISTIDDTMLNSFTIKAP---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERKRRDKINQRMKTLQKLVPNSSKTDKASMLDEVIEYLKQLQAQVQMMSR---------------------------------------------------------------------------------------------------------------- -------------------------------PLRQFLRSLCSNS--CWKYAVFWKLQQHSPMILTWEDGCFDYLNphescesmiRDgyTMqEDfikfccckmYPGrSggcpiNLVVADM-SCY-QYALGE-G-VVGRVACTGCHCWVYSDDIgsaeLmsKSQHPDEWLLQFAAGIKTILLVSIfPHGVLQLGSLEKISK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEIHIWTERERRKKMRNMFSNLHALLPQLpPKADKSTIVDEAVNYIKTLQQTLQKLQKQKlEKLQGaTtlsyesPiitsqKaApDsReAflaDQqGSSNNlpIPinmsNTfpvqlSpacfqtWSSPNVVLNVCGDD-AQISVCSPKKPGLFTTICYVLEKHKIEVVSAHISSDQF--------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLHHMISERKRREKLNESFHALRMLLPPGAKKDKASVLFNTRDYLNNLKLQVSEMEERNRMLEsqltREDEIEE-DNGASN-------ERVDVqiaralesssLVQRVALR-ITVRVECDMAD-LLLRALECLKEMGgLTLVSVNANTFSQ--------------------------------- --------------------------------LQHTLRSLCTSSNsSKWVYAVFWRILPRNypppkwdlgggaldrskgnkrNWILVWEDGFCDFAACacDQGEqrksgsGyANGkgFQPELFFKMSHE-VYNYGE-G-LIGKVAADNSHKWVYKEPNNeqEinfisswnnsVDPQPRTWEAQfNSGIQTIAIIAVREGVVQLGSFNKVAEDLNYVILLQRKFSYL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------RKMFYLISMYYCFPFDK-PSIPFQSFNTGRPIWVSDLKGCFEHYQTRSFLAKMAQFQTVAFVPVKSGVVELGCsMRSFPEDQSIIQLLN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQAKNLVTERNRRNKIKKGLFTLRYLVPRITKMDRAAILADAVDHIKELQMQVRELKDEVR------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKLKALQTLVPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VASKNLISERKRREKLQKSLLDLRALVPKITKMDKVSILSDAIEHVQDLKQKVEMLENLSttvEDGsidqataecSKSsgSNLEvsEAddeghNQyhaSedASCSarcdyqsNSSSQdwamhqvshTFLAQLDVTKLEHGLYKLNFTCKQQPGVLVQLSQAIEAFVIEIVHTNIVVITPTkVTCSFVVKMSS--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKTIVSERKRRVRMKEKLYELRALVPNITKMDKASIIADAVVYVKDLQAHARKLKEEV-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSRNLVSERNRRKRLNEQLCALRSQVPHVTKMNKRAILSDAFTYLKGILEETAKEEEKLTTIAtKdENFVLDVDEAQrVNkPEQCrqREHpEISQMEVDMVDREHFMLKLSCSKEMGVLRSVQRMIESLGMDVTSTSINPLDEH-------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRSHSEAERRRRQRINGHLARLRSLLPNTTKTDKASLLAEVIEHVKELKRQTSAMLAAAAaGEGDDD----AAGR--AQLLPTEADELAVDAAEDGEGRLVVRasLCCEDRPDLIPDIARALAALRLRARRAEITTLGGRVRSVLLIT------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSFTTERHRREHFNEKFKVLRSLVPNPTKNNRASIVGDAIAYIKGLLRTVDEAEILVEKTRSsrdqrnkRHKTEDDaaGDQiKNSKMmqplgdpnelTrSwlqRKCKDTEVDVRIVDNE-TTVKLvQRKKINCLVFVISKALDELQLDLHHVAA-------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVEVDVKILGSE-AMIRVQCPDQDYPYAKLMNALKSLGLQVYHASISSVKEMMIQDIVARVPYG--FTSEEAMRMGIIKRW--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IQLQHLLSERKRREKINDSFKALRNALPPSSKRDKTSILMRARDYINSLQSRVSELEEK--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLQMLRSLMPAyyVHRGDQASIVGGAIEFVRELQQLLQCLESVHHHHHEqQpPPliLPPTlDHHDQT--AESKSWLAEVEVRLSGLF-GMIKILSGRRRGQITKNISAVECLHLQILQTHITTIEQLVVCSFSVKMSRE-AMLTAEDVANSIQQILN-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRQREEKRyNRQLRALSNLLPGSKaELDEVLVVENATKYIKHLEERVDSLERRLDSTTGEE-DEQSsvvlsEDTKSD--SDSDSSLPQILVYISLRD-VIISIQCKNHKNIIWETISEVEKQQLSVISFNTMSFGRAeLVINILAKIDEKF-SVTAGflanNMRQALLKL---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTDKATLLGDAVNYIRQLEEKVKTLEEKASERTVEStiLVKKShlstGDHTSDAEGSPfSDAFPKITASLNGNS-ILVRVQCEKRKGLFVKVLSEIERHHLSVINTNVMPFASSSL-NIT--IEEGFSMTTT-------------- --------------------------------LQHTLRSLCIHENSQWVYAVFWRILPRNypppkwdlqggaydrsrgnrrNWILAWEDGFCNFAA-STGEcnpgassvygNseVryQGLQPELFFKMSHE-IYNYGE-G-LIGKVAADHSHKWIFKEPQDQeinflsawhnpADSHPRTWEAQfQSGIKTIALIAVREGVIQLGSVHKVMEDLSYVVLLRKKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRNLVSERNRRKRLNEQLCVLRSLVPHITKMDKRTILSDAISYLKGILE----------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAAIHNQSERRRRDRINQKMKALQKLVPNASKTDKASMLDEVIEYLKQLQAQVQMMS----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRKSHITVERNRRKQMNEHLSVLRSLMPCfyVKRGDQASIIGGVVDYINELQQILQSLEAKKQRKvysevlSprivssprpsplspRKPplspRLnlpiSpRTpqpGspyrprlqQAagylspTmASaSlepspTssSssindninelvaNSKSAIADVEVKFSGPN-VLLKTVSPKIPGQAVKIISALEHLSLEILHFDISTVDETMLNSFTIKVR---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTHSEAERKRRERINGHLSTLRQLLPNSTKTDKASLLGDVINYLKDLKRQVSVVASPSTNQTA--TVSSSicHrRSLPATDVEDNIHVTTITLSPMEHRSAILRatICCEDCPDLLPNILKTFQDLRLKIIKAEIVAIDGG-------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNEYLRILRSLMPGsyVQRGDQASIIGGAIEFIRELEQLIQCLESQKRRRlyggsgdTPRPVVDAAgggapistqqhHqlpqvpppppppffpPSlpfpvaSAGdgdgaAakIvldleAggpdaGglreevaeNKSCLADIEVRALGAD-AMIKILSRRRPGQLIKTIAALEDMQMSILHTNITTIEQTVLYSFNVKILGE-ARYSAEDIAGAVHQILS-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMHIWTERERRKEMRNKFSNLHALLPNLPpKTDKATIVEATINYIKNLQDKIHKLEMLKvEREHAialanaatAasadTAlqappPEHdsvvaaaTremalaDmvhaweQqQEAAatgGShgghSVPPpppslqtWTGPNMTASLCGDD-AFITLSLPHQGGLVAGAVSVLERHHIDVVTATVSSSE---------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KCSKMDKASLLGDTNQYMKELQQRVKFLEKEIKNNPSKRsaKVPS-DVSLSegSDYSSNeEDIVPEINVRVFDES-ALINIYCYKQNGVVGRIPSEMERLHLSVRDMNIMSFSRTCL------------------------------ -------------------------------NMHQLLRSLCLNT--DWKYAIFWKLKHRARMILTWEDAYYDNPD-DYdSlDNkscqktLEQihgghfsHDPLGLAVAKMSyHVYSLGE-G-IIGQVAVTGKHQWICADNHAAGSgssfEFADGWQSQfSAGIRTIVVVAIvPLGVVQLGSLNKVIEDMGLVTHIRNIFLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------TIPLNS-G-IYGQSLISNQPVWLNVSDGLNSGA-------SEENDGTRVLVPVAGGLIELFVLKQVPEDPHIVDFVMNQCN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPSSyaQRGDQASIVGGAINYVKELEHILQSMEPRRTTTTT-HEVDTStsslmspfsefftypqySTKSSSSATENSSSPAEIEVTVAEGH-ANIKIMSKKKPRQLLKLVDSIQSLRLTLLHLNVTTLDNSILYSISVKVPA--------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTNAQVHILAERKRREELTRCIIALSATIPGLKKTDKVSVLREAVNYVKQLQERVKELENQMR------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMTHITVERNRRRQMNVYLNSLRSLIPSsyILRGDQASIVGGAIDFVKILEQQLQSLEAQKITQQISTR----D------SNVEQTSKLRIDATVIESH-VNLKIQCQRKQGQLLRSIIWLEKLRFTVLHLNVTSpCNASVSYSFNLKMEDDCTLTSADEITAAVRQIFD-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKRQQCKNLVAERKQRKKAQRP--------PLQAQMDRASILGDAIDYIVGLQNQVKALQDVLED------------------------------------------------------------------------------------------------------------ ---------------------------------EQQLAALVNY--IGWSYVVVWSLPQ---RALVWQlwpAGSS-------------FQQTLFYTAYKSCQFPFGH-G-HAGIAVIRREHVWVTGVDVTNTSVFEQRDFLQATIIQSLLCIPLLDGVLEIGSTDTILEIDSLLQTIRTFLYA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTRDHIMSERKRRQLMAEIFIALSAIIPGSNKIDKSSVLSEAINYVKQLKGRIAVLERV--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGECRSKRLIAEQESRTMYRDQIHALRSLVPKISKMDENSILGDAVDYIKDLQMKVRNLKEEHGKSLA--RLR--DNAESSC--LDPKTDTEAHVEVIGKRDFLVKILSLNK------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAERRRRNRQNESFERIRGIVPSALKMDKITLLGETVEYIKSLKQRLKQLEEINMALSSSgqdagSfKCEDIKVIPSR--THSPTQDM-TQATPEDEDTLKIEvvrNDCSQ-EDTAIDIFTCLRDLELTVTHASVSTNVYRIHATIKVKMPK--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPITHTDVERRRREKLSKLFIALRHVVQTNKSssqiikrsTIKTLVLEDAVAVINELKTNITALEFEGEILRSQIKsPERIDKI--EKMGVMEHKLLNIEVTKVGKDVMLIRMQSDKMNHPAARLMTVLKELDFEIGFASLSVIENITIQHVTILMSDTtdRILYTKDQLVTVLNAKL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPEVEIEVKILRLE-AVIRVQCNRKNHPAARFMSALKELDLDVYSANVSAVKDLMIQQATVKMSSQ--IYTQKQLNDALYAKL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTQEHVIAERKRREKMQQQFVTLATIVPDLTKTDKISLLGSTIEYVKQLEEKVKTLEGQNA------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------QRILVWGDGYYNGAIktRKTVqpmevgaveaslqrsqqlrDlyeslsagetkqtarrpsaalSPEDlTESEWFYLMCVSFSFPPGT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKVSHIAVERNRRKQMNEHLSVLRSLMPCfyVKRGDQASIIGGVVDYITELQQVLQSLEAKKQRKSynelvmsPrllasprtlpispqKSQFSprpislpispRTPQPlspyrpmphlpfispsldypsPSNSFttSesgnelmaNSRSTGAEVEVKFVGGN-LLLKTCSNRIPGQATKVVAILENLSLEVIQANISVVDDTMFNSFTIKVGVAC-KLSADELAQHIQET---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THIAVERNRRKQMNEYLSVLRSLMPEsyVQRGDQASIIGGAINFVKELEQRLQLLGAQKETSEKSDGVEASslpfsefftfpqySTSSTrceNSVaamnetMSAkqSTSVVDIEVTMVESH-ANLKIRSKRRPKQLLKVVSGLLTMRLTILHLNVTTLHQIVLYSLSVKVEDDCKLSSVDEIATAVYEML--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNYLAERSRRRKLSDKLLTLRSQVPIITNL----IIDDAITYIQELQSTVKVLSNQLFEKD--VSIEEENnKKQSDeEVfAEekkQSDIKEDVVVRGIDGDKFQVKIIIEKRRGRFTRLLEDMAFYGFNLSETNVSTSNGAFLVTSWVE------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHITVERNRRRQMNEHLKALRSLTPSfyVKRGDQASIIGGAVEFIKEMQQLLRALEAKKQRRSVSPRSPPPAQPApAPakSLGAcCNTAVADVEARISGPN-VVLRTLSKRRPGQLVRLVAALERHAFDVLHLSVSSMDDTVLYCFVVKCG---------------------- --------------------------------LQQSLRSLCGK--SGWCYAVFWRLKRRNRMVLTWEDAYCDYSAAaAASaaaaaaaaaaggnllDqaaNsgaPGAssssHDQIGLAVAKmCYHVYSLGE-G-IIGRVAFTQKHQWVFGRVdgTLHEKYPAGWASQFAAGIQTIAVISVPQGVVQLGSTQRIMEDLEMVSHVRTMFCT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VELMAKRRCRKKLNDRLYMLWSVVPKISKglhsnvfrcskMDRTSILGDAIHYLRELLQRNNDLHNERES------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDLQLDVKVMGNNDVMIRVQSENVNYPGARLMSALRDLEFQVHHASMSCVNGLMLQDIVAKIPYG--LTTEEAIKSALLWKLQQ- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNQDHIIAERKRREKLSQCLIALAALIPGLKKMDKASVLGDAIKYVKELPRTFE-------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STTEHALAERVRREKLSKHFTALSSLVPGLTKMDKASVLGTAIKYLKEIGRT---------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHNLSERRRREKINERMKTLQELIPRCNKTDKSSMLDDAIEYVKSLQMQIQMMSA---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKLKALQTLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTV---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LHNISERRRRERIRGKLQALQELIPNCNKSDRASMLDDAINYIKSLKLQVEMMSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDKMKKRLYQLRALVPNITKMDKALIVGDVVSYVQELQMKAKNLKTEVA------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAAVNHMMAERRRRMKQKENFTALRRLVPTISKADKASTLIDAITYLKDLQNKIQEMKASKE------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKSHSEAERRRRERINTHLATLRTLLPSSTKTDKASLLAEVIDQVKTLKRQVSEIAEYG------P-VPT-D---------HDELSIEKVPSsaEIGDGRLYIRasLCCDDRPDLYNDLMETIDTLRLRTLKAEISTLGGRIKNVFLMTL----------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSQMSKESTLTDAISYIKHLQQQIVELQIELSTIPDEDGEKQ-GSSSSTATKAPlETVqlQGKVELSPIGQNKYHLKVISKNRNGAFTKLLEDLSQMGAEVTEVSSVAFSGFSETVLCLEVKDEK-EIHMADLKQQLLTM---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNDHLAVLRSLMPPsyVQKGDQASIVGGAINFVKELEHLHQSLKVHKQLKqTRNGPFnETpigtplTmflaNPqySSTNAaVvaATNpnsaDAALADIEVTLVESH-ANLKVLSKRRPKQLLCLVLGLHELRLAVLHLNLTTVEPMVLYSFNLKVEEDCELASADDIAAAVHRIM--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQILIPNSSKTDKASMLDDAIEYLKQLQLQVQDNE----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TERQRRGKMSEKFGVLRSLIPKPgGKHDKASILTEATDYIRELLRTIGHLRGLVEAKQRRtadkSRRPSaAsDeagmESSSSqhdPAgrprSallprcSWlqrSYKDTSVDVRTVEDD-VTIKVVRRTTADCLLLVSRALHDLRLELLHLAAANIGDSLVLVINSKIEKG-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDMKHPASEKLRRIHFSDKFQALRTLIPNPSKNDRATIIVDAIGYINELKMRVNELKNEIDLKKemmrmkRQRIVEEDgamimeaDEDqvVMNkSImSNwhhqrkcTKNSSTEVDVRVMEDE-VSIKLVQqkemmiKKRMNCLVFVSKALDELRLDLQHVAGGLIGDHY------------------------------- --------------------------------------------------------------------------------------------MSMTQSFIYRD-S-LLGQAFFNCSPIWVAGTDRL----------------STLVCIPTPNGVVELGSIDFIFQNIDLMNNVTVLFNFD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNMSERRRRERINEKMKALQELIPNCSKADKASMLDDAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSHCEAERRRRERINRHLATLRSMVPSTEKLDKAALLAEVINHMKELKTNAVEISKCYS-------IP------------SDIDEVRVEVedVMKDGN-FLVKasLCCEDRPELFADLRLTLQSLQLKTVRAEISTLGGRIKNVLVMTSDRNYnnaeRQLCMTSIRQALKSILD-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKLRALQELVPHCNKTDKASILDEAIEYLKSLQMQVQIMW----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMEACKSHKEAERRRRQRINAHLSTLRSLLPNTTKTDKASLLAEVVHHVKELRKQAADVAPRHRDL-----CF---CGTTTTIeAPWpfPGESDEATLSYCDCEGnsklLKATLCCEDRPGLNRDLARAIRSVRAKAVRAEMTTVGGRTKSVVMMQWAGPGgDEEEIRALKRALKAVVE-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHCEAERRRRERINGHLARLRSLLPSTTKTDKASLLAEVIEHVKALKRQTSVITGES-------PLP------------TEADELTVDAAAEDDGRLVItaSLCCDDRPGLLPELIRALKSLRLRALKAEITTLAGRVKNVLVITA----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSDRRRRGKMKEDLYALRSLVPYMSKMDKASIAGDAASYLQELQTQAENLKAEIASIRRSLVYEDAySfaEmRAADLYPSLlTHKIYKMDVVQLDKREYCAQLVSSNGQGAATSIFKALHTLSlagFDIPsfHMAVSQRNYFLTFPFIVTMD---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRENHIWSERQRRKGMNYLFSTLRSLLPHPtSKTDKSTVVGEIIKYIQSLQVKLEMLTKKRQQVMaARtlsafHQMStKAfvsngltlvDHSSdPSSmtaITAlpppGrESclqsyLGSNVGLHVCGLN-VFITTSSPrGRRGLLQQLLVTIHKHNLDVINATISTSNASIFHCLHCQASQNAEVLN-NDLHSALQSVI--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGRDGETKHFATERERRQNLNDKYKVLRSLVPKPTKADRASaVVGDAIEYIKDLQRTVNELKLLVEK------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGRMKEKLYALRSLVPNITKMDKASIIGDAVLYVQDLQMQAKKLKAEISGLEASLaGSERYQESMNNPakirVNHPiCKKIFQLDMFQVEERGFYIKLVSNKGEGVAASLYKALESLsNFTLQNSNLTTVYDRFSLTFTLN------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLAKLRSILPNTTKTDKASLLAEVIQHMKELKRQTSLISD----T---CPVP------------TEADELTVDSSYDDgDGNVVIKAsfCCQDRTDLMNDVINALKELRLKTLKAEITTVGGRVKNVLFIS------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMQHMVSERRRRERLNASFHSLWQLLPPGSKKDKTSVLCKTVSYVRTLKDEIYELEEKN-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKLTRGFMLLRAVVPNITKVDKVSLMGDAIAYINEIQNKLKDIKTENE------------------------------------------------------------------------------------------------------------- --------------------------------LKEALKSLCGV--NQWSYAVFWKIGCQNTKLLIWEECYYEPASSiSGLQNPELsfgewegcwgSETssqlgsqpwdKVHLLINkMMlnnRINIVGE-G-LVGRAAFTGNHQWILANNYNRdAHppeVLNEVHLQFSAGMQTVAVIPVlPHGVVQLGSSLTIMENMGFVNDVKSLILQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEGNDHIIAERMRRKKITQHFIALSALIPGLKKVDKATVLEEAIKYVKELEEQVKVLEEK--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDMKHHASEKLRRIHFSDKFQALRTLIPNPSKNDRATIIVDAIGYINELKMRVNDLRNEIDLKKemmrmkRQRIVEEDgamimeaDEDqvVMNkSImSNwhhqrkcTKNSSTEVDVRVMEDE-VSIKLVQqkemmiKKRMNCLVFVSKALDELRLDLQHVAGGLIGDH-------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEQSDHILRERQRRDDMTSKFAILESLLPIGVKRDRSTIVDDSIEYVKNLHHRIKELQQRKVELQQaaavKsvGKiargcrreaLKvlQPgSPSKLNekpvatprpPISQeelsrihSllRSCLEKMEVHADLPHQVVIEMVCKPQPRLQSNILQCLEHLNLDVMQCSITKIAHRLICVITAKPQE--------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQVSV----------------------------------------------------------------------------------------------------------------- -------------------------------NFKEQIALSVRSI--QWSYAIFWSISSTQlSRVLSWGEGYYNRDI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNQHLNALRSLMPSsyIQRGDQASIVGGAIRFVEELEQVAQSLRLQMQLRES-IALEDLpamQTQilpfPEGSYACSQSSDVNVEVLMVSPTSIIVKVLVTKRPRQLLHTLHAFNLLSLKVRQLKITSLEITILYSFDLEVEEQTIFCSPFNLAKSIHHIL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPSsyVQRGDQASIIGGAIEFVRELEQLLQCLESQKRRRlyGDqggpsTSAlslVQQppqpplgfppslqeTpGGAAmvPThyqedQmrlveMdptncTGgllweetaeSKSSIADVEVKMSGFN-ALIKILSRRRPSQLIKVIADLEHLHFTILHTNITTIEQTVLYSFNVQVASEA-RFSAEDIASSVQQ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEMHIWTERERRKKMRNMFSNLHALLPHLpMQADKSTIVDEAVNHIKNLQQTLEKLEKQKLeRLQEHNpfgsqsSsiTNsqtnpyesreAflADQGsTSNNnpitisSigtSNlmsPPpipvafqtWSSPNVVLNICGEE-AQISVCSPKKPGLFTTICYVLEKHKIDVVSAQISSDQN--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPHCNKTDKASILDEAIEYLKSLQMQVQIMW----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQLQVQIMS----------------------------------------------------------------------------------------------------------------- --------------------------------LQHTLRSLCSCSdsssSSKWVYAVFWRILPRNypppkwdygggaldrskgnkrNWILVWEDGFCDFYEceRAGSGYLKGrFGADVFFKMSH-EVYNYGE-G-LVGKVAADNSHKWVFRDAPneNDPsfisswnvsiEPQPRAWEFQfNSGIQTIAIISVREGIIQLGSFDKIVEDLNLVISIQRKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNLSERRRREKINEKMKALQELIPRCNKSDKASMLEDAIEYVKSLQMQIQMMS----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHITVERNRRKQMNEYLAVIRGLMPSSyaQRGDQASIVGGAINFVKELEQQLQTLEARKRSNNNNvfspsPQpFsdffsfPQysirpdANDGSSTSTTKSRlPAMAEIEVTMVESH-ANIKILSKKRQRQLLKMVAGLQCLWITILHLNVTTIEQMVLYTLSVKLEDGCQLSTVDEIADAVN------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAALRSLMPAsyVQRSDQASIIGGAINFVRELEKLVQSLEAHKRIKQRSasPPFAdfftfpQYssNPSRCaTSAANesihepvveNKLSAADIEVTMVDSY-ANLKILSPQRPKQLLKLVVGLQNLHLTTLHLNVTSIDEMVLYSFSLKVEDECQLTSVDEIAAAVHQLV--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIVVERNRRRLMNEHLCALRSLMPSsfVQRGDQASIIGGAIDFIKELEQMLLSFQAEKVSRSSPSPAEDGwSPaaATVSSffVspqyTgycfglrrADeeGESEVDVEVTAVQGH-VNLKVAGRRRPGQLVKAIAAIEELRLTVLHLSITSLDAV-------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPHCNKTDKASMLDEAIEYLKSLQLQVQM------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRLMNDHLTALRSLMPSsyIQRGDQASIVGGAIDYVKELEQLHQSLQAQKRMKKSD-LLEQsgcrgssssetTSTstSSsSttTgilatsspqtcqfgNMksetgelGNcttteginvrqsyeftavRKSGGVEVHVTVIQNH-VNLKVECPRRAGLLLNAIVALEDLGLTVLHLNIMALENSAQYST--------------------------- -------------------------------TLQRHLLTLIEGARESWTYAIFWQSSVIDyggPALLGWGDGYYKGEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIVTSL-KLDRASILGDAINFVKELQKQVKDLQHELEDQSDDegtnnnnnygrSEiLNQNginnvvglkpdqleNAPSngfhmggaaaaaSNgDVggvaeppkpkheSDScdkqRQMEPQVEVAQLDVNEFFIKVFCEHKHGGFVRLIEALNSLGLEVTNVNVASFRTLVSNVFKVE------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKLKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPPSyaQRGDQASVVGGAINYLKELEHHLQSMDPTVNTPaTKEAGdgagdlMNTIAASSSGPfsdFfafpqysrrpSsSSvAEGTAEIEVTMVESH-ANVKILAKKRPKQLLKLVASIQSLRLTVLHLNVTTRDDSVLYSISLKVEEGSQLNTVEDIAAAVNQIL--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEIDVKIIGWD-VMIRVQCSKKDHPGARFMEALKELDLEVNHASLSVVNDLMIQQATVKMGSQ--FFNHDQLKVALMT----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEVHNLCERKRRDKINKKMRILKELIPNCNKVDKASMLDDAIDYLKTLKLQLQIMS----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQTYDHIIAERKRREQLSQRFVALSTIVPGLKKIIIPLPLN--IDLIMKILHAVREIIIII-------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPQSKNLVAERKRRKKLNERLYdCLRSLVPNISKLSNDGRWKKrnAnniCGNHTNLQP--ETLSQNGNTIvNKQGTYELpnrfhvgTeGDigniSKQNqdsDITNDRGQemEPQVGVIQLDGNEFFVTVFFEHKPGRFVRLMDALDSLGLEVTNAF-TSFRSLVSNVFKVEKKDT-AVVQADHVRDSLLEI---- -------------------------------LLQQTLRGLCFD--TGWCYAVFWKLKRQARQVLTWEDAFYLQSKAdGMNssgqastrqcfgQqtsglaDMED--PIALAVSKMSyHVYSIGE-G-IIGRVAFTNKHQWVFSSNIKGsatggasnkkanihmqSKYPSGWDQQFAAGIKTIAIIAVPQGVVQFGSTTVIAEDLKLVGRAKSLFGTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNIHLNSLRSLIPSsyIQRGDQASIVGGAIDFVKILEQQLQSLEAQKMNQQSDHN----NRDiSSNElcASNEeeQSRKLRVEATVIESH-VNLKIQCPRKQGQLLRSIILLEKLRFTVLHLNITSpINTSVSYSFNLKMEDDCNLGSADEITAA-------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSVVPTVSRMDKASLLADAVAYITELKGKVDSLESQLQIMRelryntnnnnnnKKSmKMSEmlsSvvsdDQSTTtgqtsfdqfstkgvssSTISShnnnnnNnntyvNKVPMEVDVKVMGCD-AMVRVQSQNVNHPS--------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THIAVERNRRRQMNEYLAALRSLMPESyaHRGDQASIVGGAIDFVKELEQLLQSLEAQKRTLlaqqqqdHKPPPIRDampspsitvTaaatttTRSGSGegkqaaatrdGMsppfagffTYpqfvcrlpPrddaddHAGAADIEVTLVETH-ASVRVMAPRRPGQLLRMVAGMEALRLTVLHLNVTTLGSLALYSLSVKVEEGCGLTTADDIAASVHHV---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKSHSEAERRRRERINAHLGTLRNLLPHPTKADKASLLGEVIDHVKELQRQADEVAGEGV--------P-----------S-GGDKVLVTLDEQeGAQVLKVAMSCEDRPELLTEVVKAIQRCKLRTLRAEMTTLGGRVRLDLLL------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQAKNLVTERNRRNKIKKGLFTLRYLVPRITKMDRAAILADAVDHIKELQMQVRELKDEVR------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLSVLRALMPDCYSdqasiirgainyayihiniyqdGDQASIIGGAINYVKELEQRLHSLVGRQkfEAGSSSAFaefftFPQYsTKAthaeNSTAMddlTAqNHSAIADIEVTMVESH-VNLKIRSKKRPKQLLKMVSGLQSLRLTILHLNVTTMDQIVLYSLSVKVEDDCKLTSVDEIATAVNQML--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRTAANHNQSERKRRDKINQRMKTLQKLVPNSNKTDKASMLDEVIEYVKQMQAQVHMVN----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLQYHVIAERRRRDILSQRLIALSALIPCLKKINKVSVLEEAVKYVEHLQERVKKLEEKVKQ------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIHSEAERRRRERINAHLATLRRMIPDARQMDKATLLARVVNQVKELKRKAAETTTQPTA-----PIP----P--------EANEITVECYTGagDDRTTYIraSVSCDDRPGLFAGLAGAFRGLRLRTLRADMASLGGRARHVFVL------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQLQVQIMS----------------------------------------------------------------------------------------------------------------- -------------------------------MLKETLKSLCCS--NGWSYGVFWRFDRRNSMLLTLEDAYYEEQMGAVIDK-------M-----LNQVHILGE-G-IIGQAAFTGKHQWIFSDAYGgEWnstssadnqDIFQdDSEFQHqfSSGIKTIAVISVEPqGVVQFGSTQKILERLEFLDQTKRLFQQM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLRTERKRREKLSSRLLMLRSL------MTRACIIDDAITYINKMQTQVESLTQELQEIEAKanSQLPKAlDQPKtkkrdePEEeeeeeeEMKKCGIQEQVKVAEIEVNKLWMKIIIEKKRGRIMKLIEAMNSFGIGLLDTNVTTTKGAFLITTSIQGKNG-------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKKRKNLEVERRRRSRIKGGEFQLRALVPNISKVNkpltraatalkvclyRASIIGDAITDITEQEKTVQELKKEDDENADPSSCKqKTriklKQGLP---DAGEILEMQVEVHrMCGSN-FFFRIVAE-----FSRQMKAMSSLGLHVEDANITTCHGLVLCYFRAEVN---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHNISERRRREKINEKLKALQELIPRCNKTDKASMLEDAIEYVKSLQLQIQMMSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSHIAVERNRRKQMNEHLAVLRQLMPCfyVKKGDQASIIGGVIDYINELQQVLQSLEAKKQRKiytnevglsPrvvssprvipqqhsnpshpspRKPppspRplinlpISpRTpqstspchNKpprqpqiqpSsitspTSnsNnsscsSVaymimmmSsynNssnnGvanelvassKSSFADVEVKFCGPN-LELKTLSSKISGQTVKIVSAIEDLALEILQVSISTAEETMLNSFTIKIGIEC-QLSAEELAQQIQQT---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASPCAVERNRRIQMNEHLKVLRSLTPCfyIKRGDQASIIGGVIEFIKEMHQVLQVLESKKRRKSLspSPspsprpTVEPsiypdTpNattRMNFSgieNVmttstfkevGAcCNSPHADVEAKISGSN-VVLKVISWRIPGQIAKIISVLERLSFQVLHLNISSMEDTVLYSFVIKIGLEC-QLSVEELT---------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMIHIAVERNRRKQMNEHLAMLRSLMPEsyVQRGDQASIVGGAIEYVKELEHLLQSLEAQKLQLLQQggtapSNTATAaATAeflTApfGQffaypqyTwsqfqnkcaSKSEGSVADIEVNLIETH-ANLKILSRKSISQLSKMVAAFQTMYLTILHLNVTTLDPLVLYSISAKVEEGCQLTSADDIAGAVHHML--- -------------------------------LLRKQLAVAVRSV--QWSYAIFWSSSSTQSGALEWGEGCYNGDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------GERWTYAIFWEAERS--GDFSPVRGFYNVDDHKF----KDKAITFFQLRDsCSETVAFVS---FLDLVFRTGNPIWLLGVDCLKSSLYFQAHQGYQYGLQTMFWIGVDQGVMEFGSTELIY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQNFAAEKQRREQLNEKYAALKSLVPNPTKSDRASIVGDAIEYINELNRTITELKILVE------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQDLIPNCNKVDKASMLDDAIEYLKTLQVQVQIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMSHIVVERNRRKQMNEHLKVLRSLTPCfyIKRGDQASIIGGVIEFIKELHRVLQTLESNKRRKSISpspnpsprPAVvlPQkyptApqpHqNPDfnfnlGTeNrhhVinkelaiGAScNSPVADVEAKISGSN-VVMKIISRRIPGQIAKIIGMLEKLSFDVLHLNISSMEDTVLYSFVIKIGLEC-QLSVEELVLEV------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEMHIWTERERRKKMRNMFASLHALLPQLpSKADKSTIVDEAVKYIKNLKQTLEKLEKQKQEKLKSvstfgseSsFImnsqwhpyEsrEAiiaDQGSSSynnnsnAIstSntsNAlsvsPpQqvafqtwSSQNVVLNICGGE-AQFCICATKKPGLLTTIAFVLEKHKIDVVSANISCNGN--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKDRSKTLISERTRRVRMKEQLYELRSLVPNITKvrsssairwrccvemqstvrsislmqMDKASIIADAIAHVKDLQSQANKLEEEISLLERGSKGEQMlhaSRRTAAeamqpleTVTTAaGSRITQVKAYQVGEGRFYVKVEGSmGDSGEPSALYSALASLScFDMESSHFSLTSEGFVFTLTSKVG---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKTIVSERKRRVRMKEKLYELRALVPNITKMDKASIIADAVVYVKDLQAHARKLREEVES------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHNLSEKKRREKINKKMRTLKELIPNCNKVDKASMLDDAIEYLKTLKLQLQIMS----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSLMPNTytqDHMDKATVLGDATKYLKQLQERVKTLEEEEQKAKNssgdlnqtvvfvkKSRLllNDDddddNdddKSSCNkenklisSTrTGghydeeddddDDEPLPEIEARCCLKN-ISIRIHCKNRKGVFVKILEEIEKFNLNVVHSSVMPFANsSLYITVISQMEVEFSMTLKdlvKNLKSAFRQ----- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DHAKHLWTEKQRRKKMKNMFQELHALLPKQPpKAKLLTIVDEAISYITTLQQTLQKLETQKlERLCSPstntsvtslihpHKLiAESflaNGSSSTGhsdNaScpnfgpfpfPlcSPpvfqtWTSSNVVLNVCGPD-AHINICSSKKPGLLTAICTVLEKHKLDIISADISSDESksMFMIHARVNAPDE-------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHITsTEKMKREKLGDQFRALSLLVPNPSKkPDRASVLASTIDYINELKGTVDYLKVLIDKKRnernKKSRIENEavagDMPTSstTNIdrdqnsfngqvrSSWsqrKSKDAEVDVRMIDGD-VTIQLivQRPKMINLLLGVSSIFDELQLDLLHISSGCIGDYYSFWFNIKILKG-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKKHSDAERRRRLRINSQFATLRTILPNLVKQDKASVLGETVRYFNELKKMVQDIPTT-------PSLEDS---------------LRLGHCNNNRDLARVVFSCSDREGLMSEVAESMKAAKAKAVRAEIMTVGGRTKCALFVQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAAIRALMPPsyVQRGDQASIIGGAINFVKEIEQLLQTMEAHKRTSQqTEHngNLspfaEfftfpQfstraTsqcNNSPSSmpadqSVTAaaSVESVADIEVTMVETH-ANLKIQSKKRPRQLLKLVAGLQSLSLTILHLNVSTVDETALYSISVKVDEGCHLNTVDEIAAAINY----- --------------------------------WQHTLQSLCAcsdsSNPSKWVYAVFWRILPRNypppkwdhggsaldrskgnkrNWILVWEDGFCDFYEceRAGY-GCGIrFGADIFFKMSHE-VYNFGE-G-LVGKVASDNSHKWVHRDSQNEtdpsfisswnssIDPQPRAWEAQfSSGIETIAVIAVREGAIQLGSLDKVVEDLNLVLNIQRKFSYL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKLHSLSERRRRDKINKRIRTLKALIPNCNKVDKASILEDAIDHLKSLQFQLQMMMS---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPAsyVQRSDQASIIGGAINFVKELEKLVQFLEAHKRIKQRSdSaPFAdfftfpQYSSNPCpkpavNeNIhehlSENKASAADIEVTMVDTY-ANLKILSPRQPKQLLKIVIGLQNLHLTTLHLNVTTIDETVFYSFSLKVEDECQLTSVDEIAAAVHQLV--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQAKNLVTERNRRNKIKKGLFTLRYLVPRITKMDRAAILADAVDHIKELQMQVRELKDEVR------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKMDKASIIKMQIDYIQNCMEQERRIQADLiqvESgkLKKNAVfdldqeiptlsrLKKkrIDHSYDSrRSTTSSMEDLELSVSYIGEKTVVVSLTCSKRTETMVKLCEVFETLKLKIIAANITCFSGRVLKTVFVQADE--------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHIAVERNRRRQMNEHLKVLRSLTPCfyIKRGDQASIIGGVIEFIKELHQVLQSLESKKRRKSLSPSPSpsprpillQPiPqlDSTFGleNVkelGAcCNSPVADIEAKISGSN-VLLKVISRPIPGQIMRIISVLERLSFEVLHLNISSMEDTVLYSFVIK------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRSHSEAERKRRQRINAHLATLRTLVPSASRMDKAALLGEVVRHVRELRGRADDAAVGAGVV-----VP------------GEG--DEVGVEEeerhegchgGGdrwRRRVRAWVCCADRPGLMSELGRAVRSVSARAVRAEIATVGGRTRSVLELDV----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHNLSERRRRDRINEKMRALQELIPNCNKTDKASMLDEAIEYLKTLQLQVQIMSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERRRRDRINEKMRSLQELIPHCNKSDKASILDEAIEYLKSLQMQVQIM------------------------------------------------------------------------------------------------------------------ --------------------------------LGDALRRLCEE--IGWSYAVFWKaIGAQNPKLLIWEDGYCGPTScppGSsGSEAlplqigekgwlrsesrsSQLgcqAEDRICSLVnkmMANQVHVVGE-G-IIGRAAFTGNHQWILHGNankdALSPEVLAEVNHQFSAGIQTIAVIPVlPHGVLQLGSTLMR-----SICEISQFFSP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAHKHSESERRRRMRINSQYATLRTILPNLIKMDKASVLAETIRRVRELKKAVEEVEEVCCT------VPDVD------------DELSLEYGEdheeKAGQ-VFIKAtlSCEDRPGLMLELINAIKSVKgsvevIRVVKAEMVTAGGR-------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNEHLRVLRALMPGsyVQRGDQASIIGGAIEFVKELQQLLQCLEEQKKRKMSfveaPPRMlgspttiIQAvaagfpGggGGmirASPpapppppPlpldVkyfDTglyeplrelyGeaKSEIAQVEVKITGSN-ANIKILSQKKPGQLLKTMTALENkLLFSILHTNVTTIDHTVLYAFEVKIGQN-------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -------------------------------QLHQVLRALCFNT--EWKYAVFWKLKHRARMMLTCEDAYYDNHEqRDLSEnkcfsevvgNlCDGhdsHDPLGLAVAKMSyHVYSLGE-G-IIGQVAVTGKHLWIFSDKHAsDAcsllEYCDGWHTQFSAGIRTVIVVAVaPHGLVQLGSLNKITEDLKLVNHIRETFFS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNLSERRRREKINEKMKALQELIPRCNKSDKASMLEDAIEYMKSLQMQIQMMST---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNESERKRRDRINQKMKTLQKLVPNSSKTDKASMLDEVIDYLKQLQAQVQMMSR---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FRSRNLTAERNRRAKLKERLMALRSVVPTITNMKKETIIDDAVNYVIELKKFVKDLRDQLS------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PETHSLSERRRRDKINKKMRALQELIPNCNKMDKASVLDEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIEYVMDLQKQVKDLQDELEETNQEddghdkqigSNlrnsnnqMdvpiPNGwldhDDSGNnprtvaaaddnkpSSdkgqqMevidhlymfyrCNTrkpsllhldAYEQPQVEVRQLEANEFFLKVLCEHKQGGFSRLLEAMSSLGLEVTNVSVTTYGSLVLNVFRVERRDDE-VVEADRVRDSLLEV---- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLARLRSLLPSTTKTDKASLLAEVIQHVKELKRQTTLI-AETS------PVP------------TEIDELTVDAADEDGR-FVIKasLCCEDRTDLLPDIIKTLRALRLRTLKAEITTLGGRVKNVLFITGD---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLQSKNFEAERERRKKLIQRLHFLRTLVPNNT-GDRASIIGDTIVYVSKLVRQVKELQEELERN----------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQSLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMIQAQDHMDKASVLEDASNYIKELQGRVKKLEGLSSPKRKNfqssvismkrSKLSTSDDEyySTDDTnscdStNPFKLSPEIEVRMSGSS-VLVKIECEKNISSFVKALNQMQKLGLTTISSSAMPFSKTrLLINIVSQIEDGFC-ITPTDLV---------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERKRRDRINQKMRTLQKLVPNSNKTDKASMLDEVIEYLKQLQAQISMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------TDTKWSFLVSMTQSFINGG-G-LPGQAFFNGSSVWVTGLERLASLSCERARQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQEHVIAERKRREKLQQQFVSLATIVPGLKKVrDKTTWLylcdhqvPAGIDYVKQLEEKVKALEQG--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEVCKSHKEAERRRRQRINAHLSTLRSLLPNTTKTDKASLLAEVVHHVRELNKQVEDVWRRDGDG------DGDGDGFcSNSqpeLdKSWlfPGECDEADLSFCDKEGMLLKvnVCCDDRPGLYGDLSRVIRSVQARVVRAEMTTVGGRTKSVVVMQWR---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNMERERRSKMTQMFTQLQTTVPGLlPKATREVIINETIEYIKELEKKKQRLEELKESMK---GVEG--TLLLP-CGNNRNC--SVTVTVSANV-AFFGIQSVARPGLITLILKVFFNHQAEILAANVSVNNGKLILAITALVQNGG-NGVVEKIKREIM------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAIAHV-----RRKKLNDRLFALRNVVTKISKMDKASIIKDAIDYIQELHEQERRIQA---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNEHLIVLRSLMPStyIQRGDQASIIGGAIDFVKELEHVLQALQNQRTYRdfnSRgysyeedESSifkehVKKQqfpHhARyASKSFSDnefahVTCEGIDVDVRLNGKC-ALVKVLAQKLPHQLLKVILSIESLHMRIMHLNITTIDKSVLYSFNLELQS--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAKVHNLSERKRRDKINEKIRALKELIPNCNKMDKASMLDDAIDYLKTLKLQLQIMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNHNASERDRRKKINSLYSSLRSLLPASDQTKKLSIpatVSRVLKYIPELQKQVERLIQKKEELLSRiSRQRDiihQeKQRKGA----VSSSSSTVSASRLGDREVVVQISTSKiHKNSLSEVLLGLEEDGLVLLNASSfESFGGRVFYNLHLQVEGDY-KLECEELSEKLLSL---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKSHSEAERRRRARINSHLDTLRSVIPGANKMDKAALLGEVIRHLKELKKNAAQACEGLM-IPKD------N------------DEISVEEQEGGlngFPySIRASLCCEYKPGLLSDIRQALDALHLMIMRADIATLEGRMKNVFVI------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHNMSEKRRRSKINEKMKALQDLIPNSNKTDKASMLDDAIEYLKQLQLRVQMLTLR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQLIHMIAERRRREKLNESFLALRSILPPQTKKDKASVLATAREYLTKLKAQVSELSHR--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- -------------------------------TLQQRLQAVMKGA-EIWSYAIFWQPSYYYpgSSLLGWGDGFYNSKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlTSTEWYYVVCMSFTFNPGQ-G-LPGRALANN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHETCMWSERQRRKKMSNMFSSLHALLPQLpAKADKSTIVDEAVSYIKSLEHTLQTLQKQRIEKlQSgmivevHPSIINsSqwylndsflaNkEGNSNtsmSTipSSPtklvcfeTWSSPNVVLNICGNE-AQFSVCSPRKPGLLTTIFLILEKHKLDVISAHISSDNHRNQYMIHAHAG---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEIHIWTERERRKKMRNMFSNLHALLPQLpPKADKSTIVDEAVNYIKTLQQTLQKLQKQkLERLQGgtttfnyEPsviapqKlaMdtrEAflADQGSlnnlasmNtNsnSNNnslpSvPRfpvlfqtWTSPNVVLNVCGDD-AQISVCSPKKPGLFTTICYVLEKHKIEVVSAHISSDCN--------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQVYHMISERKRREKLNDSFHTLRSLLPPCSKKDKTTVLTNAASYLKALEAQVSELEEKNAK------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIKHHASEKQRRVHFSDKFQALRTLIPNPSKNNRATIIADAIGYIDELKMRVNELKVQVDIKKErikrRrSMVEEYgavimedNQDdqqvmmnKSTNwhhqIKSSKNSNTEVDVRIMEDE-VIVKFVQHKqmlkGVNCLLLVSKALDELQLDLQHVAGGLIGDHYSYLLNSKICEG-------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHNLCERKRRDRINEKLMTLRQLMPNSNKTAKASILDEAIEYIKLLQSQLQAWSA---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLDEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGKTDRASIVGDAIEYIKELLRTVEELKILVDKKRRErikrHKTQDeENGPveaggdqqGfnmSKSInwrSSwlqRKSKDTEVDVRIIDDE-VTIKLVQQKKINCLLLVSKALDELQLDLHHVAGGLIGDYY------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHTMSERKRREKLNDSFVALKAVLPPGSKKDKTSILIRAREYVKSLESKLSELEEKN-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKPRRRNVRisEDPQS--VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYIKFLKRQVQELQHQP-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERRRRDRINEKMRSLQELIPHCNKADKASILDEAIEYLKSLQMQVQIMW----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPISHMEAERQHRDRLNRRSCELHAAVTTVSRMDKVSLLADAVAYISELHDSV--------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSHSEAERRRRERINAHLATLRTMVPCTDKMDKAALLAEVVGHVKKLKSAAARVGR-------CSPVPSG------------ADEVAVDeASATggGgEGPLLLRatLSCDDRADLFVDVKRALQPLGLEVVGSEVTTLGGRVRLTFLVSCGSRGAAAAAmASVRHALQSVLD-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKSHSEAERRRRERINNHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQTSLI-AETS------PV--------------PTEMDELTVDTADEdGKFVLKasLCCEDRSDLLPDLIKTLKALRLRTLKAEITTLGGRVKNVLFIA------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNMSEKRRRSRINEKMKALQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLARLRSLLPNTTKTDKASLLAEVIQHVKELKRQTSQIAE----TSP---V--------------PAEVDELTVDTSDENgCFVIKasLCCEDRSDLLPDLIKTLKALRLRTL------------------------------------------ -------------------------------NLQNKLSDLVDRPNasnFSWNYAIFWQISR----VL--GSGIYNLCS-KYH-----SLIH-FF--KLTFRFINSGMMilQFPKYDLSNFESVNfaiFFKSSTICSVGLMRSFLVKYIGIQTIVLVPTDIGVVKLGSAKFV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------LDRvNDTEMFFLAPMHFMFPPGE-G-GPGKCFASGKH--------------------------TVVLFSTDVAVVELGSVRSVLESLELLQSIRSSFST-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISKNLMSERNRRKRLNKQFFTLRSMVPRITKMDKRSILVDALTYLQDILDQ---------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRTLISERKRRSGMKEKLYALRALVPYITKMDKASIVGDAARYIQDLQTQARNLRSEIAKL----------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKRLNDRLYMLRSVVPKISKV---------------------------------------------------------EVRVREGRAVNIHMFCARRPGLLLSTMRALDNLGLIFSRLSSVV------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNMSERRRRDRINEKMRALQELIPNCNKIDKASMLEEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDDHFQRDQHRREYFNQSMQALKCLVPNLTKGDRASIVGDAIEYIKELLRTVNELKLLVD------------------------------------------------------------------------------------------------------------- -------------------------------ALRQFLTGLCNNS--CWDYAVFWKLWHQIPAVLSWEDGYYDQPKlRTTIekssgmlyfDGysefIDDetsqiYGTAVQYpiellIAdMPTQQYTLGE-G-LVGQVASTYNYCWISLeASQFKNKHFDfpEEWLPHvLAGVKTMLLVSVhPHGVLQLGSSHEVAENAAVVNHIKETFI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEYLAVLRSLMPDSyvQKvcfhlfsfclislqmqikdftshvSDQASIIGGAINFVKELEKLVQTLEARKRIKQRaDPaPFaELfTfSrySSSSSqraklaadEITSeTkkaEnmAPATDIEVSMVDSH-CNLKVLSPRRPKLLLKLVVGLQNLHLSTLHLNVTTIDDIVFYSFSLKVEEECQLASVDKIATAVHQLI--- -------------------------------------------RRERWTYAIYWESDGLSnsslGHTLSPVKGFYNMDDFKFKD----KAVSFFQLReSWPDNLTFGS---VLCQVFSTSIPIWRAGEDPLASSMYYRPRQGHEYGLQTMSWIRLADGVMEFGSTELIHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------LQHTLRSLCIHENSQWVYAVFWRILPRNypppkwdgQGgaydrsrgnrrnwILVWEDGFCNFAA-STAeinsgDcpgssvygNCEyqqyqGLQPELFFKMSHE-IYNYGE-G-LIGKVAADHSHKWIYKEPndqEINflsawhnsADSHPRTWEAQfQSGIKTIALIAVREGVVQLGAVHKVIEDLSYVVLLRKKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLAKLRSLLPNTTKTDKASLLAEVIQHVKELKRQTSLIA-ETSPVP--TEID---ELT---VDNA---SDE----FEDGK-FVIKasLCCEDRSDLLPDLIKTLKALRLKTLKAEITTLGGRVRNVLFIT------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIHREIERQRRQEMSSLYASLRQLLPLEYIKGKRSTsdhILEAANYIEQLQKKVKVLEDKRDKLKKESSSSNVDYPKSGS-SSHSSPAAIVTVKVCLDG-MEILVNCSVegEGFRLSRVLQVLLQEGLSIVNCSCTKVNTRFLHTIRTEVSDSPIIIDADVIQQKLA------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ICGNHVLSKRKRREKLNQRFMILKSLVPSNNNviklpfpvvvtqeffcvfgglcfdihvteyvehkclssvallnslaffmhTDKVSILDDTIKYLQDLERKVEELITC--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLEEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATEFKSKNLEAERRRRGRLNSNILALRAVVPNITKMSKESTLSDAIDHIKKLQNQVLELQRQLADSPGEA-WEKQGSASCSeSFaaTENMPYQGQVELVPLGPYKYHLKIFCK-KAGIFTKVLEALCSYNAQVLSLSTITFYGYAESVFTIEVK---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLDIDVNIIGCD-AMIRIQCNKKNHPAARLMAALNELELDVHHATVSVLNDLMIQQANVNMGSR-------------------- ---------------------------------EQQLAALVNY--IGWSYVVVWSLPQ---RALVWQlwpAGSS-------------FQQTLFYTAYKSCQFPFGH-G-HAGIAVIRREHVWVTGVDVTNTSVLEQRDFLQATIIQSLLCIPLLDGVLEIGSTDTYQRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTHISVERNRRKQMNEHLAILRSLMPAsyVQRNDQASIIGGVVEFLKELQQLLNSLETQKRRRAyvAEaisPRVSGESGGPSprGSIvhqhsprgttqelvATSRSPLADVEVKLAGGAHVILRTLSHKStRGQLLHLIAALECMNLEILHLNITTLQQSVLYTFTLKIGIEC-RLSVDDLA---------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LELRVSEVGDHVLVVSVTCRKRRDAMARVCRAIEDLRLRVITANVTSVAGCHVHTVFVEVR---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRRQKLSRLFLSLASRIPGLQKGEKqARIVGETTSYIRQLKQRVLSLEQQALKRRTQdQTMDSAqschiftDEGSfcssdgnSNNIS-SMNGASDIEVQLSdeNDD-ILIAVHCQKDDDVLPKLLLEMRKLHLTPSNINVMPFGNYMDVTIIAQKQE--------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRKLQSS--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVQDHIIAERKRRELLSHMIISLSAMIPGLKKVDKTTVLGSAIKHMKELQEKVKNTESAPK------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQSLVPNSSKTDKASMLDDAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIHREVERQRRQEMSNLYSSLRSLLPPEYIKGKRSIsdhITEAVNYIKDLEKNVKELGEKRDQLKDSFSSESTrSTKNVGCSSSSSSSSYNVSIHKFsgGLQ-IEISAGYEDEDpFPLSRALQVLFEEGLSVVSCVSTKVNQRWIHHIQCEVTDTT-CIDSNRLQQRLMS----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLHHMISERRRRERLNESFQTLRALLPPGSKKDKATVLASTTEYMNKLIAQVSELEEKNRQLEAQLhqranGLssrPgQweAqQgGSGSSErvqvdVttgastSSsSsSGQPREVSIR------VTVRAECDVSE-LVVRVLARLKEMGrFTVVAVDARQRSSgHAQASLTLRATAGD-VFDETSLKEAVAKAV--- -------------------------------NLQQGLCQIVDGS--SWNYAIFWQIASSKsgRSVLMWGDGHCRDPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRLMNDHLATLRSLMPSsyVQRGDQASIIGGAIDFVKELEQHLLSLRAQKRLResaavRSRPNDdEPchTsvlHDGffISpqyTgysqSqqrrrDANGeeaqqeDGTGVDVEATVVQGH-VNLKVAGRRRRGQLVRAIAAMEELRLSVLHLNVASLEPsSILYSLSLKMEEECKLGSADEVATAVHQ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMHRDIERQRRQEMATLYASLRSLLPLEYIKGKRSIsdhMNEAVNYIKHLQKKIKELSAKRDELKKLSNLSSSSSPS-E-SSNS-SSPSSVTVHPCCGG-VEIVISTGFReqGLPLSRVLEVLLEEGLSVVSCVSTKVNERLLHTIQSEVDDP-------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQMMSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHGKLNYKFYTRYAIVSNISKMEKASLLGNAISYINELRLKLQALESDE-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKFISKNLEAERKRRKKLSDRQLELRSLVPIITN-----------------------LE--------------------------------VQVNHiSGTK-LWIKIVFQKKRGSLTKLMEAINVLGFDLTDTSVTTSRGASLVTSSAEFAGNfpCELLDADQVKKFLFEIIR-- -------------------------------------------------YGLFWSISPKQPGVLEWGDGYYNGDI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRAVLHEKLQLLRSIT-NSHALNETSIIVDASKYIEELKQKVERLNQDIAASST---------SS-S--SNDQDPLPVVTVETLEKG-FLINVFSEKsCPGLLVSVLEAFEDLGLNVLEARVSCTDSFRLQAVGGEDEEEGENINAQVVKQAVVQAIK-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKNHSEAERRRRARINAHLDTLRGLVPEAKKMDKAALLAEVINHLRKLKGNAEEAMQQYVIPtdADEIRVEQ-----------GQGEVVDLEFET-----IKASLCCAYRPGLLSNLRQVLVDLGLIVLSAEVATLEGRMKSIM--------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMMHREIERQRRQEMASLYASLRSLLPLEYIKGKRSTsdhVNEAVNYIKHLQRKIKELSSKRDELKKLSNLS-SFGSENE--SSSSSSlPNHVVVRPClgGVE-IVFSSSFCEQQFPLSRVLQVLLEEGLNVVSCISSKVNERLIHTIQSEVND--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSKNLITERNIRKKIKDGLFKLRALVPKISKMDITAILTDAIEYIGNLQEEEMNLSNELK------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKNLEAERRRRSKLNNRLFTLRSL------MSKESTLVDAIDYIQKLQKRICDLKLELSKL----------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQFHNLSEKRRRSKINEKMKALQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQTLAV---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEKHNISERRRREKINEKMKALQELIPRCNKTDKASMLEDAIEYVKSLQMQIQV------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEEHIIAGRSWCEKLNQKFIALSALIPDLKKARKASVLEDAVKHVKDLQEKVKALEEQN-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTFPTEREKRVHFNDRFIDLKNLIPNPTKIDRASIVGEAIDYIKELLRTIEEFKMLVEK------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNHNASERDRRKKMNSLYSSLRSLLPAADQMKKLSFpatVSRALKYIPELQEQVERLIQKKEELLlrisRQGGSEIYqeEQKR-N--SRG-RSLSTVSASRLSDNEVAVQISTSKvHRFPLSEVLQYLEEDGFLLLNASSFeSFGGRVFYNLHLQVETDNYKMICEALSEKLLS----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEASRSHKEAERRRRQRINSHLSTLRTLLPNTTKTDKASLLAEVVNHVKELRRRAMEVARRST--------DQCGGGgGGdGGMVSWpfPSEEDEATLCYCDNEnKVMrATVCCDERSGLNGDLMQAIRSVHVRVVRAE--------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKNHSEAERRRRERINAHLATLRGLVPCSEKMDKATLLAEVINQVKQLKKKAVEISKGYN-------IPM------------DTDEVRVEPHAngTNDGTFSIRasLCCDYCPELFSELRQALDTLQLKPNKGRDFNL----------------------------------- -------------------------------TLMQRLQALIEGARESWTYAIFWQSSYDYsgGTVLGWGEGFYKDER---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLDEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARTHMLAERRRRVRENEHYDALRKLIPPTSRMDKATVLAETIKLVKKLRRRVGQLEKGNPDNSGTPnlslvtsedsQIGTTspssrgepgspipartGAGSSEPelqegkppGgrfldSclvpApapSqedNKEIVEVDRRACiPTE-LRAKIRTSHRPDTVIHILTCLKDLGLEVLSTNISIEKDWVYADFQLKMNE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNEHLRVLRALMPPsyIQRGDQASIIGGAIEFVKELEQLLQCLESQKRRRMmANPtSTPQPlgygytsDNqlvhhqqqqDPSlvQqlDiqegVleTavqlheevaQAKCAMVDIEVKVVERSEALIKILSQRRPRQLLHTIIALQdHLQFSILHTNVTTIDNTVLYSFTVKINND-------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNQLQHTMSERKRREKLNDSFVALKAVLPPGSKKDKTSILIRAREYVKSLESKLSELEEKNR------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMTRIMVERKRRKQMNEHLRVLRSLMPGsyVKRGDQASIIGGVIEFVRELEELLPCLESQKRRRileetgHRQTgGMTRpTNPSSCpvtrvaNqtqpliitkNIteleGggglleemtENKSCLADVEVKLLGFD-AMIKILSKRRPGQLLMTMAALEDLHLSILHTSITTMEQTVLYSFIVKAS---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSKINEKMKALQSLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKVHNLSERKRRDKINEKIRTLRELIPNCNKTDKASMLDDAIEYLKNLKLQLQIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMSHVNVERNRRKQMNEHLTVLRSLMPCfyVKRGDQASIIGGVVEYISELQQVLQSLEAKKERKTyaevlsprlvpsprpsppvlspRKPpispRIShqhlllhpispRTplptspygGHppqlplipqpprSyslgdpppyspaSSSsspSVSSnhesslinelvanSKSALADVEVKFSGAN-VLLKTVSHKIPGQVMKIIAALEDLSLEILQVNINTVEETMLYSFTIKAR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQVQELQS---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVAARHRRERISEKIRVLQRLVPGGTKMDTASMLDEAAHYLKFLKAQVQALEG---------------------------------------------------------------------------------------------------------------- ---------------------------------EQQLAALVNY--IGWSYVVVWSLPQ---RALVWQlwpAGSS-------------FQQTLFYTAYKSCQFPFGH-G-HAGIAVIRREHVWVTGVDVTNTSVFEQRDFLQATIIQSLLCIPLLDGVLEIGSTDTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ --------------------------------LQHTLRSLCIHENSQWVYAVFWRILPRNypppkwdgqgaydrsrgnrrNWILVWEDGFCNFAAsAAeMSsgEcsgsgstaygNSDfqqyQgLQPELFFKMSHE-IYNYGE-G-LIGKVAADHSHKWIYKEPndqEINflsawhnsADSYPRTWEAQfQSGIKTIALISVREGVVQLGAVHKVIEDLSYVVMLRKKLSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQVM------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQTSLIA-ETS------PVP------------TEIDELTLDTSDEDGK-FVIKasLCCEDRSDLLPDLIKSLKALRLRTLKAEITTLGGRVKNVLFIT------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAQFHNLSERRRRCKINEKMKSLQKLIPNSNKTDKASMLDEAIKYLKQLQLQVQTLAV---------------------------------------------------------------------------------------------------------------- -------------------------------NLQNKLSDLVECPNaanFSWNYAIFWQISRSKsgELVLGWGDGCCREPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PHSIAERLRREKIAERMKNLQELVPNSNKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------LKEALKTLCSR--NQWSYAVFWKIGCNNSKLLIWEECYYEPLPcCvppSVIGKvPMGeFEGCWFSsesqfampenhaadrVCSlinkMMvnNSVnIVGE-G-IIGRAAFTGNHQWILSNNFNG-DAYPPEVYTEmhcqfSAGMQTVAVIPVlPHGVVQLGSFLPIMENIGFVNDVKSLILQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILSLKIIGWD-VMIRVQCSKNHHPGARFMEALKELDLEVNHASLSVVNDLMIQQATVKMMGS-QFFNHDQLKVALMAKVG-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQV------------------------------------------------------------------------------------------------------------------- ---------------------------------------------SKWVYAVFWRILPRNfppprwefggtaldfskgnkrNWILVWEDGFCDFNEceRSGSGYLNGrFGADVFFKMSHE-VYSYGE-G-LVGKVAADNSHKWVYNDShnECESSyiaswnasVEpqPRAWEFQfNSGIQTIVIIAVREGIVQLGSFNKIAEDLNLVISIQRKFSYL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEVHNLYERKRRDKINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQFQVQMMS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMIRVQSVKRNHPAARLMNALKDLDLEVHYASVSVVKDLMLQQATVKMTNR--SYTQEQLTAALYSRLA-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEAHNLSERRRREKINEKMRALQNLLPNCNKEDKASMLEEAIEYLKTLQFQLQTMSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMAHIAVERNRRKQMNEHLRVLRSLMPGsyVQRGDQASIVGGAIEFLSELEQLLQCLESQKRRRilGETNDMHGGdmtttmitSSPiTStNpliitgNVteleGGGgiqeekaekKSCLADVEVKLLGFD-AMIKILSRRRLGQLIMTIAALEDLHLSILHTNITTMEQTVLYSFNVKVE---------------------- -------------------------------LLQQTLRHLCTD--SDWIYAVFWRILPRNypppkwdsessffdrskgnkrNWILVWEDGFCDFVIcAKSiafNepnssrssqtscssgyfDDyytSKDmnyMQPELFFKMSHE-VYNFGE-G-LIGKVAADNSHKWVYKEplegdaHEYPSswaqgslDPYPRTWEAQFqSGIETIAIVAVKEGVIQLGSLKKTYEDLNFVLFLQRKFNY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------SSSEMFFLASMYFSFPWGL-G-GLGKCFASGKHLWISDMFKSGFDYCVRSFLAKSTG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHVLGERERRKEMNQLFARMEAVLPEPpPKMTKPALVDEVLKYIQELQVELEDLSEKRKAAQKAAQMRRA---------LHPTPAPNVAVTMCGSS-ALVTVISKRQQDLFSKILHLVTRFQVELVGASVSTASSSMFHHIHIKACKQ--DFSSEALEEALRQLV--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRERMHIFAERERRRKIKNMFTDLRELVPSLtSKADKASIVGEAISFIRGLEETVTDLERR--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEMHNLSERRRRERINERMKTLQELIPRCNKTDKVSMLEDVIEYVKSLQLQIQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTKEFKSKNLEVERRRREKLSRRLLMLRTI------------IVDAITYIEKLQDEVQNLSQQLHQMEATS--EETTETKIDeieAVeyMKNWGIQEDITVAQIDKNKFWVKIIIEKKRGGFSKLMETLNYFGIELMDTNLTTTKGAFLITSCMQGKNGE-RLEINQIKDLLQDII--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKVDKSSMLEEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASKSHSDAERRRRERINTHLNTLRNLLPNTTKTDKASLLAEVVRHVKELKQHAKGTEGHG------P-IP--------------GEADELTVVHpepSSSL-IMATLCCEDRPGLLSELTNAFKALRLRTVRAEITTLGGRVKNVFFID------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASILGDTIAYVKHLRKKIETLETQSKGIeanieqsRSEywlnrtSSLKElrSgirvSEserarSLSPePGrdkTKmRKtqqvTRETTVEVSIIESD-ALLELQCGYREGLLLDIMKMLKEkLRIEITTVQS-------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADAVSYVNELRSKLQALEANKEDLQAQiqgLRKERESapaQrPESDlKMTNggGRCHGVEIEVKLLGSE-AMIRLQSQKRNHPAAVLMAARS------------------------------------------------- --------------------------------LKEVLKTLCG--PSQWSYAVFWKIGCQNPKLLIWEECHYESTPhpdipfGEWdgCwGSyeilsglrihAEDrVQLLINKMMNNNQVNVVGE-G-ILGRAAFTGNHQWFLANNHIRdAhppEVQNEVHLQFSAGMQTVAVIPIlPHGVVQLGSSLAISENIGFVNYVKSLILQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEKQRRERLGKKFELLKSLIPNPTKPDRATIVADTIDHIKELLRTVDELKILVGKKRSKNarsiKLEIQNdvhcdmESSsikSNidesdhglngSMrSSWiqrRSKSTFIDVRIIEDE-VYIKLEQRKRVDCFLIVSRVLDELQLELLHLSCGNVGDNH------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRMNHIAVERNRRKQMNYFLSILKFMMPPSySQpNDQASIIEGTINYLKKLEHRLQSLETQLKATKPNIFsdffmFPQYSTTASSSPSSHyhhKrlPAVADVEVTMVEKH-ANIKVLTKTRPRLLFKIINEFYSLGLSTLHLNLTTCKDMSLFTFSVKVEAD-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRSHSEAERRRRERINTHLATLRTIVPSSIKSDKASLLAEVIDQVKRLKRQVSDVYCY-GSMPSE------------------CDELFVEGDPsSEKGRIMIRVslCCDDRPDLMADLKHALDMLKLCTVKVEMSTLGGRMKNDFQVAPK---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNFSERRRRDRINEKLKALQELLPNCTKTDKVSMLDEAIDYLKSLQLQLQMLV----------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKLLALSAAIGlKKTKLDKASILEKTKHYVEQLQERIKELEQNVGFN----NIC------SNNCRTGNNILPDVKVKVLQKE-ILLTIHCQKQKSVMLKILTHLESLNLLVQTSNILEFGKFALeITIVAQMGDGYN-ITMEELLKSL------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERNRRNRINEKLKALQDLIPNSSKTDKASVLDEAIEYMKTLQMQLQMVS----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIHKGHVMPD---KLKENEKLLVLRSMVPSISEVDKASVLDDTIKYLKELEARAEEMESCME------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAVHNQSERRRRDRINEKMKALQKLVPNASKTDKASMLDEVIKYLKQLQAQIQLISS---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPHCNKSDKASMLDEAIEYLKSLQLQVQMMWM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISKNLMSERNRRKRLNQQYLTLRSIVPNITKMDKRTVLVDALAHLQNILRQTeIEIENQNKISSStavddhgDamvdsSsspnssvlnvKMdhipchgaalvEKNvvDVNVDDDqlqplfqtvlpIepaiTSlpSEraifPAIIKMEAEKLDEERYLIKIVFNKVLGTMGQVQRSVEMLkGFDFINVSVSEYDQHHM------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAVHNQSERRRRDRINQKMKALQKLVPNASKTDKASMLDEVIEYLKQLQAQVQMMSN---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALRNHSEAEKRRRERINGHLTSLRSLIPDTNKMDKASLLAEVLNHLKELRRNAAEATKSILV---PMDI------------------DEVRVEQHdggsdGDS-CAIRasLCCDFKHEILSDLRQALDALHLKTVRAEIATFGGRMIYVFVIT------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DHDLHIFTERERRKKMKNMFSTLHALLPQLpDKADKATIVGEAVTYIKSLEGTVQKLEKLKQeRKRAQqlaagagssrassarhPaPlpapaapaassREANladmvhswNaqeaaanEalAaaEavaggsSSAVaaSlPrGavpfpapapgfqTWSGQNVVVSVAGNE-AYINLHTPRQPGTLTKLLFVLERHRIDVVTATISSQDGFHMFGIHAR------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVHNLSERRRRDRINQKMRALQELIPHSNKSDKASMLDEAIEYIKSLQLQVQPMN----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYIKFLKRQVQELQHQP-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLDEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ---------------------------------------------KGFEYSIVWEIDNK-LGLLTAKTGYYIPGC---------GKIKTFYNSSMTlRAFPLGL-E-IPGRVAYSGQVEWCDHVHEEAVCRFHRVNEAKMYGVQTVLGIPIACGVLEFGSSQKIPQCPQILRYIHNVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMIHIAAERNRRRLMNEYLAVLRSLMPPsyVQRGDQASIIGGAINYVKELEQLLQSLEAHKRMK-Q--GL---NACSSS-HGSDEvvemMKIADIEVKMVESH-ASLKVLLKKRPKQLLKIVSGLQGLKLTTFHLNITTVDQMVLYSFSLK------------------------ -------------------------------DLQRRLLDLVEGPRdrpgLGWNYAIFWQISRAKsgDLVLGWGDGSCRDPR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERSRRRKLNEKLYALRSL-------DKASIIKDAIDYVQQLQEQERT------------------------------------------------------------------------------------------------------------------- -------------------------------LLKQALKTLCGSN--QWAYAVFWKIGCQNPKLLIW-ECHYEPSIcslpkRIAgTeraelpfgewEgcwvssevcsssNgiqPEERVSSLINRMMMDKPFNIvGE-G-IVGRAAFTGNHQWILSSNYTKDAHppevLNEMHHQFSAGMQTVAVIPVlPHGVVQLGSSLAMMENIGFINDVKSLILQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQVHHMISERRRREKLNENFQHLRSLLPLGTKKDKASVLASTTDYISCLKDQVKELCKR--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGLPAKNLMAERHRRKKLNDRLYMLRSVVPKISKMDRASILGDAVDYLKELLQRINNLHNELES------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQVQELQPT--------------------------------------------------------------------------------------------------------------- --------------------------------LQQSLRSLCGK--SGWCYAVFWRLKRRNRMVLTWEDAYCDYSAAaAASaaaaaaaaaaggnllDqaaNsgaPGAssssHDQIGLAVAKmCYHVYSLGE-G-IIGRVAFTQKHQWVFGRVdgTLHEKYPAGWASQFAAGIQTIAVISVPQGVVQLGSTQRIMEDLEMVSHVRTMFCT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQMQVQMMSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQEHVIAERKRREKLQQQFVSLATIVPGLKKvrdkttwlylCDHQVPSTTRLQLKKQLEEKVKVLDEQG-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKISHITVERNRRKQMNEHLGVLRSLMPCfyVKRGDQASIIGGVVDYIKELQQVLRSLEAKKNRKAyadqvlvspRlpvvKstppisPRlaaavpIsprtptrpgspyKPgavgvsarplhhTaaATSaysysmspamtpTSsSSttTqyshherlSpqrqppappflptldSlvtelaaraaraarrlstGatGLLAPDVKVEFAGAN-LVLKTVSHRAPGQAIKIIAALESLSLEILHVSISTVDDITVLSFTIKIGIDC-ELSAEELVQEIQQT---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFKILKSLVPGGSKMDTVSMLEEAINYVKFLKAQIWLHQAA--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSLEEQ--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFRHMMRERQRREKLSQSYADLYSMLSSRSKGDKNSIVQSAAIYVRELKGAKEQLQRRNEEL----------------------------------------------------------------------------------------------------------- ---------------------------------------------IGWSYAVFWRAIGSpKPKHLVWEDGHWHGKA-QLSgcddsssqDNllaefrshGEGSIDE-LVSNSMVPQFhVIGD-G-IVGRAALIGDHQWILRDVANDSGPI-LSHLAElknqfVSGIQTIVIIPVMpYGVVQFGSTMRVMENNLFVNNVRATFMK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLQSN--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERRRRDRINQKMKALQKLVPNASKTDKASMLDEVIEYLKQLQAQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERRRREKINEKLKALQELIPRCNKTDKASMLEDAIEYVKSLQMQIQMMSM---------------------------------------------------------------------------------------------------------------- -------------------------------VFEAQLQQLLESRQhQRWAYAIFWRPTT---SVLRWESGHLIDSV-------DRclaTDIEWFYALSLSRSYPVDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFLTERERRALFNDRFFDLKNLIPNPTKGGEASIVQDGIVYINELRRLVSELKYLVEKKKCGarhNnievdnkntiygtsKIEHPfskmrlNDDdeenmekkKPeSDVidqCSwlqRKSKVIDVSVRVIDDE-VTIKVVVKKKINCLICVSKVLDQFHLDLHYVAGGNFGDHHSFLLKTKVS---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIKVERNRRKQMNEYLAVIRSLMPSsyVQRGDQASIVGGAIRFVKELEQQLQALEVQKRAIMnghsPQPQpLPFGdfftfpqysSHQTSDgAVGSctiTKnrlPAMAEIEVILVESQ-ANIKILSKKRHSQLMKIVVGFQCLWLTILHLNVTTLEEMVLYTISVKIEERCQLSTVDEIADAVN------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDKINKKMRALKELIPNCNKVDKASMLDEAIEYLKTLQLQVQMMSI---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EACNSHKEAERRRRQRINAHFSTLRSLLPNTTKTDKASLLAEVVHHVRELKRQVEDVGRRGRDGcCSNSRPEL-DKS------WPfPGECDEATLSFCneGGKLLKATICCEDRPGLNHDLSRVIRLVQAKVVRAEMTTVGGR-------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERRRREKINEKMKALQELIPRCNKTDKASMLEDAIQYVKSLQMQIQRQR----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSHSEAERRRRERINRHLAVLRSMIPCADKLDKAALLAQVINHVKKLKNNAAEISEGYT-------IP-------S---DVDEVRVEVEGDAMKSGSFIVkaSLCCEEGPEILTDLRQALQSLHLKIIGAEISTLGGRVKNVLVM------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRQMNVHLNSLRSLIPSSSilRGDQASIVGGAIDFVKILEQRLLSLEAQKMT----P----------------QTSKLRIDATVVERH-VNLKIqYCQRKQGQLLRSIVLLEKLGFTVFHLNITSpCNTSVSYSFNLKMEDDCNLESADEITEAVRQIF--- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REFKSKNLETERRRREKLSSRLLMLP------------TIIEDAITYIEKLQDKVQSLSQELHQIEAtseEtaeTKIDEIDAA--QD-MKDLGIQEEVRVAQIDGNKLWVKIIIEKRKGRFRKLMEALNNFSIELIDTNLTTTKGAFLITSCIQDR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKTQVQSLERA--------------------------------------------------------------------------------------------------------------- MNNLtFSPSLSSSM-----LSLTQQTPAilysSPADLLQQKLRFVVETSPDRWTYVIFWQKMTDDhsgRSYLVCVDGHFGGNK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNGNKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDHSLSERRRRERINSKLRALQELIPNCNKVDKASMLNEAIEYLKAHQMQVQVMA----------------------------------------------------------------------------------------------------------------- ----------------------------------------------GWSYAVFWKAIGaADPVHLVWEDGYCGHAScPAGSDpseAlPTDvgcaaaADTmTMCSLvnkVMASQVHVVGE-G-TVGRAAFTGNHQWIIHGTAndhgIPSEVAaEMSYQ-FRVGIQTIAIIPVlPRGVLQLGSTGVVLENKSFMTHAKKLCSQL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHSLSERRRRDKINKRMRILKDLIPNCKKVDKASMLDEAIEYLKTLQLQLQIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINEQLGILRKLIPKSEKMDKAALLGSAIDHVKDLKQKATEISKTFTI-PTE--VDEVtvdcDVSQATNPSSTN----------KDKDSTFIraSVCCDDRPELFSELIRVLKGLRLTIVRADIASVGGRVK------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRERINNHLAKLRSLLPSTTKTDKASLLAEVIQHVKELKRQTSIIAEQCPV----P-TET--------------DELTVDNAsDKDGK-LLIKasLCCEDRSDLLPDLIKTLKALRLRTLKAEITTLGGRVKNVLFITAD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSEAERRRRQRINGHLAKLRSLLPNTTKTDKASLLAEVIEHVKELKRQTAAITAEGGALL----LPT------------EADELTVDAAGSDEdGRLVVraSLCCDDRSDLIPDLARALKSLKLRARRAEIATLGGRVKNVFIITAH---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQFHNLSEKRRRSKINEKMKSLQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQTLAV---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRELQA---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQM------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRIDKESILKDTIKYLKDLEARIEELESCKNSMEFKpsprrNsldVVEQTsdnyenrrkkfrvNKRKACdideSlheTgSelnrgTPkDGLSPQVKVRIKELE-VVIEINCPSRELFLLDFMEAINNL-LDAHMVQSSTLDNLVTLTLKSKFR---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLNHNASERDRRKKLNTLYSSLRSLLPASDQTKKLSIpatISRVLKYIPELQKQVEGLIQKKEELlssiSKKGDYSDINENQSK--GGIRSSLSTVSASQLGEREVMIQICsLKNNRSSLSEILLNLEEEGLLLLNASSFeSFGGRVFYNLHLQVQE--------------------- -------------------------------GLRQLLNSFCTNSP--WKYAVLWKLGHQSPMSLTWEDEYFVYAIPsESmesiSsDvysNseiiPSQFESSMDlVVAHMShLKYTLGK-G-VVGKVAHTGKHYWVSYDDIFTSkanwtmvDECPEEWLFQfALGIKTIVLIHVlPHGVVQLASLEMVAEDSSITAFIKDRFTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMHSEAERRRRERINGHLAMLRSMVPCTDKLDKAALLAEVITHVNKLKSNATEMSKGLS-------IP------------SDADEVRVEVNRDGTktESFLIKasLSCEDRPDLLADVRQTLHYLHLKTVQAEICTSGGRIKIAFVITCD---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQLLRSV-TKSNAANKTSILVDASKYIKELKDKVEAASAA-A-L-NSSS----SSTSGSAMA-ATVSVSSVDVDSSERG-FRINVSMERsRPGLLVSVLEAFEDLGLDVLDADVSCADDT-------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTM---------------------------------------------------------------------------------------------------------------- -------------------------------NLSKKLSSLVEWPnsdSFSWNYAILWQQTVsrSGHQVLGWGDGCCREPNQsEGpvSrceeeemrwqemrkrvlqklqrvfgesDedNyalsLENvTATETFFLASMYFFFNHGE-G-GPGSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRSHSEAERRRRERINAHLARLRSLLPNTTKTDKASLLAEVIQHVKELKRQTSEITEEA-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERRRRDKINERMKTLQKLVPNSSKTDKASMLDEVIDYMKQLQAQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISHSTVEKQRRDRINSLIDELRELVPPQQRSNnngaagpglearrpKHVVLADTIQLLKHLQQKLAVTTVEPPAggAplpldvqgtyHNQNgggwggpggRVpgmPSqdddTaNSeGKsKGSSSQDDggapqmphqmTQNAGVTVE-RGPDCYYVQVTCPDRKGLLSDIINALRQLPLEIRTAAVTTTNGTVRDVFEVKLDDP--SLTPEDVQNLVHDAL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRREKISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQVDELQS---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANGREEPLNHVEAERQRREKLNQRFY----------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------GLQNKLQDLVEADgkSLRWNYAIFWQLSHTKsgELVLGWGDGSCREPH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNFSERRRRDKINEKLKALQELLPNCTKVhtDKVSMLDEAIDYLKSLQLQLQE------------------------------------------------------------------------------------------------------------------- -------------------------------NLQNMLQDLVEPNgsNFRWNYSIFWQISHSRsgELVLGWGDGCCREPH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlIDAEWYYLVCMSIVINSGH-C-LPGRALTNSEKIWYCMAQFQDSKVFCHSLMAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------QTFAPGC-G-MLRQTLLIGSPVWLTVARGMESvALCEQARQARMFGLRTMTCVPLAYGaVVELGSTQEIYQNVEFLNKIRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AETHNESERKRRGKINEKLRALQELIPNANKTDKASILTEAIDYLKKLRLRLQVMC----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQSLIPNSSKTDKASMLDEAIEYLKQLQLQVQMISM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQVM------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEMHLSIERGRRKKMKEMFDDLSALLPQLpSKADKATIVNEAVDYIKVLQETLEKLERKKEERAEHV-LKQImGESSSaGSVSEkqkGfdkTWAASNMVLNIRGNE-AQFSICSVHKPGLMTNIASVLEKHNIELISATISANG---------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRQNHIAVERNRRRQMNEYLAALRALMPPSyaRRGDQASIVGGAIDFVKELEHHLQSLQAQRRHHPAaaghgsErfPGfftFPQystAaaaAndvdDASSSSGGEgrpttRPGAVADVEAAVSEGH-ATVKVLAPRRRRMLLRLLLGMQRRGLAALHLNASTTADQmVLYTFSLKMGDGWQLSSAGDVAAAVH------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRAALYEKLQLLRSVT-NSHALNKASIIVDATKYIEELKQKVDGLNQELATAES---------------SISQDELPMVTVETLERG-FLINVFSEKsCPGLLVSILEAFEELGLDVLDARVSCEDTFRLEAVGGESEENE-SIDAQVVKQAVLQAI--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKIHNLSERKRRDKINKKMRALQELIPNCNKVDKASMLDEAIDYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------FEAAVESLCndSLWNYAVLWKLRHESPMILTWEDGYFNYPKpRELVesitnvgyckgatDmfSpqLETntsnGSLEDYPvgllAADMShLHYALGE-G-VVGKAAFTRVHCWVSFNSIFTgdvqlIPECPEEWLVQfASGIRTILLVPVlPHGVLQLGSLEEVAEDVNIIANVKGRFHG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------GWSYAVFWKAIGaADPVHLVWEDGCCGHAScSagsEASEvgcEPGNSVCRLVRKVMASQVHVVGQ-G-TIGRAAFTGNHQWIVHDAAND--HNLRSEVAAemnhqfIAGIQTVAIIPVlPRGVLQLGSTSVVMENTNFVLQYKKLCSQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKPKRRNVRisDDPQS--VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLQP---------------------------------------------------------------------------------------------------------------- --------------------------------LQHTLRSLCIHENSQWVYAVFWRILPRNypppkwdgqgaydrsrgnrrNWILVWEDGFCNFAA-SAaeinsGDcpsssvygNceyqQYQgLQPELFFKMSHE-IYNYGE-G-LIGKVAADHSHKWIYKEpndQEINflsawhnsADSHPRTWEAQfQSGIKTIALIAVREGVVQLGAVHKVIEDLSYVVLLRKKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSMEEHA-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RESHIWSERQRRKGMNHLFSTLRSLLPQPTSkaassssssslaprlrtdvssravrlvwrhggcysTDKSTVVSEIIKYIQGLQVKLDELQKKRAEIlRRKSmDVTMVgglNSPTSgiaTSVgvgvavplslvaaANNEcclqsFVLPNVALHISGNN-AFITMSSPKKRGLFCRILLIMQSHKLAVLNAHISTSNATVFHCLHVMTPEPGCDFPKEALQTALQN----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRREKIAERMKNLQELVPNSNKTDKASMLDEIIEYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIEYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------KLQQMLQSVVQNF--GWTYSLFWKLCPQQgfllILILFHSEDHYDIRT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------GLQEALRSLCYNT--EWCYAVFWKLNH---KILEWEEGFYKPSK-TIcctSscqtlpsDGcIEVaVDK-MSY-----HMYSIGN-G-VIGQVACGNTHQWIFSSRGKEHP--TEWHEQFAAGIQTIAVIAVHQGVVQLGSTDVTTEDLNLVGHVKALLLR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------AKWVYAVFWRILPRNfpppkweyggcmldrskgnkrNWILVWEDGYCDFYEcgRAARGHVNGrFGADVFFKMSHE-VYNYGE-G-LVGKVAAENGHKWVFRDSQSEneasimatwnvsLDLQPRAWEAQFnSGIQTIAVISVREGIIQLGSLDKVVEDRNLVASIQRKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKKHSEAERRRRMRINGQYETLRNILPNLIKTDKATVLAETVRLVRELRTTVSDLEAVCRGRTKDCVFP------------GEADKLSLEHSDEDKGGVLVKVtfSCEDRPGLMSEVAREVRSVKGRVVKSEMVTVGGRTKSVLWVQ------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRTHITVERNRRRLMNEHFATLKSLIPSylVQRGDQASIVGGAINFVKDLEQQLLSLQAKKQSRTTATsaaTLEGFfISPQYTGYSrCSGEGGVDVEATLVQGH-VNLKVAGRRAAPQLVRLIASLQELKMSVLHLIVTTMDAHcVLYCFNLKMEEGCRLGSADEIAAAVHHIF--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGKEFKSKNLEAERRRRGRLNGNIFALRAV------MSKEATLSDAIEHIKNLQNEALELQRQLADSPGEA-WEKQGSASCSeSFvpTENTHYQGQVELISLGSCKYNLKIFWTKRAGLFTKVLEALCSYKVQVLSLNTISFYGYAESFFNIEVKGEQDVVM-VELRSLLSSI---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPLSRV-EERLSRDQIKQLIHMLRVMVPANSKTSVECLLDSTKTYINELKGKHQSSECHKEYLQKQ--LE--------------SLVNNINVGIAGRN-ATILIQCSKNH-SPSTLMVALMELELDVYNATWTVVNDLMMLHAVVNMESG--FYTQEQLRLALLAKLG-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNFSERRRRDRINEKLKALQELLPNCTKTDKVSMLDEAIDYLKSLQLQLQMLV----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPNCNKVDKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------MPQSFSTGS-G-LPGNALLAARPIWITTALS------------------DAPCVPIGTGVLELGSTKFIFQTTESIPRILSFFNQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------ADFLRSLVQS--FGCTYICLWAYDSISSNRLFFLDGFYNVRNnQPSS-SL-GSVAQRLFHQYRALTFDVND-DCVPGLAFRNQLPYLeLQQLDllRLASTEIQ-TQFFQEARIKTAVFMGCNKGEIELGFSNMSQVD--IQTALKSLFPEDFStrsqqidqnpPssssssfrslstgspEYSsllfsipgtSqshfpetlggapsmqpVhqqaiQalaqvpsqfptpeGEHdaimrailhvisptsqqhqphqnlpynsvvhPGASAfqryrsDnlgpnmasNfRRqslMKRsfaffRnlnfmRMREriqatsrpisTQLHHMISERRRREKLNENFQALRALLPPGTKKDKASILIAAKETLSSLMAEIEKLSKRN-------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQKLVPGGSKMDTASMLDEAANYLKFLRSQVKALENL--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKTQVQSLERA--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMHREIERQRRQEMANLYASLRSLLPLEYIKGKRSIsdhMNEAVNYIKHMQKKIKELSIKRDKLKKLSNSSDLS-VSSG---SSSNSPNCVTVSPCRGG-VEILISSSFkeEGFPLSRVLEVLLEEGLNVVSCVSTKVNERLLHTIQSEVND--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERRRREKINEKMKALQELIPRCNKTDKASMLEDAIEYVKSLQMQIQMMSM---------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RERGFRHMMNERMRREKQKQSYLALHSMLPAGTKNDKNSIVQSAAKYIHELKGAKEELQRRNE------------------------------------------------------------------------------------------------------------- --------------------------------LRPFLQSLCCNSP--WNYAVFWKLKHHDEMTLAWEDGFCDILKQsDAmaSpvEdlyfknsNmilssaltpslLDGTPGD--YLVgyaiaEMSHsSHVVGS-G-VVGEAAVKGNASWIYADSiQadvLnsilVSKYPDEWLLQFAAGIKTILLLPViPDGVLQLGSTEMVSEDAVLVAYLKNKFE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKNHSEAERRRRERINAHLSTLRGLVPCTEKMDKATLLAAVISQVKELKKDAL--EASKGFL-----IPT-D-----------DDEVKVEPYFDgaKDGTIsfKASICCDYRPELLSDLRQALDSLPLKMVKAEISTLGSRLKNEFVF------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEKQRRERLGKKFELLKSLIPNPSKPDRATIVSDTIEYIKELLRTVDELKVRV-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLQST--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQKIVPGGTKMDTASMLDEAANYLKFLRSQVKALENL--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQVQSLQAN--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AETHNESERKRRGKINEKLRALQELIPNANKTDKASILTEAIDYLKKLRLRLQ-------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKTQVQSLERA--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKRREKISQSFSSLSALIPGLKKRDKSSVLGDAIEYLKQLQERMETLEEQVAKR----------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHNLSERRRRDKINKRMRVLKELIPNCNKVDKASMLDEAIEYLKTLQLQLQIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEMHNISERRRREKINEKMKALQELIPRCNKTDKASMLEDAIEYVKSLQMQIQMMSTG--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSLERA--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSLERA--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSREQQKAVMIKKQLQSLRS--NSHPQHSKTSVILDASKYIQELKQKVEKMNQDIVAATAQ--V-----ST-T---SQNPSPMQLRVEAQEKS-FSIKIFTESsCRGLLVFILEAFEELGLDVLHARVSCSNNFLLEAVgTINNDED-EIVDAEKVEQAVLQAIQ-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIENIQKERERREKMTEMFSVLQSIVPNLLpKATREKIVTDTIQYIQGLEEERERLETLKKSLL--P--ES-MAATPH-CT---NWNSAVDVTVSGGGVVFFGIrlVCR-RRHLATEIFEVFEKHEAEVLAATVLVNGGHhqqrrLGVTVTAVVGGD--GDDVEKIKRDIL------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERRRREKINEKMKALQELIPRCNKTDKASMLEDAIEYVKSLQMQIQA------------------------------------------------------------------------------------------------------------------- --------------------------------MRDRMSYVCESK--GFDYGIFWKLDRRRT-SLMPDESVISPRI-A-------TDTSklkLFVNTSktLFTRYVLGF-G-MPGRVCHSGNYEWHEDISLLPGWSFQRKVQAERAGLKTIICVPVENGVVEFGLTDEMDHSVNIVQYVQKMCK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPAMNLMAERHSRKKLNDRLYMLWSVVPKISKTDGWSFYAwDVIEYLKELLQRINDLHNELEST----------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSKRDKGSVVREAVDYVKRLKERVKELENQKRENTNSRSLT--KKP-----TSVEEELPEMKISVSDRE-VLIGIFCHNPNNTLVKVLSLLDNLHLSTRCSSVLPFGTStFKVTIIAKMNDEYSM----------------- -------------------------------TLQQILRSLCSNT--DWNYAVFWKLNHHSPMVLTLEDVYYVNHERGLmPKSlHGGchaHDPLGLAVAKMSyHVHSLGE-G-IVGQVAISGQHQWIFSEYLNDSHSTLqvhNGWESqISAGIKTILIVAVGsCGVVQLGSLCKVEEDPALVTHIRHLFLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAALHEKLQLLRSV-TNSHALNKTSIIMDASKYIEELKKKVDMLNQEIECTQS--S-------------IRDNPLPMVTVETLEKG-FLINVSSEKsYPGLLVSILEAFEELGLDVVQARASCTDTFHLEAVGGDIQV--ESMDAQVVKQAVLQAI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPAMNLMAERRGRKKLNDRLYMLWSVVPKISKV---------------------------------------------------------EVKMREGRAVNIHMFYSQRPDLLISTMKALYDLGLDIQQSVIRCFNGFALVVFHAEVR---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHIFSERQRRKGMTHLYTTLLSLLPDAKpKTDRCKVLTDAMDYIQELRMQVEELGSQKAELMAslaeqEGDHHGTdyqsgvdGVAaNSSTITGiSeemKEeilSSADVAVRFCGRE-AFITLNSCKRKGVWSGILQILHEQEMDIFNVTLSSGNEMDHHCIHAKVLN--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKNLQLQLQIMS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQASIVGGAINFVKELEQLLQSLEAHKRIKQCQCQhqspFAniftfpQYTTTKCkedSPAaagkEGseSRPVVADVEVTMVESH-ANIKVLSKRRPRQLLKMIAGFQSLNLTILHLNVTTANHSVLYSFSVKVEETVQVTCVDDIASAVH------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RITHIAVERNRRRQMNQHLSVLRSLMPQPfsQKGDQASIVGGAIDFIKELEHQLLSLEAQKLQKDKLNqTVTSsTSqDSNcepenphlSlSqfflhsydpSqeNrngStSSvKTAMEDLEVTLIETH-ANIRILSRRRGfqwtsvvantgpPQLSKLVAALQSLSLSVLHLSVTTMETFAIYSISTKVEESCQLSSVDDIAGAVHHML--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLILGDAIEYVLELQKQVKNLPDELEETNPED------E--------GAKQNAQVEVKQLDEDESYVKVLCEQKLGGFTRLMEAVISLGLEVTNVNVATYQSLVLNVFRVK------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDKINKKMRALKELIPNCNKVDKASMLDEAIEYLKTLQLQVQMMSI---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQLHHMISERKRREKLNESFHTLKSLLPPGTKKDKASVLTTAREYLTSLRAQVAELSKR--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHILSERQRRKSMRESFSILQSLVPKLKlkHTDRITVLTEVITYIQSLRGALDELERKKADMmeflglSGKHRSrRQEDDlqATVTyidPGNNldDkDGelvAMVEVTVRMCGPD-VFLTLNAPQRRGVWSGVLSLLQKFSIEVSNATLASSGNSSFHCIHAKAMDVStlkGVNLQEELERVIVKELG-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQVQELQSN--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNMSERRRRDRINEKMRALQELVPHCNKTDKASILDEAIEYLKSLQMQVQIMW----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLRHVETEQRRRDRINEGFKALRELLPTTEKMDKATFLMACVAYIRQLQAVMQQLLS---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRDKRRESLEQTLQQLRDV-TNSTALNKASIIADASKYIEELKQKVEGLNSELGINE----------SSSN---SQIDELPAVTVKTLKKG-FLINVLLENnSPGMLVSVLEAFEELGLDVLDARVSCEDSFQLEAVGRESHKN-DSVDAQVVKQAVLQAIKK- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNFSERRRRDRINEKLKALQELLPNCTKTDKVSMLDEAIDYLKSLQLQLQMLV----------------------------------------------------------------------------------------------------------------- -------------------------------GVRQGLCKTVEGS--NWTYTIFWQVSRSKsgNSALIWGDEHFREPKGsEVgggicSgeqklekgdtkkwvlqklhacfggsekDDyaetLDSvSDVEMLYLTSMYYSFPFDM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPHCNKTDKASILDEAIEYLKSLQMQVQIMW----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNSNKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQRLVPGGSKMDTASMLDEAANYLKFLRSQVKALENL--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTEELNQQLQILQSLIPNSTQTDPRSILEDTRDYLQRIHEETERIEKELSQRHLEN-GS--SSGSSSSSSSRRPKILRVETEKLMEGRFVVKISWKRGPGVAGHVQRVIESLDLNVKMTSINVVdeknPDEMLTTAFVKVMKET-PMTEEELCDQLMSR---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYMKFLKKQVQSLEQAA-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEVERRREMQDKYQTLRNLIPNPnpTKYDRASVIGDAVEYVKELLQTVNELKILVEKKRRARemskghneedSIENkGHkhESSsvmeplgdpddqSNNGslrNSWiqrKSKDTGVDVTIVGDE-VTIKLVQRKNLNCLLSVSKVLDELQLDLYHVAGGHNNDHYSFLFKTKIYEG-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFKILQSLVPGGSKMDTVSMLEEAIHYVKFLKAQIWLHQA---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRSKTLISERTRRVRMKEQLYELRSLVPNITKvssssaicarscvemqstMDKASIIADAIAHVKDLQSQANKLEEEINLLESGSNGEQmlqAsSRGAAvgmqpqETATTaAGSRITQVNAYQVGEGRFYVKVEGSMGDgGEPSALYSALASLScFDMESSHFSLI----------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLCERKRRDKINKRMRILKELIPNCNKTDKASMLDDAIEYLKTLKLQLQIMK----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRLQRRMALRRKLHILRTL-TNSKSVKRSSIIMDAFLYIYKLKLKLEAIKREYSNLmaiKREY-L-----NL----LK-HIQvPKEVKVEKIGEG-FVVKVTCEKGGDKLVSILEAFEEMGLNVVQARVSCNHFFSM-EAIVVAQDQ-QTLDVRDVTQAILKAIE-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLTVLRSLMPDsyIQRGDQASIVGGAIECVKELEQLLQSLEAKKRLLQQQQGGSGPhDNTTTifpPPlaqffaypqysLyqNpNeykSknTPAIADIEVTLIETH-ANLRILSRRRPRQLLKMVAGFQTLHLSILHLNVTTFDPLV------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQSLEKK--------------------------------------------------------------------------------------------------------------- -------------------------------VLQNILRSLCLNT--DWNYAVFWRLKHRSRMVLTWEDAYHDNCERQGhSenkcssEtqqNfLSGpsHDPVGLAVARMSyHVYSLGE-G-IVGQVAISGKYQWIFADKLVSSlhSSFESSdgWQSqFSAGIKTVVVVAIvPYGVVQLGSLNTVFEDVKLVVHIKDAFSA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNMSEKRRRQRINEKMKALQKLIPNSSKTDKASMLDEAIDYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKKHALSERKRRKRINCHYDSLRQFFPRLLKTDKASVLTETVRHLKELKNMVADVAQSHDDGERCSG-Q---QSF----F-IPDEKDEMSVRYCdsGNKtTVRAIICCEDRPGLNQDLTEAIRSVHGKAVKAEMATVGGRTKAEVVVEWPECG-GGGeddVGLLKRALKAVV--- ---------------------------------------------------------------------------------VDHvTDQEWFYLLSMSWNFACGE-GlissrrtrSIPGRAFQFGQHIWICDTVKPINFHCARLELAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------MGSSGLIRENWGLIQQAKSLFWSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------MTRSFAAGD-G-ILGRAFGSGSYVWLSGDEQFQLYECERVKDARTRGIQTLVYLSTSFGprdGFMLGNTLFIPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSKINEKMKALQSLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIGLQSKNFEAEMERRNKLCHRLHFLRTLVPNNTGKDRASIIGDTIVYVSKLVRQVKELQEELERN----------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNMSEKRRRSRINEKMKDLQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQSQLQCF------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNHSEAERRRRERINAHLATLRTMVPCSDKMDKAALLAEVITHVKKLKATAARIRDHCA-------VPADADDVAVELVQ--GAPP----S-TTGG-VLVKatLSCADGADVFAEVKHALRPLRLSVVGSEVTTLGGRVRFTFVI------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIKTHVLSERRRREKLNEMFLVLKSLVPSINKV----------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEKNRRNQMKALYSKLNSLVPHQSSREALSLpdqLDEAANYIKKLQINLEKMKEKKDSLMG---IEKSNSSSSSSGSVVGLKSPQIEIHEMGSA-LEVVLITGLdCQFMFNEIIRVLHEEGAEIVNASFSVVDDTVFHTIHCKVG---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFLTERERRALFNDRFFDLKNLIPNPTKGGEASIVQDGIVYINELRRLVSELKYLVEKKKCGarhNNIEvdnkntiygtskieHPfskmrlNDDdeenmekkKPeSDVidQcSWlqrKSKVIDVSVRVIDDE-VTIKVVVKKKINCLICVSKVLDQFHLDLHYVAGGNFGDHHSFLLKTKI----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHL-----------RGDQASIIGGAIEFVRELEQLLQCLESQKRRRllGESPIVQAADTpppqqppflppGASNfaghqNdgqIfeTTaeSKSCLADVEVKVIGFD-AMIKILSRRRPGQLIKAIAALEDLQLNILHTNITTIEQTVLYSFNVKA----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRLMHITVERNRRKLMNEHLSALRSLLPQsyIQKGDQASIIGGAIQFVKELEYVLQALQTEKSRAKAypmNcpySKAEAVhpqqpaNKLeHSDNlqleVdrSllwaikredThIESKGIKVDIILLESS-VVVKVLAQKLPNQLFKLTSSIESLHMKIVELSITTVGDNLLYSFNLQVEGGSQSYSVDAIAHMIL------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTKERDLSSKFDALKELIPNPSKeRDIASVVGDAINYIRAIXRTVDELKLLVEKEKAreakgssddEHKVETEgkmvpixdpDDGSYNEsLrSSwiqRKSKDTEVDVRIVDNE-VTIKLVQRKKIDCLVHVSQVLDQLNLDLQHVAGGHIGDFCSYLFNTKMCDGS------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDDAIRYLKSLQTQVQNSEQG--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQTNRRQQINHNLSYLHSLLPEsyIQKGDEASILGGAINYVKELEEELQVLCAKNSTA---NLLQDANIGASDGCrGYqlSTPCGDHIQVTMGGENhnNVELKLHSKWRPKLLPRFMSQIESLMLTVLHFNLSRTDQFVLCSLSLKVEDGSKFTSVK------------- ---------------------------------IQLLQGLCSD--GLWRYAIFWSFESEMnGWILTWGDGYVDKVVedKQVGDlsagptvskNqivPSScynkgypfCPIEAALLRMSSHLYPLGE-G-IIGKVALIGQHCWISANELCSisMHNYReDWLLQFAAGIKTVLLVPVvPHGVLQLGSLDMCSIDALLDKTI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINAQLATLRKLIPKSDKMDKAALLGSAIDQVKDLKRKAMEASKNMT---VPTDMD---EVTID--------STMVEDHSRNNiE-IKVSVSCDDRPELFTELIQVIKGLRLTTIRADMASVGGRIKSIL--------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLHARSVVPKISKIDRASIIGDAIDYLKELLQRIHDLHNELGL------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEKRRRSRINEKMRALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQILSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKVSMLDEAIEYLKQLQLQVQ-------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERRRRDRINEKMRALQELIPNSNKTDKASMLDEAIEYLKMLQLQLQMMS----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKNQVQSLERA--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LMHRDIERQRRQEMATLFASLRSLLPLEYIKGKRAVsdhMNGAVNYIKDLQKRIKELSAKRDELKRESC-QSSNPDARG-SSSGKSFPASVMVQPCVSgvE-VVVSSGSSPQALPLSRVLEVLLEEGLEVVSCLSTRVNERLIHTIQVEVND--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHTMSERKRREKLNDSFVALKAVLPTGSKKDKASILIRAREHIRSLESKLSELEEKN-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERRRREKINERMKALQEVIPRCNKSDKASMLEDAIDYVKSLQMQIQMMSTG--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKGSILRDAVEYIQQLQEQERRMLAEISLL------E---------------SAAEVRVTGAGDKLLVVSVACRHRKDAMAKVCRVLQSLQLAIISANVTVASGTVTHTALLQRQ---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PASKNIVLERNRRQKLFQRFFCLQSRVPNITKMDKA-------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKSLQELVPNGNKTDKASMLDEIIDYVKFLQLQVKVLS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPNCNKaknsflgsekkrADKASMLDEAIEYLKMLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RITHIAVERNRRRQMNQHLSVLRSLMPQPfsQKGDQASIVGGAIDFIKELEHQLLSLEAQKLQKDKLSqTVTSsTSqDSNcepenphlSlSqfflhSydpShenrngStSSvKTAMEDLEVTLIETH-ANIRILSRRRGfqwtsvvattgpPQLSKLVAALQSLSLSVLHLSVTTLETFAIYSIS-------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQTLIPNSSKTDKASMLDDAIEYLKHLQLQVQV------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQKVLNKKLQKQRIK-PEFTSEKKSDILMDALNYINQLKQKVEDMTKEYGELINQ-----G----------HHQPTMDVKVEKLENNCFMVRVTCEKVQDLLISLMEAFEEMGLDVLHADINCNQNFHM-EAIIEAEDE--TLDVESVTQSIYEVLE-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVHSLSERRRRDKINEKMRALQELIPNCNKVDKASVLDEAIEYLKTLQLQVQIMSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERIRALQELVPSVNKTDRAAMLDEIVDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHNLSERRRRVKINERMKTLQELIPRCNKTDKSSMLDDAIEYVKSLQMQIQMMSAG--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQFHHMMSERKRREKLNESFDVLRTLLSPDTRKDRVSVLAGTRDCMNAMREQISCLEEKNRALEAHLTApEdPTDEAES------SGERVEIRVnrmpessssqlgHQIELR-VTVRVKCDAV-GLLLRVLRRLKEMGsLSVVSMEARGF----------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AETHNLTEKRRRRKINEKLRTLQQLVPGCdDKSNQASILDQTIQYLKSLQQQIQVMSK---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNSNKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRREKISERIRILQRLVPGGMKMDTASMLDEAIRYVKFLKRQVKELQIG--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLISERRRRGRMKEKLYALRSLVPNITKVDKA-----ALQYVHNHQYQLSQYVIT--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMHRDIERQRRQEMANLYASLRSLLPPEYIKGKRSIsdhMNEAVNYIKYLKKRIKELSVKRDKLKKLSNSSSLDAGSSS--SSSSSPNSCVAVHPCLGG-VEIVISSGFGdqGWPLSKVLQVLLEEGLDVVNCVSTKVNERLLHTIQSEVSDP-------------------- ------------------------------------------------------------------------------------------------------------------------------DDYDCE--SEAEEEGFEANPLIPAPAAAVRISSSSS-------------------------------SS---SKRS-----R-AAEVHNLSEKRRRSKINEKMKALQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLTMR--------------------------------------------------------------------------------------------------------------- -------------------------------SLRQFLRSLCEDL--QWDYAVFWKLRHRSLMLLTWEDGYCNYPKpRQYvegmSDNvhlgetdgvasfdheIDVangSSAGyplGLAVASMScalYSF--GE-G-YVGGATSTGKHHLIF-ADEFDSKLlpeFPDEfHLQFAVGIQTVLLIPVtPHGVVQLGSLQKIS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKV----------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------SKWVYSVFWRILPRNyppprwefgggaidrakgnerNWILVWEDGYCDFYECEGAGNgyMKGrFGPEVFFKMSHE-VYSYGE-G-LVGKVAADNSHKWVFRDSqnELESNFisswnmsiepQPKAWEAQfNAGIQTIAIIAVREGIVQLGSLDKVVEDINLVIKIQRKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VERRRRKRLNDRLSMLRSIVPKISKFDV---------------------ER-------------------------------------EQD-TRISICCATKPGLLLSTVNTLEALGLEIHQCVISSFNDFSLQASCSEVS---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSHSEAERRRRERINAHLATLRGLVPCTEKMDKATLLAEVISQVKQLKKTATESSKGL-------IIPM-DA---------DEVRVEPEPNTEGDKNIslRVSLCCDYRPELLSELKQALDALHLNMVKADISTLGSRVKNVL--------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQKLVPGGNKMDTASMLDEAANYLKFLRSQVKALEQ---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSERRRREKQNEDFIALRSLLPFGTKKDKASILFNSRQYLTSLKAQVAELSKQN-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERRRRDRINKRLKSLKELVPNCNKSDRASVLDDAVNYVKALRHQLEMMSAQ--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRREKIAERMKNLQELVPNSNKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQLHHVISERRRRERLNDSFQTLRALLPPGSKKDKANVLASTTEYMAKLVSQVTQLRE---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQLQVQMMSM---------------------------------------------------------------------------------------------------------------- -------------------------------ALHEALRNVCLN--SDWTYSVFWTIRPRPrvrggngckvgddngSLMLMWEDGFCRGRGAcDCLDEidGEDPVRKAFSKMS-IQLYNYGE-G-LMGKVASDKCHKWVFKEPsECepnISNYWQSSFDAVppewndqfSSGIQTIAVIQAGHGLLQLGSCKIVSEDLHFVLRMRHTFES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------LREALRRLCVE--IGWSYAVFWRLIDSPgPKHLVWHDGYWCGKP-QLSglnDavahgNsfavlqaqGEGSIDELVNKTMVPQVHVLGD-G-MVGVAAVSGNYQWILRELYGDQETmaEDLAFLNNqfSAGIQTIVVIPVPpHGAIQLGSTKRWN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNFSERRRRDKINEKLKALQELLPNCNKTDKVSMLDEAIDYLKSLQLQLQMLV----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDKINEKMKALQELIPRCNKSDKASMLDDAIEYLKSLQLQVQMLSS---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKERCRRHMMKERTRREKQKQSYLALHSLLPFATKNDKNSIVEKAVDQIRKLQRLKKELERRNNVLEAKSAKD--HD---------KMSGTKIRFN----------LQEPLSgIDSMVEVLQCLKSMGTKLKTVQANFSPHEFSATMNI------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKvIGKALVLDEIINYIQSLQRQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSHCEAERRRRERINRHLATLRSMVPSTKKvggcsplltykLDKAALLAEVINQVKELKTNAVEISK-------RYFIP----S------DTDEVRVKVEDVMKDGN-FLVKasLCCEDQPELIADLRHTLQSLQLKMVRAEISALDSQ-------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNESERKRRDRINQKMKTLQKLVPNSSKADKASMLDEVINYLKQLQAQVQVMSR---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVLSM------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LHNMSERKRRGRFREKIETLQQLIPNCNKADRASVLDDAVKYLKRLKLQVEMLAM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEKHKEAERKRRSRINEQYDSLRTKLPNLVKMDKASVLAETVRYVRELKKTVTKLKAVRRIGDTEF-I-----------FPGGENKLRVVYCQGEGGLAKVILSCEDKLTLISEVTRALGSVKGKVIRAEMVTVGGRT------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLMMR--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRTHIAVERNRRRQMNDYLAGLRSLMPPSyaQRGDQASIVGGAINYVKELEQLLQSLEVQKSVRSSRdgSRsTDPGGRspfagfftfpqySTiaSSahcspdSsgVSNAchnvvkpEAGVADIEVTMAEGH-ASLKVLVRRLPRQLLKLVAGLQQLRVPALHLNVTTLDTMALYSFSLKVEDGSKLGSVEDIAAAVHEILA-- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNESERKRRDRINQKMKTLQKLVPNSSKTDKASMLDEVIDYLKQLQAQVQVMSR---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERKRRDRINEKMKALQELVPHCNKSDKASILDEAIEYLKSLQLQVQVQNS---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQLQVQMM------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAKKHSEAEKRRRMRINGQYAALRILLPDLIKMDKASVLAETIRQLKELKVNVSELEAVSGGTSGEI-----------TVFPSGADKLNVE--HCNDEQGLVkaTLSCEDRPGLMSAITRALRSVKAKVVKAEMVTVGGRTRNVLWVQ------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHTISERKRREKLNGSFVALKAVLPPGSKKDKTSILIRAREYVKSLESKLSELEEKNR------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKDAAVTHAVAERKRRERINSHLHTLKKLFPHLPKKDKPRVLTEAVTQLKELRKNVAQqLESEGNYN-----------GLSS-LF-LPGENDEVIVNYCdninEERTVKATICCEDRPGLNRDLSSAIRSVQGRVIKAEMATVGGRTKAEMVVVlgkAGGGE--KDIGQLKRALKAVVE-- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WIFGLRRRRQRINEKMKALQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLWA---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAAIHNQSERKRRDIINQKMKALQGLVPNANKTDKASMLDEVINYLKQLQAQIQMMNR---------------------------------------------------------------------------------------------------------------- -------------------------------NYPPRLKILVDGS-SGGCYGIEWTLTESGR--LVH-NSHYDPEW-HV-DAMGPSYKGGFSKRSVTYSFMPGQ-G-AVGEAFARKELIFLQEVQRLNrhlSTPFQRADLAKEFGIHSILFVPYPDGVLEIGSTKKFATSADFL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AETHNLYERQRRDKINKKLRVLKDLIPNCNKVDKASLLDDAIEYLKALKLHLQIM------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDKINGKMRALQQLIPRSTKADKASLLDKAIGYLKSLQSQVQSLQSQVQM------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHMISERKRREKLNDSFLALKTVLPPGSKKDKTSILIRAREYVKSLESKLSELEEKNR------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AESHSLSERRRRDRINEKMRALQDLIPNCSKLDKAAMLDEAIEYMKFLQQQVQMMW----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHITVERNRRKQMNEHLAVLRSLMPEsyVQRGDQASIVGGAIEFVKELEHLLQSLEAKKLQIlqqSNEdStilKLMRPpfAqffvypQytwSQAPNkYTSkTQAAIADIEVTLIETH-ANLRILSRKSPRQLSQLVAGFQALSLTILHLNVTTMDPLVLYSISAKA----------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIHKGHVMPD---KLKENEKLLVLRSMVPSISEVDKASVLDDTIKYLKELEARAEEMESCMD------------------------------------------------------------------------------------------------------------- -------------------------------QLQQILRILCYNT--EWNYAVFWKLNCKPKMLLTWEDAFFANHEpldpaRNLSvDstfeNEDNnylQNPLGLAMAKMSpLVYSLGE-G-IIGQVALTGDHQWILTDKPTPttwlPLECSDGWHAQfSAGIRTAVVVSVfPLGVVQLGSLNNVIEDVNLVILVKNLLYS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------LRPFLHSLCCNSP--WSYAVFWKLEHQHETILVWEDGFWDNPKpRYpTEkriegfylErsnmiNpsgftssmLDEtpGDYPIgLAVAEMSRaSHVVGK-G-IIGEVALTGNARWIYSDALMTnifdiCPCCPSMwLYQFDCIIKTIRFLPFiPYGVLQLGSNEMVLEDEALIANVKDKFES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLVPNANKTDKASMLDEVIEYLKHLQLQVR-------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNDYLAVLRSLMPPSyaQRGDQASIVGGAINFVKELEQLLQSLEARRRRSSQRPspGVNGDDdyaapftgfftfpqysmrvaATdTAPehaplaaaaDAthregdedASgSkPSAVADVEATMVESH-ANLRVLSRRRPRQLLRLVVGLQGHRLTVLHLNMSSSGQMVMYSFSLKVEDDCQLTSVDEIAAAAHQILE-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRRRSKINEKMKSLQKLIPNSNKTDKASMLDEAIEYLKQLQLQVQTLAV---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIDYLKTLQLQVQIMSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKVRNAP------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKHSATEQRRRSKINDRFQILRELLPNSDqKRDKASFLLEVIEYIRFLQEKVQKYESS--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHITVERNRRRQMNVHLNSLRSIIPSSyfLRGDQASIVGGAIDFVKILEQHLQSLEAQKITQ--------------------QTSRLIIDATVMERH-VNLKIQCCqRRQGQLVRSIFLLEKLGLTVLHLNVTSPcNASVAYSFNLKV----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQMHHMISERKRREKLNESFDALRMLLPRGSKKDKASVLDNTKNYLNTLRTQISELDER--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQMIQDRVKELREIVPNGAKCSIDALLERTIKHMLFLQSVtkhADKLKQTGESKiiSKEGGllLKDNFEGGATwafEVGS-QSMVCPIIVEDLnpPRQ-MLVEMLCEER-GFFLEIADLIRGLGLTILKGVMEARNDKIWARFAVEANR---DVTRMEIFMSLVRLL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AASKNVVSERNRRKKLNDRLFALRSVVPNITKVT---------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSKNAGSERKRKQRLNTKLFMLWSLVPMVTNMTKESIFNDAITYIKKLKDEVKSLTQELQAM----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSLEEQA-------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AECHNLSERRRRDKINKRMRVLKELIPNCNKVDKASMLDEAIEYLKTLQLQL--------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACNSHSEAERRRRQRINAHLSTLRTLLPNTTKTDKASLLAEVVRHVTELRKRAADVAGQNGDG----CC---SGGGSE--SWTfPGETDEVTLGYYEGDERLIKatLCCEDRPSLNRDLTQAIGSVRARVVRAEMATVGGRTKSVVVMQ------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHNQSERRRRNKINEKMRALQELIPNANKTDKASMLDEAIEYVKMLQAQLQFMSMR--------------------------------------------------------------------------------------------------------------- -------------------------------TLQKRLSTLIEGAHESWTYAIFWQSSVVDyggPFLLGWGDGPYG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARHRRERISDKIRVLQKIVPGGNKMDTASMLDEAANYLKFLRSQVKALESL--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDRNAVEKNRRlqtKDLNSKLASLIPNQPSKEILPLRDMLEQATNYVVELKQNAEELKRRKVELEGDNKVG-----------SQDERLPVLTIRDMDSI-LEVNLItGLNNNLKLHEVLSVLKEEGVEVESASYSSVGNQTFYTIHGKA----------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERKRRDRINQKMKTLQKLVPNSSKTDKASMLDEVIEYLKQLQAQVQMMS----------------------------------------------------------------------------------------------------------------- ----------------------------------------------GWSYAVFWKAIGAaDPVHLVWEDGFCGHAScSAGSEAPDAgCepGSSVCTLVrkiMASQIHVVGE-G-TIGRAAFTGNHQWIIHDPANDHS--LRSEVsaemnyQFVAGIQTIAIIPVlPRGVLQLGSTNVVVEDTNLVLQYKKLCSQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSHNLSERRRRDRINKRMRALQELLPNCDKVDKASVLDEVIEYLKTLQLQLQIMST---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKKHSDAERRRRLRINDQYSTLRTTLPNLVKMDKASVLAETIKSVRELQKSVKELKKRCQGR----DVYA-FPS----------EANQLNLCYSDDNTGLLKatLSCEDKPGLMSDLTRAVKSVKGRVVKAEMVTVGGRT------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKvIGKALVLDEIINYIQSLQRQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRSHSEAERKRRQRINAHLATLRTLVPSASRMDKAALLGEVVRHVRELQGRANDATE---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKNHSEAERRRRERINAHLATLRGLVPSTEKMDKATLLAEVISQVKELKKNAMEASK--GFL---IPMD----------------ADEVKVEPYDDeggDgsmSYCATICCDFRSEILSDLRQTLDSLPLHLVKAEISTLAGRMKNVFVF------------------------- ------------------------------------------------------------VSVLEWSEGSYNGEIktRKTTqstepdtdqmglqrskelrdlyesllsgDsnrqirrpstslSPEDlTEAEWYYLLCMSFTFSTGQ-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERRRRDRINQKMKALQRLVPNASKTDKASMLDEVIEYLKQLQAQVQMMHS---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKLMNGYLAVLRSLMPEshVQRGDQASIVGGAIEFVKELEHLLQSLEAKKLKQHQGltgPdyDIEDAtATSKfpPPPfaqffvypqytwsqIpnkfTSkTKASIADIEVNLIETH-ANMRILSRRSPRQLSKLVAGFQTLYLTVLHINVTTMDPLVLYSISAKVC---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRREKISQRIRILQRLVPGGTKMDTASMLEEAIHYVKFLKKQVQELQSN--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFKILQSLVPGGTKMDTVSMLEEAIHYVKFLKTQIWLHQT---------------------------------------------------------------------------------------------------------------- -------------------------------ALHEALRSVCLN--SDWTYSVFWTIRPRPrvrggngckvgddngSLMLMWEDGFCRGRVSDCLEEIDGEDPvrKAFSKMS-IQLYNYGE-G-LMGKVASDKCHKWVFKEPTeCepnISNYWQSSFDALppewtdqfESGIQTIAVIQAGHGLLQLGSCKIIPEDLHFVLRMRHTFESL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMNHIAIERNRRKQMNQSLSVLRSLMPHsyVQRGDQTSIVGGAINFVKELEQKLQWLSTEKEVKQRPNfdffKFPQFSTSSsSTrvnnnSIpmNEStvEiqPTIADIEVNVTEKN-ANFKIRWKRLPPQLLKLVSGLNDMSLTILHLNLTSDDRTVLYSLSLRI----------------------- --------------------------------------------------------------------GGLNGDIyaRR----LDGvSDVEMFHLTSMCYAFKLDSIshC-GPGESYKSGKSIWVSDA-----------------------------GVVELGSVKSTSEKQSYVDMVRSAFGES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNQVHHMISERKRREKLNKSFFALRSELPPRTKKDKASILMATREYLMELKSRISIIKSK--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARLRRERISEKIRILQRMVPGGTKMDTASMLDEAVHYVKFLKKQLESLERA--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAQDHTIAERKRREKISNRLIELSNLIPGLTKTDKVTILSDAV------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISQRIRILQRMVPGGTKLDTASMLDEAVHYLKFLKKQVQSLEQA--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGKHTQAKNLHAERRRRKKLNDRLYALRSLVPRITKVHRITIRSDH-------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHILSERQRRKSMRESFSILQSLVPKLKlkHTDRITVLTEVITYIQSLRGTLEELERKKADImellglSAkgKSRlcladVEGTityvNsnDSGSSDekggdrAGgwcnlqNGeRVAMVEVTVRMCGAD-VFVTLNTPHRRGVWSGVLLLLQKFRIEVSNATLATSGDSSFHCIHAKAT---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLEGQPSKNLMAERRRRKRLNDRLSMLRSIVPKISKV----------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHALHIWTERERRKKMKNMFSTLHALLPKIPgKADKASIVGEAIGYIKTLEDVVQKLETLkMERVRAHQwaaaaaaAVaangggEGSSHSqpprhaTAvtvaPaPVaaavNaqapqkkaaAAaaptlqTWSAPNITLTMAGVD-AFINMCLPRQRASFTTVAFVLEKHQIDVVTSTISADHDKSLFSVHVRLNE--------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKTQVQSLERA--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHKEAEKKRRERINAHFSTLRRLVPNSAKMDKACLLGRVIDQVKELNRKVTDISQV-SRVPKEV-----NEV----------SVVECSISHNddDDD-LYMkaSVCCEDRPDLFAQLTEAFQKLRLRTIKAEVVSLGGRT------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLHIWTERERRKKMRNMFSNLHALLPHIpPKADKSTVVDEAVKYIKKLEDLAEEMEKLRAERPSPTPVCRNpipNPGQDFPATFKTWTSANVTVNVCGRD-AHISICSgrsRRRSGLLTGVCSVMEKHELELVSAHIS------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKHSETEQRRRSKINDRFQKLREIIPNSEqRRDKASLLLEVIDYIQFLQHKVSKLE----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQAEKRRRERINTHLSTLRRLVPSATKLDKATLLGRVIDHVKELKRKALEIGNSFT-------VP-------T-----ETDDVTVECDRNGalKDRFIIRasLCCDDRPELYTDLIQALHGLKLRTVRADMATLGG--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADITVCIEETE-ATIEMHCPWRECLLLEIMDVISNLQLDAHSVKSSTSDGIISLTINSKFRGT-RIITAEKIKSALM------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RERCFRHMMNERMRREKQKQSYLALHSMLPPGTKNDKNSIVQMAAKRIQELQRYKEELERRNMELEA--NLA-----------ANEK---N---KVEGAK-IRLRVANPSSgIDSMLEVLKCLKNLGSKTRSIQSNFSPQEFSAVLEI------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------LQHTLRSFCIHENSQWVYAVFWRILPRNypppkwdtqgaydrsrgnrrNWILAWEDGFCNFAASttgETSsgDspayaNHEyqqylGLQPELFFKMSHE-IYNYGE-G-LIGKVAADHSHKWIFKEPTdqeINflstwnnsADSYPRTWEAQfQAGIKTIALVAVREGVIQLGSINKVIEDLSYIVMLRKKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAQVHNLSERMRRDRINEKMRALQELIPHCNKTDKASMLDEAIDYLKSLQLRVQMMW----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKViGKALVLDEIINYIQSLQRQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVHREIERQRRQEMATLYASLRSLLPLEFIKGKRSIsdhMNEAVNYIKHLQKNIKELSAKRDKLKKLSNSS--SNPESH--EGSSHSSCnTVTVHPCNGG-VEILINsGFReEGFPLSRVLEALLEEGLNVVSCVSTKVNGRLLHSIQCEVSDS-------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQMQVQDQ------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFRVLRSLVPGGSKMDTVSMLEQAIHYVKFLKAQVSLHQAA--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEVHNLSEKKRREKINKKMRTLKDLIPNCNKVDKASMLDDAIDYLKTLKLQLQ-------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMHRDIERQRRQEMATLYASLRSLLPLEYLKGKRSIsdhMHEAVNYIKHLQKNIQELEIKRDKLKKLS-----NSSTLSATetGSISCLPDSVTVNPCWPG-VEVLISSSLKEevVPLSRVLESLVEEGLTAVSCVSTKVNERLLHTIQAEVMDP-------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEACKSHREAERRRRQRINSHLSTLRSLLPNAAKSDKASLLAEVVEHVKRLKKQAAEVAC-VDGG--EPgAVR----S--E--AWPlPGECDEATVSWCEGeaNRVKATVCCEDRAGLNRDVTRAIRSVQAKPVRAEMMTVGGRTKSVVVVEWG---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERRRRDRINEKMRALQELIPHAHKSDKASMLDEAIEYMKSLQLQLQWLW----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKSHKEAERRRRERINGHYSTFRNLVPNGDKLDKASLLAEIVRKVKELKKLAAAAV---AS-----------QSSSSRGFWAiPNEKDELTVDyykddLISSE-MMIRVsfSCEDRVDLLSDLIKVLKKsAQGKVVRAEISTIGGRTKSVILIQ------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARHRRERISDRIRVLQKIVPGGNKMDTASMLDEAANYLKFLRSQVKALESL--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVAARQRRHRISDRFKILQSLVPGGSKMDTVSMLEEAIQYVKFLKAQIWLHQA---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVSMDRTAILGDTIDYVKELTERIKTLEDETGATPEELNLLSTTKSfssSSNDeeMPMRNSTKFVVEKQGNGGN-TRIEICCTTSPGALISTVSALDVLGLEIEQCAISCFGDIAMQASCSQEEGRNRVTCTDEIKQAMFT----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRREKISEKIRVLQKLVPGGTKMDTASMLDEAANYLKFLRSQVKALES---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAQVHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQVM------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKHSATEQRRRSKINDRFQILRDLIPHSdQKRDKASFLLEVIEYIRFLQEKVQKYESS--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQRLVPGGSKMDTASMLDEAANYLKFLRSQVKALEN---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CEEHVSLDK--R-TKNEKFMLLRSVVPYISEVDKASILNDTIKYLKRLKARVEE------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERVRVLQRLVPGGTKMDTASMLDEAIRYIKFLKRQVQELHSA--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHNLSERRRRDRINEKMRALQALVPSCNKVDRASMLDEVIEYLKSLQMQVQ-------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRAPVSKKLLTLRSIS-KSHAHSKTSIILDASKYIQNLKRKVEEMNQQIIASA----------ST-S--TSQNPFPVQVKVETLEKG-FLIKVFSEKScPGLLVFILEAFEELGLDVLQARVSCSDNFLLEAVGGENDnQSAEQKDAQVVKEAVLQAIQ-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRREKIAERMKNLQELVPNSNKTDKASMLDEIIEYVRFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------NLTERVRPIVGL--NGWDYCVYWKLSEDQR-YVEWLGCCCAGTENNnQNDeEqhifpfssVASsCRDTMFphprmktcdLLSQLPISIPLDS-G-IHAQALLTNQPNWVNYSKSLDSNILE-------QTIGTKVLIPVPGGLVELFVTKQVPEDVQVIDFITTQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATIHNQSERRRRDRINEKMKALQKLVPNASKTDKASMLDEVIEYLKQLQSQVHMMSNA--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHNLSERRRRDRINEKMKALQELIPRCNKSDKASTLDEAIEYMKSLQLQVQMMSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------RWKYAVFWKLNHHFPMNLTWENGYQKRNEVEESmwDDvnfksPDElyfsrgesTDYSGDYsvrllMIEMShRKYNLGE-G-VVGKVALARDHCWVSCEDILTSKfdtdlitECPDeWFLQIACGIKTIVLVPVLpLGVLQFGSFEEVAEDLEFVTTVKEKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNQSERRRRDRINKRLKSLKELVPNCNKSDRASVLDDAVNYVKALRHQLEMMSAQ--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRNRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKKLQLQVQMLSAR--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKvIGKALVLDEIINYIQSLQRQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMGENCIsVVNAIEQMQDLDQRLKKLEEKQTNEasSKEDELP-----------DEKCGVDQIQARVNRTN-VLLKLQCRKRKGVLVKLLMELDKLNLDVVSASIVPFGSFVLDiTITAEVVKEF-SGSAEDVVTTIRNCL--- --------------------------------LKEALKSLCGV--NQWSYAVFWKIGCQNPKLLIWEECHCEFIPssglpHGSgmenSevpfEDwegcwvspetrisqLDGQAVeSIYFLVNkMMmnnQVNIVGE-G-IVGRAAFTGKHQWILSENYTRDAHppevLNEVHHQFSAGMQTVAVIPVlPHGVIQFGSSLAIMENAGFVNDVKSLILQL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMHRDIERQRRQEMATLYASLRSLLPLEYIKGKRSIsdhMHEAVNYIKHLQKKIEELSEKRDELKRLSNSS---SSS-SVIDNGsSMSDSTIVVRPCSAG-VEVVISSQG-ALPLSRVLEVLVEEGLDVVSCVSTRVNERLLHTIESEVSDG-------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKKQVQSLER---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSEKRRRSKINEKMKALQSLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNQSERRRRDRINDRMRALQELIPNSNKTDKASVLDEAIEYLKNLQTQLQFMSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRRLMNDHLASLRSLIPSsyIPRGDQATVVGGAIDYVKQLEQQLVALQAAAATRRGVAgAVGTAATAAADGVfvspqyaSYSeargCCGGVDVEAMaAVGGH-VRVRVAGRRWPGRLVRAVAALEDLRLAVLHLAVTSVGhDAVVYCFNLKMEDGCEVATADEVAAVVHQIF--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSEKRRRDRINERMRALQELIPNCNKTDKASMLDEAIEYLKSLQMQLQIMA----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERKRRDRINEKMRVLQELIPNCSKVDKASMLDEAIEYLKYLQLQVQIMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNMSEKRRRSRINEKMRALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQILSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERINERMKALQELVPSCNKTDRAAMLDEIVDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------DFQSALNSALNHICefTDWDYGEVWIPESD-GTILELSPAWYISPR-S----SDRtYALEQFRLCSEEFILPPGE-G-LPGRVWSSQQPEWIVDVSAQSETYFLRNQIAKAFGVKAGLGIPIIvNdeviAVLVFFMLKARDEDEQLIKLIEAIANQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFASERQRREWLNEAFWALRMLLPNP-KCDRVSNVEDAIEYIHELNRTVKELKILVEQ------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHIAVERNRRRQMNDHLKVLRALTPAfyIKRCDQASIIGGAIEFIRELHT-------------------------------------------------------------AARIVALLESLHLEVLHVNISTMDDTALHSFVLKIG---------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARHRRERISERLRVLQRLVPGGSKMDTASMLDEAANYLKFLKSQVRALET---------------------------------------------------------------------------------------------------------------- -------------------------------VLREKLKSLCVS--NGWSYGVFWRFDQRNSMLLTVEDAYYEEQM-GIV--INN---------MLPQVHVLGE-G-IVGQAAFTGKHQWIFSDAHNEGifQDDSELYCQFSSGIKVIAVILVEsQGVVQFGSTQKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVSHSTVEKQRRDRINSLIDELRELVPPQFecgegqpaedsesKRPKHVVLSDTIKLVRNLQQKLNIAAAEPKKetegLSSTSqgaagelgssKgLRTGaaratAargRSgSMNhdSSqgSGtptlptnPsENTNIEigVVVEQEDDC-FYVKVNCKDRNGLLSDIIRALKSMPLEIRTAAITTTNTgTVSDVFEVDLDYC--KLSPEEVQNQVHEVL--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRFLQST--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRCKINEKMKALQSLVPDSSKTDKASMLDDAIEYLKHLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIHSEAERRRRERINAHLATLRRILPDAKQMDKASLLASAVNQVRELKKSATEVAAPVP-----P--E----------------ANEVTVQCyaGGGEhactSVHATVSCDDRPGLLADIAGALRRLRLRPLRADMSCLGGRTQHAFVLRS----------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDKKRRDKINQRMKTLQKLVPNSSKTDKASVLDEVIEYLKQLQAQVQMMSR---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQVQELQANQ-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAARHRREKISERIRILQRMVPGGTKMDTASMLDEAVRYVKFLKRQLQELQAN--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERKRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTPQLQVQMMS----------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRAPISHSTVEKQRRDRINSLIDELRDLVPPQQPqaaqqqgasiaandaaeaesrRPKHVVLADTIALLKHLQQRVSFGAVQAGGQqlaagGsgNgggqlpmggPPAMgfagmEGAaNSeGmaSgmpggsGSASkqepqgaSSQpdddcgRAPGPGVTVEKGPDC-YYVQVRCPDRKGLLSDIMDTLRRLPLEVRTAAVTTTNGMVRDVFEVRPDDP-------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQQLIPHSNKTDKASMLEEAIEYLKSLQLQLQV------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKSLQELVPNANKTDKASMLDEIIDYVKFLQLQV--------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AARKKACREKARREKLNERFLELARLVDPGKepKTDKLTILTDAIKYVQQIT------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------LPGRTFAAGHHIWLCDADYADSKDFSRSLLAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRSHSEAEKRRRERINGHFDKLRHLLPSNVKRDKASLLAEAIRRLKELKLQTSEISAM-GPIPDESdevTVECSGEFPS---DSG---------KSSGQPVVMASFSCDDRSDLLPELITTLKSLRLKTIRAEIQTLEGRMRHVLHVTCE---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIDYIVGLQKQVKDLQDEREA------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISERKRPEKLNDSFQILRSFLPPGTKKDKASVLSNTTEYLSSLKSQVAELAKR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQMQVQVLPS---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERIRALQELVPSVNKTDRAAMLDEIVDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRRVKISERMKALQELVPNANKTDKASMLDEIIEYVKFLQVQVKLLS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEMHNQTERRRRDKIKAKLKALQELIPNSHKLDRASMLDEAIAYMKSLQQQIQIMS----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARLRRERISERIRVLQRLVPGGTKMDTASMLDEAIHYVKFLKSQVQSLELA--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPRCNKTDKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKHSATEQRRRSKINDRFQMLRDLIPNSdQKRDKASFLLEVIEYIQFLQEKVQKYEGS--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESHILSERQRRKGMNHLFSTLASLLPEtCSKSDKSTIVSEIISYIHLLRKDLEDLDKKRSDVlRSaSPraamAIKDSGSpSpsicTtTNdrgskNAGGGddhpgmiqqqSQQASNVILSVCGSD-AFITMICASKnRSVFSKVLLLLDHHKFRVLDANISTNASTTFHYFHVKALNS--QLPKDALQRDL------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNKTSIIMDASKYIEELKQKVERLNQDTASSQS----------SSE---PTDNTLPMVTVETLEKG-FLINVFSEkNQPGMLVSILEAFEDLGLDVLDARVSCTDSFRLEAVGGEVR---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASRSHSEAEKRRRDRINAQLSTLRKLIPKSDKMDKAALLGHVVEQVREHSKIAKEVSK-------SSAVPT--------------ETDEVTVDHSnddssqdNRNiYFRASICCDDRPELFAELNGAIKGLGLIIHHAEITSIGGRMKSNLIL------------------------- --------------------------------VHKALQRLCRN--YGWSYGVFWRFDHTNSLLLTMEDAYYEEHV-GVI--ID---N------MLLQVHVLGN-G-IVGQSAFTNTHRWMFSDAVVsiDNHDmiQDNSEIhhQFSYGIETVVLISVePRGVVQFGSTQKIPESMEFVDQTKRLFREI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------NFKEQLALSVRSI--QWSYAIFW--------VLSWGEGYYNGDIktRKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHIAVERNRRRQMNDHLKVLRSLTPAfyIKRGDQASIIGGAIDFIKELQTLLQSLEAQKK------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNSHSEAERKRRQRINHQLSRLRQLLPHTSRMDKAGLLTEVVREIRDLRRRAADAVGPNDDC-----W---GPS-----FPGEEDEVLLDCSGDGEsgRTATASFCCQDRSGLFRDVGEAIRSSRIRPARVEMATVGGRTKAVLVV------------------------- --------------------------------MKATLKNLCCS--NGWSYGVFWGFNQQNSLLLTLRDAYYEEQM-GGL--IDD---------MLLQVHILGS-G-VIGQVAFTKNHKWMDSDANSEWQNhhgsFDSCELlqddsefyGQfSCGIKTIAVISVEpWGVVQLGSTQKLPERMEFVDEVKKLFQE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRMVPGGTKMDTASMLEEAIHYVKFLKMQVQSLERA--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FRCIVPNISKMGRASILGDAIEYLKEVVQNISDLHNELES------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AESHSLSERRRRDRINEKMRALQDLIPNCSKLDKAAMLDEAIEYMKFLQQQVQMMW----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRASILGDAIEYMKELLQRINDLQNELEST----------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQVM------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARHRRERISERLRVLQRLVPGGSKMDTASMLDEAANYLKFLKSQVKALETL--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAAARRRRERISERLRVLQRLVPGGSKMDTASMLDEAANYLKFLKAQVAALES---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATDPHSIAERLRREKIAERMKNLQELVPNSNKNDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHLSIERGRRKKMKEMFDDLSALLPQLpSKADKATIVNEAVNYIKVLQETLEKLERKKEERAED-GLKQImGKSCCAvSVSEkqkvGfdKtWAASNMVLNIRGNE-AQFSICSVHKPGLMTNIVSVLEKHNIELISATISTNGN--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQVMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKvIGKALVLDEIINYIQSLQRQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISDRVRVLQRFVPGGTKMDTASMLDEAIHYVKFLKLQLQTLEQ---------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------SWRC-AHELQIYECERVKETRMHGIQNLVCVATSCAVLELASLDVIKEDWGLVYLSKSLFGSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRSVVPSwISKieiaMDRTSILGDAIDYMKELL------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKNLKAERRRREKLKSRMLELRSLL------NKETIITDAIDYIKELQSSVTDLQNEIVEMEAEmaheqPseiiqvpseeKMENwGieiklKPRVVSqvqPVtdSNlRvmiKidhvmLTCSDVEVTRIDENKSWMKIVFGKKAGGFTKLIEAM-------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIAARHRRERISERIRILRRLVPGGSRMNTASMLDEAIQYVKFLKRRVRELESS--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRRERIAERMKSLQELVPNGNKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPSCNKTDRAAMLDEIVDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPHCNKTDKASILDETIEYLKSLQMQVQIMW----------------------------------------------------------------------------------------------------------------- --------------------------------LQHTLRSLCSysdSSsssSSKWVYAVFWRILPRNypppkwdyggsaldrskgnkrNWILVWEDGFCDFHEceRAGSGYVKGrFGADIFFKMSHE-VYNYGE-G-LVGKIAADNSHKWVHKEIPNENdpgfisswnmsiEPQPRAWESQfNSGIQTIAIISVREGIIQLGSLDKMVEDLNLVISIQRKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHNAYERDRRKQLNELYSSLRSLLPDADHTKKLSIpttVSRVLKYIPELQKQVENLEKKKEELTRANCKPGVL-NM------SESTAPIVSATCLNDREIMVQVSLLSnmaAALPLSKCIKVLENEGLHLISSSTSSTfQNRTFYSLHLQR----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTSKNLMAERRRRKRLNDRLSMLRSIVPKITKVcDNQSQL----------------------------------------------------------A-LSCDLISATSPGVLISTVSALEVLGLEIEQCVVSCFGDFAI------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKNLEVERRRREKLSTRLLMLRSL------MNKATIVEDAITYIETQQNIVQSLSYELH------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKNHSEAEKKRRARINAHLDTLRSLVPGTSKnligargdvreifqvgacislvflMDKASLLAEVITHLKELKSQATEASEGLLM-P--LDI------------------DELRVEQQegdlhGGpYIITASICCDCKPGVLSDLRQALDAFHLIIMRAEIATLEGRMKNVFV-------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRSKHSVTEQRRRSKINERFQILRDLIPHnDQKRDTASFLLEVIQYVQYLQEKVQKYEGSY-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQMHHVIVERRRRQKQSQSFQILRHLVPQVSKKDNASLLGETAEYLRSLRSQLGELETRN-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMRALQELVPNTNKTDRAAMLDEILDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------VQEMLRSLCSS--SNWVYAVFWKVLPRNypppkwdyggggvldrskgnrrNWILVWEDGYCDLYEchqRSVNGylNEEGtrrrsFGADVFFKLSHE-VYSYGE-G-LVGKVAADNSHKWVFRDTPKDnntlmtswnvsIDPQPRAWDSQfNSGIQTIAVISVKEGIVQLGSFHKIDEDLNMVISIQRKFSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIHVLSERRRRSGMNQLFSKLHSFLPDQTaKTDKISVVAETINYIHYLQQRLRTRSNKRAGGADTAaSSESheTDNILSNTDSSDYAILPEISVKSHADKDHFITIKCAKKGNLLPSIILVAEGQNLEVMDAFVSTNDTVAFHCLHLKA----------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFKILQSLVPGGTKMDTVSMLEEAIQYVKFLKTQI-WLHQ---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERIRALQELVPSVNKTDRAAMLDEIVDYVKFLRLQVKVISSS--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CRSKHSETEQRRRSKINERFQSLMDIIPQNdQKRDKASFLLEVIEYIHFLQEKVQMYEGS--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRSHCEAERRRRARINSHLDTLRSLVPGAMKllmpmnatvidnlnsqMDKASLLAEVVSHLKELKRSAAEASDGF-------FIPM--------------DFDEVIVEredgFEGAPySIRASLCCDFKPGLLSDLKQALNGLHLIIMRAEIATLGGRMKNVLVMTSRkEG--KVNHSEVRQALRSVLD-- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPRCNKTDKASMLDEAIEYLKALQLQVQMMSS---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQLQHTISERKRREKLNGSFVALKAVLPPGSKKDKTSILIRAREYVKSLESKLSELEEKN-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQLYHMMSERKRREKLNDSFHTLRSLLPPCSKKDKTTVLINAAKYLKSLETEITELEGTNT------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDQASIIGGAIEFIRELEQLIQCLESQKRRRlygdqPRPVRdasgsADPGgsgstppppiqShaappffvsPSlqfpmaNSGNgfVagdfmidlaACggglreevaeNKSCLADIEVRVLGFD-AMIKILSRRRPGQLIKTIAALEDMQMSILHTNITTIEQTVLYSFNVKITSDS-RFSAEDIACSVQQIF--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRREKIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQLHHMISERRRREKINETFEALRKLLPPDAKKDKASVLTRTREYLTSLNAQVEELRKRNQKLEAQvqqlPTKEVAEeGSESSNerIelrVAHVSESTSEEQRIIDLQ-VVLRGECPIQE-ILIRILEFLNQ------------------------------------------------ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKAEQQRRNKFKRSLESLKKIVPTITKKDKVAVIYSAIEYIRQLESRISSLKKELEEAAPGfLDMENSatlfargGVNVSGeqDlglhyienpAgPSSSPATTHVVVEGtEGGETLNLRVEANYHARSLPKLLNVLQDLDVVVVAMDYGCKNERFRATVRVKTSRNV-RRSNHELEQTLCRAL--- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERNRRERIADRMKALQELVPSVNKTDKASMLDEIIEYVKFLQLQVKILSMC--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAAARRRRERISERIRVLQKLVPGGSNMDTASMLDEAANYLKFLRTQINALKA---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKSNITEKKRRNKISERIRTLQTPVPNCNKelnlqhlqKHKASILGDAIEYIKFLQMQLQMVQS---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARQRRHRISDRFKMLKSLVPGGSKMDTVSMLEEAINYVKFLKAQIWLHQAAL-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRREKIADRMKALQELVPNSNKTDKASMLDEIIEYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESHIWSERERRKGMNRLFCILRSLLPEPsSKTDKSTVVGEIIKYISFLRLSIEELTKKKSDIlQRAARVSQSTSGDSGAIivNqrsqetlpSfqSvvFVSTPLVALHVCRDN-VFLNMTCSRRASLFVNILWAMRQHQLILLNATVSAHGSQIIYCIHSKAKDIN-HFARESLHSALLT----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRREKIAERMKNLQELVPNSNKTDKASMLDEIIEYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSTVSERNRRKKLNDKFFALREAVPKISKLRV---------------------------------------------------------TSMGEKTLFVSLTCSQAREATARICEVFESLKvMKIITASVTTVSGMVKTTILIEADG--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERKRREKINEKMKALKELIPRCNKSDKASMLDDVIDYVKSLQMQIQIMST---------------------------------------------------------------------------------------------------------------- -------------------------------ALQHKLTLLVDNSSlCSWTYAIFWQLSSADgQMILGWEDGYFSTTN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGNLIKERLRREQMSQNFFVLQSMLPSLPKnvkIAKEKIANEAVNYIKYLQGEASRLESKKAQFEEATMAEAVAmRRCGNS-SSKSSSPPLVRVFIPRTA-RFFAVECPNRPGTVTHILKVFENHEAEVLEARISVDDRRELLTFTS------------------------- -------------------------------ILRQLLRSLCHNSP--WNYAVFWKLEQCNRMLLTWEDGYCDFSRcgepaQsllKSvwiSemDgNvlfgNETssgNESSVGYpiqlavanMSCLL--YSMGE-G-VVGKVASTAKYCWVFSDSVsaginseLIPGYPDMWMQQFATIIQTILLMPIIpHGKDQFDSYETVMEDPMYRTHMKDMMNT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEKNRRNHMKNLYSKLNSLLPNNNNPKeeplsLPDQIDEAINYIKSLEEKVKMAKEKKESLLMGRKRSR-S-GACS--NSSETKPPQIEIHEMGSS-LEIVLTCGLDnQFIFYEIIRILHEENIEVKSANSSLLGNSMFHVVHAEIP---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINQRLRILQNLVPNGTKVDISTMLEEAVQYVKFLQLQIKLLSSD--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINAQLATLRKLIPKSDKMDKAALLGSVVEHVKDLKRKA--LEASKAVT-----VP-------T-----EVDEVTIDYFYLDqdkKN-IFIKasVCCDDRPELFSELTQALRSLNLTTVRADMASLGGRIK------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHNLSERRRRDRINEKMRALQALVPSCNKVDRASMLDEVIEYLKSLQMQVQAMSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRVLQSS--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERIRALQELVPSVNKTDRAAMLDEIVDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFLAQRRRSKINEKMKALQSLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHNLSERRRRDRINEKLKALQELLPHCTKTDKASMLDEAIEYLKSLQIQLQMMW----------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------LDHvTDTEMFFLASMYFSFPNGH-G-GPG-------LIWLN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPPSHARSEKARRDRINDNIETLKDLVPIQGNNDKASVLEQTAEYIKGLQAKMAELEAKCSAMGlspGEPVsggGENSagtNSggiagtgagaagvSVSpaaTaslsggSAgdlaalrerSPSedalaparavPSpqvsGSAEPVVTIDEgssPETLFIKVVCPDRRGVLHAILNVMKRLSLDVTRAVIATP----------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ---------------------------------KEALKTLCGV--NHWSYAVFWKTGSQNPNLLIWEDCYYKPTPcygrpwisgngiskipyRDHNacsassEtsNLqHGvpVGNRVHLLVNkMMadnHINVVGE-G-LVGRVAFTGNHQWILSENYYREthppEVLKDVCLQFSAGMQTVAVIPIlPHGVAQFGSYLPIAEDIGFVNGVMSLIAEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERKRRERIANRMKELQDLVPNANKTDRISMVDEIIDYVKFLQLQTKVFF----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIQEHVASERRRREKMHHQFATLASIIPDIAKTDKVSLLGSAIQYVHKLEEKLKALKE---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRRERIAERMKSLQELVPNTNKTDKASMLDEIIEYVRFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGALKEKFQLLRSI-TNSHAENETSIIMDASKYIQKLKQKVERFNEDTTAEQ----------SSSE---PTDPTTPMVTVETLEKG-FMINVFSGkNQPGMLVSVLEAFEDIGLNVLEARVSCTDSFSLHATGGENEDGE-SMDAEAVKQAVTDA---- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRMTHIAVERNRRKQMNEHLRVLRSLMPGsyVQRGDQASIIGGSIEFGRELEQLLQCLVSQKRRRlygdnPSNSNpaTRQIgggvmGDATtvtglvqqqqqhpmmfppPNclsNVagdhqTgfdAavdqeeeiaeNKSCLADVEVKVLGFD-AMIKILSRRRPGQLIRTIAALEDLKLVIMHTNITTIEQSVLYSFNVKFP---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFPTERERRVHFNDRFFDLKNLIPNPTKIDRASIVGEAIYYIKELLRTIEDLKMLVE------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLQAS--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASILERATSLIRQLRERPETVLqCHLETKTNN---EK---G-APAVKKARISLPEVEVRSLEEE-VLITVYCKKKyTGIIDEILSVIQKLHLTIKSSNFMPFGSTAMHiTVIGQMNDELCETtdcLAEKLRQSILK----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSHHVISERKRREKLNEQFNALKALLPLEPkiKKDKATLLVNTKNYLNLLKAQIKELEERN-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSHSEAERRRRERINAHLATLRTMVPCTDKMDKAALLAEVVGHVKKLKSA---------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNRSERRRRERINEKLKILRDLIPHTDKTDKATLLEEAIEYLKALQAQIMVMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINAQLATLRKLIPKSDKMDKAALLGNVVYHVKDLKRKAMDVSKSITVP---SEIDEV--TIIE--CDPDQDESYAKVKILKHN-IVISVCCDDRPELFSELIQVLKGLRLINQDHNI-------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRILGD---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNQSERRRRDKINQKMKTLQKLVPNANKTDKASMLDEVIDYLKQLQAQVHMIS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRIKEKMRALQELIPHCNKTDKASILDETIEYLKSLQMQVQV------------------------------------------------------------------------------------------------------------------- --------------------------------LHQILRSLCLN--TEWKYAMFWKLKHRARMVLTLEDAYYDNHNqHDLSenncfrDsleNLHGghysHDPLGLVVAKMSyQVYSLGE-G-IVGQEAVSGKHQWIFVDKHVNS-SCSSLELSDgwqsqfEAGIRTIVVVAgVPQGVVQLGSLNKVFEDVKLVSHIRDVFFS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMMSERRDQKaaALQEKLQILRSIT-HSHALSNASIIMDASKYIKELKQKVVRLNQEIACAQDT--R-------------RHNSYPTVTVETLHHG-FLINVFSDKsCPGLLVSVLEAFDELGLSVLQATASCADSFRL------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAHNQSERRHRDRINGKMKALQKLVPNASKTDKASMLEEVIKYLKQLQAHVQLITS---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQKSS----------------------------------------------------------------------------------------------------------------- ---------------------------------PQQVEAEFEKAQKRWTYAIYWELDRPSnsplGGTFSPGKSFNNGNI-AYSffDLIDSgPDTI----------F---Q-S-VIDQVFSTSKPICLVEKDLLASSPYYRGREGLDYGLQTMYWIRIADGVMEFGSTELIH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRSKHSETEQRRRSKINERFQILRDLIPQNdQKRDKASFLLEVIEYIQFLQEKLQMYEGS--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IHNLSERRRRDRINAKMKALQELIPRCNKSDKASTLDEAIEYMKSLQLQVQ-------------------------------------------------------------------------------------------------------------------- -------------------------------ALHEALRNVCLN--SDWTYSVFWTIRPRPrvrggngckvgddngSLMLMWEDGFCRGRVAECLEEIDGEDPvrKAFSKMS-IQLYNYGE-G-LMGKVASDKCHKWVFKEPSeCepnISNYWQSSFDALppewtdqfESGIQTIAVIQAGHGLLQLGSCKIIPEDLHFVLRMRHTFESL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARKRREKISEKIRVLQRLVPGGSKMDTASMLDEAASYLKFLRAQIKALEG---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRSHSEAERRRRQRINGHLATLRSLLPAATRLDKAALLGEVVRQVRELRVRVEEVAV---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRPTPRVHSLSERKRRHKINKKMRELQALLPNSDKVDKASVLDNAIEYLKTLQLQVQIMS----------------------------------------------------------------------------------------------------------------- ---------------------------------------------YDWTYSVFWTIRPRPrcrggsackvgedngSLMLMWEDGYCHVDQRPVtgqSannmhimapnngihgsstmscNDqllnvdqrlnhGADvEDPVWKAFRKMSiQLYNYGE-G-LMGKVASDKCHKWVFKESpECeagISSYWQSSFDAHppewvdqfAAGIQTIAVIQAGQGLLQLGSCKVIAEDLHFVLRMRHAFES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNHNASERDRRKKINSLYSSLRSLLPASDHTKKLSIpstVSRVLKYIPELQEEVEGLIQKKEELLSRisGREdlitHQEKKKKS----KAWSSLFSVSASQLNDKEVVIQISTFKiNKNPLSEILSNLEEDGLVLLNASSFeSFEGRVFYNLHLQVERSM-RLECEMLSEKLLS----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIHIWTERERRKKMNGMFSTLHSLLPHLNsKADKSTIVDEAINYIQTLEGTMKGLMKRKGEMSNASstmmptslALLQAsqhgmaeTDSvckVSPTisfggeIkpsgsgSStptSEAqfrTqlSKNVVLNMCGND-AFITICSPRgRLGLLCRVLFVIESHNLHVLNAHICTTNDTIMYMVHAQTTE--------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHSQAEKRRRDRINAQLATLRKLIPKSDKMDKAALLGSVVDHVKDLKRKAMDVS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIADRMKALQEMVPNANKTDKASTLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNLSEKRRRSKINEKLKALQNLILNSNKIDKASLLDEAIEYLKQLXLQVQCWXSF--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQAEHIIRERQRRDDMAAKYQILESLLPPAAKRERAVVVEDAISLVKDLQQKKEELLKRRAHLklmalhqSgespryrrsKKTcPFHDsAgvltasckKISPncdtdspiSSSImvpqnmikpsSVttndaTmStisvQHLLQIHVHFSEEE-IVIEMVCHRyPPNFQSRLLQAVESFGLDVTRCSIQRLPH--------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLVPNANKTDKASMLDEVIEYLKHLQLQVRILSM---------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNLSEkVRRRSRINEKMRALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQ-------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTYDHIVAERKRREQLSQRFVALSALVPGLKKV----------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPRCNKTDKASMLDEAIEYLKSLQLQVQMMSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLKILQNLVPNGTKVDISTMLEEAVQYVKFLQLQIKLLSS---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDQASIIGGVIEFIKELQQVLQALESKKRRKSLSPSPSPSpppplplfHQpnhSPIgfEDVkelGAcCNSSVADVEAKISGSN-VILRTISHRIPGQIVRIITVLEKLSFEVLHLNISSMEDTVLYSFVIKIGLQC-QLSVEELA---------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRELHIITERERRRRMSEMFTKLHGLLPTLpDKVDKSSIVMEAIHYIKSLEGTVSELEKQKLERDfaAGGKLAAAaNGGVSSSVaaampmgmATPTWSGPNVVLSLSGNY-AYIHMSVARRPGVLTMVTAVLEKHGIDVVTTGISSDR---------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQVHNLNERLRRQKLKEKMKTLQELIPNCNKRDKASTLDDAIKYIKTLQYHVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRNHREAEKRRRERIKSHLDRLRTVLACDPKIDKASLLAKAVERVRDLKQRTAGIGEAAP---AHL-FPT--------------EHDEIVVLPSGGgagaaSVFEASVCCDDRSDLLPELIETLRSLRLRTLRAEMATLGGRVRNVLV-------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRIKEKMRALQELIPHCNKTDKASILDETIEYLKSLQMQFQIM------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIHNESERKRRDRINQKMQTLQKLVPNSSKTDKASMLDEVIDHLKQLQATVQMMNR---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSKHSATEQRRRCKINDRFQILRDLIPQCDqKRDKASFLLEVIEYVKFLQEKVQKYET---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRESgHELHIRTERERRKRMRNMFEELQTLLPHLQpKADKSSIVDETVRYIKMLENTVDNLKEQKlERIqlgiarlStvnnpimtpQKLRvgtsLEQFlaDKGSaSNSaaitpknnnnVtgipllNTNvptdfeTWSSDNVVLNVCGEE-AHISVCCPKKPGLFTFICHVLEKNKIDIVHAHVSSD----------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAIDHMYEERRRRKRQRECLGELRKLVPNIRKRDKVTVLEHTIMFIEELQCKADELAR---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IQLLHVRSERKRREKINDSFEALKNALpPSCCKRDKTSILMRARDYINSLKSRVSELEEN--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNLAERRRREKINERMKTLQQLIPRCNKSTKVSMLEDVIEYVKSLEMQINQFMPH--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMRHINNERQRRILMNNLLDSLQSLLPDAHpRKDRCTLLTDVIEHVQSLEREIRQLEARTAQMKRLKvTVRSSaspTSnqmlpgmSsEGPtvpLcVrnwhvefMTPkhrlfNNSSTNMTVSSGdDLEEFIITFASPSTRGLLPHVLQLLQQNEIDVIDATLSTTGDDqFLWYIHAKVPKG--KLTSDQIKSLFSN----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHILSERQRRKSMRESFSILQSLVPKLKlkHTDRITVLTEVITYIQSLRGALDELERKKADMmeflglSGKHrsrRQEDDLQAtvtyidPGNNlddkVdNSGvwsvlkDGelvAMVEVHVRMCGPD-VFLTLNAPQRRGVWSGVLSLLQKFSIEVSNATLASSGNSSFHCIHAKAMDVStlkGVNLQEELERVIVKELG-- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSIKVTDKASILGEAINYVKQLQECVKELEKQNNDNKRGPTepvifLNKTqllcryNEDSSSEeeeeVeEDwrSkeeKQVLLDVEARMLEKEkEVLIEIHCEKENEIEVKILEQLEDIGV--------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSEKRRRSRINEKLKALQNLIPNSNKTDKASMLDEAIEYLKQLHLKVQMLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLRILQNLVPNGTKVDISTMLEEAVQYVKFLQLQIKLLSS---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ICGNHVLSERKRREKLNQRFMILKTLEPSNKLlieffcvfgglwfdihvtecvehnclssvallnslaffmnADKVSILDDTVKYL---ERRVEELVT---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARMRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKTQVQSLERAA-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERKRRDRINERMKALQELIPHCNRTDKASILDEAIDYLKSLQMQLQVM------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTNITEKRRRNKISERIRTLQTLVPNCNKRHKASILGDAIEYIKFLQMQLQMVQS---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSS---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QATDSHSLAERARREKIKKKMQFLQDLVPGCNKItNKAAILDEIITYVQCLQMEVEVLTMKLAA------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERKRRDRINERMKALQELIPRCNKSDKASMLDEAIEYMKSLQLQIQVIS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVVEVRLREGRAVNIHMFCARKPGLLLSTMRALDNLGLDIQQAVISCFNGFALDVFRAEQcREGQ-DVLPEQIKAVLLDSA--- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQVMW----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISQKIRILQRLVPGGTKMDTASMLDEAVHYVKFLKRQVQTLEQA--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRSKHSVTEQRRRSKINERFQILRDLIPHSDqKRDTASFLLEVIEYVQYLQEKVQKYEGS--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EREEPVDD--TE-RRREKINEKMKALQELIPRCNKTDKASMLEDAIQYVKSLQMQIQRRREKI-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKHSATEQRRRSKINDRFQMLRELIPHSDqKRDKASFLLEVIEYIQFLQEKVQKYEGS--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHIAVDRN-RKQLNKKLRILKSLMSGsyVQRGDQASIIGGAIEFARELEQLLQCLESQKRGGLRE---E-TA--------ENKSCLADVEVKLLEFE-AMIKKLSRRRPGQLIKTIVTLEDLHLSIPHTCMTTMEQTVLYSFIVKAS---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HETHIWTERERRKKMKNMFTDLHALLPHLpSKVDKATIIEEAVKYIKSKESELQKLEKRKEERLQlqqiqsaSTTLEsptsqwlqypydHNNNNnnnningnnfvsAANtendinNIigtsSNNnNnnnvnyNnslavgfhtwSSPNVVLNTFGEM-AQFCVCYPKNLRLYTTIAYVLQKYKIEVLSAHISSDHNRRFYMIQAQIN---------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQQMLSM--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERVRREKISERMKYLQDLVPGCNKItGKAGMLDEIINYVQSLQRQVEFLSMKLA------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGGMRINEKMRALQELIPHCNKTDKASILDEAIEYLKSLQMQVQIM------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARRRRHRISRRFKALRAIVPGGTKMDTASMLDEAIEYIKFLRNQIWMLK----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFRVLRSLVPGGSKMDTVSMLEQAIHYVKFLKAQVSLHQAA--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSKNLVAERKRRKKLNDRLYTLRSIVPKITKA----------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISQKIRTLQRLVPGGTKMDTASMLDEAIHYVKFLKTQVHSLEL---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISERFKILRSLIPGGDtrNMDTVSMLEEAIQYVKFLKSQIWLHQT---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKNHSEAERRRRERINGHLATLRGLVPSTEKMDKATLLAEVIKQVKELKKSAVEAS-------KGFVIP--------------MDADEVKVEPCDGSmSYSATICCDFRPEIISDLRQTLDSLPLHLEKAEISTLAGRMKNVFVF------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARLRRERVSDRLRVLQKLVPGGSKMDTASMLDEAASYLKFLKSQVQALETL--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSIAERIRREKISARMKTLQDLVPGCDKvIGKASMLDEIINYVQSLQNQVEELT----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMKALQELIPRCNKADKASMLDEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPSCNKTDRAAMLDEIVDYVKFLRLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEKNRRNQMKNLYSQLNSLLPNHNSKEALPLpdqIDEAINYIKSLETKLEKSKEKKESLMGRKR-SYSCTTNSE--PSSSLKSPQIEIHEMGSN-LEVVLITGLDNqFIFYEIIRILHEEGVEVVNANFSVVGNSVFHVVHAKIG---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARQRRHRISERFKILQSLVPGGSKMDTVSMLEEAIHYVKFLKTQIWLHQ----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQLQVQIMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQLQVQIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHNLSERRRRDRINEKMKALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQMM------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TATSHMYTERRRRKRQRECFTKLRTLVPNIRKKDKVtTVVEHAITFIKELQNKVDKLETLI-------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlGDTELYYLVCMTYAFCPGQ-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGPDIDIQALRDE-VIVRVSCPLDVHPISRVIHAFKEAQITVVESKISTRNDTVFHT---------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGTKMDTASMLDEAIRYVKFLKRQIRLLQSS--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQRLVPGGSKMDTASMLDEAASYLKFLQSQVKALESF--------------------------------------------------------------------------------------------------------------- --------------------------------SQESLANVVRSS--GGEYGIFWQHVPTR----------------------NElKPISWYAHdnecmrRSSTFAFAPGA-G-HVGRAWLSQEPGLIADVHAPESEAFERRLLAVHYGIRSIAFVPSCGSVFEIGTQHI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIAARQRRERISEKIRILQRLVPGGTKMDTASMLDEAVHYMKFLKKQVQSLERA--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEVHIWTERERRKKMRSMFVTLHSMLPKVpSKADKSTIVDEAINYIKSLEQKMQRLLKKKSEKVK-SAVqqsEASgdgDKAknkmVSDSeIlvtqrgSNsSfrTLSSSNVVFNLCGAD-AFITICASARPNLLSRIFSCvIQMLRMDVRNVQITDTSDN-------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHTISERRRRDRIKEKMGELQALIPNCNKSDKVSILDHAIGYLKALKNQIEMMSK---------------------------------------------------------------------------------------------------------------- -------------------------------NLQQGLRHVVEGS--DWDYALFWQASNVNstdGCVLIWGDGHCRVKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTQCMPHTEVERKYREKLNAELERLRRAVPMLPQSDaadmgaakpsKSMVLAVAIDYIKELERQRDAAVEEVERL----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRMSKESTLTDAIDYIKQLQKQVYDLRLELSKIPDEEGEKQGSASSTETMAPTlNiQCQRTVELSPIGQKKYHLVIISENKHVGFTKLLEAISNFGAEVTNINSTTFSGFSHSVFSIDVKDNGEMLMTE-LRKLLLAIV--- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARHRREKISQKLRILQRLVPGGTKMDTASMLDEAVHYVKFLKKQLKSLGQAV-------------------------------------------------------------------------------------------------------------- --------------------------------LQHSLRGLCIHESSLWVYAVFWRIIPRsypQpnwdfqggtydklkgfnkYWMLAWEDGFCNFVAsKdeKNSkegsstDNncstqqFNGLQPELFFKMSHEF-YNYGE-G-LIGKVAADQGHKWVYNEDSDQETMFsawhlledthPRTWAAQfQSGIKTIALIAVEEGVLQLGAAQKVTKDISYVLELQKKFS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKHLGQLFSSMKQLKEKVKELEVAAAQHnTAKSmvMVKKYklPMNNDDNGNDDDNGFSQIPAFVCDKE-VVLKVHCE----LLIKLIAVVVRHDLSITNCGVIPFENLTLdITIVAQMEEGFKNNVKG------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKTLQLQVQVW------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERQRRERIAERMKELQGLVPNANKTDKAIMLDEIIEYVKFLQLQSKIFSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRTLVSERRRRGGMKEKLYALRAL------MDKASIVGDAVPYVQNLQMQAKKLKSEIA------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARLRREKISERIRILQHLVPGGTKMDTASMLDEAINYVKFLKSQIQSLER---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKSLQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSSD--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKVLQDLVPGCNKvIGKASVLDEIINYIQSLQCQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEKNRRIHMKALYSKLDSLLPNSKSSEGValplpDRLDEAVNYIKGMQERLERMKERKRQLMGSM-------GTSE--QATNSRKPHIEVQDLGSG-LRViLISSSCDWSVFCEVVRVLEEEGGEILNANFTVVGDKAFHIIHSLVGEDNSgEAdkVLERLKKAIRAI---- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAMMEQREKSQLQEKFLALLHTDSSTSKDHKAKILDDTIRYLKELRKRLNVNEADSTHKNTQasPATsSRGrkyGDGLASPinledleletagveISPhlNVDNGPQIEVRMMENQHVMVKLTAKDRPGLFNDIMVVLRSLKLDIQHANIRTRNNGQRHDIFAaKMQ---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAHIAVERNRRKQMNENLAVLRSLMPCfyVKRGDQASIIGGVVDYIKELQQVLHSLEAKKQRKvytdqvlSpRppatvaasccspRppplsPRlppqlLKSTpplsprlavpiSprTpptpgspyrllrlppppppaSGSNyaSpaMtpthhetaapsldaiaaelSAyaSrqalGGglLLPDVKVEFAGAN-LVLKTVSQRSPGQAVKIIAALEGRSLEILHAKISTVDDTAVNSFTVKIC---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQFHNLSEKDRRSKINEKMKALQKLIPNSNKTDKASMFDETIEYLKQLQLQFSTLG----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKMSHVTVERNRRKQMNEHLTVLRSLMPCfyVKRGDQASIIGGVVEYISELQQVLQSLEA---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMHNISERKRREKINEKMKALQELIPRCNKSTKASMLDDAIDYVKSLQMQIQMMP----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARQRRERIGERIRILQQLVPGGTKMDTASMLDEAICYLKFLKAQVRKMETT--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEQRRRDKINDKMRTLQQLTPRCSKTDKASTLEEVIQYVKSLQHQIQVMSA---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSHRQAEKRRRDRISAQLATLRKLVPKSDKMDKAALLGSVIDHVKELKRKAVEVSEAfIVPTEvDEVTIDCDpAHGvTSTTTSN---------SNINRGN-FLItaSVCCDDRPDLFSELIQILKGLKLTALRAEMASVGGRIK------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALSHSEAERRRRERINAHLESLRGLVPSNEKMDKATLLAEVVSQIKQLRATASQ------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRSHSEAERKRRQRINAHLATLRSLLPSASQMDKAALLGEVVRYVRELRGDADAGTV--A----GVAV--------------PGESDEVGVeeerwddRENAKR-VRAWVCCADRPGLMSELGRAVRSVSARAVRAEIATVGGRTR------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQVEHVLRERQRRDDMSCKIAILEGLLPPCPKRDRASIVHDSVQYVKSLQQGVEELQKKLVALKRSNgspatTITTtittTqisslpqlAKATSpsSSpardsTSpaidAGvedtEtvpPklfHLVEFHVQLEGCSEAAKLTRCKCRSDYLSSTMRVLEQLNVEVSRCSVTKMFDHFMCVIVAKMS---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKViGKALVLDEIINYIQSLQRQV--------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISERIRILQCLVPGGTKMDTASMLDEAIRYVKFLKRQVQQLQPT--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQVHNISERRRRDKIKGKMTALQELIPHCRKKDRASILEDAVNYVKALQLQLEMM------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARQRRHRISDRFKILQSLVPGGSKLDTVSLLEEAIQYVKFLKAQIWLHQA---------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REAAKS-NITEKKRRNKISERIRTLQTPVPNCNKKHKASILGDAIEYIKFLQMQLQW------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLEEAIEYLKTLQLQVQMMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRRERIAERMKALQELVPNANKTDKASMLDEIIDYVKFLQLQVKVLS----------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LYQRLSAKH-NVPW-WKGDQASVIGGVIEFIKELQQVLQALESKKQRKSLSPNPspstPRplplpakPNHSPIGleTVgdvGAcCNSSLADVEARIAGSN-VVLKIVCGRIPGQILKIIAVLEKFSFEVLHVNISSMEDTVLYSFIIKV----------------------- -------------------------------ALHEALRSVCLN--SDWTYSVFWTIRPRPrvrggngckvgddngSLMLMWEDGFCRGRVTDCLEEIdgEDLVRKAFSKMSI-QLYNYGE-G-LMGKVASDKCHKWVFKEPTeCEpnvSNYWQSSFDALppewtdqfESGIQTIAVIQAGHGLLQLGSCKIIPEDLHFVLRMRHTFESL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------LHEALRNVCVN--SEWTYSVFWTIRPRPrsrggsgngckvgeengSLMLMWEDGYCRSSKpRVnrVpGpfngngcmDklvksssfDcleeLDADDPvrKTFRKMS-IQLYNYGE-G-LMGKVASDKCHKWVFKEPtECEtgiSNYWQSSFDAHppewtdqfASGIQTIAVIQAGHGLLQLGSCKIIPEDLHFVLRMRHTFESL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRREKISEKIRILQRLVPGGTKMDTASMLDEAVHYVKFLKKQLKLLEQA--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRREKISEKIRILQRLVPGGTKMDTASMLDEAVHYVKFLKKQLKSLEQA--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKPHIVAERKRRSRLRDYFGELQALIPQIPeKSDKGTIVGHAIDYIQSLEKTKAMLEKR--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRREKIAERMKNLQELVPNASKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINERMKALQELIPRCNKSDKASMLDEAIEYLKSLQLQVQMMSTG--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSHSEAERRRRKRINGHLATLRNLLPKTIKADKASLLAEVVRCIRELKKTTDELSA---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------MVCIPFANGVVELGSTELIMQSLGLMNKVRALA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQVSHMISERRRREKLNGSFDQLRSLLPPGSKKDRATVLMKTKDYLKTLKDQISELQLEN-------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRDRINEKMRTLQELIPNSNKTDKASMLDEAIEYLKMLQVQLQMMSMR--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVAARQRRHRISDRFKILQSMVPGGTKMDTASMLDEAINYVKFLKAVIWFHEN---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKNIMAERERRNKFNKTLYDLRSV------MSKTAIILDAINYIQELQEQE--------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKGDQASIIGGVVDYIKELQQVLQSLEAKKQRKvysevlSpRplsspRPsplsprppplspRMalpiSpRTPQPGSpymprkqqNyvsptlapShessspffcsISelaaNSKSAVADVEVKFSGPN-VILKTASHRIPGQVLKIIAALEGLALEILHVSISTTDDTMLNSFTIKVM---------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKTVEKNRRMHMKDLCSKLASLIPKEHftssKdtLTQLDSLDQATSYIKQLKERVEELKQRKESAlLNG-GTST-SSSTSSGDgSegSSGFELPVVEVRDQDST-LEVNLISGlNKPFMLHEVISVLEEEGAEVVNANFSVVGDKIFYTIHSQAI---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINEKMKALQELIPRCNKTDKASMLDEAIGYMKSLQLQVQMMW----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAMSHVEAERSRRDKLNRRFCDLRAAVPTMSKTDRASLLADAT------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKQLQQRIQKLQEQKNDNRKVeSmiQVKRSkifiDNNPHD-QNNFRQTLPEIEVRVSQND-VLIRIQCDKQSGSMINILNQIENLQMIVQNSNFLPFGNNMLDiTIVAQMN---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIHNQSERKRRDRINQRMKTLQKLVPNSSKTDKASMLDEVIEYLKQLQAQVQMMSR---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKSSILADAYEYIEKLQRQVEELNYELDMESylgDDlchceddcSCCEHNlSPSStertaeSNAgleSSSGsdcGCSQPTVEIVRTEEG-LKIHIECDKRPGLLVEIMELLESRGLNVEQASIACVDQLVFDGISSEIEGNdaedsRhmTHVNAEDVEASLRSLIA-- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHMNKASIIVDASKYIQELKEKVEYLNQDIGTSE-------------------SRLPAQVMVKTLEKG-FLINVFSDtNCPGLLVSILEAFEELGLDVLDARVSCSDTFQLEAV-GEDNHGHaDSIDAQVVKQAVLQAI--- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARLRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLKTQVQSLEQAAA------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVERNRRIHMKGLCFKLASLIPPHHfKPskEMLSqqdQLDQAASYIKQLRERIEKLKRRKEQaMTS--SIGT-SSSMGSNSMMIGSRLPVVELRDLGSS-LEViLISGLNKNFMLYEVISILEEEGAEVVSASFSTVGDKVFHTIHAQVK---------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARKRRERISEKIRILQRLVPGGTKMDTASMLDEAIGYVKFLKSQIRKLQK---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAVHNQSERKRRDKINQKMKALQKLLPNSSKTDKASMLDEVIEYLKVLQAQIQMMNR---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILKRLVPGGTKMDTASMLDEAIRYVKFLKRQILELQRSN-------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNLTEKRRRCKINERFKTLQQLVPGCDKSNQASTLDQTIQYMKSLQQQVQAMS----------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------PEDlTETEWFYLMSASYSFPPGV-G-LKGTTLCNvayqepASHVNLPGPRKVVQSVsHGEAPSGqgiIDHGHNIIWLGPKkPRGVPKLGGPAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLEEAIEYLKQLQLQVQASS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERIRALQDLVPSVNKTDRAAMLDEIMDYVKFLRLQVKVLD----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADKRRRETLK-QFIVLSTLLPSITKTDKISIIEEAVKHIRQLKEEIDKLKQY--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRNRINEKMRALQELIPNCNKVDKASMLEEAIEYLKTLQMQVQIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TALHNLSERRRRDKINKKMRALQALIPNCNKVKKASILDEAIAYMRTLQLQLQMMS----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYATLLRRERIAERMKALQELVPSANKTDKASMLDEIIDYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLRILQNLVPNGTKVDISTMLEEAVQYVKFLQLQIKLLSS---------------------------------------------------------------------------------------------------------------- -------------------------------SLRSFLQSLCCNSP--WNYAAFWKLKYQPEMVLTWEDSFCDIAKqRDAfVpiedfyfdslDDvlcsnfnsrhLDGslvecpiglAVAE---MSSASHVF--GK-G-VVGVAAFTGVPRWVYSNNIAadvfDSvfaDEYpDEWLLQFVAGIETILLLPViPHGVLQLGSLETVAEDALLVSLIRQHFDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRRERIAERMKGLQELVPNANKFDKASMLDEIIDYVKFLQLQVK-------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERKRRDRINEKMRVLQELIPRCNKADKASMLDEAIEYLKSLQLQVQMMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNESEKKRRNKINVRLKALQSLIPNSNKTDKASVLDEAIEYTKMLQAQVQFMSMK--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERRRRNRINDKMNALRELIPNASKTNKAALLDEAIKYLKNLQLQLQVMSV---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSQRRRRNKINEKMRALQELIPNCNKTDKASILDEAIVYLKTLQLQVQIMS----------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFKILQSMVPGGAKMDTVSMLDEAIRYVKFLKAQIWFHQ----------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKV----------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQGREkNRSKHSETEQRRRSKINERFQMLRDLIPKNdQKRDKASFLLEVIEYIQFLQEKVNLYEG---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKASILGDAIEYVKELQKQVRDLQDELEKN----------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATDNHSLAERARREKISERMKILQDLVPGCNKvIGKASALDEIINYIQSLQSQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEKNRRNKMKYLYSMLNSLVPrNYNNQDpKEakSlpdQIDEAAKYIKRLEARVNEAQEKRNTLaGRKRLHSSTAPDSSASKSAvQTFKSPKMDIQVHWPA-LEVTIISEMCnHFIFYDAVRVIREERAEVINVNFSVVGSSVYHLIRAEIGEG-------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKvIGKALVLDEIINYIQSLQQQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSHSFSERRRRDRINEKIRALRRLIPNCSKVDKATTLNEAIEYLRALQMQLQLAEEK--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPLNHFLTWKKKLEDLNEKYQTLRSLVANPTKADRVSILSDVINMIHDLKKEEESLLDEKQKRqhRRQLRLEMrANgkrqrtmESETGvkevqslSMealCNRkvSKNGTEIEVRIVCDE-VDIHISQKHMPRFLIRVITAIEGgLKLEILDCCGGVIHNCDVYRFRLKIQ---------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINERMKALQELIPHCSKTDKASILDEAIDYLKTLQMQLQVM------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRRRDRINEKMRALQELIPNCNKVDKASMLDEAIEYLKSLQLQVQIMS----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVHNLSEKqRRRSRINQKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR--------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQPSKNLMAERRRRKRLNDQLSMLRAIVPKISKVCT--------------------MHL---------RWR----G----------------VWTPGWK-FVV------------QGVNTREALGLEIQQCVISCFNDFTMQSSCSEESEQRTMLSSKDIKQALFRS---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERKRRDRINERMKALQELIPRCNKSDKASMLDEAIEYMKSLQLQIQMMSM---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARLRRERISDRIRVLRRLVPGGSKMDTASMLDEAILYVKFLKKLVGELQSST-------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAVVQPERRLRSRLHEQFALLRAAVPNLRTDERASILTGAYEYIERLKRQEEELLCELGVESscDEEdlsccedEVscsscrgaeERAveSRpgdcSKFNSLScgSdcGcSSQPTSVEVVRTEAG-FRIHIECGMRPGLLLAIMELLESSGLSVEEATVECEERLVFNGIGL------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AESHNLSEKRRRNRINEKLKTLQELIPNSSKTDKASILDEALEYLKTLQSQLQIMIM---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARLRRERISERIRVLQRMVPGGTKMDTASMLDEAVRYVKFLQTQVQSLERA--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSHSEAERRRRERINAHLDTLRTLLPYREKMDKATLLGEVVRQVKELKKAATEASK-------GFLVP--------------VDDDEVIVETCNDEangtyCFKASICCDYRPQLLTDLRQALDALPIKMVKAEISTLGSRLRKDFVF------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNLSEKRRRSKINEKLKALQNLIPNSNKTDKASMFDEAIEYLKXLQLQVQCWXSF--------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKRRDRINQKMKTLQKLVPNSSKTDKASMLDEVIDYLKQLQAQVQVMSR---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHNFSERRRRDKINEKLKALQELLPNCTKnmqlvqTDKVSMLDEAIDYLKSLQLQLQMLV----------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERKRRDTINEKMRTLQELIPNCNKVDKASMLDEAIEYLKTLQLQLEIMS----------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQVHNLSERRRRDRINEKMRALQELIPHCNKTDKVSMLDEAIEYLKSLQLQVQ-------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSEKRRRSKINEKMKALQSLIPNSNKvirrkkatfnfnvhelgfcwvcagnlsvfvcwfcglqTDKASMLDEAIEYLKQLQLQVQ-------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDPHSIAERLRREKISERMKNLQQLVPNSNKTDKASMLDEIIEYVKFLQVQLKVLSM---------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNSNKTDKASMLDEIIEYVKFLQLQVKVLSM---------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSS---------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARERRHRISDRFRVLRSLVPGGSKMDTVSMLEQAIHYVKFLKAQVSLHQAA--------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARHRRERISEKIRILQRLVPGGVKMDTASMLDEAIRYVKFLKRQIRQLQSG--------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKLDEQLDDLRAVLPNSATKSKerTSVVLDAYQYIATLQRQVEDLSAELLEEAvlSPAQTqDEEcEQRDTLSSYSSVRQQPLVEVVRRDGL-LEVWIVCANRPGLLVDVMEAVESRGFAVTQARIACHNDIVVEYLSLE------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSHSDAERRRRERINSHLSTLRGLLPTTVKMDKAAVLAEVIKRMKQLKRAAAKEVSETC---TALNIPSCtDEVQVE--NYGDDDEEEEEEEEEKKNVvkMKASISCDDRPEIFSDLRRIFETLRLRMVSSEISTMGTRLK------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEVHSLSERRRRDKINKRMRILKDLIPNCKKVDKASMLDEAIEYLKTLQLQLQR------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSSD--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRIKEKMCVLQELIPHCNKTDKASILDETIEYLKSLQMQVQRLVPQVQ------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQWLACNI-------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVERQRRQQMSILCASLRSSLPFEMIKGKRSVsdhIGEAVNYIQYLKQKINELSVKRDKLKEMSNssmLETGNER-----SSDSSNlVKCVNVNPIPGG-VEI-VICSGFEegsSLLSEVLEILLEEGCDVVHCVSTKVNGRLFHTIKSEVED--------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPHSIAERLRRERIAERMKALQELVPNSNKTDKASMLDEIIEYVKFLQLQVK-------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHSLAERARREKISERMKILQDLVPGCNKvIGKALVLDEIINYIQSLQRQVEFLSMKLEA------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PASLLADAAAYIAELRARVARLESDARQAAA-ARFEPSscGGGGNASYhggGggGGaaPGLDEAVEVRKMGRDAAAVRVTTTGARHAPARLMGALRSLELPVQHACVMRVHGAtTVQEVLVDVPAA--LQDGDALRAALLQRLQD- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVERNRRNKMKNLYSQLNSLLPSHNPKegiPVRAQIGEAIKYIKSLETKVKMSKEKKERLLeKKRTLSGC---SSNAsEAKGSQNPPKIEVHETGSA-IQVILTCGVdKNFIFCEILRILCELNVEVVSINSTMVGDSVMHAVHCEVG---------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNSHSLAERVRREKISERMKFLQDLVPGCNKVtGKAVMLDEIINYVQSLQQQVEKX------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHNLSERKRRDRINEKMRVLQELIPRCNKADKVSMLDEAIEYLKSLQLQVQMMST---------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAARQRRERISERIRVLQGLVPGGSKMDTASMLDEAASYLKFLRSQVKALEEL--------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVHNLSERRRRDRINERMRALQELIPHSNKSDKASMLDEAIEYMKSLQWQLQLLW----------------------------------------------------------------------------------------------------------------- MDDLLTLSSSSYPNSPHPFSSPSQPAVVPVSITQRRLESFLSARPEHWSFAIMWSPTPSDPQLLSWAAGQLSTTSHSVPDALDDTLVDWLYATSLTRSFQLTDSSSIIARSLATPAPIWLSGTVKLNSAGCDRAREAQMHGIKTLVCIPIAGGVVELASTNLLQEDSMLLQQVQATFAETPVAACGSVGSAESDPQQQMRRPRKGTDSAVSTDHVSAERQRREKLNHRFYALRSVVPHVSKMDKASLLADAVSYIKELRARVNELESRTRAPKQKRAGAACGFHASRNKQLRGLADCSVQVRMLGEDNVLIKVQSENAESAPARVMWALRELEVGVHHATMSSLKDMMVVDVMGTIPAGSGLETRERMRAALFSKIADE